LOCUS       NM_005872               1275 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens BCAS2 pre-mRNA processing factor (BCAS2), mRNA.
ACCESSION   NM_005872
VERSION     NM_005872.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1275)
  AUTHORS   Yao,X., Wang,C., Sun,L., Yan,L., Chen,X., Lv,Z., Xie,X., Tian,S.,
            Liu,W., Li,L., Zhang,H. and Liu,J.
  TITLE     BCAS2 regulates granulosa cell survival by participating in mRNA
            alternative splicing
  JOURNAL   J Ovarian Res 16 (1), 104 (2023)
   PUBMED   37248466
  REMARK    GeneRIF: BCAS2 regulates granulosa cell survival by participating
            in mRNA alternative splicing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1275)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1275)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1275)
  AUTHORS   Wang,L.P., Chen,T.Y., Kang,C.K., Huang,H.P. and Chen,S.L.
  TITLE     BCAS2, a protein enriched in advanced prostate cancer, interacts
            with NBS1 to enhance DNA double-strand break repair
  JOURNAL   Br J Cancer 123 (12), 1796-1807 (2020)
   PUBMED   32963349
  REMARK    GeneRIF: BCAS2, a protein enriched in advanced prostate cancer,
            interacts with NBS1 to enhance DNA double-strand break repair.
REFERENCE   5  (bases 1 to 1275)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1275)
  AUTHORS   Lee,S., Ha,S., Chung,M., Kim,Y. and Choi,Y.
  TITLE     Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary
            epithelial cells
  JOURNAL   Cancer Lett 188 (1-2), 121-126 (2002)
   PUBMED   12406557
REFERENCE   7  (bases 1 to 1275)
  AUTHORS   Maass,N., Rosel,F., Schem,C., Hitomi,J., Jonat,W. and Nagasaki,K.
  TITLE     Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human
            primary breast cancer
  JOURNAL   Cancer Lett 185 (2), 219-223 (2002)
   PUBMED   12169396
  REMARK    GeneRIF: The BCAS2 gene was amplified in two of 60 primary breast
            cancer tissues, but not in other cancer cells, providing the first
            evidence of amplification within this region and indicating that
            BCAS2 gene codes for a nuclear protein.
REFERENCE   8  (bases 1 to 1275)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 1275)
  AUTHORS   Nagasaki,K., Maass,N., Manabe,T., Hanzawa,H., Tsukada,T.,
            Kikuchi,K. and Yamaguchi,K.
  TITLE     Identification of a novel gene, DAM1, amplified at chromosome
            1p13.3-21 region in human breast cancer cell lines
  JOURNAL   Cancer Lett 140 (1-2), 219-226 (1999)
   PUBMED   10403562
REFERENCE   10 (bases 1 to 1275)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF184377.1, BC039238.1 and BC022880.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005872.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039238.1, AK222637.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369541.4/ ENSP00000358554.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                BF184377.1         31-107
            78-1273             BC039238.1         78-1273
            1274-1275           BC022880.1         1285-1286
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..1275
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /note="BCAS2 pre-mRNA processing factor"
                     /db_xref="GeneID:10286"
                     /db_xref="HGNC:HGNC:975"
                     /db_xref="MIM:605783"
     exon            1..117
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..702
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /note="spliceosome associated protein, amplified in breast
                     cancer; breast carcinoma amplified sequence 2;
                     spliceosome-associated protein SPF 27; DNA amplified in
                     mammary carcinoma 1 protein"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor SPF27"
                     /protein_id="NP_005863.1"
                     /db_xref="CCDS:CCDS874.1"
                     /db_xref="GeneID:10286"
                     /db_xref="HGNC:HGNC:975"
                     /db_xref="MIM:605783"
                     /translation="MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYR
                     PTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITA
                     WQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHI
                     QDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANK
                     ENIRQDF"
     exon            118..210
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /inference="alignment:Splign:2.1.0"
     exon            211..281
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /inference="alignment:Splign:2.1.0"
     exon            282..443
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /inference="alignment:Splign:2.1.0"
     exon            444..494
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /inference="alignment:Splign:2.1.0"
     exon            495..575
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1275
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1073..1078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /note="hexamer: AATAAA"
     polyA_site      1096
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /note="major polyA site"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /note="hexamer: AATAAA"
     polyA_site      1275
                     /gene="BCAS2"
                     /gene_synonym="DAM1; Snt309; SPF27"
                     /note="major polyA site"
ORIGIN      
        1 gcaggcaaac ctgaggtcct cagaatggcg ggcacaggtt tggtggctgg agaggttgtg
       61 gtggatgcgc tgccgtattt tgatcaaggt tatgaagccc ctggtgtgcg ggaagcggct
      121 gcagcgctgg tggaggagga aactcgcaga taccgaccta ctaagaacta cctgagctac
      181 ctgacagccc cggattattc tgcctttgaa actgacataa tgagaaatga atttgaaaga
      241 ctggctgctc gacaaccaat tgaattgctc agtatgaaac gatatgagct tccagccccc
      301 tcctctggtc aaaaaaatga cattactgca tggcaagaat gtgtaaacaa ttctatggcc
      361 cagttagagc atcaagcagt tagaattgag aatctggaac taatgtcaca gcatggatgt
      421 aatgcctgga aagtatacaa tgaaaatcta gttcatatga ttgaacacgc acagaaggaa
      481 cttcagaagt taagaaaaca tattcaagat ttaaactggc agagaaagaa catgcaactc
      541 acagctggat ctaaattgag agaaatggag tcaaattggg tatccctggt cagtaagaat
      601 tatgagattg aacggactat tgttcagcta gaaaatgaaa tctatcaaat taagcagcaa
      661 catggagagg caaacaaaga aaacatccgg caagacttct gaaaagacaa tttagcaggt
      721 agaagaaaag ttgggctttc acaaaaggca tctgaacttt taatgaactt tgaaggacaa
      781 cagcatcttc ccaaaaccat tgatgtttaa gtgtttagaa atcatagaag gtgtaggctg
      841 ctgtggtaat tctatttgta tatctcaaca gaattaaaat gtctagcttg gtggtatttt
      901 tatagccata aaagaaaatc tttaggcttt caaaataagg atgactttag aataatattg
      961 tgtcatagaa ttaattttca gccatgtgga ccatattttg tatccaagga tccttattta
     1021 aagctttcaa catgtacagg aagttggaaa tttttggttt atgactttgt ctaataaaga
     1081 gatagttcta aacacattct tgatcaccaa acaacttcag aaagacagtg actgtacagt
     1141 tatcattatc atcatcatcg tcatcatcat aggtaacagt tatatcaagc ttaatatgtg
     1201 ctgaacattg ttctgaacac tttaggtaga tgaactagat gtatgtgaat aaaaattatt
     1261 tggtcctcac aaaaa
//
