LOCUS       NM_003567               3229 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens BCAR3 adaptor protein, NSP family member (BCAR3),
            transcript variant 2, mRNA.
ACCESSION   NM_003567
VERSION     NM_003567.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3229)
  AUTHORS   Zhao,G., Chen,H. and Luo,J.
  TITLE     CircBCAR3 sponges miR-27a-3p and mediates ferroptosis in human
            B-prolymphocytic leukaemia cells via SLC7A11
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 181-187 (2023)
   PUBMED   38063095
  REMARK    GeneRIF: CircBCAR3 sponges miR-27a-3p and mediates ferroptosis in
            human B-prolymphocytic leukaemia cells via SLC7A11.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3229)
  AUTHORS   Pavanelli,A.C., Mangone,F.R., Yoganathan,P., Bessa,S.A.,
            Nonogaki,S., de Toledo Osorio,C.A.B., de Andrade,V.P., Soares,I.C.,
            de Mello,E.S., Mulligan,L.M. and Nagai,M.A.
  TITLE     Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3
            expression in patients with Luminal A and B breast cancer subtypes
  JOURNAL   Breast Cancer Res Treat 192 (1), 43-52 (2022)
   PUBMED   35031902
  REMARK    GeneRIF: Comprehensive immunohistochemical analysis of RET, BCAR1,
            and BCAR3 expression in patients with Luminal A and B breast cancer
            subtypes.
REFERENCE   3  (bases 1 to 3229)
  AUTHORS   Steenkiste,E.M., Berndt,J.D., Pilling,C., Simpkins,C. and
            Cooper,J.A.
  TITLE     A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics
  JOURNAL   Elife 10, e67078 (2021)
   PUBMED   34169835
  REMARK    GeneRIF: A Cas-BCAR3 co-regulatory circuit controls lamellipodia
            dynamics.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3229)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3229)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3229)
  AUTHORS   Cai,D., Felekkis,K.N., Near,R.I., O'Neill,G.M., van Seventer,J.M.,
            Golemis,E.A. and Lerner,A.
  TITLE     The GDP exchange factor AND-34 is expressed in B cells, associates
            with HEF1, and activates Cdc42
  JOURNAL   J Immunol 170 (2), 969-978 (2003)
   PUBMED   12517963
REFERENCE   7  (bases 1 to 3229)
  AUTHORS   Lu,Y., Brush,J. and Stewart,T.A.
  TITLE     NSP1 defines a novel family of adaptor proteins linking integrin
            and tyrosine kinase receptors to the c-Jun N-terminal
            kinase/stress-activated protein kinase signaling pathway
  JOURNAL   J Biol Chem 274 (15), 10047-10052 (1999)
   PUBMED   10187783
REFERENCE   8  (bases 1 to 3229)
  AUTHORS   van Agthoven,T., van Agthoven,T.L., Dekker,A., van der Spek,P.J.,
            Vreede,L. and Dorssers,L.C.
  TITLE     Identification of BCAR3 by a random search for genes involved in
            antiestrogen resistance of human breast cancer cells
  JOURNAL   EMBO J 17 (10), 2799-2808 (1998)
   PUBMED   9582273
REFERENCE   9  (bases 1 to 3229)
  AUTHORS   Johnston,S.R.
  TITLE     Acquired tamoxifen resistance in human breast cancer--potential
            mechanisms and clinical implications
  JOURNAL   Anticancer Drugs 8 (10), 911-930 (1997)
   PUBMED   9436634
  REMARK    Review article
REFERENCE   10 (bases 1 to 3229)
  AUTHORS   Dorssers,L.C. and van Agthoven,T.
  TITLE     Genetic mechanisms of estrogen-independence in breast cancer
  JOURNAL   Pathol Res Pract 192 (7), 743-751 (1996)
   PUBMED   8880875
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN337133.1, AF124250.1,
            BQ015705.1 and AL109613.11.
            
            On Nov 23, 2018 this sequence version replaced NM_003567.3.
            
            Summary: Breast tumors are initially dependent on estrogens for
            growth and progression and can be inhibited by anti-estrogens such
            as tamoxifen. However, breast cancers progress to become
            anti-estrogen resistant. Breast cancer anti-estrogen resistance
            gene 3 was identified in the search for genes involved in the
            development of estrogen resistance. The gene encodes a component of
            intracellular signal transduction that causes estrogen-independent
            proliferation in human breast cancer cells. The protein contains a
            putative src homology 2 (SH2) domain, a hall mark of cellular
            tyrosine kinase signaling molecules, and is partly homologous to
            the cell division cycle protein CDC48. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein (isoform
            1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF124250.1, GQ891488.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260502.11/ ENSP00000260502.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CN337133.1         4-11
            9-3179              AF124250.1         2-3172
            3180-3184           BQ015705.1         19-23               c
            3185-3229           AL109613.11        31578-31622         c
FEATURES             Location/Qualifiers
     source          1..3229
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..3229
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /note="BCAR3 adaptor protein, NSP family member"
                     /db_xref="GeneID:8412"
                     /db_xref="HGNC:HGNC:973"
                     /db_xref="MIM:604704"
     exon            1..240
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     exon            241..568
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..2729
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /note="isoform 1 is encoded by transcript variant 2;
                     breast cancer anti-estrogen resistance protein 3;
                     dJ1033H22.2 (breast cancer anti-estrogen resistance 3);
                     novel SH2-containing protein 2; SH2 domain-containing
                     protein 3B; breast cancer antiestrogen resistance 3
                     protein; epididymis secretory sperm binding protein;
                     BCAR3, NSP family adaptor protein; mig-7; migration
                     inducting gene-7"
                     /codon_start=1
                     /product="breast cancer anti-estrogen resistance protein 3
                     isoform 1"
                     /protein_id="NP_003558.1"
                     /db_xref="CCDS:CCDS745.1"
                     /db_xref="GeneID:8412"
                     /db_xref="HGNC:HGNC:973"
                     /db_xref="MIM:604704"
                     /translation="MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQD
                     VSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGET
                     FTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIP
                     RQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQ
                     FEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREG
                     SLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLK
                     AHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEAL
                     RGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCA
                     QGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPL
                     LETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARI
                     LGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRA
                     ATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEK
                     QLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIM
                     LNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQT
                     ERYEKFNQILTALSRKLEPPPVKQAEL"
     exon            569..608
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     exon            609..737
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1180
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1284
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1937
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2053
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2225
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2337
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2550
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..3229
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3161..3166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /note="hexamer: AATACA"
     polyA_site      3179
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /note="major polyA site"
     regulatory      3203..3208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
                     /note="hexamer: ATTAAA"
     polyA_site      3229
                     /gene="BCAR3"
                     /gene_synonym="AND-34; MIG7; NSP2; SH2D3B"
ORIGIN      
        1 agagctgcgc ctgctgctgg ccgggcgggg gacggggccg ggaccggagc cggagctgcg
       61 gggcgcaccg gctagacgcg cgcgggattc tcggcgggca cgccccgcgg accatgagcg
      121 tccccagctc cgggagcagc cgcggcgcgg gcggtgcgag gccggccgcg cggcgccttt
      181 gagccccagc cggaggtcca gagatcctga gagcccgagc gcccagcgcc gcgccgggag
      241 agttgagaat tatggctgca ggaaaatttg caagccttcc cagaaacatg ccggtgaatc
      301 accagttccc cctggcctca tccatggacc ttctgagcag caggtcccct ctcgctgagc
      361 atcgcccaga tgcctatcaa gatgtgtcta tacatggcac ccttccacgg aagaaaaaag
      421 gtcctcctcc cataaggtcc tgtgatgact tcagtcacat gggcaccctc ccccactcca
      481 aatccccacg gcagaactcg cctgtgaccc aggatggcat ccaggagagc ccatggcagg
      541 accggcacgg cgaaaccttc accttcaggg atccacatct tctggaccca actgtggaat
      601 atgtgaagtt ctccaaggag aggcacatca tggacaggac ccccgagaaa ctgaagaagg
      661 agctggagga ggagctgctc ctgagcagcg aggacctgcg cagccatgcc tggtaccacg
      721 gccgcatccc ccgacaggtg tctgaaaacc ttgtgcagcg agatggtgac ttcctagttc
      781 gtgactctct gtccagccct gggaactttg tcctgacctg tcagtggaag aacctcgctc
      841 agcacttcaa aatcaaccgg acagttctgc gactcagcga ggcctacagc cgcgtgcagt
      901 accagttcga gatggagagc ttcgactcca tccccggcct ggtgcgctgc tacgtgggca
      961 accgccggcc catctcccag cagagtggcg ccatcatctt ccagcccatc aacaggacgg
     1021 tgcctctgcg gtgcctggag gagcattatg gcacctcccc aggccaggcc cgggagggca
     1081 gcctcaccaa gggaaggccg gatgtggcca agaggctgag cctcaccatg ggtggcgtcc
     1141 aggcccgaga gcagaatttg cccaggggaa acctcctcag aaacaaagaa aagagtggta
     1201 gccagcccgc ctgcctggat cacatgcagg acagaagagc cttgtccctc aaagcccacc
     1261 agtcagagag ctacctgccg attggctgca agctgccacc tcagtcctcg ggtgtggaca
     1321 caagcccctg cccaaactca cctgtgttca ggacgggaag cgagcctgcc ctgagcccag
     1381 cagtggttcg gagggtctcc tcagacgcca gggctgggga ggcgctgagg ggatcagaca
     1441 gtcaactgtg ccctaagccc ccgcctaagc cctgcaaggt gccgttcctc aaggttccct
     1501 cgtctccctc tgcctggctc aactcagagg ccaactactg tgaactgaac ccagcgtttg
     1561 ccacaggctg cggcagggga gcaaagctac cctcatgtgc ccagggaagc cacacagaac
     1621 tgctcacagc caagcagaat gaggcgccag gtccccggaa ctctggcgtc aactacttga
     1681 tccttgatga tgatgacagg gaaagacctt gggaacctgc ggcagctcag atggagaagg
     1741 ggcagtggga caagggcgag tttgtgacgc ccctcctgga gactgtctcc tccttcaggc
     1801 ccaacgagtt tgagtcaaag ttccttcccc ctgagaataa gcccctggaa acagcaatgt
     1861 tgaaacgtgc aaaagaactg ttcaccaaca acgaccccaa ggtcatcgcc cagcacgtac
     1921 tgagcatgga ctgcagggtt gctaggatac ttggagtctc tgaagagatg aggaggaaca
     1981 tgggggtgag ctcaggcctg gaactcatta ccttgcctca cggacaccag ctgcgcctgg
     2041 acataattga aagacacaac acaatggcca tcggcattgc agtggacatt ctgggatgca
     2101 cgggcacttt ggaggaccga gcggccactc tgagtaagat catccaggtg gcggtggaac
     2161 tgaaggattc catgggggac ctctattcct tctcagctct catgaaagcc ctggaaatgc
     2221 cacagatcac aaggttagaa aagacgtgga ctgctctgcg gcaccagtac acccaaactg
     2281 ccattctcta tgagaaacag ctgaagccct tcagcaaact cctgcatgaa ggcagagagt
     2341 ccacatgtgt tcccccaaac aatgtatcag tcccactgct gatgccgctt gtgacgttaa
     2401 tggagcgcca ggctgtgact tttgaaggaa ccgacatgtg ggaaaaaaac gaccagagct
     2461 gtgaaatcat gctgaaccat ttggcaacag cgcgattcat ggccgaggct gcagacagct
     2521 accggatgaa tgctgagagg atcctggcag gttttcaacc agatgaagaa atgaatgaaa
     2581 tctgcaagac tgaatttcaa atgcgattgc tatggggcag caaaggtgca caagtcaatc
     2641 agacagagag atatgagaaa ttcaaccaga ttttaactgc cctctcgcgt aaattggaac
     2701 ctcctcctgt aaagcaggca gagctttgat aactctccag agaaccttta gaatatcttt
     2761 tcaagtttcc ccagcttcat ctttgggaaa gcttactgtt tttgataaag taataatgtg
     2821 caaatctgac aatatacaag cttttagtat ccacaggata ttaaacgtgt aaattgcaca
     2881 gagcacactt atttatgaat tgtctaaagt tactactgat tttaaaatga ataatttatt
     2941 attaaggtaa ctactgctaa tgttgatcag caaatttaag agaagaccta gctatgttgg
     3001 ctggttgctt tctattatca tggtatttga ccattttagt tttaattcca tgtcagataa
     3061 gtgtaaatag aagagtttaa aagcatgaaa catttcagaa ggtatcagtt atatgatatt
     3121 ctttaaacaa atatgaaaaa tgtaaatact catgaatgaa aatacatctt tttgtgaaac
     3181 agttgtatcc agtctctttc atattaaaca actcatcttg gtacaataa
//
