LOCUS       NM_014567               4085 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens BCAR1 scaffold protein, Cas family member (BCAR1),
            transcript variant 6, mRNA.
ACCESSION   NM_014567
VERSION     NM_014567.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4085)
  AUTHORS   Delage,L., Lambert,M., Bardel,E., Kundlacz,C., Chartoire,D.,
            Conchon,A., Peugnet,A.L., Gorka,L., Auberger,P., Jacquel,A.,
            Soussain,C., Destaing,O., Delecluse,H.J., Delecluse,S., Merabet,S.,
            Traverse-Glehen,A., Salles,G., Bachy,E., Billaud,M.,
            Ghesquieres,H., Genestier,L., Rouault,J.P. and Sujobert,P.
  TITLE     BTG1 inactivation drives lymphomagenesis and promotes lymphoma
            dissemination through activation of BCAR1
  JOURNAL   Blood 141 (10), 1209-1220 (2023)
   PUBMED   36375119
  REMARK    GeneRIF: BTG1 inactivation drives lymphomagenesis and promotes
            lymphoma dissemination through activation of BCAR1.
REFERENCE   2  (bases 1 to 4085)
  AUTHORS   Li,H., Li,L., Qiu,X., Zhang,J. and Hua,Z.
  TITLE     The interaction of CFLAR with p130Cas promotes cell migration
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (2), 119390 (2023)
   PUBMED   36400248
  REMARK    GeneRIF: The interaction of CFLAR with p130Cas promotes cell
            migration.
REFERENCE   3  (bases 1 to 4085)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 4085)
  AUTHORS   Camacho Leal Mdel,P., Sciortino,M., Tornillo,G., Colombo,S.,
            Defilippi,P. and Cabodi,S.
  TITLE     p130Cas/BCAR1 scaffold protein in tissue homeostasis and
            pathogenesis
  JOURNAL   Gene 562 (1), 1-7 (2015)
   PUBMED   25727852
  REMARK    GeneRIF: BCAR1 has a pivotal role in the regulation of tissue
            homeostasis in pathological conditions such as cancer. (Review)
            Review article
REFERENCE   5  (bases 1 to 4085)
  AUTHORS   Nikonova,A.S., Gaponova,A.V., Kudinov,A.E. and Golemis,E.A.
  TITLE     CAS proteins in health and disease: an update
  JOURNAL   IUBMB Life 66 (6), 387-395 (2014)
   PUBMED   24962474
  REMARK    Review article
REFERENCE   6  (bases 1 to 4085)
  AUTHORS   Barrett,A., Pellet-Many,C., Zachary,I.C., Evans,I.M. and Frankel,P.
  TITLE     p130Cas: a key signalling node in health and disease
  JOURNAL   Cell Signal 25 (4), 766-777 (2013)
   PUBMED   23277200
  REMARK    Review article
REFERENCE   7  (bases 1 to 4085)
  AUTHORS   Brinkman,A., van der Flier,S., Kok,E.M. and Dorssers,L.C.
  TITLE     BCAR1, a human homologue of the adapter protein p130Cas, and
            antiestrogen resistance in breast cancer cells
  JOURNAL   J Natl Cancer Inst 92 (2), 112-120 (2000)
   PUBMED   10639512
REFERENCE   8  (bases 1 to 4085)
  AUTHORS   Vuori,K., Hirai,H., Aizawa,S. and Ruoslahti,E.
  TITLE     Introduction of p130cas signaling complex formation upon
            integrin-mediated cell adhesion: a role for Src family kinases
  JOURNAL   Mol Cell Biol 16 (6), 2606-2613 (1996)
   PUBMED   8649368
REFERENCE   9  (bases 1 to 4085)
  AUTHORS   Sakai,R., Iwamatsu,A., Hirano,N., Ogawa,S., Tanaka,T., Mano,H.,
            Yazaki,Y. and Hirai,H.
  TITLE     A novel signaling molecule, p130, forms stable complexes in vivo
            with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
  JOURNAL   EMBO J 13 (16), 3748-3756 (1994)
   PUBMED   8070403
REFERENCE   10 (bases 1 to 4085)
  AUTHORS   Dorssers,L.C., van Agthoven,T., Dekker,A., van Agthoven,T.L. and
            Kok,E.M.
  TITLE     Induction of antiestrogen resistance in human breast cancer cells
            by random insertional mutagenesis using defective retroviruses:
            identification of bcar-1, a common integration site
  JOURNAL   Mol Endocrinol 7 (7), 870-878 (1993)
   PUBMED   8413311
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314722.1, AK295809.1,
            AB040024.1, BU730553.1, AC009078.6 and BQ016861.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014567.4.
            
            Summary: The protein encoded by this gene is a member of the
            Crk-associated substrate (CAS) family of scaffold proteins,
            characterized by the presence of multiple protein-protein
            interaction domains and many serine and tyrosine phosphorylation
            sites. The encoded protein contains a Src-homology 3 (SH3) domain,
            a proline-rich domain, a substrate domain which contains 15 repeat
            of the YxxP consensus phosphorylation motif for Src family kinases,
            a serine-rich domain, and a bipartite Src-binding domain, which can
            bind both SH2 and SH3 domains. This adaptor protein functions in
            multiple cellular pathways, including in cell motility, apoptosis
            and cell cycle control. Dysregulation of this gene can have a wide
            range of effects, affecting different pathways, including cardiac
            development, vascular smooth muscle cells, liver and kidney
            function, endothelial migration, and cancer. [provided by RefSeq,
            Sep 2017].
            
            Transcript Variant: This variant (6) has an alternate 5' sequence,
            as compared to variant 1. The resulting isoform (6) is shorter and
            has a different N-terminus, as compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040024.1, AJ242987.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153946 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000162330.10/ ENSP00000162330.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AK314722.1         5-371
            368-1404            AK295809.1         282-1318
            1405-2952           AB040024.1         1404-2951
            2953-3236           BU730553.1         18-301              c
            3237-3739           AC009078.6         127922-128424       c
            3740-4079           BQ016861.1         19-358              c
            4080-4085           AC009078.6         127576-127581       c
FEATURES             Location/Qualifiers
     source          1..4085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..4085
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /note="BCAR1 scaffold protein, Cas family member"
                     /db_xref="GeneID:9564"
                     /db_xref="HGNC:HGNC:971"
                     /db_xref="MIM:602941"
     exon            1..154
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2755
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /note="isoform 6 is encoded by transcript variant 6; Cas
                     scaffolding protein family member 1; Crk-associated
                     substrate p130Cas; breast cancer anti-estrogen resistance
                     protein 1; BCAR1, Cas family scaffolding protein; BCAR1,
                     Cas family scaffold protein"
                     /codon_start=1
                     /product="breast cancer anti-estrogen resistance protein 1
                     isoform 6"
                     /protein_id="NP_055382.2"
                     /db_xref="CCDS:CCDS10915.1"
                     /db_xref="GeneID:9564"
                     /db_xref="HGNC:HGNC:971"
                     /db_xref="MIM:602941"
                     /translation="MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWW
                     LCSLHGRQGIVPGNRLKILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPM
                     LPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSP
                     ATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRV
                     GQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKG
                     PNGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFA
                     KAKPFDPARTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRE
                     RVLPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPG
                     REPLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAV
                     AAVQSAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGR
                     GGSGATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPN
                     PTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKEL
                     LEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSD
                     RQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDT
                     LSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHS
                     TQQFRRVLGQLAAA"
     exon            155..775
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /inference="alignment:Splign:2.1.0"
     exon            776..937
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1054
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..2152
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2242
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..4085
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3212..3217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /note="hexamer: AATAAA"
     polyA_site      3231
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
                     /note="major polyA site"
     polyA_site      4085
                     /gene="BCAR1"
                     /gene_synonym="CAS; CAS1; CASS1; CRKAS; P130Cas"
ORIGIN      
        1 ggaccggctc tgggtggccg aggcggcagc tgcgcggcgg caccggggcg gctgcggcgc
       61 gctcggagcc ccgagggcac gcggcccggg cagctcggtg tgcgcccccg cgagagccgg
      121 ggccccaggc ccgccggaca ccatgaacca cctgaacgtg ctggccaaag cgctctatga
      181 caatgtggcc gagtccccgg atgagctctc cttccgcaag ggtgacatca tgacggtgct
      241 ggagcaggac acgcagggcc tggacggctg gtggctctgc tcgctgcatg ggcgccaggg
      301 catcgtgcct gggaaccgcc tcaagatctt ggtgggcatg tatgataaga agccagcagg
      361 gcctggcccc ggccctcccg ccaccccggc ccagcctcag cctggcctcc atgccccagc
      421 gcctccggcc tcccagtaca cgcccatgct ccccaacacc taccagcccc agccagacag
      481 cgtctacctg gtgcccactc ccagcaaggc tcagcaaggc ctctaccaag tcccgggtcc
      541 cagccctcag ttccagtctc ccccagccaa gcagacatcc accttctcga agcagacacc
      601 ccatcacccg tttcccagcc cggccacaga cctgtaccag gtgcccccag ggcctggagg
      661 ccctgcccag gatatttacc aggtgccacc ttctgccggg atggggcatg acatctacca
      721 ggtccccccg tccatggaca cacgcagctg ggagggcacg aagcccccgg caaaggtggt
      781 ggtgcccacc cgcgtggggc agggctatgt atacgaggcc gcccagccgg agcaggacga
      841 gtacgacatc ccgcgacacc tgctggcccc ggggccacag gacatctatg atgtgccccc
      901 ggttcggggg ctgcttccca gccagtatgg ccaggaggtg tatgacacac cccccatggc
      961 tgtcaagggt cccaatggcc gagacccgtt gctggaggtg tatgacgtgc cccccagtgt
     1021 ggagaagggc ctgccaccgt ccaaccacca cgcagtctac gacgttcctc catcggtgag
     1081 caaggatgtg cccgatggcc cactgctgcg tgaggagacc tacgatgtgc cccccgcctt
     1141 cgccaaggcc aagccctttg acccggcccg caccccactg gtactggctg cgccccctcc
     1201 agactccccg ccggccgagg acgtgtatga cgtgccgccc ccggctcctg acctctacga
     1261 cgtgccccct ggcttgcggc ggcctggccc gggcaccctg tacgatgtgc cccgtgaacg
     1321 ggtgcttcct cctgaggtgg ctgatggtgg cgtggtcgac agtggtgtgt atgcggtgcc
     1381 tcccccagct gaacgtgaag ccccggcaga gggcaagcgc ctgtcggcct ccagcaccgg
     1441 cagcacacgc agcagccagt ctgcgtcctc cttggaggtg gcagggccgg gccgggaacc
     1501 cctggagctg gaagttgctg tggaggccct ggcacggctg cagcagggtg tgagcgccac
     1561 cgttgcccac cttctggacc tggcaggcag cgccggtgcg actgggagct ggcgtagccc
     1621 ctctgagcca caggagccgc tggtgcagga cctgcaggct gctgtggccg ctgtccagag
     1681 tgccgtccac gagctgttgg agtttgcccg cagcgcggtg ggcaatgctg cccacacatc
     1741 tgaccgtgcc ctgcatgcca agcttagccg gcagctgcag aagatggagg acgtgcacca
     1801 gacgctggtg gcacatggtc aggccctcga cgctggccgg ggaggctctg gagccaccct
     1861 tgaggacctg gaccggctgg tggcctgctc gcgggctgtg cccgaggacg ccaagcagct
     1921 ggcctccttc ctgcacggca atgcctcact gctcttcaga cggaccaagg ccactgcccc
     1981 ggggcctgag gggggtggca ccctgcaccc caaccccact gacaagacca gcagcatcca
     2041 gtcacgaccc ctgccctcac cccctaagtt cacctcccag gactcgccag atgggcagta
     2101 cgagaacagc gaggggggct ggatggagga ctatgactac gtccacctac aggggaagga
     2161 ggagtttgag aagacccaga aggagctgct ggaaaagggc agcatcacgc ggcagggcaa
     2221 gagccagctg gagttgcagc agctgaagca gtttgaacga ctggaacagg aggtgtcacg
     2281 gcccatagac cacgacctgg ccaactggac gccagcccaa cccctggccc cggggcgaac
     2341 aggcggcctg gggccctcgg accggcagct gctgctcttc tacctggagc agtgtgaggc
     2401 caacctgacc acactgacca acgccgtgga cgccttcttt accgccgtgg ccaccaacca
     2461 gccgcccaag atctttgtgg cgcacagcaa gttcgtcatc ctcagcgccc acaagctggt
     2521 gttcatcggg gacacactgt cacggcaggc caaggctgct gacgtgcgca gccaggtgac
     2581 ccactacagc aacctgctgt gcgacctcct gcgcggcatc gtggccacca ccaaggccgc
     2641 tgccttgcag tacccatcgc cttccgcggc ccaggacatg gtggagaggg tcaaggagct
     2701 gggccacagc acccagcagt tccgccgcgt cctaggccag ctggcagccg cctgagggtg
     2761 gtgaccccag gagggaggca ggggaggggt gcggcggtcc cagctccctg gctcccatgt
     2821 caagagtcgc tgtgccacag gcttagggac aggaccccag ctctgcgtcg gtcctggtgc
     2881 cctggatgcc caggaatctg tatatattta tggccgggca gggtgtgggg ccatgcctcc
     2941 tcaggagccg aagcccaggg gccggccagt ggccttcccc agcatgcacc acgggcccgg
     3001 gttgggtcac cagacggggc tggagtgtga gggtcctgca gcctgcagga cctcgtgcca
     3061 ccccgagggc tgagcctggt cccacgaggg tgccgtgtcc cctgacaggg ccagtgcagt
     3121 ttggtgtgtc ctccgcctta ccaggagaag aacctgaaga actatttttc gttattggtt
     3181 ttccaatcat ttgactaaga gtctccattt aaataaagtt tttaaaagga agagcagctg
     3241 cctgagggtg gcagatgaga gcagcccggg gtgggtgacg gttctgggga aggcacccgg
     3301 gggcaagggc catgcgtggc atctcccggg agggcagagg aggagtgggt ctctctagaa
     3361 gaaaaccaag gaacgccgag gctgggtgtc tcctggaggc ggggtgaggc ctgcagctgg
     3421 ccacaaggcc ctgggagcca gggcagagcc tgggcccaag aaagggggca gtttcagagc
     3481 tgcagggtct ggggcccaga aagcacagcc tgggcatggc ccctgcaacc ctagggagct
     3541 gccacagtga gcacctgccc atgcccacag ctggcatctg gagtgagggc agattggggc
     3601 aggaacagct gcacaagggg acgggttcct gtgagccgag ggcaccgctg ggggctgcat
     3661 ccagagctct gcttaaaaga atctcatccc agcctgcgga actcccgaag tgcacatgga
     3721 attatacctg gacctggcat ctgagttggg agggaggggc ttggagaaga cccttgccct
     3781 gggcaagtgt gtcccccttc gtggctcccc cacccagcag cccgcagccc agatggaagc
     3841 ttcagggtgc ttggaacccc tggtgctgct cccagccctg accgttctgc atatgaacat
     3901 gggccttggt ttccccatct gtatgaagaa gggagtaggg ctgggtgatt cgcaagccct
     3961 cctgatctta cctctacaga ggttgtcccc gtgacagcat ctgtcccccc acctcagcca
     4021 catcatgctc agcccacctg ccttggtgag gacacagagg taaaggtgta tgcagttgct
     4081 ctcaa
//
