LOCUS       NM_021948               3297 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens brevican (BCAN), transcript variant 1, mRNA.
ACCESSION   NM_021948
VERSION     NM_021948.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3297)
  AUTHORS   Chia,R.S.L., Minta,K., Wu,L.Y., Salai,K.H.T., Chai,Y.L., Hilal,S.,
            Venketasubramanian,N., Chen,C.P., Chong,J.R. and Lai,M.K.P.
  TITLE     Serum Brevican as a Biomarker of Cerebrovascular Disease in an
            Elderly Cognitively Impaired Cohort
  JOURNAL   Biomolecules 14 (1), 75 (2024)
   PUBMED   38254675
  REMARK    GeneRIF: Serum Brevican as a Biomarker of Cerebrovascular Disease
            in an Elderly Cognitively Impaired Cohort.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3297)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3297)
  AUTHORS   Jonesco,D.S., Karsdal,M.A. and Henriksen,K.
  TITLE     The CNS-specific proteoglycan, brevican, and its ADAMTS4-cleaved
            fragment show differential serological levels in Alzheimer's
            disease, other types of dementia and non-demented controls: A
            cross-sectional study
  JOURNAL   PLoS One 15 (6), e0234632 (2020)
   PUBMED   32559242
  REMARK    GeneRIF: The CNS-specific proteoglycan, brevican, and its
            ADAMTS4-cleaved fragment show differential serological levels in
            Alzheimer's disease, other types of dementia and non-demented
            controls: A cross-sectional study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3297)
  AUTHORS   Giamanco,K.A. and Matthews,R.T.
  TITLE     The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating
            Glioma Cell Invasion and Motility
  JOURNAL   Adv Exp Med Biol 1272, 117-132 (2020)
   PUBMED   32845505
  REMARK    GeneRIF: The Role of BEHAB/Brevican in the Tumor Microenvironment:
            Mediating Glioma Cell Invasion and Motility.
            Review article
REFERENCE   5  (bases 1 to 3297)
  AUTHORS   Faryna,M., Konermann,C., Aulmann,S., Bermejo,J.L., Brugger,M.,
            Diederichs,S., Rom,J., Weichenhan,D., Claus,R., Rehli,M.,
            Schirmacher,P., Sinn,H.P., Plass,C. and Gerhauser,C.
  TITLE     Genome-wide methylation screen in low-grade breast cancer
            identifies novel epigenetically altered genes as potential
            biomarkers for tumor diagnosis
  JOURNAL   FASEB J 26 (12), 4937-4950 (2012)
   PUBMED   22930747
  REMARK    GeneRIF: Data indicate that median methylation levels of BCAN,
            HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30%
            higher than in normal samples, representing potential biomarkers
            for tumor diagnosis.
REFERENCE   6  (bases 1 to 3297)
  AUTHORS   Olin,A.I., Morgelin,M., Sasaki,T., Timpl,R., Heinegard,D. and
            Aspberg,A.
  TITLE     The proteoglycans aggrecan and Versican form networks with
            fibulin-2 through their lectin domain binding
  JOURNAL   J Biol Chem 276 (2), 1253-1261 (2001)
   PUBMED   11038354
REFERENCE   7  (bases 1 to 3297)
  AUTHORS   Nakamura,H., Fujii,Y., Inoki,I., Sugimoto,K., Tanzawa,K.,
            Matsuki,H., Miura,R., Yamaguchi,Y. and Okada,Y.
  TITLE     Brevican is degraded by matrix metalloproteinases and aggrecanase-1
            (ADAMTS4) at different sites
  JOURNAL   J Biol Chem 275 (49), 38885-38890 (2000)
   PUBMED   10986281
REFERENCE   8  (bases 1 to 3297)
  AUTHORS   Gary,S.C., Zerillo,C.A., Chiang,V.L., Gaw,J.U., Gray,G. and
            Hockfield,S.
  TITLE     cDNA cloning, chromosomal localization, and expression analysis of
            human BEHAB/brevican, a brain specific proteoglycan regulated
            during cortical development and in glioma
  JOURNAL   Gene 256 (1-2), 139-147 (2000)
   PUBMED   11054543
REFERENCE   9  (bases 1 to 3297)
  AUTHORS   Aspberg,A., Miura,R., Bourdoulous,S., Shimonaka,M., Heinegard,D.,
            Schachner,M., Ruoslahti,E. and Yamaguchi,Y.
  TITLE     The C-type lectin domains of lecticans, a family of aggregating
            chondroitin sulfate proteoglycans, bind tenascin-R by
            protein-protein interactions independent of carbohydrate moiety
  JOURNAL   Proc Natl Acad Sci U S A 94 (19), 10116-10121 (1997)
   PUBMED   9294172
REFERENCE   10 (bases 1 to 3297)
  AUTHORS   Seidenbecher,C.I., Richter,K., Rauch,U., Fassler,R., Garner,C.C.
            and Gundelfinger,E.D.
  TITLE     Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs
            as secreted and cell surface glycosylphosphatidylinositol-anchored
            isoforms
  JOURNAL   J Biol Chem 270 (45), 27206-27212 (1995)
   PUBMED   7592978
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358372.1, BC027971.1,
            AL365181.24 and AL590666.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021948.4.
            
            Summary: This gene encodes a member of the lectican family of
            chondroitin sulfate proteoglycans that is specifically expressed in
            the central nervous system. This protein is developmentally
            regulated and may function in the formation of the brain
            extracellular matrix. This protein is highly expressed in gliomas
            and may promote the growth and cell motility of brain tumor cells.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.154141.1,
                                           SRR1660809.80700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329117.10/ ENSP00000331210.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AY358372.1         185-220
            37-1676             BC027971.1         10-1649
            1677-1677           AL365181.24        163597-163597
            1678-3013           BC027971.1         1651-2986
            3014-3014           AL590666.8         7870-7870
            3015-3297           BC027971.1         2988-3270
FEATURES             Location/Qualifiers
     source          1..3297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..3297
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /note="brevican"
                     /db_xref="GeneID:63827"
                     /db_xref="HGNC:HGNC:23059"
                     /db_xref="MIM:600347"
     exon            1..159
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            160..258
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2903
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; chondroitin sulfate proteoglycan BEHAB;
                     chondroitin sulfate proteoglycan 7; brevican core protein;
                     brain-enriched hyaluronan-binding protein"
                     /codon_start=1
                     /product="brevican core protein isoform 1 precursor"
                     /protein_id="NP_068767.3"
                     /db_xref="CCDS:CCDS1149.1"
                     /db_xref="GeneID:63827"
                     /db_xref="HGNC:HGNC:23059"
                     /db_xref="MIM:600347"
                     /translation="MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAP
                     LQGVLGGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNE
                     AYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFL
                     YREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQ
                     TPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAY
                     CQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFL
                     FPNQTGFPNKHSRFNVYCFRDSAQPSAIPEASNPASNPASDGLEAIVTVTETLEELQL
                     PQEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEG
                     KALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQ
                     APARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVG
                     EATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAPAGTS
                     VQAQPVLPTDSASRGGVAVVPASGDCVPSPCHNGGTCLEEEEGVRCLCLPGYGGDLCD
                     VGLRFCNPGWDAFQGACYKHFSTRRSWEEAETQCRMYGAHLASISTPEEQDFINNRYR
                     EYQWIGLNDRTIEGDFLWSDGVPLLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDV
                     PCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVLRYRCREGLAQRNLPLI
                     RCQENGRWEAPQISCVPRRPARALHPEEDPEGRQGRLLGRWKALLIPPSSPMPGP"
     exon            259..633
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            634..808
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            809..936
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1230
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1464
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..2109
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2217
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2376
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2459
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2604
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2795
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..3297
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3271..3276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /note="hexamer: AATAAA"
     polyA_site      3297
                     /gene="BCAN"
                     /gene_synonym="BEHAB; CSPG7"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccgaa tgtcctgcgg ccccagcctc tcctcacgct cgcgcagtct ccgccgcagt
       61 ctcagctgca gctgcaggac tgagccgtgc acccggagga gacccccgga ggaggcgaca
      121 aacttcgcag tgccgcgacc caaccccagc cctgggtagc ctgcagcatg gcccagctgt
      181 tcctgcccct gctggcagcc ctggtcctgg cccaggctcc tgcagcttta gcagatgttc
      241 tggaaggaga cagctcagag gaccgcgctt ttcgcgtgcg catcgcgggc gacgcgccac
      301 tgcagggcgt gctcggcggc gccctcacca tcccttgcca cgtccactac ctgcggccac
      361 cgccgagccg ccgggctgtg ctgggctctc cgcgggtcaa gtggactttc ctgtcccggg
      421 gccgggaggc agaggtgctg gtggcgcggg gagtgcgcgt caaggtgaac gaggcctacc
      481 ggttccgcgt ggcactgcct gcgtacccag cgtcgctcac cgacgtctcc ctggcgctga
      541 gcgagctgcg ccccaacgac tcaggtatct atcgctgtga ggtccagcac ggcatcgatg
      601 acagcagcga cgctgtggag gtcaaggtca aaggggtcgt ctttctctac cgagagggct
      661 ctgcccgcta tgctttctcc ttttctgggg cccaggaggc ctgtgcccgc attggagccc
      721 acatcgccac cccggagcag ctctatgccg cctaccttgg gggctatgag caatgtgatg
      781 ctggctggct gtcggatcag accgtgaggt atcccatcca gaccccacga gaggcctgtt
      841 acggagacat ggatggcttc cccggggtcc ggaactatgg tgtggtggac ccggatgacc
      901 tctatgatgt gtactgttat gctgaagacc taaatggaga actgttcctg ggtgaccctc
      961 cagagaagct gacattggag gaagcacggg cgtactgcca ggagcggggt gcagagattg
     1021 ccaccacggg ccaactgtat gcagcctggg atggtggcct ggaccactgc agcccagggt
     1081 ggctagctga tggcagtgtg cgctacccca tcgtcacacc cagccagcgc tgtggtgggg
     1141 gcttgcctgg tgtcaagact ctcttcctct tccccaacca gactggcttc cccaataagc
     1201 acagccgctt caacgtctac tgcttccgag actcggccca gccttctgcc atccctgagg
     1261 cctccaaccc agcctccaac ccagcctctg atggactaga ggctatcgtc acagtgacag
     1321 agaccctgga ggaactgcag ctgcctcagg aagccacaga gagtgaatcc cgtggggcca
     1381 tctactccat ccccatcatg gaggacggag gaggtggaag ctccactcca gaagacccag
     1441 cagaggcccc taggacgctc ctagaatttg aaacacaatc catggtaccg cccacggggt
     1501 tctcagaaga ggaaggtaag gcattggagg aagaagagaa atatgaagat gaagaagaga
     1561 aagaggagga agaagaagag gaggaggtgg aggatgaggc tctgtgggca tggcccagcg
     1621 agctcagcag cccgggccct gaggcctctc tccccactga gccagcagcc caggaggagt
     1681 cactctccca ggcgccagca agggcagtcc tgcagcctgg tgcatcacca cttcctgatg
     1741 gagagtcaga agcttccagg cctccaaggg tccatggacc acctactgag actctgccca
     1801 ctcccaggga gaggaaccta gcatccccat caccttccac tctggttgag gcaagagagg
     1861 tgggggaggc aactggtggt cctgagctat ctggggtccc tcgaggagag agcgaggaga
     1921 caggaagctc cgagggtgcc ccttccctgc ttccagccac acgggcccct gagggtacca
     1981 gggagctgga ggccccctct gaagataatt ctggaagaac tgccccagca gggacctcag
     2041 tgcaggccca gccagtgctg cccactgaca gcgccagccg aggtggagtg gccgtggtcc
     2101 ccgcatcagg tgactgtgtc cccagcccct gccacaatgg tgggacatgc ttggaggagg
     2161 aggaaggggt ccgctgccta tgtctgcctg gctatggggg ggacctgtgc gatgttggcc
     2221 tccgcttctg caaccccggc tgggacgcct tccagggcgc ctgctacaag cacttttcca
     2281 cacgaaggag ctgggaggag gcagagaccc agtgccggat gtacggcgcg catctggcca
     2341 gcatcagcac acccgaggaa caggacttca tcaacaaccg gtaccgggag taccagtgga
     2401 tcggactcaa cgacaggacc atcgaaggcg acttcttgtg gtcggatggc gtccccctgc
     2461 tctatgagaa ctggaaccct gggcagcctg acagctactt cctgtctgga gagaactgcg
     2521 tggtcatggt gtggcatgat cagggacaat ggagtgacgt gccctgcaac taccacctgt
     2581 cctacacctg caagatgggg ctggtgtcct gtgggccgcc accggagctg cccctggctc
     2641 aagtgttcgg ccgcccacgg ctgcgctatg aggtggacac tgtgcttcgc taccggtgcc
     2701 gggaaggact ggcccagcgc aatctgccgc tgatccgatg ccaagagaac ggtcgttggg
     2761 aggcccccca gatctcctgt gtgcccagaa gacctgcccg agctctgcac ccagaggagg
     2821 acccagaagg acgtcagggg aggctactgg gacgctggaa ggcgctgttg atcccccctt
     2881 ccagccccat gccaggtccc tagggggcaa ggccttgaac actgccggcc acagcactgc
     2941 cctgtcaccc aaattttccc tcacaccctg cgctcccgcc accacaggaa gtgacaacat
     3001 gacgaggggt ggtactggag tccaggtgac agttcctgaa ggggcttctg ggaaatacct
     3061 aggaggctcc agcccagccc aggccctctc cccctaccct gggcaccaga tcttccatca
     3121 gggccggagt aaatccctaa gtgcctcaac tgccctctcc ctggcagcca tcttgtcccc
     3181 tctattcctc tagggagcac tgtgcccact ctttctgggt tttccaaggg aatgggcttg
     3241 caggatggag tgtctgtaaa atcaacagga aataaaactg tgtatgagcc caggcaa
//
