LOCUS       NM_025057               3113 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens basal body orientation factor 1 (BBOF1), mRNA.
ACCESSION   NM_025057
VERSION     NM_025057.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3113)
  AUTHORS   Chien,Y.H., Werner,M.E., Stubbs,J., Joens,M.S., Li,J., Chien,S.,
            Fitzpatrick,J.A., Mitchell,B.J. and Kintner,C.
  TITLE     Bbof1 is required to maintain cilia orientation
  JOURNAL   Development 140 (16), 3468-3477 (2013)
   PUBMED   23900544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005484.2, DB484577.1, DB493409.1, BC044808.1, BC104979.1,
            AK026842.1 and AL834487.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_025057.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044808.1, SRR1803611.222344.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394009.5/ ENSP00000377577.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC005484.2         121735-121741       c
            8-70                DB484577.1         4-66
            71-580              DB493409.1         2-511
            581-1413            BC044808.1         513-1345
            1414-1760           BC104979.1         438-784
            1761-2124           BC044808.1         1691-2054
            2125-3104           AK026842.1         1151-2130
            3105-3113           AL834487.1         2373-2381
FEATURES             Location/Qualifiers
     source          1..3113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..3113
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /note="basal body orientation factor 1"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
     exon            1..186
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1720
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /note="coiled-coil domain-containing protein 176;
                     coiled-coil domain containing 176"
                     /codon_start=1
                     /product="basal body-orientation factor 1"
                     /protein_id="NP_079333.2"
                     /db_xref="CCDS:CCDS32119.2"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
                     /translation="MPSKGKDKKKGKSKGKDTKKLIKTDESVVDRAKANASLWEARLE
                     VTELSRIKYRDTSRILAKSNEDLKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQQ
                     LNETKEKAQEEKDKLEQKYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVE
                     RELDDLKENLRNTERIHQETLRRLESRFFEEKHRLEQEAEKKIIMLAERAHHEAIVQL
                     NDAGRNVFKENDYLQKALAYHLKETDALQKNSQKLQESHTLLLHQKEINDLLVKEKIM
                     QLVQQRSQIQTLQKKVVNLETALSYMTKEFESEVLKLQQHAMIENQAGQVEIDKLQHL
                     LQMKDREMNRVKKLAKNILDERTEVERFFLDALHQVKQQILISRKHYKQIAQAAFNLK
                     MRAACTGRTEYPKIRTFDGREHSTNSVNQDLLEAEKWTHIEGNVDIGDLTWEQKEKVL
                     RLLFAKMNGCPSRKYNQSSRPPVPDYVVSDSGETKEFGDESKLQDKIFITQQIAISDS
                     SGEVVLPTIPKEPQESDTGTF"
     exon            187..415
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     exon            416..481
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     exon            482..625
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     exon            626..706
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     exon            707..777
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     exon            778..922
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1416
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1518
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1593
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1708
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..3113
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3094..3099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /note="hexamer: AATAAA"
     polyA_site      3113
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /note="major polyA site"
ORIGIN      
        1 gctctccgcg cgccgtcagc ggcgcgggtg gggcattgcc agctcggcgt cccggttccc
       61 ttggagacag agctggccag ggcggccgcg gctgggcaac tacgacagcg gagcccctgg
      121 ggaagccaag atgccgtcga agggaaagga caaaaagaaa ggcaagagca aaggcaaaga
      181 cacgaagaag ttaataaaaa cagatgaatc tgtggtggac agagccaagg ccaatgcctc
      241 cctttgggag gccaggttgg aagtcacaga actctctagg attaagtatc gtgatacttc
      301 acggatactg gcaaaaagta atgaggactt aaagaaaaag caatgtaaaa tggagaaaga
      361 cataatgtca gtattaagtt acctgaagaa gcaggatcag gagaaagata atatgattga
      421 aaaactgaaa cagcaattaa atgaaacaaa ggaaaaagcc caagaggaga aggataaatt
      481 ggaacaaaag tataccaggc aaattaatga actagaggga cagttccatc aaaaagccaa
      541 agaaattggc atgattcaca cagagctgaa agcagtaaga caattccaga agagaaaaat
      601 ccaagtggag agagagttag atgatctgaa agagaattta agaaacacag agcggataca
      661 tcaggagact cttagaagac tggaaagcag attttttgaa gaaaagcacc gactagaaca
      721 agaggctgaa aagaagataa taatgctagc agagagagcc caccatgagg ctattgtgca
      781 attgaacgat gctggaagaa atgtttttaa agagaatgat tatcttcaga aagctctggc
      841 atatcacctg aaggaaactg acgctctaca aaaaaactcc cagaagttgc aagagagtca
      901 tactttactt ttacatcaaa aggagatcaa tgatctgttg gttaaggaaa agattatgca
      961 acttgtccag cagagatcac aaatccaaac ccttcagaag aaggtagtaa acttggagac
     1021 tgctctgagt tacatgacca aagagtttga gagtgaagtt ttaaaactgc agcaacacgc
     1081 aatgatagag aaccaagcag gtcaggtaga aattgacaag ctgcagcacc ttcttcagat
     1141 gaaggacagg gaaatgaatc gtgtgaagaa gctggccaag aacatactgg atgagagaac
     1201 agaagtggaa agattctttt tagatgctct gcaccaagtg aagcaacaga tcctaattag
     1261 caggaagcat tataagcaga tagcacaagc tgctttcaat ttaaaaatga gagcagcatg
     1321 tacaggaaga acagaatatc ccaaaatcag aacatttgat ggcagagagc acagcaccaa
     1381 tagtgtgaat caggatcttc tggaggccga aaaatggaca catattgaag gaaatgtgga
     1441 tattggagat ttgacctggg agcagaagga aaaagtattg cgattgctct ttgcaaaaat
     1501 gaatggctgt ccttctagga aatacaacca gagttctagg cctccagttc cagactatgt
     1561 tgtttctgac agtggggaaa caaaggaatt tggggatgaa agtaagcttc aagataaaat
     1621 cttcatcacc cagcaaattg caatatcaga ctcttctggt gaagtggtgc tacccactat
     1681 tccaaaagaa cctcaggagt ctgacacagg aaccttctga gaagcactga ttatgacctc
     1741 acagatgctg ctggcagtcc cttccttgca gaatccttgc tcctgaatat ctttaagaaa
     1801 atttcttaaa ggaaaagaca aaaaatttaa ctcaaaagtt acctgtttgc catagaaatt
     1861 ggtgtctccc ctgaaggagg atcgagagcc ggtgaatgag aacattggca aaggcactgg
     1921 aatggggaca ttcactccca cctaaaacag aacaaatccg tgtcatatcc taaggacaaa
     1981 ggaactctcc atttagaaac acaaaggcat cagagaccag ttttaaatac ccaccttcta
     2041 ccctatcctc taccccatga actttcattc ctgaggaaga aatggggcaa tgtgggaggt
     2101 catgggggca atcttaaacc aatgactcac cattatttac tgtttcctct taggaaatag
     2161 taaatggata taagaatctc ttaaaaattc tgttcacgaa cctgtccaac atccaccaag
     2221 tgggcatatt tccgagcagt ggctccattg gtggtgaaga tggcagttcc atttccatat
     2281 gggttgttat ttacaatctg gatggcttca tccaatgttt ctgtctccag aaccacaaga
     2341 actggaccaa aaatctcctc tttgtaacag gtcatatttg gctgccagga gtgatgcatc
     2401 cagaaaagaa gtcagctttt tggattctga gtattttatg cttatttggt actttcactt
     2461 actacacatc atttacgtgg acaactttca tattactaat ctcttttcat ttcaaatcac
     2521 ctatttaaaa aaaaagtcct ctctcaagtg tattccgtct tccaagttac caatcatata
     2581 aacaacttgg aattcctatc aacaataacc acacttcctt taagggactg tatctttagt
     2641 tcatgaccca tcatcagctg cctttttaat acctgaacga ctagtttcat ccaattgtta
     2701 tcaaaaagtt acatgaaaat ttatttttta taaatccaat ctatagtaaa tataccagga
     2761 taatttttct ctttacagaa accccatgct gttttctgta acataaataa tccattctta
     2821 ttcactcctt tgcctcccaa atatgtctgt atgtttatat tttgatatca ggtcgcagac
     2881 actcaaaaca tccttcacca tgcaattaat gtttgttgct gataaacgga tttttctgta
     2941 tggttctgtg gcaagagatt tcataatttc tactgcactt acattcaaca cttgatgatt
     3001 cactattata gtaaggatat atgaatttca aaaaatgcct cataacctca atttttaagt
     3061 catgttagct gagagacttt caaagttttg ataaataaaa attgacaagt caa
//
