LOCUS       NM_024112                704 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens bublin coiled coil protein (BBLN), mRNA.
ACCESSION   NM_024112
VERSION     NM_024112.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 704)
  AUTHORS   Chen,X., Zhang,H. and Xiao,B.
  TITLE     C9orf16 represents the aberrant genetic programs and drives the
            progression of PDAC
  JOURNAL   BMC Cancer 22 (1), 1102 (2022)
   PUBMED   36307773
  REMARK    GeneRIF: C9orf16 represents the aberrant genetic programs and
            drives the progression of PDAC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 704)
  AUTHORS   Morimoto,E., Tsuboyama,K. and Tomari,Y.
  TITLE     Fusion with heat-resistant obscure (Hero) proteins have the
            potential to improve the molecular property of recombinant proteins
  JOURNAL   PLoS One 17 (6), e0270097 (2022)
   PUBMED   35714106
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 704)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 704)
  AUTHORS   Remmelzwaal,S., Geisler,F., Stucchi,R., van der Horst,S.,
            Pasolli,M., Kroll,J.R., Jarosinska,O.D., Akhmanova,A.,
            Richardson,C.A., Altelaar,M., Leube,R.E., Ramalho,J.J. and Boxem,M.
  TITLE     BBLN-1 is essential for intermediate filament organization and
            apical membrane morphology
  JOURNAL   Curr Biol 31 (11), 2334-2346 (2021)
   PUBMED   33857431
REFERENCE   5  (bases 1 to 704)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 704)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   7  (bases 1 to 704)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   8  (bases 1 to 704)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 704)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   10 (bases 1 to 704)
  AUTHORS   Gilley,J. and Fried,M.
  TITLE     Extensive gene order differences within regions of conserved
            synteny between the Fugu and human genomes: implications for
            chromosomal evolution and the cloning of disease genes
  JOURNAL   Hum Mol Genet 8 (7), 1313-1320 (1999)
   PUBMED   10369878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB493059.1 and BC001857.2.
            
            On Nov 23, 2018 this sequence version replaced NM_024112.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM550794.1, SRR1163655.129104.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372994.2/ ENSP00000362085.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                DB493059.1         72-162
            92-704              BC001857.2         1-613
FEATURES             Location/Qualifiers
     source          1..704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..704
                     /gene="BBLN"
                     /gene_synonym="C9orf16; EST00098; Hero9"
                     /note="bublin coiled coil protein"
                     /db_xref="GeneID:79095"
                     /db_xref="HGNC:HGNC:17823"
     exon            1..222
                     /gene="BBLN"
                     /gene_synonym="C9orf16; EST00098; Hero9"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..395
                     /gene="BBLN"
                     /gene_synonym="C9orf16; EST00098; Hero9"
                     /note="UPF0184 protein C9orf16"
                     /codon_start=1
                     /product="bublin coiled-coil protein"
                     /protein_id="NP_077017.1"
                     /db_xref="CCDS:CCDS6893.1"
                     /db_xref="GeneID:79095"
                     /db_xref="HGNC:HGNC:17823"
                     /translation="MSGPNGDLGMPVEAGAEGEEDGFGEAEYAAINSMLDQINSCLDH
                     LEEKNDHLHARLQELLESNRQTRLEFQQQLGEAPSDASP"
     exon            223..704
                     /gene="BBLN"
                     /gene_synonym="C9orf16; EST00098; Hero9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      686..691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BBLN"
                     /gene_synonym="C9orf16; EST00098; Hero9"
                     /note="hexamer: ATTAAA"
     polyA_site      704
                     /gene="BBLN"
                     /gene_synonym="C9orf16; EST00098; Hero9"
                     /note="major polyA site"
ORIGIN      
        1 ctctgggcgg agatctgctg ccgcgttcta cccttccggc ccgtgttcta tccgccgcct
       61 ccaccttcca tccggcgccg gctttcggcg cgacggtcgc cgcgttccat cgtcgcgcgg
      121 cccttcgggc gcccgagccc gcaatgtcgg gccccaacgg agacctgggg atgccggtgg
      181 aggcgggagc ggaaggcgag gaggacggct tcggggaagc agaatacgct gccatcaact
      241 ccatgctgga ccagatcaac tcctgtctgg accacctgga ggagaagaat gaccacctcc
      301 acgcccgcct ccaggagctg ctggagtcca accggcagac acgcctggag ttccagcagc
      361 agctcgggga ggcccccagt gatgccagcc cctaggctcc aagagccccc aaccgggacc
      421 caaccctgcc tccctgggct aggctctggc ctgggcactc accccctggc ttagacacct
      481 tctcaagggc tggccttcag ggacccctgg tgggtctgcc tgcctgggcc acccttcctg
      541 cctgggcctc cccttggcct acctgggcca gcccccacca cctggcatgc cctcctgggg
      601 ccaagagtgg gcctgcaacc cacccacttg cctgcccacc caactcctgg gcgctcccca
      661 ctctgcccag gccttgagtg tccacattaa atgggtctcc caca
//
