LOCUS       NM_013450               8145 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens bromodomain adjacent to zinc finger domain 2B (BAZ2B),
            transcript variant 1, mRNA.
ACCESSION   NM_013450
VERSION     NM_013450.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8145)
  AUTHORS   Ros,J., Vivancos,A., Tabernero,J. and Elez,E.
  TITLE     Circulating tumor DNA, and clinical features to guide rechallenge
            with BRAF inhibitors in BRAF-V600E mutated metastatic colorectal
            cancer
  JOURNAL   Ann Oncol 35 (2), 240-241 (2024)
   PUBMED   37866812
  REMARK    GeneRIF: Circulating tumor DNA, and clinical features to guide
            rechallenge with BRAF inhibitors in BRAF-V600E mutated metastatic
            colorectal cancer.
REFERENCE   2  (bases 1 to 8145)
  AUTHORS   Breindl,M., Spitzer,D., Gerasimaite,R., Kairys,V., Schubert,T.,
            Henfling,R., Schwartz,U., Lukinavicius,G. and Manelyte,L.
  TITLE     Biochemical and cellular insights into the Baz2B protein, a
            non-catalytic subunit of the chromatin remodeling complex
  JOURNAL   Nucleic Acids Res 52 (1), 337-354 (2024)
   PUBMED   38000389
  REMARK    GeneRIF: Biochemical and cellular insights into the Baz2B protein,
            a non-catalytic subunit of the chromatin remodeling complex.
REFERENCE   3  (bases 1 to 8145)
  AUTHORS   Arumugam,K., Shin,W., Schiavone,V., Vlahos,L., Tu,X., Carnevali,D.,
            Kesner,J., Paull,E.O., Romo,N., Subramaniam,P., Worley,J., Tan,X.,
            Califano,A. and Cosma,M.P.
  TITLE     The Master Regulator Protein BAZ2B Can Reprogram Human
            Hematopoietic Lineage-Committed Progenitors into a Multipotent
            State
  JOURNAL   Cell Rep 33 (10), 108474 (2020)
   PUBMED   33296649
  REMARK    GeneRIF: The Master Regulator Protein BAZ2B Can Reprogram Human
            Hematopoietic Lineage-Committed Progenitors into a Multipotent
            State.
REFERENCE   4  (bases 1 to 8145)
  AUTHORS   Scott,T.M., Guo,H., Eichler,E.E., Rosenfeld,J.A., Pang,K., Liu,Z.,
            Lalani,S., Bi,W., Yang,Y., Bacino,C.A., Streff,H., Lewis,A.M.,
            Koenig,M.K., Thiffault,I., Bellomo,A., Everman,D.B., Jones,J.R.,
            Stevenson,R.E., Bernier,R., Gilissen,C., Pfundt,R., Hiatt,S.M.,
            Cooper,G.M., Holder,J.L. and Scott,D.A.
  TITLE     BAZ2B haploinsufficiency as a cause of developmental delay,
            intellectual disability, and autism spectrum disorder
  JOURNAL   Hum Mutat 41 (5), 921-925 (2020)
   PUBMED   31999386
  REMARK    GeneRIF: BAZ2B haploinsufficiency as a cause of developmental
            delay, intellectual disability, and autism spectrum disorder.
REFERENCE   5  (bases 1 to 8145)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 8145)
  AUTHORS   Ferguson,F.M., Dias,D.M., Rodrigues,J.P., Wienk,H., Boelens,R.,
            Bonvin,A.M., Abell,C. and Ciulli,A.
  TITLE     Binding hotspots of BAZ2B bromodomain: Histone interaction revealed
            by solution NMR driven docking
  JOURNAL   Biochemistry 53 (42), 6706-6716 (2014)
   PUBMED   25266743
REFERENCE   7  (bases 1 to 8145)
  AUTHORS   Ferguson,F.M., Fedorov,O., Chaikuad,A., Philpott,M., Muniz,J.R.,
            Felletar,I., von Delft,F., Heightman,T., Knapp,S., Abell,C. and
            Ciulli,A.
  TITLE     Targeting low-druggability bromodomains: fragment based screening
            and inhibitor design against the BAZ2B bromodomain
  JOURNAL   J Med Chem 56 (24), 10183-10187 (2013)
   PUBMED   24304323
REFERENCE   8  (bases 1 to 8145)
  AUTHORS   Arking,D.E., Junttila,M.J., Goyette,P., Huertas-Vazquez,A.,
            Eijgelsheim,M., Blom,M.T., Newton-Cheh,C., Reinier,K.,
            Teodorescu,C., Uy-Evanado,A., Carter-Monroe,N., Kaikkonen,K.S.,
            Kortelainen,M.L., Boucher,G., Lagace,C., Moes,A., Zhao,X.,
            Kolodgie,F., Rivadeneira,F., Hofman,A., Witteman,J.C.,
            Uitterlinden,A.G., Marsman,R.F., Pazoki,R., Bardai,A., Koster,R.W.,
            Dehghan,A., Hwang,S.J., Bhatnagar,P., Post,W., Hilton,G.,
            Prineas,R.J., Li,M., Kottgen,A., Ehret,G., Boerwinkle,E.,
            Coresh,J., Kao,W.H., Psaty,B.M., Tomaselli,G.F., Sotoodehnia,N.,
            Siscovick,D.S., Burke,G.L., Marban,E., Spooner,P.M., Cupples,L.A.,
            Jui,J., Gunson,K., Kesaniemi,Y.A., Wilde,A.A., Tardif,J.C.,
            O'Donnell,C.J., Bezzina,C.R., Virmani,R., Stricker,B.H., Tan,H.L.,
            Albert,C.M., Chakravarti,A., Rioux,J.D., Huikuri,H.V. and
            Chugh,S.S.
  TITLE     Identification of a sudden cardiac death susceptibility locus at
            2q24.2 through genome-wide association in European ancestry
            individuals
  JOURNAL   PLoS Genet 7 (6), e1002158 (2011)
   PUBMED   21738491
REFERENCE   9  (bases 1 to 8145)
  AUTHORS   Tang,W., Basu,S., Kong,X., Pankow,J.S., Aleksic,N., Tan,A.,
            Cushman,M., Boerwinkle,E. and Folsom,A.R.
  TITLE     Genome-wide association study identifies novel loci for plasma
            levels of protein C: the ARIC study
  JOURNAL   Blood 116 (23), 5032-5036 (2010)
   PUBMED   20802025
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 8145)
  AUTHORS   Jones,M.H., Hamana,N., Nezu,Ji. and Shimane,M.
  TITLE     A novel family of bromodomain genes
  JOURNAL   Genomics 63 (1), 40-45 (2000)
   PUBMED   10662543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009506.5 and AC008277.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_013450.3.
            
            Summary: This gene belongs to the bromodomain gene family. Members
            of this gene family encode proteins that are integral components of
            chromatin remodeling complexes. The encoded protein showed strong
            preference for the activating H3K14Ac mark in a histone peptide
            screen, suggesting a potential role in transcriptional activation.
            This gene may be associated with susceptibility to sudden cardiac
            death (SCD). [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMEA1965299,
                              SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000392783.7/ ENSP00000376534.2
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AC009506.5         169851-170157       c
            308-350             AC009506.5         109432-109474       c
            351-497             AC009506.5         32184-32330         c
            498-686             AC009506.5         7222-7410           c
            687-854             AC009506.5         1851-2018           c
            855-1048            AC009506.5         391-584             c
            1049-1252           AC008277.4         169507-169710       c
            1253-1645           AC008277.4         168801-169193       c
            1646-2252           AC008277.4         163255-163861       c
            2253-2546           AC008277.4         161361-161654       c
            2547-2607           AC008277.4         159698-159758       c
            2608-2716           AC008277.4         158809-158917       c
            2717-2818           AC008277.4         158439-158540       c
            2819-3029           AC008277.4         142833-143043       c
            3030-3122           AC008277.4         135520-135612       c
            3123-3184           AC008277.4         135347-135408       c
            3185-3250           AC008277.4         131097-131162       c
            3251-3316           AC008277.4         129327-129392       c
            3317-3361           AC008277.4         127843-127887       c
            3362-3427           AC008277.4         126267-126332       c
            3428-3568           AC008277.4         119843-119983       c
            3569-3823           AC008277.4         116851-117105       c
            3824-4038           AC008277.4         115653-115867       c
            4039-4113           AC008277.4         114104-114178       c
            4114-4357           AC008277.4         113057-113300       c
            4358-4420           AC008277.4         105189-105251       c
            4421-4565           AC008277.4         103543-103687       c
            4566-5215           AC008277.4         80206-80855         c
            5216-5489           AC008277.4         79505-79778         c
            5490-5645           AC008277.4         79176-79331         c
            5646-5806           AC008277.4         77984-78144         c
            5807-6012           AC008277.4         68065-68270         c
            6013-6148           AC008277.4         67440-67575         c
            6149-6295           AC008277.4         63038-63184         c
            6296-6561           AC008277.4         56151-56416         c
            6562-6705           AC008277.4         55309-55452         c
            6706-8145           AC008277.4         49477-50916         c
FEATURES             Location/Qualifiers
     source          1..8145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..8145
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /note="bromodomain adjacent to zinc finger domain 2B"
                     /db_xref="GeneID:29994"
                     /db_xref="HGNC:HGNC:963"
                     /db_xref="MIM:605683"
     exon            1..307
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            308..350
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            351..497
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..6859
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /note="isoform a is encoded by transcript variant 1;
                     bromodomain adjacent to zinc finger domain protein 2B"
                     /codon_start=1
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2B isoform a"
                     /protein_id="NP_038478.2"
                     /db_xref="CCDS:CCDS2209.2"
                     /db_xref="GeneID:29994"
                     /db_xref="HGNC:HGNC:963"
                     /db_xref="MIM:605683"
                     /translation="MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSST
                     INPCGHLFRTAGDQPFNLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALA
                     AHPQLASFPGAEWWRTTDAHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKS
                     NRNGPEKGVNGSINGSNTSSVIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSK
                     NQPLDARVDKIKDKKPRKKAMESSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEED
                     QSIEESEDDDSDSESEAQHKSNNQVLLHGISDPKADGQKATEKAQEKRIHQPLPLASE
                     SQTHSFQSQQKQPQVLSQQLPFIFQSSQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQ
                     AKKETYMKLIVPSPDVLKAGNKNTSEESSLLTSELRSKREQYKQAFPSQLKKQESSKS
                     LKKVIAALSNPKATSSSPAHPKQTLENNHPNPFLTNALLGNHQPNGVIQSVIQEAPLA
                     LTTKTKMQSKINENIAAASSTPFSSPVNLSTSGRRTPGNQTPVMPSASPILHSQGKEK
                     AVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPSSKDSEDSNEDEEEDDEEEDEEDDE
                     DDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESDSDTEGEKTSMKLNKTTSSVKSP
                     SMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGTSSSTLTSSPHSGTSKRRRVT
                     DERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKLRQYPEVIKYLSRNGIMDI
                     SRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRAMEGRRGRPPNPDRQRA
                     REESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQIKLLRKLQKQEQAR
                     VAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELRAQQILEAKKKKK
                     EEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEARKKAEEKERL
                     KQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRIPGLVLSGS
                     TFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLVRLLSAA
                     VCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTKAFQA
                     HTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHAKK
                     TGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
                     KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFG
                     QDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSL
                     NCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGAN
                     GCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTL
                     TEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPV
                     GLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSF
                     LTSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPED
                     LKALLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVE
                     NWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTK
                     LCKEHDGEFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWR
                     RALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHT
                     YCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTED
                     EDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILT
                     EMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLV
                     FDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS"
     exon            498..686
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            687..854
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1048
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1252
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1645
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..2252
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2546
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2607
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2716
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2818
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..3029
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3122
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3184
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3250
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3316
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3361
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3427
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3568
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3823
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..4038
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4039..4113
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4114..4357
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4358..4420
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4421..4565
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4566..5215
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            5216..5489
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            5490..5645
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            5646..5806
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            5807..6012
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            6013..6148
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            6149..6295
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            6296..6561
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            6562..6705
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     exon            6706..8145
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8123..8128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /note="hexamer: AATAAA"
     polyA_site      8145
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /note="major polyA site"
ORIGIN      
        1 acttggttca tgaagccttc gcctagaagt gaagctgctg aacaaacctt gagaagaatc
       61 atctcctgct tcaatctgct gctggatagg aactaatcag agagagagag gcggaagacg
      121 gagaaggagg gagtcgaagg ctttcccgat cacaaatctc acctccacta caactctctt
      181 tatacttttc ttgcagaaat aataatagaa ataaggaggt ggtggggttt ccaaaaatct
      241 taaccttcaa ccatctgggg aaaaggcaaa aatcccatct accgcaactc tcagttcgag
      301 agtaaaggtt tcccaacagt gatgtcacaa gattgaccac attgatcaca atatggagtc
      361 tggagaacgg ttaccatcct cagcagcctc ctctactaca ccaacttcat cttcgacacc
      421 ttctgtggct tcagtagttt caaaaggtgg cctttccact ggagttgctt cacttagctc
      481 tacaatcaac ccatgtggac atttattcag aacagctggg gatcaaccgt ttaacctgtc
      541 cacagtgtcg agtgccttcc caatggtcag ccacccagtc tttggtctac attcagccag
      601 ctcagggcat tcagaatttg gtggtttggg gacacttggt acacccacag ccttagccgc
      661 acatccccaa ctagcatctt ttccaggtgc agaatggtgg cgaacaactg atgctcatac
      721 tcgtacagga gcaaccttct ttccaccatt actgggaatt ccaccactat ttgctccccc
      781 agcccagaat catgattctt cttcattcca ttcaaggact tcgggaaaaa gtaatcgaaa
      841 tggtcccgaa aaaggtgtaa atgggtcaat aaatggaagt aatacatcat ctgtaattgg
      901 tatcaacaca tctgtactat ccactactgc ttcaagttcc atgggacaaa ctaaaagtac
      961 aagctcaggt ggaggaaatc gaaaatgtaa tcaggaacaa agcaaaaacc agcctttgga
     1021 tgctagagtt gacaaaatca aagataagaa accaaggaag aaagcaatgg aaagttctag
     1081 caacagtgat agtgattcag gcacatcatc agacacctca agtgaaggca ttagtagcag
     1141 tgattcagat gatctagaag aagatgaaga agaagaagat caaagtattg aagaaagtga
     1201 agatgatgat tctgattcag agagtgaagc acaacataaa agtaacaacc aggtgctatt
     1261 acatggtatt tcagacccaa aagcagatgg acagaaagca actgaaaaag cccaggaaaa
     1321 aagaatacac cagccattac ctcttgcgtc tgaatcccag actcactcat tccaatccca
     1381 gcagaagcag cctcaggttt tgtcacagca gcttccattt attttccaaa gctctcaggc
     1441 aaaggaggaa tctgtgaaca aacacaccag tgtaatacag tctacgggat tggtgtccaa
     1501 tgtgaaacct ttatctttgg taaatcaagc caaaaaggaa acttacatga aactcatagt
     1561 tccttctcct gatgttctta aagcagggaa taaaaatacc tctgaagaat ctagtttatt
     1621 gaccagtgaa ttgagatcca aacgggaaca atataaacag gcattcccat cacagttaaa
     1681 gaaacaagag tcatcgaaga gcctgaagaa ggttattgca gctttgtcaa atccaaaagc
     1741 aacctctagt tcaccagcac atccaaaaca aacattagaa aacaaccacc caaatccatt
     1801 cttgacaaat gcacttttag gtaatcacca accaaatgga gttattcaaa gtgtcattca
     1861 agaagctcct ctagcactta ctaccaaaac taaaatgcag agcaagatta atgaaaacat
     1921 tgctgctgca agtagcaccc ctttttcctc acctgtaaat ctgagtacaa gtgggagaag
     1981 aacccctggc aatcagacac ctgtaatgcc ctctgcctct cccatcctgc atagtcaagg
     2041 gaaggaaaaa gcagttagca ataatgtaaa cccagtaaaa acacagcatc actcccatcc
     2101 tgcaaaatct ttagtggaac aattcagagg aacagattca gacattccca gtagtaaaga
     2161 ttctgaagat tcaaatgagg atgaagagga agatgatgaa gaagaagatg aggaagatga
     2221 tgaagatgat gaatctgatg acagccaatc agaatcagat agtaattcag aatcagatac
     2281 agaaggatca gaagaagaag atgatgatga taaagaccaa gatgaatcag atagtgatac
     2341 tgaaggagag aaaacttcaa tgaaactgaa taaaacaact tcctctgtca aaagcccttc
     2401 catgagtctc acaggtcact caacacctcg taacctccac atagcaaaag ccccaggctc
     2461 tgctcctgct gccttatgtt ctgaatccca gtcacctgct tttcttggta catcttcttc
     2521 cacacttact tcaagcccac actctggcac ttccaaaaga agaagagtaa cagatgaacg
     2581 tgaactgcgt attccattgg aatatggctg gcagagagag acaagaataa gaaactttgg
     2641 agggcgcctt caaggagaag tagcatatta tgctccatgt ggaaagaaac ttaggcagta
     2701 ccctgaagta ataaagtatc tcagcagaaa tggaataatg gatatctcaa gggacaattt
     2761 cagcttcagt gcaaaaataa gagtgggtga cttctatgaa gccagagatg gaccgcaggg
     2821 aatgcagtgg tgtcttttga aagaagagga tgtcattcct cgtatcaggg caatggaagg
     2881 tcgtagagga agaccaccaa atccagatag acaacgagca agagaggaat ccaggatgag
     2941 acgtcggaaa ggtcgacctc caaatgttgg caatgctgaa ttcctagata acgcagatgc
     3001 aaagttgcta agaaaactgc aagctcaaga aatagccagg caagcagcac aaataaagct
     3061 tttgagaaaa cttcaaaagc aggaacaggc tcgggttgct aaagaagcca aaaaacaaca
     3121 agcaataatg gctgctgagg agaagcggaa gcaaaaagaa cagataaaga ttatgaaaca
     3181 gcaggaaaaa attaagagaa tacagcaaat cagaatggaa aaagaacttc gagctcagca
     3241 aattctagag gctaaaaaga aaaagaagga agaagcggca aatgccaaat tattggaggc
     3301 cgagaaacga ataaaggaaa aagaaatgag aagacaacaa gctgttcttc tgaaacatca
     3361 ggaacgagag cgaaggcgac aacacatgat gcttatgaaa gctatggaag ctcgtaaaaa
     3421 agcagaagaa aaagagcggt tgaaacaaga aaaacgtgat gagaaaagat taaataaaga
     3481 gcgtaaacta gagcagcgaa gattagaatt agaaatggca aaggaactaa agaagcctaa
     3541 tgaagacatg tgcttagcag accaaaagcc tttgccagag ttgcctcgta ttccaggact
     3601 tgttctctct ggaagtacat tttcagactg tctcatggtg gtgcagttct tacgaaactt
     3661 tggtaaagtt ttgggctttg atgtgaatat tgatgttcca aacctgagtg ttcttcaaga
     3721 gggattgcta aatatagggg acagcatggg tgaagtacaa gacttgcttg tgaggctcct
     3781 ctcagctgct gtatgtgatc caggtctaat aacaggatac aaggctaaaa cagctcttgg
     3841 agaacatttg ctgaatgttg gtgtgaatcg agacaatgtt tccgagattt tacagatatt
     3901 tatggaagcc cactgtggac aaactgagct tactgaaagt ctgaagacca aagcttttca
     3961 ggctcacact ccagcacaga aagcttcagt cctggctttc ctgatcaatg aactggcatg
     4021 cagcaagagt gtggtcagtg aaatcgacaa gaacattgat tatatgtcaa acttgaggag
     4081 agataaatgg gtggtagaag gtaaactccg caagctcaga atcattcatg ctaagaaaac
     4141 aggcaaaaga gacacttcag gtggcattga tctgggagaa gagcagcatc ccttgggcac
     4201 acccactcca ggacgcaagc gaagaaggaa gggaggagac agtgattatg acgatgatga
     4261 tgacgatgac agtgatgacc aaggggatga agatgatgag gatgaagaag ataaagaaga
     4321 caaaaaagga aaaaagactg atatctgtga agatgaggat gaaggtgacc aagcagcaag
     4381 tgttgaagag ctggaaaaac agattgaaaa actgagtaaa caacagagtc agtacagaag
     4441 gaagctcttt gatgcgtctc actcattgcg ttcagtgatg tttggccaag atcgttacag
     4501 acgccggtac tggattcttc cccaatgtgg ggggattttt gtagaaggca tggagagtgg
     4561 tgaaggacta gaagaaattg caaaagaaag agaaaaactg aaaaaggcag aaagtgtcca
     4621 gatcaaagaa gaaatgtttg agacttctgg ggacagttta aattgttcaa atacagatca
     4681 ctgtgaacaa aaggaagatc ttaaagaaaa agataacaca aatctattcc ttcagaaacc
     4741 tggctctttt tccaaattaa gcaagctttt ggaagtagct aagatgcctc ctgagtcaga
     4801 ggttatgacc cccaaaccaa atgctggtgc aaatgggtgc acgttgtctt atcagaacag
     4861 tggaaaacat tcactgggca gcgttcagtc aacagcaacg caaagcaatg tggaaaaggc
     4921 agactctaat aatctgttta atactggttc aagtggtcca gggaagttct acagtcctct
     4981 ccccaatgac cagttactaa aaacgctgac tgaaaagaat agacaatggt ttagtctttt
     5041 gccacgaaca ccctgtgatg acacttcact tactcatgcc gatatgtcaa ctgcttcttt
     5101 ggtgactcct cagtctcagc caccatctaa gtcaccttca cctaccccag ctcctcttgg
     5161 atcttctgct cagaatcctg ttggcttaaa tccatttgct ttatcacctc ttcaggtgaa
     5221 aggtggagta tctatgatgg gacttcagtt ttgtggatgg cccactggtg tggttacttc
     5281 taatattcca tttacatcat ctgtacctag tctaggatcg gggttagggt tatcagaagg
     5341 aaatggtaat tcattcttga cttccaatgt tgcttcaagt aaaagtgaat ctccagtacc
     5401 acagaatgaa aaggccactt cagctcaacc tgcagctgtt gaagtagcaa aaccagtaga
     5461 ttttcctagt ccaaaaccta ttccagaaga aatgcagttt ggttggtgga gaattattga
     5521 cccagaggac ctaaaagctt tgctcaaagt gctgcatctc agaggaataa gagaaaaggc
     5581 attacaaaaa caaattcaga aacatttgga ttatattact caagcctgcc tcaagaataa
     5641 ggatgttgct attattgaac tgaatgaaaa tgaagaaaac caagtaactc gagatattgt
     5701 ggagaactgg tcagtagaag aacaagcaat ggaaatggat ttgagtgtcc ttcaacaggt
     5761 agaagatcta gaaaggagag ttgcatcagc aagtttgcaa gtgaagggtt ggatgtgtcc
     5821 agagcctgca tcagaaaggg aggacttggt atattttgaa cataaatcat ttactaaatt
     5881 gtgcaaggag catgatggag aatttactgg cgaagacgaa agcagtgcac atgcactaga
     5941 acggaagagt gacaaccccc tagatatagc tgtaaccagg ctggctgatt tggagcggaa
     6001 cattgaaaga agaattgaag aggatattgc tccagggctc agggtatgga gaagggcatt
     6061 atcagaagct cgcagtgctg cacaggtagc tctgtgcatt cagcaattac agaaatcaat
     6121 agcatgggaa aaatcaatta tgaaagttta ctgccaaatc tgtcgaaagg gagataatga
     6181 agaactgctt cttctttgtg atggctgtga caaaggctgt catacctact gccatagacc
     6241 caagattaca acaatcccag atggagactg gttttgtcca gcttgcattg ctaaggcaag
     6301 tggtcaaact ctaaaaatca aaaaacttca tgtcaaagga aaaaagacta atgagtcaaa
     6361 gaaaggcaag aaggtaactt taacaggaga tactgaagat gaagactctg catctacaag
     6421 tagttcacta aaaagaggaa acaaagacct caagaaaaga aaaatggagg aaaacacttc
     6481 tattaacttg tcaaaacaag aaagttttac ttcagttaag aaacctaaaa gagatgactc
     6541 caaggaccta gctctttgca gtatgattct gactgaaatg gaaactcatg aggatgcatg
     6601 gccttttcta cttcctgtaa acttgaaact tgttcctggt tataagaaag ttattaagaa
     6661 gcctatggat ttttccacaa ttagagagaa actaagtagt ggacagtatc caaaccttga
     6721 aacctttgct ctagatgtca ggcttgtttt tgacaactgt gaaacattta atgaagatga
     6781 ttctgatata ggcagagctg gccacaatat gaggaagtat tttgaaaaaa agtggacaga
     6841 tactttcaaa gtgagctgaa gttataataa tctctttatt tttttccttc taaacaagga
     6901 caaatgagac cagcaatgtg aactgtattt acataaacgt gcaaggcaca tacataatga
     6961 ctttcttttt ccttaagtat aaaaaaaaag tatcagaaga atgataccat ttttaaaggc
     7021 ttcattccta caacaaccaa ggccctcggt tattggtttg tgtgatttat cagctaattt
     7081 aggtagaaca gggaagcaca cccaaagaat tttcaaagga aagggtgtta tagtgcaata
     7141 gcaattaaaa tatatcaaat cgcactgaat actcaacacc agagctctaa tgtgggaaat
     7201 ggttctcctt tccctctcaa taaatatcta tttttcattt ttttactttg tagtttattt
     7261 tttagtgaat gtatttaatt ttatgaatta tttatgatta aaccacatcc agaatcttcg
     7321 ttttctgtga aaaggaagaa ctagaaaatt gctttaaatc ttgaaaatac aaggaatgtt
     7381 ttaaaatata aaacaaagcc aagttaaact gtttacactg atgtgctata aaagcaccaa
     7441 aaagaaactt tactgtagag ttacaagtac atttatatat atatgttgct gcatcacttg
     7501 tgtagttaaa ttgtatttca aaacagtgaa aaaattgaca tgtatatact gttcattctt
     7561 gtttatatta agtcttgttt taaatatgta ttatgtgtat atattgtttg cagacattat
     7621 tgttcatgcc ttagaggatt gtagcatttt attttcgtct gaaggtaatg atagctatac
     7681 agtctgtaca gtaattatcc tctaccaaca ctgtggcgtc tccttaatct tggtagtgcc
     7741 tgcctttgaa acagggtgta ggggatatta gttttccatt tttctatttt gttatataat
     7801 tttaagccac cagggcctaa attaaagtat aatcatttgt atccatgtgg aataaaattg
     7861 tgacaatttc ctacgcacac agtatttttt catagaaaca tttccctccc atttgccttg
     7921 cctcagaaat aaatttaaaa gacgtttgta accactgtgt tttatctact gtgtgttgtg
     7981 gtggcctgtt ggaggcaaat agatcagatt ttttttgtac ctacgtaaga gtacttgaag
     8041 ttttatttaa aataaaatgt tgtggaaaag gtagcattct ttttttagga gtgttatttt
     8101 tcactatgtg tggcacggat acaataaaag acttttacaa actaa
//
