LOCUS       NP_038478               2168 aa            linear   PRI 03-OCT-2024
DEFINITION  bromodomain adjacent to zinc finger domain protein 2B isoform a
            [Homo sapiens].
ACCESSION   NP_038478
VERSION     NP_038478.2
DBSOURCE    REFSEQ: accession NM_013450.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 2168)
  AUTHORS   Ros,J., Vivancos,A., Tabernero,J. and Elez,E.
  TITLE     Circulating tumor DNA, and clinical features to guide rechallenge
            with BRAF inhibitors in BRAF-V600E mutated metastatic colorectal
            cancer
  JOURNAL   Ann Oncol 35 (2), 240-241 (2024)
   PUBMED   37866812
  REMARK    GeneRIF: Circulating tumor DNA, and clinical features to guide
            rechallenge with BRAF inhibitors in BRAF-V600E mutated metastatic
            colorectal cancer.
REFERENCE   2  (residues 1 to 2168)
  AUTHORS   Breindl,M., Spitzer,D., Gerasimaite,R., Kairys,V., Schubert,T.,
            Henfling,R., Schwartz,U., Lukinavicius,G. and Manelyte,L.
  TITLE     Biochemical and cellular insights into the Baz2B protein, a
            non-catalytic subunit of the chromatin remodeling complex
  JOURNAL   Nucleic Acids Res 52 (1), 337-354 (2024)
   PUBMED   38000389
  REMARK    GeneRIF: Biochemical and cellular insights into the Baz2B protein,
            a non-catalytic subunit of the chromatin remodeling complex.
REFERENCE   3  (residues 1 to 2168)
  AUTHORS   Arumugam,K., Shin,W., Schiavone,V., Vlahos,L., Tu,X., Carnevali,D.,
            Kesner,J., Paull,E.O., Romo,N., Subramaniam,P., Worley,J., Tan,X.,
            Califano,A. and Cosma,M.P.
  TITLE     The Master Regulator Protein BAZ2B Can Reprogram Human
            Hematopoietic Lineage-Committed Progenitors into a Multipotent
            State
  JOURNAL   Cell Rep 33 (10), 108474 (2020)
   PUBMED   33296649
  REMARK    GeneRIF: The Master Regulator Protein BAZ2B Can Reprogram Human
            Hematopoietic Lineage-Committed Progenitors into a Multipotent
            State.
REFERENCE   4  (residues 1 to 2168)
  AUTHORS   Scott,T.M., Guo,H., Eichler,E.E., Rosenfeld,J.A., Pang,K., Liu,Z.,
            Lalani,S., Bi,W., Yang,Y., Bacino,C.A., Streff,H., Lewis,A.M.,
            Koenig,M.K., Thiffault,I., Bellomo,A., Everman,D.B., Jones,J.R.,
            Stevenson,R.E., Bernier,R., Gilissen,C., Pfundt,R., Hiatt,S.M.,
            Cooper,G.M., Holder,J.L. and Scott,D.A.
  TITLE     BAZ2B haploinsufficiency as a cause of developmental delay,
            intellectual disability, and autism spectrum disorder
  JOURNAL   Hum Mutat 41 (5), 921-925 (2020)
   PUBMED   31999386
  REMARK    GeneRIF: BAZ2B haploinsufficiency as a cause of developmental
            delay, intellectual disability, and autism spectrum disorder.
REFERENCE   5  (residues 1 to 2168)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 2168)
  AUTHORS   Ferguson,F.M., Dias,D.M., Rodrigues,J.P., Wienk,H., Boelens,R.,
            Bonvin,A.M., Abell,C. and Ciulli,A.
  TITLE     Binding hotspots of BAZ2B bromodomain: Histone interaction revealed
            by solution NMR driven docking
  JOURNAL   Biochemistry 53 (42), 6706-6716 (2014)
   PUBMED   25266743
REFERENCE   7  (residues 1 to 2168)
  AUTHORS   Ferguson,F.M., Fedorov,O., Chaikuad,A., Philpott,M., Muniz,J.R.,
            Felletar,I., von Delft,F., Heightman,T., Knapp,S., Abell,C. and
            Ciulli,A.
  TITLE     Targeting low-druggability bromodomains: fragment based screening
            and inhibitor design against the BAZ2B bromodomain
  JOURNAL   J Med Chem 56 (24), 10183-10187 (2013)
   PUBMED   24304323
REFERENCE   8  (residues 1 to 2168)
  AUTHORS   Arking,D.E., Junttila,M.J., Goyette,P., Huertas-Vazquez,A.,
            Eijgelsheim,M., Blom,M.T., Newton-Cheh,C., Reinier,K.,
            Teodorescu,C., Uy-Evanado,A., Carter-Monroe,N., Kaikkonen,K.S.,
            Kortelainen,M.L., Boucher,G., Lagace,C., Moes,A., Zhao,X.,
            Kolodgie,F., Rivadeneira,F., Hofman,A., Witteman,J.C.,
            Uitterlinden,A.G., Marsman,R.F., Pazoki,R., Bardai,A., Koster,R.W.,
            Dehghan,A., Hwang,S.J., Bhatnagar,P., Post,W., Hilton,G.,
            Prineas,R.J., Li,M., Kottgen,A., Ehret,G., Boerwinkle,E.,
            Coresh,J., Kao,W.H., Psaty,B.M., Tomaselli,G.F., Sotoodehnia,N.,
            Siscovick,D.S., Burke,G.L., Marban,E., Spooner,P.M., Cupples,L.A.,
            Jui,J., Gunson,K., Kesaniemi,Y.A., Wilde,A.A., Tardif,J.C.,
            O'Donnell,C.J., Bezzina,C.R., Virmani,R., Stricker,B.H., Tan,H.L.,
            Albert,C.M., Chakravarti,A., Rioux,J.D., Huikuri,H.V. and
            Chugh,S.S.
  TITLE     Identification of a sudden cardiac death susceptibility locus at
            2q24.2 through genome-wide association in European ancestry
            individuals
  JOURNAL   PLoS Genet 7 (6), e1002158 (2011)
   PUBMED   21738491
REFERENCE   9  (residues 1 to 2168)
  AUTHORS   Tang,W., Basu,S., Kong,X., Pankow,J.S., Aleksic,N., Tan,A.,
            Cushman,M., Boerwinkle,E. and Folsom,A.R.
  TITLE     Genome-wide association study identifies novel loci for plasma
            levels of protein C: the ARIC study
  JOURNAL   Blood 116 (23), 5032-5036 (2010)
   PUBMED   20802025
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   10 (residues 1 to 2168)
  AUTHORS   Jones,M.H., Hamana,N., Nezu,Ji. and Shimane,M.
  TITLE     A novel family of bromodomain genes
  JOURNAL   Genomics 63 (1), 40-45 (2000)
   PUBMED   10662543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009506.5 and AC008277.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 5, 2006 this sequence version replaced NP_038478.1.
            
            Summary: This gene belongs to the bromodomain gene family. Members
            of this gene family encode proteins that are integral components of
            chromatin remodeling complexes. The encoded protein showed strong
            preference for the activating H3K14Ac mark in a histone peptide
            screen, suggesting a potential role in transcriptional activation.
            This gene may be associated with susceptibility to sudden cardiac
            death (SCD). [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMEA1965299,
                              SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000392783.7/ ENSP00000376534.2
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2168
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     Protein         1..2168
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2B isoform a"
                     /note="bromodomain adjacent to zinc finger domain protein
                     2B"
                     /calculated_mol_wt=240329
     Region          1..29
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          140..348
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          409..428
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          459..479
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          528..698
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          719..740
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          744..816
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(756,758,760,767,769,778,781,785)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          <830..>1055
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          841..872
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          1021..1043
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          1089..1151
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1265..1341
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          1372..>1404
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Site            1462
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Site            1465
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Site            1467
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          1503..1542
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          1582..1607
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          1670..1694
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Site            1680
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          <1712..1751
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1932..1980
                     /region_name="PHD_BAZ2B"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2B (BAZ2B); cd15630"
                     /db_xref="CDD:277100"
     Site            order(1940,1946..1950,1968..1971)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277100"
     Region          1998..2040
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Site            2014
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Site            2019
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9UIF8.3)"
     Region          2065..2161
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(2089,2094,2097,2136,2140,2146)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..2168
                     /gene="BAZ2B"
                     /gene_synonym="WALp4"
                     /coded_by="NM_013450.4:353..6859"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS2209.2"
                     /db_xref="GeneID:29994"
                     /db_xref="HGNC:HGNC:963"
                     /db_xref="MIM:605683"
ORIGIN      
        1 mesgerlpss aassttptss stpsvasvvs kgglstgvas lsstinpcgh lfrtagdqpf
       61 nlstvssafp mvshpvfglh sassghsefg glgtlgtpta laahpqlasf pgaewwrttd
      121 ahtrtgatff ppllgipplf appaqnhdss sfhsrtsgks nrngpekgvn gsingsntss
      181 vigintsvls ttasssmgqt kstssgggnr kcnqeqsknq pldarvdkik dkkprkkame
      241 sssnsdsdsg tssdtssegi sssdsddlee deeeedqsie esedddsdse seaqhksnnq
      301 vllhgisdpk adgqkateka qekrihqplp lasesqthsf qsqqkqpqvl sqqlpfifqs
      361 sqakeesvnk htsviqstgl vsnvkplslv nqakketymk livpspdvlk agnkntsees
      421 slltselrsk reqykqafps qlkkqessks lkkviaalsn pkatssspah pkqtlennhp
      481 npfltnallg nhqpngviqs viqeaplalt tktkmqskin eniaaasstp fsspvnlsts
      541 grrtpgnqtp vmpsaspilh sqgkekavsn nvnpvktqhh shpakslveq frgtdsdips
      601 skdsedsned eeeddeeede eddeddesdd sqsesdsnse sdtegseeed dddkdqdesd
      661 sdtegektsm klnkttssvk spsmsltghs tprnlhiaka pgsapaalcs esqspaflgt
      721 ssstltssph sgtskrrrvt derelriple ygwqretrir nfggrlqgev ayyapcgkkl
      781 rqypevikyl srngimdisr dnfsfsakir vgdfyeardg pqgmqwcllk eedviprira
      841 megrrgrppn pdrqrarees rmrrrkgrpp nvgnaefldn adakllrklq aqeiarqaaq
      901 ikllrklqkq eqarvakeak kqqaimaaee krkqkeqiki mkqqekikri qqirmekelr
      961 aqqileakkk kkeeaanakl leaekrikek emrrqqavll khqererrrq hmmlmkamea
     1021 rkkaeekerl kqekrdekrl nkerkleqrr lelemakelk kpnedmclad qkplpelpri
     1081 pglvlsgstf sdclmvvqfl rnfgkvlgfd vnidvpnlsv lqegllnigd smgevqdllv
     1141 rllsaavcdp glitgykakt algehllnvg vnrdnvseil qifmeahcgq telteslktk
     1201 afqahtpaqk asvlafline lacsksvvse idknidymsn lrrdkwvveg klrklriiha
     1261 kktgkrdtsg gidlgeeqhp lgtptpgrkr rrkggdsdyd ddddddsddq gdeddedeed
     1321 kedkkgkktd icededegdq aasveelekq ieklskqqsq yrrklfdash slrsvmfgqd
     1381 ryrrrywilp qcggifvegm esgegleeia kereklkkae svqikeemfe tsgdslncsn
     1441 tdhceqkedl kekdntnlfl qkpgsfskls kllevakmpp esevmtpkpn agangctlsy
     1501 qnsgkhslgs vqstatqsnv ekadsnnlfn tgssgpgkfy splpndqllk tlteknrqwf
     1561 sllprtpcdd tslthadmst aslvtpqsqp pskspsptpa plgssaqnpv glnpfalspl
     1621 qvkggvsmmg lqfcgwptgv vtsnipftss vpslgsglgl segngnsflt snvasskses
     1681 pvpqnekats aqpaavevak pvdfpspkpi peemqfgwwr iidpedlkal lkvlhlrgir
     1741 ekalqkqiqk hldyitqacl knkdvaiiel neneenqvtr divenwsvee qamemdlsvl
     1801 qqvedlerrv asaslqvkgw mcpepasere dlvyfehksf tklckehdge ftgedessah
     1861 alerksdnpl diavtrladl ernierriee diapglrvwr ralsearsaa qvalciqqlq
     1921 ksiaweksim kvycqicrkg dneellllcd gcdkgchtyc hrpkittipd gdwfcpacia
     1981 kasgqtlkik klhvkgkktn eskkgkkvtl tgdtededsa stssslkrgn kdlkkrkmee
     2041 ntsinlskqe sftsvkkpkr ddskdlalcs miltemethe dawpfllpvn lklvpgykkv
     2101 ikkpmdfsti reklssgqyp nletfaldvr lvfdncetfn eddsdigrag hnmrkyfekk
     2161 wtdtfkvs
//
