LOCUS       NM_001300905            8938 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens bromodomain adjacent to zinc finger domain 2A (BAZ2A),
            transcript variant 2, mRNA.
ACCESSION   NM_001300905 XM_005268599
VERSION     NM_001300905.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8938)
  AUTHORS   Liu,Y., Wang,J., Guo,J., Zhang,Q., Wang,S., Hu,F., Wu,J., Zhao,Y.,
            Zhang,J., Yu,Y., Li,Y. and Zhang,X.
  TITLE     Pan-cancer and multi-omics analyses revealed the diagnostic and
            prognostic value of BAZ2A in liver cancer
  JOURNAL   Sci Rep 14 (1), 5228 (2024)
   PUBMED   38433277
  REMARK    GeneRIF: Pan-cancer and multi-omics analyses revealed the
            diagnostic and prognostic value of BAZ2A in liver cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8938)
  AUTHORS   Zhou,X.J., Xu,H.M., Huang,G.S. and Lin,B.R.
  TITLE     Nasopharyngeal carcinoma derived exosomes regulate the
            proliferation and migration of nasopharyngeal carcinoma cells by
            mediating the miR-99a-5p BAZ2A axis
  JOURNAL   Braz J Otorhinolaryngol 90 (1), 101343 (2024)
   PUBMED   37925811
  REMARK    GeneRIF: Nasopharyngeal carcinoma derived exosomes regulate the
            proliferation and migration of nasopharyngeal carcinoma cells by
            mediating the miR-99a-5p BAZ2A axis.
REFERENCE   3  (bases 1 to 8938)
  AUTHORS   Roganowicz,M., Bar,D., Bersaglieri,C., Aprigliano,R. and Santoro,R.
  TITLE     BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes
            implicated in prostate cancer
  JOURNAL   Life Sci Alliance 6 (7), e202301950 (2023)
   PUBMED   37184661
  REMARK    GeneRIF: BAZ2A-RNA mediated association with TOP2A and KDM1A
            represses genes implicated in prostate cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8938)
  AUTHORS   Chen,S., Zhou,M., Dong,A., Loppnau,P., Wang,M., Min,J. and Liu,K.
  TITLE     Structural basis of the TAM domain of BAZ2A in binding to DNA or
            RNA independent of methylation status
  JOURNAL   J Biol Chem 297 (6), 101351 (2021)
   PUBMED   34715126
  REMARK    GeneRIF: Structural basis of the TAM domain of BAZ2A in binding to
            DNA or RNA independent of methylation status.
REFERENCE   5  (bases 1 to 8938)
  AUTHORS   Pena-Hernandez,R., Aprigliano,R., Carina Frommel,S., Pietrzak,K.,
            Steiger,S., Roganowicz,M., Lerra,L., Bizzarro,J. and Santoro,R.
  TITLE     BAZ2A-mediated repression via H3K14ac-marked enhancers promotes
            prostate cancer stem cells
  JOURNAL   EMBO Rep 22 (11), e53014 (2021)
   PUBMED   34403195
  REMARK    GeneRIF: BAZ2A-mediated repression via H3K14ac-marked enhancers
            promotes prostate cancer stem cells.
REFERENCE   6  (bases 1 to 8938)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   7  (bases 1 to 8938)
  AUTHORS   Mayer,C., Schmitz,K.M., Li,J., Grummt,I. and Santoro,R.
  TITLE     Intergenic transcripts regulate the epigenetic state of rRNA genes
  JOURNAL   Mol Cell 22 (3), 351-361 (2006)
   PUBMED   16678107
REFERENCE   8  (bases 1 to 8938)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 8938)
  AUTHORS   Strohner,R., Nemeth,A., Jansa,P., Hofmann-Rohrer,U., Santoro,R.,
            Langst,G. and Grummt,I.
  TITLE     NoRC--a novel member of mammalian ISWI-containing chromatin
            remodeling machines
  JOURNAL   EMBO J 20 (17), 4892-4900 (2001)
   PUBMED   11532953
REFERENCE   10 (bases 1 to 8938)
  AUTHORS   Jones,M.H., Hamana,N., Nezu,Ji. and Shimane,M.
  TITLE     A novel family of bromodomain genes
  JOURNAL   Genomics 63 (1), 40-45 (2000)
   PUBMED   10662543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB215236.1, AK023842.1 and AC090681.13.
            
            On Jun 2, 2019 this sequence version replaced NM_001300905.1.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter, differs in the 5' UTR, and uses a downstream start codon,
            compared to variant 1. The encoded isoform (2) has a shorter
            N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.7090.1, AK023842.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000549884.6/ ENSP00000447941.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               DB215236.1         6-120
            116-1584            AK023842.1         1-1469
            1585-1813           AC090681.13        42189-42417         c
            1814-1874           AC090681.13        41989-42049         c
            1875-1983           AC090681.13        40825-40933         c
            1984-2085           AC090681.13        40530-40631         c
            2086-2296           AC090681.13        40152-40362         c
            2297-2397           AC090681.13        37049-37149         c
            2398-2463           AC090681.13        36663-36728         c
            2464-2697           AC090681.13        36246-36479         c
            2698-2952           AC090681.13        35489-35743         c
            2953-3167           AC090681.13        35001-35215         c
            3168-3242           AC090681.13        34633-34707         c
            3243-3423           AC090681.13        33936-34116         c
            3424-3483           AC090681.13        33775-33834         c
            3484-3628           AC090681.13        33129-33273         c
            3629-4275           AC090681.13        31962-32608         c
            4276-4498           AC090681.13        31596-31818         c
            4499-4654           AC090681.13        31359-31514         c
            4655-4806           AC090681.13        31097-31248         c
            4807-5096           AC090681.13        30617-30906         c
            5097-5229           AC090681.13        30380-30512         c
            5230-5376           AC090681.13        30118-30264         c
            5377-5606           AC090681.13        29545-29774         c
            5607-5663           AC090681.13        29371-29427         c
            5664-6165           AK023842.1         5547-6048
            6166-8938           AC090681.13        26012-28784         c
FEATURES             Location/Qualifiers
     source          1..8938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..8938
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /note="bromodomain adjacent to zinc finger domain 2A"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
     exon            1..202
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            203..340
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..5916
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /note="isoform 2 is encoded by transcript variant 2; TTF-I
                     interacting peptide 5; bromodomain adjacent to zinc finger
                     domain protein 2A; TTF-I-interacting protein 5;
                     transcription termination factor I-interacting protein 5"
                     /codon_start=1
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform 2"
                     /protein_id="NP_001287834.1"
                     /db_xref="CCDS:CCDS73483.1"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
                     /translation="MEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQG
                     KSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPSVAYDCLWNYSQYPSANPG
                     SNLKDPPLLSQFSGGQYPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNF
                     DSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAE
                     KEMTSVVAENGTGLVGSLELEEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCL
                     DDPSHLPDQLEDTPILSEDSLEPFNSLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPV
                     ISALDCPSLNNATAFSLLADDSQTSTSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQ
                     EEMETQSSDFPPSLTQPAPDQSSTIQLHPATSPAVSPTTSPAVSLVVSPAASPEISPE
                     VCPAASTVVSPAVFSVVSPASSAVLPAVSLEVPLTASVTSPKASPVTSPAAAFPTASP
                     ANKDVSSFLETTADVEEITGEGLTASGSGDVMRRRIATPEEVRLPLQHGWRREVRIKK
                     GSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERD
                     TPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITEL
                     LNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQET
                     KSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKT
                     LATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGLTLPSGAFSDCLTIV
                     EFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLKAALHDPGFPSY
                     CQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRTQPFQAQPPQQKAAV
                     LAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVLAKRTGRSEVEME
                     GPEECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRRGRRDGEVDATASSIPELERQI
                     EKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTEGNLVPEEV
                     IKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSMQPRHLK
                     SPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQSQHDL
                     SQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESSPDPQAL
                     WFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLA
                     GLAPKRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSG
                     WWWIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIFEPRQLPA
                     FQEGIMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDSTREDLAYCE
                     HLSDSQEDITWRGRGREGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPTHEV
                     VLEKALLSTPNGAPEGTTTEISYEITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAW
                     EKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQV
                     EGEFTQKPGFPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSK
                     RRRLSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMR
                     ERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQ
                     ANL"
     exon            341..934
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1120
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1339
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1813
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1874
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1983
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2085
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2296
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2397
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2463
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2697
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2952
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3167
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..3242
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3423
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3483
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3628
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..4275
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4276..4498
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4499..4654
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4655..4806
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4807..5096
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            5097..5229
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            5230..5376
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            5377..5606
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            5607..5750
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     exon            5751..8938
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8578..8583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /note="hexamer: AATAAA"
     polyA_site      8604
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /note="major polyA site"
ORIGIN      
        1 actcctcccc cgccggccat gttggctcct ctcgggcccc gcggttgagc cgcgtccccc
       61 tcccccttcc cgaaccccgg accccagacc ccctccccag cgggcgtctc cacccgttct
      121 ggcgcccgga gcgcggccat gtgaaccgct tgtaccccgg ggagagacga gccccgagcc
      181 cggctggacg ccgctgcctc agaaatggag gcaaacgacc attttaactt tactggcctt
      241 ccccctgcac ctgctgcctc aggactgaaa ccctctcctt cctcagggga gggcctctac
      301 actaacgggt ctcccatgaa cttcccccag caagggaaaa gtttgaatgg ggatgtgaat
      361 gttaatggct tatctactgt atctcacact actacttcag ggattttgaa ctctgctccc
      421 cactcctcca gcacctcaca cctccatcac cccagcgtgg cctacgactg tctctggaac
      481 tactcacagt acccatctgc caatcctggc agcaacctca aggacccacc ccttctctcc
      541 cagttctcgg ggggacaata cccactcaac ggcatccttg ggggcagccg gcaaccttca
      601 tccccaagtc ataacactaa ccttcgggct gggagccaag agttctgggc caacggtacc
      661 cagagtccca tggggcttaa ctttgattca caagaactgt atgattcctt tcctgaccag
      721 aattttgagg tgatgcccaa tggaccccct agttttttca cctccccaca gacttctcct
      781 atgttgggat ctagcattca aacctttgca ccctcccagg aggtaggcag tggtatccat
      841 cctgatgagg cagcagaaaa ggagatgact tcagttgtgg cagagaatgg cactggcttg
      901 gtaggcagct tggagctgga agaagagcag ccagaactga agatgtgtgg ctacaatggc
      961 tctgtccctt ctgtggaatc gttacaccaa gaggtctcag tcctggtccc tgaccccaca
     1021 gtgagctgtt tagatgatcc ttcacatctt cctgatcaac tggaagacac tccaatcctc
     1081 agtgaagact ctctggagcc cttcaactct ctggcaccag agccagtgag tggaggacta
     1141 tatggtattg atgacacgga gctgatgggt gcagaggaca agctgcctct tgaggacagc
     1201 cctgtgattt ctgcccttga ttgcccttcc ctcaataatg ctactgcctt cagtctcctg
     1261 gcagatgata gtcaaacatc aacctctatc tttgccagtc ccacctctcc acctgtccta
     1321 ggggagtctg tcctgcaaga taacagcttt gacctgaata atggtagtga cgctgaacag
     1381 gaagaaatgg aaactcaatc ttcagacttc ccaccatccc tgacccagcc agctcctgat
     1441 cagtcatcca ctattcagct acatccagca acctcaccag cagtctcgcc aacaacctcc
     1501 ccagcagtct ccctagtggt ttctccagca gcctccccag aaatctctcc agaagtttgt
     1561 cccgcagctt ctacagttgt ctctccagca gtcttctcag tggtctctcc agcttcctca
     1621 gcagtcctcc cagcagtctc cttagaagtc ccgttgacgg cttcagtgac atccccaaaa
     1681 gcctctcccg taacttcccc agcagctgcc tttccaacag cctccccagc aaataaggat
     1741 gtcagcagct ttctagaaac cactgctgac gtggaagaga tcactggaga aggactcact
     1801 gcttctggta gtggtgatgt catgaggaga cgtattgcta ccccagaaga agttcgtctt
     1861 cccctccaac atgggtggcg gagagaggtg cgcatcaaga agggcagcca ccgatggcag
     1921 ggggagacct ggtattatgg cccctgtggg aagaggatga agcaatttcc agaagtgatc
     1981 aagtacctga gccgcaacgt ggtacacagt gtccgccgag agcacttcag cttcagtccc
     2041 cgtatgcctg ttggagattt ctttgaagaa agagacacgc cagagggctt gcagtgggtg
     2101 cagctctcag cagaggagat cccgtcgagg attcaggcaa ttactggcaa acggggtcga
     2161 cctcgaaaca ctgagaaggc taagactaag gaagtcccca aggtgaaacg gggtcgaggt
     2221 cggccaccta aggtcaaaat cactgagcta ttgaacaaga cagacaaccg ccccctaaag
     2281 aaactggagg cccaagaaac attgaatgag gaggataaag caaagattgc taaaagcaag
     2341 aagaagatga ggcagaaggt tcaacgggga gagtgtcaga ctactatcca agggcaggcc
     2401 agaaataagc ggaaacaaga gaccaagagc ttaaagcaga aggaagctaa gaagaaatcc
     2461 aaggctgaga aagaaaaagg aaagacaaag caggaaaaac tgaaggaaaa agtcaagagg
     2521 gaaaagaagg agaaggtaaa aatgaaggaa aaggaggagg tgaccaaagc caagccagcc
     2581 tgtaaagcag ataagaccct ggccacacag aggcgcttgg aggaacggca gaggcagcag
     2641 atgatcttgg aggaaatgaa gaagccgaca gaggatatgt gtctgactga ccaccagccc
     2701 ctgcctgact tctcacgagt ccctggtctg acattgccca gtggagcctt ctcagactgc
     2761 ttgaccattg tggagttcct gcatagcttt ggcaaggtgc tgggctttga tcctgccaaa
     2821 gatgtgccta gcctgggggt cctgcaggag ggactcctgt gtcaaggtga cagcttgggt
     2881 gaggtgcaag acctgctggt caggctgctg aaggctgcac tccatgatcc tggctttccc
     2941 tcctactgtc agtccctaaa gatcttgggg gagaaggtgt ctgagatccc actgacaaga
     3001 gacaatgtgt cagagatcct gcgctgcttc cttatggcat atggagtaga gccagccctc
     3061 tgtgaccgcc tgcgcaccca gccttttcag gcccagccac cccagcagaa ggctgctgtc
     3121 ctggccttcc ttgtgcatga gctcaatggc tccaccctca tcatcaatga gattgacaag
     3181 actctggaga gtatgtccag ctacaggaaa aacaagtgga ttgttgaagg ccggctccgg
     3241 aggctgaaaa ctgttctggc caagcgaact gggcggtctg aagtagagat ggaagggcca
     3301 gaggaatgcc tgggacggag gcgcagttct cggatcatgg aggagaccag tggcatggaa
     3361 gaagaggaag aagaggagtc tatagcagct gtccctggcc gcaggggtcg aagagatgga
     3421 gaggttgatg ccacagcatc tagcatccca gagctagagc gccagataga aaaactcagc
     3481 aagcgtcagc ttttctttcg caaaaagctg cttcactcat cccagatgct tcgggcggtc
     3541 tccctgggtc aggaccgcta cagacgtcgc tactgggtat tgccgtattt ggctggtatc
     3601 tttgtagaag gaacagaggg gaacttagtt cctgaggagg tgataaagaa ggaaactgac
     3661 tccttaaaag tggcagccca tgcgtcactc aaccctgccc tcttctctat gaagatggag
     3721 ttagctggct ccaacaccac tgccagttct cctgcccggg cccgaggccg acctcgaaaa
     3781 actaagcccg ggtctatgca acctaggcat cttaagtccc ctgtcagggg tcaggattca
     3841 gaacagcccc aggcccagct tcagcctgag gctcagcttc atgctcctgc ccagccccag
     3901 cctcagcttc agcttcagct tcagtcccat aaggggttcc tggagcaaga aggctcccct
     3961 ttgtcactgg gtcagagcca gcatgacctc agccagtcag ccttcctgtc ttggctgagc
     4021 cagactcaga gccatagctc cctgttgagc agctcagtcc tcacacctga tagcagtccg
     4081 ggaaaactag acccagctcc atcacaaccc ccggaggagc cagagcctga tgaggcagaa
     4141 tccagccctg atcctcaagc actctggttt aacatctcag cccagatgcc ctgcaatgct
     4201 gcccccacac cgccccctgc agtttctgag gaccaaccca ctccctcccc tcagcagctt
     4261 gcctcctcca agccaatgaa tagacctagt gctgccaacc cttgttctcc agtgcagttc
     4321 tcttccacgc ccttggctgg gttggcccct aagaggcgag caggagaccc tggagaaatg
     4381 ccacagagtc ccacagggct gggacagccc aaacggagag ggagacctcc cagtaagttc
     4441 ttcaaacaga tggaacagcg ttacctaacc cagctgacag cccagcctgt cccacctgag
     4501 atgtgctcag gctggtggtg gatacgagat cctgagatgt tggatgccat gctcaaggcc
     4561 ctacaccccc gaggtatccg ggagaaggca cttcacaaac accttaacaa gcacagggac
     4621 ttcttgcagg aagtctgcct gcggccctca gctgacccca tctttgagcc caggcaacta
     4681 cctgcctttc aagaagggat tatgagctgg tcccccaaag agaagacata cgagacagac
     4741 ctagcagtgc ttcaatgggt agaggagctg gagcagcggg ttatcatgtc tgatctgcag
     4801 attcggggct ggacatgtcc tagcccagac tctacccgtg aagacttggc ctactgtgag
     4861 cacctctccg actcccagga ggatatcacc tggcgaggtc ggggcaggga gggactggca
     4921 cctcagcgta aaactaccaa ccctttggac ctggctgtga tgcggctggc tgccctggaa
     4981 cagaatgtag aacggcggta cctgcgggag cccctctggc caactcatga ggttgtgctg
     5041 gagaaggccc tgcttagcac acctaatggt gcccctgagg gcaccactac agagatatca
     5101 tatgagatca cccctcgcat tcgtgtctgg cgccagaccc tcgagcggtg ccggagcgca
     5161 gcccaggtgt gcttgtgcct gggccagctg gagaggtcca ttgcctggga gaagtctgtc
     5221 aacaaagtga catgtctagt ctgccggaag ggtgacaatg atgagtttct tctgctttgt
     5281 gatgggtgtg accgtggctg ccacatttac tgccatcgtc ccaagatgga ggctgtccca
     5341 gaaggagatt ggttctgtac tgtctgtttg gctcagcagg tggagggaga attcactcag
     5401 aagcctggtt tcccaaagcg tggccagaag cggaaaagtg gttattcgct gaacttctca
     5461 gagggtgatg gccgccgacg ccgggtactg ttgaggggcc gagaaagccc agcagcaggg
     5521 cctcggtact cggaagaagg gctctccccc tccaagcggc ggcgactctc tatgcggaac
     5581 caccacagtg atctcacatt ttgcgagatt atcctgatgg agatggagtc ccatgatgca
     5641 gcctggcctt tcctagagcc tgtgaaccca cgtttggtga gtgggtaccg gcgcatcatc
     5701 aaaaatccta tggatttttc caccatgcgg gagcggctgc tcaggggagg gtacaccagc
     5761 tcagaggagt ttgcggctga tgccctcctg gtatttgaca actgccagac tttcaacgag
     5821 gatgactctg aagtaggcaa ggctgggcac atcatgcgcc gcttcttcga gagccgctgg
     5881 gaggagtttt atcagggaaa acaggccaat ctgtgaggca agggaggtgg ggagtcacct
     5941 tgtggcatct ccccccacct tccaaacaaa aacctgccat tttcacctgc tgatgctgcc
     6001 ctgggtccag actcaagtca gatacaaccc tgatttttga ccttgccctt ggcagtgccc
     6061 cacatcctct tattcctaca tccctttctc ccttccctcc tcttgctcct caagtaagag
     6121 gtgcagagat gaggtccttc tggactaaaa gccaaaaaaa gaaagaaaaa aataattttt
     6181 cttttctgtt ttatttgcta attaaaaatg gggaggggga aagtcgtccc tacttcctcc
     6241 tccctgcttc ctctcctccc ctgtacgtgc cccagcattc tggggttatt taacaatagc
     6301 aatagttcta gtgaatgtgt gaaaccaaga aacactctgt actgtgtgcg gacccgcagt
     6361 gacggccagt aaagtggact taactcccaa gtgtgtcgcg ccggacaccg ggccctggac
     6421 atgctgcttc catgttcagt cccttccctg cttctcgctg tctttctttt cccacctccc
     6481 accccccagt tttcagattt tctctcatcc aataatgtaa aactatcgtg tacgggttcc
     6541 tccctccttt tctcttctcc caaatctttt cccttcaaag gaaaaaaaaa tgttcagagg
     6601 tccctgtctt ctgtccccat cttcctgccg atagctatcc cctgtatgat gttggatgct
     6661 cctcacatgc tgagtttcca gccttttctg aaactcagta gctggggaga gggcagggag
     6721 gcttcctggg ccttccagcc tccttcccca cctccttccc aaaccctctt gggaactcct
     6781 cagggacaac tactgctgag tttgggtgca ccctaagatg gaggccaggt agcaatgggg
     6841 ccggcctcag agagagcgct gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtcggc
     6901 ctcagagcgc gctgtgtgtg tgtgtgtgtg tgtcagcctc agagcgcgcg ctgtgtgtgt
     6961 gtgtgtgtgt gcgtgcttgt gaccctgtat tgtttgatag gatccattca gtttccccaa
     7021 gtacctgttt tcattcccat ttttcccatt gtttaaaacc atcacttttt tgtctttggg
     7081 aaaccacagg aacaatttct ctggagacaa ggctgtgtct ctctcctggt catttttgtt
     7141 ccagcctctt cagactgtgc aatctttcag caggaactcc ctctcttctc ggtagctttg
     7201 aatcttaagc ttctacggga gagtggtaga actggatcat ttcctaatcc catttagttg
     7261 tgcttttctt catttacttc ataccccagg accccttccc cagcagcaga gaccctggag
     7321 cacaggagag tagggaggag gggttctggg tccatcactg ccctacatgt gactatgtcc
     7381 aagttaagcc cccaacacga gaggaaagct gctgactccc agctatagcc atgggcactt
     7441 ggccccctgc ttttcctgct cagcagagcc cctcccttca gagattacgg gtacttgcac
     7501 tggggaggtg gctgctggct ggcccaagca gagagctgag gcatccaaga aatgttccat
     7561 tggggggtgg gggtgccagg tgaggtggag cattccttgt attctggcag cactgaagag
     7621 ccactgaagg gggtaggggc agtgtaggtc ctggggcagc ccctttattc ctttatgccc
     7681 cttctccctc atagcctatt tctaaagtcg ccttttctgt cagataaacc tcaaaacttt
     7741 taattttatt tgagattttt ttttgctttt aagaggtgga ttgaagaata tttgaattga
     7801 ctttatatta tgcataaata tttatatttt atctaaataa ctgcgctgta acaaactttg
     7861 tgttagacag ttgaaactgt tagagttggg ggctctgctt tttccccctg gcaattttcc
     7921 cctggtataa gatgtgctag attaatttca ttgtgaggtg gatgggggag tgaaattgtg
     7981 aggtggatgg gggagtgaaa tctccatggt tcctgctttg tgttcctctc ccagctccat
     8041 ctctttccct agggaccagg cactcatatg gcggggtggg gtcctagcct cagtttgaag
     8101 aagtgggggc tggagcgggg ttgggggtgg tagggatagg gcatgatcaa aggggccatt
     8161 tcttgctttt ctttcctcat cttcactgcc cccttgagct aggtggattt tctcttcatg
     8221 acaagagtat ttggtaggga aagcaggttt aaaataaaaa gacaacccac cccctgccct
     8281 tttgcttccc tcccatcagt ctggttgaca ggaagaaacc acaccatcaa caccaacaag
     8341 tttctgtgtt ccttttacag caaaagggac tttttatata accaaatgtg gtgttttagt
     8401 gactttttga taatgtacag ttttttgtga atttaaattt atttctttct atatttttag
     8461 gaccaatctc atttttaata aggttaaaaa gaaaaaaaaa gtctagcgaa aaaactcctg
     8521 tttttgccat gtgatgttcc acaagtgcag ctgtagaaaa gtgcttgtca gttgttgaat
     8581 aaaaaaaacc acatttgata gagattcaaa agactctgtg tattcatctt cccttctaca
     8641 cacctgaggg ggagacggcg ttgggatagg tatgactggc ttaagagacc acaggcaagg
     8701 gaacaacagg ggctcctgtt ccataccctc tgtgtggatg gaaagggtca ttagtgctcc
     8761 tgcctaaatg tctggctgag ttgctggagc aaagggggat tcagtgcatc caggtcctgc
     8821 cttgtgagat gtggccccag cttcctaagc tgccacctct gtgttcctgt catagcaaat
     8881 atgggaccat caccagctta ccacttccca ctcacggata agacaccaag acgtagac
//
