LOCUS       NM_013448               5729 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens bromodomain adjacent to zinc finger domain 1A (BAZ1A),
            transcript variant 1, mRNA.
ACCESSION   NM_013448
VERSION     NM_013448.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5729)
  AUTHORS   Siddappa,M., Hussain,S., Wani,S.A., White,J., Tang,H., Gray,J.S.,
            Jafari,H., Wu,H.C., Long,M.D., Elhussin,I., Karanam,B., Wang,H.,
            Morgan,R., Hardiman,G., Adelani,I.B., Rotimi,S.O., Murphy,A.R.,
            Nonn,L., Davis,M.B., Kittles,R.A., Hughes Halbert,C.,
            Sucheston-Campbell,L.E., Yates,C. and Campbell,M.J.
  TITLE     African American Prostate Cancer Displays Quantitatively Distinct
            Vitamin D Receptor Cistrome-transcriptome Relationships Regulated
            by BAZ1A
  JOURNAL   Cancer Res Commun 3 (4), 621-639 (2023)
   PUBMED   37082578
  REMARK    GeneRIF: African American Prostate Cancer Displays Quantitatively
            Distinct Vitamin D Receptor Cistrome-transcriptome Relationships
            Regulated by BAZ1A.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5729)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5729)
  AUTHORS   Li,X., Ding,D., Yao,J., Zhou,B., Shen,T., Qi,Y., Ni,T. and Wei,G.
  TITLE     Chromatin remodeling factor BAZ1A regulates cellular senescence in
            both cancer and normal cells
  JOURNAL   Life Sci 229, 225-232 (2019)
   PUBMED   31085244
  REMARK    GeneRIF: results revealed chromatin remodeling modulator BAZ1A
            acting as a novel regulator of cellular senescence in both normal
            and cancer cells, indicating a new target for potential cancer
            treatment
REFERENCE   4  (bases 1 to 5729)
  AUTHORS   Oppikofer,M., Sagolla,M., Haley,B., Zhang,H.M., Kummerfeld,S.K.,
            Sudhamsu,J., Flynn,E.M., Bai,T., Zhang,J., Ciferri,C. and
            Cochran,A.G.
  TITLE     Non-canonical reader modules of BAZ1A promote recovery from DNA
            damage
  JOURNAL   Nat Commun 8 (1), 862 (2017)
   PUBMED   29021563
  REMARK    GeneRIF: promotes recovery after DNA damage, in part by recruiting
            SMARCA5 to damaged chromatin
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5729)
  AUTHORS   Sun,H., Damez-Werno,D.M., Scobie,K.N., Shao,N.Y., Dias,C.,
            Rabkin,J., Wright,K.N., Mouzon,E., Kabbaj,M., Neve,R., Turecki,G.,
            Shen,L. and Nestler,E.J.
  TITLE     Regulation of BAZ1A and nucleosome positioning in the nucleus
            accumbens in response to cocaine
  JOURNAL   Neuroscience 353, 1-6 (2017)
   PUBMED   28412501
  REMARK    GeneRIF: Results from the study suggest that acute cocaine exposure
            increased Baz1a expression in nucleus accumbens while repeated
            cocaine exposure produced the opposite effect. Findings implicate
            BAZ1A in molecular and behavioral plasticity to cocaine and offer
            new insight into the pathophysiology of cocaine addiction.
REFERENCE   6  (bases 1 to 5729)
  AUTHORS   Collins,N., Poot,R.A., Kukimoto,I., Garcia-Jimenez,C., Dellaire,G.
            and Varga-Weisz,P.D.
  TITLE     An ACF1-ISWI chromatin-remodeling complex is required for DNA
            replication through heterochromatin
  JOURNAL   Nat Genet 32 (4), 627-632 (2002)
   PUBMED   12434153
REFERENCE   7  (bases 1 to 5729)
  AUTHORS   Bozhenok,L., Wade,P.A. and Varga-Weisz,P.
  TITLE     WSTF-ISWI chromatin remodeling complex targets heterochromatic
            replication foci
  JOURNAL   EMBO J 21 (9), 2231-2241 (2002)
   PUBMED   11980720
  REMARK    Erratum:[EMBO J 2002 Jun 17;21(12):3212]
REFERENCE   8  (bases 1 to 5729)
  AUTHORS   Poot,R.A., Dellaire,G., Hulsmann,B.B., Grimaldi,M.A., Corona,D.F.,
            Becker,P.B., Bickmore,W.A. and Varga-Weisz,P.D.
  TITLE     HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1
            and two novel histone-fold proteins
  JOURNAL   EMBO J 19 (13), 3377-3387 (2000)
   PUBMED   10880450
REFERENCE   9  (bases 1 to 5729)
  AUTHORS   Bochar,D.A., Savard,J., Wang,W., Lafleur,D.W., Moore,P., Cote,J.
            and Shiekhattar,R.
  TITLE     A family of chromatin remodeling factors related to Williams
            syndrome transcription factor
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1038-1043 (2000)
   PUBMED   10655480
REFERENCE   10 (bases 1 to 5729)
  AUTHORS   Jones,M.H., Hamana,N., Nezu,Ji. and Shimane,M.
  TITLE     A novel family of bromodomain genes
  JOURNAL   Genomics 63 (1), 40-45 (2000)
   PUBMED   10662543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB032252.1, AF213467.1, AF221130.1, CB217757.1 and AL050089.1.
            
            On Nov 24, 2018 this sequence version replaced NM_013448.2.
            
            Summary: The BAZ1A gene encodes the accessory subunit of the
            ATP-dependent chromatin assembly factor (ACF), a member of the ISWI
            ('imitation switch') family of chromatin remodeling complexes
            (summarized by Racki et al., 2009 [PubMed 20033039]).[supplied by
            OMIM, Apr 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF213467.1, ERR3218370.553944.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360310.6/ ENSP00000353458.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AB032252.1         288-430
            144-1933            AF213467.1         29-1818
            1934-4952           AF221130.1         1653-4671
            4953-5226           CB217757.1         306-579
            5227-5729           AL050089.1         2715-3217
FEATURES             Location/Qualifiers
     source          1..5729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.1-q13.2"
     gene            1..5729
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /note="bromodomain adjacent to zinc finger domain 1A"
                     /db_xref="GeneID:11177"
                     /db_xref="HGNC:HGNC:960"
                     /db_xref="MIM:605680"
     exon            1..223
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            224..394
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..4952
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /note="isoform a is encoded by transcript variant 1;
                     ATP-dependent chromatin remodeling protein; bromodomain
                     adjacent to zinc finger domain protein 1A; hWALp1; CHRAC
                     subunit ACF1; ATP-utilizing chromatin assembly and
                     remodeling factor 1; williams syndrome transcription
                     factor-related chromatin-remodeling factor 180"
                     /codon_start=1
                     /product="bromodomain adjacent to zinc finger domain
                     protein 1A isoform a"
                     /protein_id="NP_038476.2"
                     /db_xref="CCDS:CCDS9651.1"
                     /db_xref="GeneID:11177"
                     /db_xref="HGNC:HGNC:960"
                     /db_xref="MIM:605680"
                     /translation="MPLLHRKPFVRQKPPADLRPDEEVFYCKVTNEIFRHYDDFFERT
                     ILCNSLVWSCAVTGRPGLTYQEALESEKKARQNLQSFPEPLIIPVLYLTSLTHRSRLH
                     EICDDIFAYVKDRYFVEETVEVIRNNGARLQCRILEVLPPSHQNGFANGHVNSVDGET
                     IIISDSDDSETQSCSFQNGKKKDAIDPLLFKYKVQPTKKELHESAIVKATQISRRKHL
                     FSRDKLKLFLKQHCEPQDGVIKIKASSLSTYKIAEQDFSYFFPDDPPTFIFSPANRRR
                     GRPPKRIHISQEDNVANKQTLASYRSKATKERDKLLKQEEMKSLAFEKAKLKREKADA
                     LEAKKKEKEDKEKKREELKKIVEEERLKKKEEKERLKVEREKEREKLREEKRKYVEYL
                     KQWSKPREDMECDDLKELPEPTPVKTRLPPEIFGDALMVLEFLNAFGELFDLQDEFPD
                     GVTLEVLEEALVGNDSEGPLCELLFFFLTAIFQAIAEEEEEVAKEQLTDADTKDLTEA
                     LDEDADPTKSALSAVASLAAAWPQLHQGCSLKSLDLDSCTLSEILRLHILASGADVTS
                     ANAKYRYQKRGGFDATDDACMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKL
                     LTLVSTRDFIEDYVDILRQAKQEFRELKAEQHRKEREEAAARIRKRKEEKLKEQEQKM
                     KEKQEKLKEDEQRNSTADISIGEEEREDFDTSIESKDTEQKELDQDMVTEDEDDPGSH
                     KRGRRGKRGQNGFKEFTRQEQINCVTREPLTADEEEALKQEHQRKEKELLEKIQSAIA
                     CTNIFPLGRDRMYRRYWIFPSIPGLFIEEDYSGLTEDMLLPRPSSFQNNVQSQDPQVS
                     TKTGEPLMSESTSNIDQGPRDHSVQLPKPVHKPNRWCFYSSCEQLDQLIEALNSRGHR
                     ESALKETLLQEKSRICAQLARFSEEKFHFSDKPQPDSKPTYSRGRSSNAYDPSQMCAE
                     KQLELRLRDFLLDIEDRIYQGTLGAIKVTDRHIWRSALESGRYELLSEENKENGIIKT
                     VNEDVEEMEIDEQTKVIVKDRLLGIKTETPSTVSTNASTPQSVSSVVHYLAMALFQIE
                     QGIERRFLKAPLDASDSGRSYKTVLDRWRESLLSSASLSQVFLHLSTLDRSVIWSKSI
                     LNARCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKTVPEGDWFCPECRPKQRSRRL
                     SSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQSEEEEYEVEQDEDDSQEEEEVSLPK
                     RGRPQVRLPVKTRGKLSSSFSSRGQQQEPGRYPSRSQQSTPKTTVSSKTGRSLRKINS
                     APPTETKSLRIASRSTRHSHGPLQADVFVELLSPRRKRRGRKSANNTPENSPNFPNFR
                     VIATKSSEQSRSVNIASKLSLQESESKRRCRKRQSPEPSPVTLGRRSSGRQGGVHELS
                     AFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEF
                     IDDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLHVTPSNVDQVSTPPAAK
                     KSRI"
     exon            395..673
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            674..817
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            818..919
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1007
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1142
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1242
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1409
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1505
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1644
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1791
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1887
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2112
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2278
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2392
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2517
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..3114
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3278
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3433
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3582
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            3583..3830
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..4057
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4524
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4667
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            4668..4755
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     exon            4756..5729
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5705..5710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /note="hexamer: AATAAA"
     polyA_site      5729
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /note="major polyA site"
ORIGIN      
        1 cttcagagcc gaaagtagat cagaaacttc ccaggagctc cgagaggcgg ggaagtggcg
       61 gtgggacgca attccccgcg cggagtcggg cagtggcagc gggagaagcg gcagccaggg
      121 gcgcggcggg gccggagaga ggcggtcccc tgggaggacg gggtctcccc tcgttgcctt
      181 tgtagtggag aaggtggaca agtggcagtc ggcgtgatcg cagggaagcg gggccggcgc
      241 gggcggccga gggtccaggc gagcccgcgg gcggacggga gatgccgctg ctacaccgaa
      301 agccgtttgt gagacagaag ccgcccgcgg acctgcggcc cgacgaggaa gttttctact
      361 gtaaagtcac caacgagatc ttccgccact acgatgactt ttttgaacga accattctgt
      421 gcaacagcct tgtgtggagt tgtgctgtga cgggtagacc tggactgacg tatcaggaag
      481 cacttgagtc agaaaaaaaa gcaagacaga atcttcagag ttttccagaa ccactaatta
      541 ttccagtttt atacttgacc agccttaccc atcgttcgcg cttacatgaa atttgtgatg
      601 atatctttgc atatgtcaag gatcgatatt ttgtcgaaga aactgtggaa gtcattagga
      661 acaatggtgc aaggttgcag tgtaggattt tggaagtcct ccctccatca catcaaaatg
      721 gttttgctaa tggacatgtt aacagtgtgg atggagaaac tattatcatc agtgatagtg
      781 atgattcaga aacacaaagc tgttcttttc aaaatgggaa gaaaaaagat gcaattgatc
      841 ccttactatt caagtataaa gtgcaaccca ctaaaaaaga attacatgag tctgctattg
      901 ttaaagcaac acaaatcagc cggagaaaac acctattttc tcgtgataaa ctaaagcttt
      961 ttctgaagca acactgtgaa ccacaagatg gagtcattaa aataaaggca tcatctcttt
     1021 caacgtataa aatagcagaa caagattttt cttatttctt ccctgatgat ccacccacat
     1081 ttatcttcag tcctgctaac agacgaagag ggagacctcc caaacgaata catattagtc
     1141 aagaggacaa tgttgctaat aaacagactc ttgcaagtta taggagcaaa gctactaaag
     1201 aaagagataa acttttgaaa caagaagaaa tgaagtcact ggcttttgaa aaggctaaat
     1261 taaaaagaga aaaagcagat gccctagaag cgaagaaaaa agaaaaagaa gataaagaga
     1321 aaaagaggga agaattgaaa aaaattgttg aagaagagag actaaagaaa aaagaagaaa
     1381 aagagaggct taaagtagaa agagaaaagg aaagagagaa gttacgtgaa gaaaagcgaa
     1441 agtatgtgga atacttaaaa cagtggagta aacctagaga agatatggaa tgtgatgacc
     1501 ttaaggaact tccagaacca acaccagtga aaactagact acctcctgaa atctttggtg
     1561 atgctctgat ggttttggag ttccttaatg catttgggga actttttgat cttcaagatg
     1621 agtttcctga tggagtaacc ctagaagtat tagaggaagc tcttgtagga aatgacagtg
     1681 aaggcccact gtgtgaattg ctttttttct tcctgactgc aatcttccag gcaatagctg
     1741 aagaagaaga ggaagtagcc aaagagcaac taactgatgc tgacaccaaa gatttaacag
     1801 aggctttgga tgaagatgca gaccccacaa aatctgcact gtctgcagtt gcatctttgg
     1861 cagctgcatg gccacagtta caccagggct gcagtttgaa aagtttggat cttgatagct
     1921 gcactctttc agaaatcctc agactgcaca tcttagcttc aggtgctgat gtaacatcag
     1981 caaatgcaaa gtatagatat caaaaacgag gaggatttga tgctacagat gatgcttgta
     2041 tggagcttcg tttgagcaat cccagtctag tgaagaaact gtcaagcacc tcagtgtatg
     2101 atttgacacc aggagaaaaa atgaagatac tccatgctct ctgtggaaag ctactgaccc
     2161 tagtttcaac tagggatttt attgaagatt atgttgatat attacgacag gcaaagcagg
     2221 agttccggga attaaaagca gaacaacatc gaaaagagag ggaagaagca gctgccagaa
     2281 ttcgtaaaag gaaggaagaa aaacttaagg agcaagaaca aaaaatgaaa gagaaacaag
     2341 aaaaactgaa agaagatgag caaagaaatt caacggcaga tatatctatt ggggaggaag
     2401 aaagggaaga ttttgatact agcattgaga gcaaagacac agagcaaaag gaattagatc
     2461 aagatatggt cactgaagat gaagatgacc caggatcaca taaaagaggc agaaggggga
     2521 aaagaggaca aaatggattt aaagaattta caaggcaaga acagatcaac tgtgtaacaa
     2581 gagagcctct tactgctgat gaggaagaag cattaaaaca ggaacaccaa cgaaaagaga
     2641 aagagctctt agaaaaaatc caaagtgcca tagcctgtac caatatcttt cccttgggtc
     2701 gcgaccgcat gtatagacga tactggattt tcccttctat tcctggactc tttattgaag
     2761 aggattattc tggtcttact gaagacatgc tgttgcctag accttcatca tttcagaata
     2821 atgtacagtc tcaagatcct caggtatcca ctaaaactgg agagcctttg atgtctgaat
     2881 ctacctccaa cattgaccaa ggtccacgtg accattctgt gcagctgcca aaaccagtgc
     2941 ataagccaaa tcggtggtgc ttttacagtt cttgtgaaca gctagaccag cttattgaag
     3001 ctcttaattc tagaggacat agagaaagtg ccttaaaaga aactttgtta caagagaaaa
     3061 gcagaatatg tgcacagcta gcccgttttt ctgaagagaa atttcatttt tcagacaaac
     3121 ctcagcctga tagcaaacca acatatagtc ggggaagatc ttccaatgca tatgatccat
     3181 ctcagatgtg tgcagaaaag caacttgaac taaggctgag agattttctt ttagatattg
     3241 aagatagaat ctaccaagga acattaggag ccatcaaggt tacagatcga catatctgga
     3301 gatcagcatt agaaagtgga cggtatgagc tgttaagtga ggaaaacaag gaaaatggga
     3361 taattaaaac tgtgaatgaa gacgtagaag agatggaaat tgatgaacaa acaaaggtca
     3421 tagtaaaaga cagacttttg gggataaaaa cagaaactcc aagtactgta tcaacaaatg
     3481 caagtacacc acaatcagtg agcagtgtgg ttcattatct ggcaatggca ctctttcaaa
     3541 tagagcaggg cattgagcgg cgttttctga aagctccact tgatgccagt gacagtgggc
     3601 gttcttataa aacagttctg gaccgttgga gagagtctct cctttcttct gctagtctat
     3661 cccaagtttt tcttcaccta tccaccttgg atcgtagcgt gatatggtct aaatctatac
     3721 tgaatgcgcg ttgcaagata tgtcgaaaga aaggcgatgc tgaaaacatg gttctttgtg
     3781 atggctgtga taggggtcat catacctact gtgttcgacc aaagctcaag actgtgcctg
     3841 aaggagactg gttttgtcca gaatgtcgac caaagcaacg ttctagaaga ctctcctcta
     3901 gacagagacc atccttggaa agtgatgaag atgtggaaga cagtatggga ggtgaggatg
     3961 atgaagttga tggcgatgaa gaagaaggtc aaagtgagga ggaagagtat gaggtagaac
     4021 aagatgaaga tgactctcaa gaagaggaag aagtcagcct acccaaacga ggaagaccac
     4081 aagttagatt gccagttaaa acaagaggga aacttagctc ttctttctca agtcgtggcc
     4141 aacaacaaga acctggaaga tacccttcaa ggagtcagca gagcacaccc aaaacaactg
     4201 tttcttctaa aactggtaga agcctaagaa agataaactc tgctcctcct acagaaacaa
     4261 aatctttaag aattgccagt cgttctactc gccacagtca tggcccactg caagcagatg
     4321 tatttgtgga attgcttagt cctcgtagaa aacgcagagg caggaaaagt gctaataata
     4381 caccagaaaa tagtcccaac ttccctaact tcagagtcat tgccacaaag tcaagtgaac
     4441 agtcaagatc tgtaaatatt gcttcaaaac tttctctcca agagagtgaa tccaaaagaa
     4501 gatgcagaaa aagacaatct ccagagccat cgcctgtgac actgggtcga aggagttctg
     4561 gccgacaggg aggagttcat gaattgtctg cttttgaaca acttgttgta gaattggtac
     4621 gacatgatga cagctggcct tttttgaaac ttgtttctaa aatccaggtc ccagactact
     4681 atgacatcat caaaaagccc attgccttaa atataattcg tgaaaaagtg aataagtgtg
     4741 aatataaatt agcatctgag tttattgatg acattgagtt aatgttttcg aactgctttg
     4801 aatacaaccc tcgtaacaca agtgaagcaa aagctggaac taggcttcaa gcattttttc
     4861 atattcaggc tcaaaagctt ggactccacg tcacacccag taatgtggac caagttagca
     4921 caccaccggc tgcgaaaaag tcacgaatct gactttgtcc ttctaaagga tatatttgaa
     4981 gaaaaacaaa ttgttcatga aaatggaaca ttaaatcatg ctgtataaag caataacaat
     5041 tgattgacca catgaaagtg tggcctgcac tatattctca attttaatat taagcactca
     5101 ggagaatgta ggaaagatat cctttgctac agttttgttc agtatctaat aagtttgata
     5161 gatgtattgg atacagtact ggtttacaga ggtttttgta catttttgag atcattcatg
     5221 tgtccagaga tcttggaaaa tattttttca cccacgattt attttgttat tgatgatttt
     5281 tttttaaagt ggtggtatta agggagagtt atctacatgg atgagtcttc cgctatagca
     5341 cagtttagaa aaggtgttta tgtcttaatt aattgtttga gtacattctt tcaacactac
     5401 acatgaatga atccaatctt ataaccttga agtgctgtac cagtgctggc tgcaggtatt
     5461 aagtccaagt ttattaacta gatatttatt tagtattgag agtaatttgt gaatttgttt
     5521 tgtatttata aaatttatac ctgaaaaatg ttccttaatg ttttaaacct tttactgtgt
     5581 ttttattcct ctaacttcct taatgatcaa tcaaaaaaag taacaccctc cctttttcct
     5641 gacagttctt tcagctttac agaactgtat tataagtttc tatgtataac tttttaactg
     5701 tacaaataaa ataacatttt ttcaaataa
//
