LOCUS       NM_018664                836 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens basic leucine zipper ATF-like transcription factor 3
            (BATF3), mRNA.
ACCESSION   NM_018664
VERSION     NM_018664.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 836)
  AUTHORS   Dabbaghipour,R., Khaze Shahgoli,V., Safaei,S., Amini,M., Tabei,S.,
            Shanehbandi,D., Rahbar Farzam,O., Baradaran,B. and Entezam,M.
  TITLE     siRNA-mediated downregulation of BATF3 diminished proliferation and
            induced apoptosis through downregulating c-Myc expression in
            chronic myelogenous leukemia cells
  JOURNAL   Mol Biol Rep 51 (1), 100 (2024)
   PUBMED   38217769
  REMARK    GeneRIF: siRNA-mediated downregulation of BATF3 diminished
            proliferation and induced apoptosis through downregulating c-Myc
            expression in chronic myelogenous leukemia cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 836)
  AUTHORS   Irfan Afridi,M., Zheng,Z., Liu,J., Liu,L., Zhang,S., Zhu,Z.,
            Peng,Y., Zhou,D. and Tu,H.
  TITLE     The bZIP transcription factor BATF3/ZIP-10 suppresses innate
            immunity by attenuating PMK-1/p38 signaling
  JOURNAL   Int Immunol 35 (4), 181-196 (2023)
   PUBMED   36409527
  REMARK    GeneRIF: The bZIP transcription factor BATF3/ZIP-10 suppresses
            innate immunity by attenuating PMK-1/p38 signaling.
REFERENCE   3  (bases 1 to 836)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 836)
  AUTHORS   Liang,H.C., Costanza,M., Prutsch,N., Zimmerman,M.W., Gurnhofer,E.,
            Montes-Mojarro,I.A., Abraham,B.J., Prokoph,N., Stoiber,S.,
            Tangermann,S., Lobello,C., Oppelt,J., Anagnostopoulos,I.,
            Hielscher,T., Pervez,S., Klapper,W., Zammarchi,F., Silva,D.A.,
            Garcia,K.C., Baker,D., Janz,M., Schleussner,N., Fend,F.,
            Pospisilova,S., Janikova,A., Wallwitz,J., Stoiber,D.,
            Simonitsch-Klupp,I., Cerroni,L., Pileri,S., de Leval,L., Sibon,D.,
            Fataccioli,V., Gaulard,P., Assaf,C., Knorr,F., Damm-Welk,C.,
            Woessmann,W., Turner,S.D., Look,A.T., Mathas,S., Kenner,L. and
            Merkel,O.
  TITLE     Super-enhancer-based identification of a BATF3/IL-2R-module reveals
            vulnerabilities in anaplastic large cell lymphoma
  JOURNAL   Nat Commun 12 (1), 5577 (2021)
   PUBMED   34552066
  REMARK    GeneRIF: Super-enhancer-based identification of a
            BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell
            lymphoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 836)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 836)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 836)
  AUTHORS   Bower,K.E., Fritz,J.M. and McGuire,K.L.
  TITLE     Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro
            invasiveness of hepatocarcinoma cells
  JOURNAL   Oncogene 23 (54), 8805-8814 (2004)
   PUBMED   15467742
  REMARK    GeneRIF: overexpression of p21SNFT in HepG2 cells leads to
            repression of matrix metalloproteinase-1 by 70-80%
REFERENCE   8  (bases 1 to 836)
  AUTHORS   Bower,K.E., Zeller,R.W., Wachsman,W., Martinez,T. and McGuire,K.L.
  TITLE     Correlation of transcriptional repression by p21(SNFT) with changes
            in DNA.NF-AT complex interactions
  JOURNAL   J Biol Chem 277 (38), 34967-34977 (2002)
   PUBMED   12087103
  REMARK    GeneRIF: correlation of transcriptional repression by p21(SNFT)
            with changes in DNA.NF-AT complex interactions
REFERENCE   9  (bases 1 to 836)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   10 (bases 1 to 836)
  AUTHORS   Iacobelli,M., Wachsman,W. and McGuire,K.L.
  TITLE     Repression of IL-2 promoter activity by the novel basic leucine
            zipper p21SNFT protein
  JOURNAL   J Immunol 165 (2), 860-868 (2000)
   PUBMED   10878360
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF255346.1, BC117491.1 and
            BG184570.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018664.2.
            
            Summary: This gene encodes a member of the basic leucine zipper
            protein family. The encoded protein functions as a transcriptional
            repressor when heterodimerizing with JUN. The protein may play a
            role in repression of interleukin-2 and matrix metalloproteinase-1
            transcription.[provided by RefSeq, Feb 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF255346.1, BC117491.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243440.2/ ENSP00000243440.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AF255346.1         146-216
            72-72               BC117491.1         154-154
            73-835              AF255346.1         218-980
            836-836             BG184570.1         608-608
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..836
                     /gene="BATF3"
                     /gene_synonym="JDP1; JUNDM1; SNFT"
                     /note="basic leucine zipper ATF-like transcription factor
                     3"
                     /db_xref="GeneID:55509"
                     /db_xref="HGNC:HGNC:28915"
                     /db_xref="MIM:612470"
     exon            1..168
                     /gene="BATF3"
                     /gene_synonym="JDP1; JUNDM1; SNFT"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..462
                     /gene="BATF3"
                     /gene_synonym="JDP1; JUNDM1; SNFT"
                     /note="Jun dimerization protein 1; Jun dimerization
                     protein p21SNFT; 21-kD small nuclear factor isolated from
                     T cells; B-ATF-3; 21 kDa small nuclear factor isolated
                     from T-cells; basic leucine zipper transcription factor,
                     ATF-like 3"
                     /codon_start=1
                     /product="basic leucine zipper transcriptional factor
                     ATF-like 3"
                     /protein_id="NP_061134.1"
                     /db_xref="CCDS:CCDS1508.1"
                     /db_xref="GeneID:55509"
                     /db_xref="HGNC:HGNC:28915"
                     /db_xref="MIM:612470"
                     /translation="MSQGLPAAGSVLQRSVAAPGNQPQPQPQQQSPEDDDRKVRRREK
                     NRVAAQRSRKKQTQKADKLHEEYESLEQENTMLRREIGKLTEELKHLTEALKEHEKMC
                     PLLLCPMNFVPVPPRPDPVAGCLPR"
     exon            169..273
                     /gene="BATF3"
                     /gene_synonym="JDP1; JUNDM1; SNFT"
                     /inference="alignment:Splign:2.1.0"
     exon            274..836
                     /gene="BATF3"
                     /gene_synonym="JDP1; JUNDM1; SNFT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      763..768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BATF3"
                     /gene_synonym="JDP1; JUNDM1; SNFT"
                     /note="hexamer: AATAAA"
     polyA_site      786
                     /gene="BATF3"
                     /gene_synonym="JDP1; JUNDM1; SNFT"
                     /note="major polyA site"
     regulatory      816..821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BATF3"
                     /gene_synonym="JDP1; JUNDM1; SNFT"
                     /note="hexamer: AATACA"
     polyA_site      836
                     /gene="BATF3"
                     /gene_synonym="JDP1; JUNDM1; SNFT"
                     /note="major polyA site"
ORIGIN      
        1 gggacagcgc ccgtaggcag ccccacgggc agggcgcgcg ggcggggcgg ggcgggccgg
       61 gccagaggag cgcccggcat gtcgcaaggg ctcccggccg ccggcagcgt cctgcagagg
      121 agcgtcgcgg cgcccgggaa ccagccgcag ccgcagccgc agcagcagag ccctgaggat
      181 gatgacagga aggtccgaag gagagaaaaa aaccgagttg ctgctcagag aagtcggaag
      241 aagcagaccc agaaggctga caagctccat gaggaatatg agagcctgga gcaagaaaac
      301 accatgctgc ggagagagat cgggaagctg acagaggagc tgaagcacct gacagaggca
      361 ctgaaggagc acgagaagat gtgcccgctg ctgctctgcc ctatgaactt tgtgccagtg
      421 cctccccggc cggaccctgt ggccggctgc ttgccccgat gaagccgggg acactcctct
      481 gcccagcaag gagccttggt cattttcata cctgggagga aggcttttcc ttcacaattg
      541 tatacagggg gcacctgtgg ccaggcctcc tcctgggagc tccaggacca gccagctgtg
      601 ttccctgcag actgggctca gcccgacatc caacaggcgc caaactcaca gagcccttgt
      661 gcagatccag catggaggcc accctcagga gtgacttctc atccaccctg gcagctagta
      721 ggttctgctg ttatgcagag ccatttcctc tagaatttgg ataataaaga tgcttattgt
      781 ctctcccttc tccagttctg ggaatttaca ggcacaatac acttcctttt cctgga
//
