LOCUS       NM_138456               2066 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens basic leucine zipper ATF-like transcription factor 2
            (BATF2), transcript variant 1, mRNA.
ACCESSION   NM_138456
VERSION     NM_138456.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2066)
  AUTHORS   Li,Y., Fan,L., Yan,A., Ren,X., Zhao,Y. and Hua,B.
  TITLE     Exosomal miR-361-3p promotes the viability of breast cancer cells
            by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway
  JOURNAL   J Transl Med 22 (1), 112 (2024)
   PUBMED   38282047
  REMARK    GeneRIF: Exosomal miR-361-3p promotes the viability of breast
            cancer cells by targeting ETV7 and BATF2 to upregulate the
            PAI-1/ERK pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2066)
  AUTHORS   Liu,J., Li,J., Tuo,Z., Hu,W. and Liu,J.
  TITLE     BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell
            infiltration in non-small cell lung cancer
  JOURNAL   J Biol Chem 299 (11), 105302 (2023)
   PUBMED   37777155
  REMARK    GeneRIF: BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell
            infiltration in non-small cell lung cancer.
REFERENCE   3  (bases 1 to 2066)
  AUTHORS   Zhou,J., Lei,Z., Chen,J., Liao,S., Chen,Y., Liu,C., Huang,S.,
            Li,L., Zhang,Y., Wang,P., Huang,Y., Li,J. and Liang,H.
  TITLE     Nuclear export of BATF2 enhances colorectal cancer proliferation
            through binding to CRM1
  JOURNAL   Clin Transl Med 13 (5), e1260 (2023)
   PUBMED   37151195
  REMARK    GeneRIF: Nuclear export of BATF2 enhances colorectal cancer
            proliferation through binding to CRM1.
REFERENCE   4  (bases 1 to 2066)
  AUTHORS   Zsurka,G., Appel,M.L.T., Nastaly,M., Hallmann,K., Hansen,N.,
            Nass,D., Baumgartner,T., Surges,R., Hartmann,G., Bartok,E. and
            Kunz,W.S.
  TITLE     Loss of the Immunomodulatory Transcription Factor BATF2 in Humans
            Is Associated with a Neurological Phenotype
  JOURNAL   Cells 12 (2), 227 (2023)
   PUBMED   36672163
  REMARK    GeneRIF: Loss of the Immunomodulatory Transcription Factor BATF2 in
            Humans Is Associated with a Neurological Phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2066)
  AUTHORS   Wen,H., Tang,J., Cui,Y., Hou,M. and Zhou,J.
  TITLE     m6A modification-mediated BATF2 suppresses metastasis and
            angiogenesis of tongue squamous cell carcinoma through inhibiting
            VEGFA
  JOURNAL   Cell Cycle 22 (1), 100-116 (2023)
   PUBMED   35949109
  REMARK    GeneRIF: m6A modification-mediated BATF2 suppresses metastasis and
            angiogenesis of tongue squamous cell carcinoma through inhibiting
            VEGFA.
REFERENCE   6  (bases 1 to 2066)
  AUTHORS   Ma,H., Liang,X., Chen,Y., Pan,K., Sun,J., Wang,H., Wang,Q., Li,Y.,
            Zhao,J., Li,J., Chen,M. and Xia,J.
  TITLE     Decreased expression of BATF2 is associated with a poor prognosis
            in hepatocellular carcinoma
  JOURNAL   Int J Cancer 128 (4), 771-777 (2011)
   PUBMED   20473897
  REMARK    GeneRIF: Decreased expression of BATF2 is associated with
            hepatocellular carcinoma.
REFERENCE   7  (bases 1 to 2066)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 2066)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   9  (bases 1 to 2066)
  AUTHORS   Su,Z.Z., Lee,S.G., Emdad,L., Lebdeva,I.V., Gupta,P., Valerie,K.,
            Sarkar,D. and Fisher,P.B.
  TITLE     Cloning and characterization of SARI (suppressor of AP-1, regulated
            by IFN)
  JOURNAL   Proc Natl Acad Sci U S A 105 (52), 20906-20911 (2008)
   PUBMED   19074269
REFERENCE   10 (bases 1 to 2066)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096702.1 and BC012330.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138456.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM134154.1, AK096702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465401 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301887.9/ ENSP00000301887.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1431              AK096702.1         75-1505
            1432-2066           BC012330.1         1296-1930
FEATURES             Location/Qualifiers
     source          1..2066
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2066
                     /gene="BATF2"
                     /gene_synonym="SARI"
                     /note="basic leucine zipper ATF-like transcription factor
                     2"
                     /db_xref="GeneID:116071"
                     /db_xref="HGNC:HGNC:25163"
                     /db_xref="MIM:614983"
     exon            1..96
                     /gene="BATF2"
                     /gene_synonym="SARI"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..882
                     /gene="BATF2"
                     /gene_synonym="SARI"
                     /note="isoform 1 is encoded by transcript variant 1; basic
                     leucine zipper transcriptional factor ATF-like 2;
                     suppressor of AP-1 regulated by IFN; B-ATF-2; basic
                     leucine zipper transcription factor, ATF-like 2"
                     /codon_start=1
                     /product="basic leucine zipper transcriptional factor
                     ATF-like 2 isoform 1"
                     /protein_id="NP_612465.3"
                     /db_xref="CCDS:CCDS8087.1"
                     /db_xref="GeneID:116071"
                     /db_xref="HGNC:HGNC:25163"
                     /db_xref="MIM:614983"
                     /translation="MHLCGGNGLLTQTDPKEQQRQLKKQKNRAAAQRSRQKHTDKADA
                     LHQQHESLEKDNLALRKEIQSLQAELAWWSRTLHVHERLCPMDCASCSAPGLLGCWDQ
                     AEGLLGPGPQGQHGCREQLELFQTPGSCYPAQPLSPGPQPHDSPSLLQCPLPSLSLGP
                     AVVAEPPVQLSPSPLLFASHTGSSLQGSSSKLSALQPSLTAQTAPPQPLELEHPTRGK
                     LGSSPDNPSSALGLARLQSREHKPALSAATWQGLVVDPSPHPLLAFPLLSSAQVHF"
     exon            97..198
                     /gene="BATF2"
                     /gene_synonym="SARI"
                     /inference="alignment:Splign:2.1.0"
     exon            199..2066
                     /gene="BATF2"
                     /gene_synonym="SARI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2045..2050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BATF2"
                     /gene_synonym="SARI"
                     /note="hexamer: AATAAA"
     polyA_site      2066
                     /gene="BATF2"
                     /gene_synonym="SARI"
                     /note="major polyA site"
ORIGIN      
        1 agagggcact gggaagtcac agctgctgag ggaccactct gctcccccgc ctaagccatg
       61 cacctctgtg ggggcaatgg gctgctgacc cagacagacc ccaaggagca acaaaggcag
      121 ctgaagaagc agaagaaccg ggcagccgcc cagcgaagcc ggcagaagca cacagacaag
      181 gcagacgccc tgcaccagca gcacgagtct ctggaaaaag acaacctcgc cctgcggaag
      241 gagatccagt ccctgcaggc cgagctggcg tggtggagcc ggaccctgca cgtgcatgag
      301 cgcctgtgcc ccatggattg tgcctcctgc tcagctccag ggctcctggg ctgctgggac
      361 caggctgagg ggctcctggg ccctggccca cagggacaac atggctgccg ggagcagctg
      421 gagctgttcc agaccccggg ttcctgttac ccagctcagc cgctctctcc aggtccacag
      481 cctcatgatt ctcccagcct cctccagtgc cccctgccct cactgtccct tggccccgct
      541 gtggttgctg aacctcctgt ccagctgtcc cccagccctc tcctgtttgc ctcgcacact
      601 ggttccagcc tgcaggggtc ttcctctaag ctcagtgccc tccagcccag cctcacggcc
      661 caaactgccc ctccacagcc cctcgagctg gagcatccca ccagagggaa gctggggtcc
      721 tctcccgaca acccttcctc tgccctgggg cttgcacgtc tgcagagcag ggagcacaaa
      781 cctgctctct cagcagccac ttggcaaggg ctggttgtgg atcccagccc tcaccctctc
      841 ctggcctttc ctctgctctc ctctgctcaa gtccacttct aacctggtct tcggagctgg
      901 gttggcccct tctttgggct caggaagcag ccttagcaca cgggcctctc ctccctcact
      961 actgggtgct gccctgcgtg gctgaccagc tggcccagga tttcacagtc gaaaaggaag
     1021 ccaccactga tgcctcccac tgtgacaggc cctgtcacca ccaatatctt atttcaacct
     1081 cacagttgac ctgagaaatc gagattatca ctccactttt tcagacaagg aaactgaggc
     1141 tcagggaagc caagtgacaa gtccaaggtc acgaagactt tcttggagcc cgaaacacca
     1201 ccctctgctc ctccttctcc tgtcctggcc caggcatcct aggggctgaa atcctggaaa
     1261 ccgtgggctg gtgtgagaag gtttgcatgc tcagagcaga gaagggctct ccccactgct
     1321 tcgtgattcc agggccagag ccatgcagtc ccagaaaccc caacctagct ggggcaggtc
     1381 cagagtccaa gccctggtgg gtagaggcca agcagaagcc ctgaagtgga ctcttgcttc
     1441 ccctagtagt gttttcagtg ccaagaagct gaaactgtga gctggagttg gggagaggtc
     1501 tggaagagga ccatctggga tttctacagc ctgggtaccc atagccacac caaggcttct
     1561 gggagattct gcagggtcag ctttccaggc tgttcccaaa tagctccctg cctccccact
     1621 gcccctaaag ccacagcaga agagccattc atctcataaa caaaaaggaa gaggaaagaa
     1681 tgaggaagga ccctgtgcaa ggttatttgc aggcagggat gggcttgtac ctgacagcac
     1741 ccacccctgt gtggccccca ggccctcatc accctcagac ccctcctaag cagttccctc
     1801 attgctcttt ggactaggct gacagcagga agagcagggc ccatgaccgg gtggaagttc
     1861 agttttggtg tctgcttcaa gagggggttt tacactctga ttccaggaca agcactctga
     1921 ggcgggtggg ggagagaaac cctggctctt cacccaggtt tcacacacat gtaaatgaaa
     1981 cactatgtta gtatctaaca cactcctgga tacagaacac aagtcttggc acatatgtga
     2041 tggaaataaa gtgttttgca atcttt
//
