LOCUS       NM_006399                913 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens basic leucine zipper ATF-like transcription factor
            (BATF), mRNA.
ACCESSION   NM_006399
VERSION     NM_006399.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Kumar,B., Singh,A., Basar,R., Uprety,N., Li,Y., Fan,H.,
            Cortes,A.K.N., Kaplan,M., Acharya,S., Shaim,H., Xu,A.C., Wu,M.,
            Ensley,E., Fang,D., Banerjee,P.P., Garcia,L.M., Tiberti,S., Lin,P.,
            Rafei,H., Munir,M.N., Moore,M., Shanley,M., Mendt,M., Kerbauy,L.N.,
            Liu,B., Biederstadt,A., Gokdemir,E., Ghosh,S., Kundu,K.,
            Reyes-Silva,F., Jiang,X.R., Wan,X., Gilbert,A.L., Dede,M.,
            Mohanty,V., Dou,J., Zhang,P., Liu,E., Muniz-Feliciano,L.,
            Deyter,G.M., Jain,A.K., Rodriguez-Sevilla,J.J., Colla,S.,
            Garcia-Manero,G., Shpall,E.J., Chen,K., Abbas,H.A., Rai,K.,
            Rezvani,K. and Daher,M.
  TITLE     BATF is a major driver of NK cell epigenetic reprogramming and
            dysfunction in AML
  JOURNAL   Sci Transl Med 16 (764), eadp0004 (2024)
   PUBMED   39259809
  REMARK    GeneRIF: BATF is a major driver of NK cell epigenetic reprogramming
            and dysfunction in AML.
REFERENCE   2  (bases 1 to 913)
  AUTHORS   Zhang,R., Miao,J., Zhai,M., Liu,R., Li,F., Xu,X., Huang,L.,
            Wang,T., Yang,R., Yang,R., Wang,Y., He,A. and Wang,J.
  TITLE     BATF promotes extramedullary infiltration through
            TGF-beta1/Smad/MMPs axis in acute myeloid leukemia
  JOURNAL   Mol Carcinog 63 (6), 1146-1159 (2024)
   PUBMED   38477642
  REMARK    GeneRIF: BATF promotes extramedullary infiltration through
            TGF-beta1/Smad/MMPs axis in acute myeloid leukemia.
REFERENCE   3  (bases 1 to 913)
  AUTHORS   Shan,F., Cillo,A.R., Cardello,C., Yuan,D.Y., Kunning,S.R., Cui,J.,
            Lampenfeld,C., Williams,A.M., McDonough,A.P., Pennathur,A.,
            Luketich,J.D., Kirkwood,J.M., Ferris,R.L., Bruno,T.C.,
            Workman,C.J., Benos,P.V. and Vignali,D.A.A.
  TITLE     Integrated BATF transcriptional network regulates suppressive
            intratumoral regulatory T cells
  JOURNAL   Sci Immunol 8 (87), eadf6717 (2023)
   PUBMED   37713508
  REMARK    GeneRIF: Integrated BATF transcriptional network regulates
            suppressive intratumoral regulatory T cells.
REFERENCE   4  (bases 1 to 913)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 913)
  AUTHORS   Najafi,A., Sabaghi,M., Asgarian-Omran,H., Valadan,R., Shekarriz,R.,
            Zaboli,E., Janbabai,G. and Tehrani,M.
  TITLE     Relative Expression of BATF and CD112 in PBMC of Patients with
            Chronic Lymphocytic Leukemia
  JOURNAL   Asian Pac J Cancer Prev 24 (6), 2171-2176 (2023)
   PUBMED   37378949
  REMARK    GeneRIF: Relative Expression of BATF and CD112 in PBMC of Patients
            with Chronic Lymphocytic Leukemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 913)
  AUTHORS   Echlin,D.R., Tae,H.J., Mitin,N. and Taparowsky,E.J.
  TITLE     B-ATF functions as a negative regulator of AP-1 mediated
            transcription and blocks cellular transformation by Ras and Fos
  JOURNAL   Oncogene 19 (14), 1752-1763 (2000)
   PUBMED   10777209
REFERENCE   7  (bases 1 to 913)
  AUTHORS   Meyer,N.P., Johansen,L.M., Tae,H.J., Budde,P.P., Williams,K.L. and
            Taparowsky,E.J.
  TITLE     Genomic organization of human B-ATF, a target for regulation by EBV
            and HTLV-1
  JOURNAL   Mamm Genome 9 (10), 849-852 (1998)
   PUBMED   9745044
REFERENCE   8  (bases 1 to 913)
  AUTHORS   Wang,X., Johansen,L.M., Tae,H.J. and Taparowsky,E.J.
  TITLE     IFP 35 forms complexes with B-ATF, a member of the AP1 family of
            transcription factors
  JOURNAL   Biochem Biophys Res Commun 229 (1), 316-322 (1996)
   PUBMED   8954125
REFERENCE   9  (bases 1 to 913)
  AUTHORS   Hasegawa,H., Utsunomiya,Y., Kishimoto,K., Tange,Y., Yasukawa,M. and
            Fujita,S.
  TITLE     SFA-2, a novel bZIP transcription factor induced by human T-cell
            leukemia virus type I, is highly expressed in mature lymphocytes
  JOURNAL   Biochem Biophys Res Commun 222 (1), 164-170 (1996)
   PUBMED   8630063
REFERENCE   10 (bases 1 to 913)
  AUTHORS   Dorsey,M.J., Tae,H.J., Sollenberger,K.G., Mascarenhas,N.T.,
            Johansen,L.M. and Taparowsky,E.J.
  TITLE     B-ATF: a novel human bZIP protein that associates with members of
            the AP-1 transcription factor family
  JOURNAL   Oncogene 11 (11), 2255-2265 (1995)
   PUBMED   8570175
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP235761.1, U15460.1 and
            BC032294.1.
            
            On Aug 31, 2019 this sequence version replaced NM_006399.4.
            
            Summary: The protein encoded by this gene is a nuclear basic
            leucine zipper protein that belongs to the AP-1/ATF superfamily of
            transcription factors. The leucine zipper of this protein mediates
            dimerization with members of the Jun family of proteins. This
            protein is thought to be a negative regulator of AP-1/ATF
            transcriptional events. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032294.1, CD743175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286639.8/ ENSP00000286639.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BP235761.1         53-57
            6-871               U15460.1           1-866
            872-913             BC032294.1         908-949
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..913
                     /gene="BATF"
                     /gene_synonym="B-ATF; BATF1; SFA-2; SFA2"
                     /note="basic leucine zipper ATF-like transcription factor"
                     /db_xref="GeneID:10538"
                     /db_xref="HGNC:HGNC:958"
                     /db_xref="MIM:612476"
     exon            1..277
                     /gene="BATF"
                     /gene_synonym="B-ATF; BATF1; SFA-2; SFA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..592
                     /gene="BATF"
                     /gene_synonym="B-ATF; BATF1; SFA-2; SFA2"
                     /note="activating transcription factor B; SF-HT-activated
                     gene 2 protein; basic leucine zipper transcription factor,
                     ATF-like; B-cell-activating transcription factor"
                     /codon_start=1
                     /product="basic leucine zipper transcriptional factor
                     ATF-like"
                     /protein_id="NP_006390.1"
                     /db_xref="CCDS:CCDS9843.1"
                     /db_xref="GeneID:10538"
                     /db_xref="HGNC:HGNC:958"
                     /db_xref="MIM:612476"
                     /translation="MPHSSDSSDSSFSRSPPPGKQDSSDDVRRVQRREKNRIAAQKSR
                     QRQTQKADTLHLESEDLEKQNAALRKEIKQLTEELKYFTSVLNSHEPLCSVLAASTPS
                     PPEVVYSAHAFHQPHVSSPRFQP"
     exon            278..382
                     /gene="BATF"
                     /gene_synonym="B-ATF; BATF1; SFA-2; SFA2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..913
                     /gene="BATF"
                     /gene_synonym="B-ATF; BATF1; SFA-2; SFA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      894..899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BATF"
                     /gene_synonym="B-ATF; BATF1; SFA-2; SFA2"
                     /note="hexamer: AATAAA"
     polyA_site      913
                     /gene="BATF"
                     /gene_synonym="B-ATF; BATF1; SFA-2; SFA2"
                     /note="major polyA site"
ORIGIN      
        1 aaagcgagcg acatgtccct ttggggagca gtccctctgc accccagagt gaggaggacg
       61 caggggtcag aggtggctac agggcaggca gaggaggcac ctgtaggggg tggtgggctg
      121 gtggcccagg agaagtcagg aagggagccc agctggtgac aagagagccc agaggtgcct
      181 ggggctgagt gtgagagccc ggaagatttc agccatgcct cacagctccg acagcagtga
      241 ctccagcttc agccgctctc ctccccctgg caaacaggac tcatctgatg atgtgagaag
      301 agttcagagg agggagaaaa atcgtattgc cgcccagaag agccgacaga ggcagacaca
      361 gaaggccgac accctgcacc tggagagcga agacctggag aaacagaacg cggctctacg
      421 caaggagatc aagcagctca cagaggaact gaagtacttc acgtcggtgc tgaacagcca
      481 cgagcccctg tgctcggtgc tggccgccag cacgccctcg ccccccgagg tggtgtacag
      541 cgcccacgca ttccaccaac ctcatgtcag ctccccgcgc ttccagccct gagcttccga
      601 tgcggggaga gcagagcctc gggaggggca cacagactgt ggcagagctg cgcccatccc
      661 gcagaggccc ctgtccacct ggagacccgg agacagaggc ctggacaagg agtgaacacg
      721 ggaactgtca cgactggaag ggcgtgaggc ctcccagcag tgccgcagcg tttcgagggg
      781 cgtgtgctgg accccaccac tgtgggttgc aggcccaatg cagaagagta ttaagaaaga
      841 tgctcaagtc ccatggcaca gagcaaggcg ggcagggaac ggttattttt ctaaataaat
      901 gctttaaaag aaa
//
