LOCUS       NM_006317               1807 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens brain abundant membrane attached signal protein 1
            (BASP1), transcript variant 1, mRNA.
ACCESSION   NM_006317
VERSION     NM_006317.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Meng,Z., Zhou,L., Hong,S., Qiu,X., Chen,Z., Liu,T., Inoki,K. and
            Lin,J.D.
  TITLE     Myeloid-specific ablation of Basp1 ameliorates diet-induced NASH in
            mice by attenuating pro-inflammatory signaling
  JOURNAL   Hepatology 79 (2), 409-424 (2024)
   PUBMED   37505219
  REMARK    GeneRIF: Myeloid-specific ablation of Basp1 ameliorates
            diet-induced NASH in mice by attenuating pro-inflammatory
            signaling.
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Zhang,L., Zhao,Z., Quan,X., Xie,Z. and Zhao,J.
  TITLE     Circ_0008285 silencing suppresses angiotensin II-induced vascular
            smooth muscle cell apoptosis in thoracic aortic aneurysm via
            miR-150-5p/BASP1 axis
  JOURNAL   Thorac Cancer 14 (22), 2158-2167 (2023)
   PUBMED   37337843
  REMARK    GeneRIF: Circ_0008285 silencing suppresses angiotensin II-induced
            vascular smooth muscle cell apoptosis in thoracic aortic aneurysm
            via miR-150-5p/BASP1 axis.
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Wang,T., Liu,X., Wang,T., Zhan,L. and Zhang,M.
  TITLE     BASP1 expression is associated with poor prognosis and is
            correlated with immune infiltration in gastric cancer
  JOURNAL   FEBS Open Bio 13 (8), 1507-1521 (2023)
   PUBMED   37243901
  REMARK    GeneRIF: BASP1 expression is associated with poor prognosis and is
            correlated with immune infiltration in gastric cancer.
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Liao,X., Li,Z., Zheng,H., Qian,W., Zhang,S., Chen,S., Li,X.,
            Tang,M., Xu,Y., Yu,R., Li,M., Song,L. and Li,J.
  TITLE     Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas
            via Epigenetic Activation of the FBXO32/NF-kappaB/MGMT Axis
  JOURNAL   Mol Cancer Res 21 (7), 648-663 (2023)
   PUBMED   36961398
  REMARK    GeneRIF: Downregulation of BASP1 Promotes Temozolomide Resistance
            in Gliomas via Epigenetic Activation of the FBXO32/NF-kappaB/MGMT
            Axis.
REFERENCE   5  (bases 1 to 1807)
  AUTHORS   Sun,F., Liu,J., Wang,Y., Yang,H., Song,D., Fu,H. and Feng,X.
  TITLE     BASP1 promotes high glucose-induced endothelial apoptosis in
            diabetes via activation of EGFR signaling
  JOURNAL   J Diabetes Investig 14 (4), 535-547 (2023)
   PUBMED   36756695
  REMARK    GeneRIF: BASP1 promotes high glucose-induced endothelial apoptosis
            in diabetes via activation of EGFR signaling.
REFERENCE   6  (bases 1 to 1807)
  AUTHORS   Behan,A.T., Byrne,C., Dunn,M.J., Cagney,G. and Cotter,D.R.
  TITLE     Proteomic analysis of membrane microdomain-associated proteins in
            the dorsolateral prefrontal cortex in schizophrenia and bipolar
            disorder reveals alterations in LAMP, STXBP1 and BASP1 protein
            expression
  JOURNAL   Mol Psychiatry 14 (6), 601-613 (2009)
   PUBMED   18268500
  REMARK    GeneRIF: proteomic assessments of membrane microdomains in
            prefrontal cortex and validation in two brain series, strongly
            implicates LAMP, STXBP1 and BASP1 in schizophrenia and supports the
            view of a neuritic and synaptic dysfunction in the neuropathology
REFERENCE   7  (bases 1 to 1807)
  AUTHORS   Carpenter,B., Hill,K.J., Charalambous,M., Wagner,K.J., Lahiri,D.,
            James,D.I., Andersen,J.S., Schumacher,V., Royer-Pokora,B., Mann,M.,
            Ward,A. and Roberts,S.G.
  TITLE     BASP1 is a transcriptional cosuppressor for the Wilms' tumor
            suppressor protein WT1
  JOURNAL   Mol Cell Biol 24 (2), 537-549 (2004)
   PUBMED   14701728
  REMARK    GeneRIF: BASP1 can confer WT1 cosuppressor activity in transfection
            assays, and elimination of endogenous BASP1 expression augments
            transcriptional activation by WT1.
REFERENCE   8  (bases 1 to 1807)
  AUTHORS   Fitzgibbon,J., Neat,M.J., Foot,N., Hill,A.S., Lister,T.A. and
            Gupta,R.K.
  TITLE     Assignment of brain acid-soluble protein 1 (BASP1) to human
            chromosome 5p15.1-->p14, differential expression in human cancer
            cell lines as a result of alterations in gene dosage
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 147-149 (2000)
   PUBMED   10965107
REFERENCE   9  (bases 1 to 1807)
  AUTHORS   Park,S., Kim,Y.I., Kim,B., Seong,C., Oh,Y., Baek,K. and Yoon,J.
  TITLE     Characterization of bovine and human cDNAs encoding NAP-22 (22 kDa
            neuronal tissue-enriched acidic protein) homologs
  JOURNAL   Mol Cells 8 (4), 471-477 (1998)
   PUBMED   9749536
REFERENCE   10 (bases 1 to 1807)
  AUTHORS   Mosevitsky,M.I., Capony,J.P., Skladchikova,G.Yu., Novitskaya,V.A.,
            Plekhanov,A.Yu. and Zakharov,V.V.
  TITLE     The BASP1 family of myristoylated proteins abundant in axonal
            termini. Primary structure analysis and physico-chemical properties
  JOURNAL   Biochimie 79 (6), 373-384 (1997)
   PUBMED   9310187
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN355202.1, BC000518.2,
            BU181147.1, BM973114.1 and HY258599.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006317.4.
            
            Summary: This gene encodes a membrane bound protein with several
            transient phosphorylation sites and PEST motifs. Conservation of
            proteins with PEST sequences among different species supports their
            functional significance. PEST sequences typically occur in proteins
            with high turnover rates. Immunological characteristics of this
            protein are species specific. This protein also undergoes
            N-terminal myristoylation. Alternative splicing results in multiple
            transcript variants that encode the same protein. [provided by
            RefSeq, Oct 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.174187.1,
                                           SRR1163658.149186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322611.4/ ENSP00000319281.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CN355202.1         82-92
            12-643              BC000518.2         1-632
            644-943             BU181147.1         144-443             c
            944-1625            BC000518.2         929-1610
            1626-1793           BM973114.1         25-192              c
            1794-1807           HY258599.1         44-57               c
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.1"
     gene            1..1807
                     /gene="BASP1"
                     /gene_synonym="CAP-23; CAP23; NAP-22; NAP22"
                     /note="brain abundant membrane attached signal protein 1"
                     /db_xref="GeneID:10409"
                     /db_xref="HGNC:HGNC:957"
                     /db_xref="MIM:605940"
     exon            1..180
                     /gene="BASP1"
                     /gene_synonym="CAP-23; CAP23; NAP-22; NAP22"
                     /inference="alignment:Splign:2.1.0"
     exon            181..1807
                     /gene="BASP1"
                     /gene_synonym="CAP-23; CAP23; NAP-22; NAP22"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..873
                     /gene="BASP1"
                     /gene_synonym="CAP-23; CAP23; NAP-22; NAP22"
                     /note="brain acid-soluble protein 1; neuronal axonal
                     membrane protein NAP-22; neuronal tissue-enriched acidic
                     protein; 22 kDa neuronal tissue-enriched acidic protein"
                     /codon_start=1
                     /product="brain acid soluble protein 1"
                     /protein_id="NP_006308.3"
                     /db_xref="CCDS:CCDS3888.1"
                     /db_xref="GeneID:10409"
                     /db_xref="HGNC:HGNC:957"
                     /db_xref="MIM:605940"
                     /translation="MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQA
                     AAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPK
                     APEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQ
                     ETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAAN
                     SDQTVTVKE"
     regulatory      1783..1788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BASP1"
                     /gene_synonym="CAP-23; CAP23; NAP-22; NAP22"
                     /note="hexamer: AATAAA"
     polyA_site      1807
                     /gene="BASP1"
                     /gene_synonym="CAP-23; CAP23; NAP-22; NAP22"
                     /note="major polyA site"
ORIGIN      
        1 agtagcggca gcggcgacga cggcggcggc agcgctccaa ctggctcctc gctccgggct
       61 ccgccgtcga gccgggagag agcctccgcc agcggccagg caccagccag acgacgccag
      121 cgaccccggc ctctcggcgg caccgcgcta actcaggggc tgcataggca cccagagccg
      181 aactccaaga tgggaggcaa gctcagcaag aagaagaagg gctacaatgt gaacgacgag
      241 aaagccaagg agaaagacaa gaaggccgag ggcgcggcga cggaagagga ggggaccccg
      301 aaggagagtg agccccaggc ggccgcagag cccgccgagg ccaaggaggg caaggagaag
      361 cccgaccagg acgccgaggg caaggccgag gagaaggagg gcgagaagga cgcggcggct
      421 gccaaggagg aggccccgaa ggcggagccc gagaagacgg agggcgcggc agaggccaag
      481 gctgagcccc cgaaggcgcc cgagcaggag caggcggccc ccggccccgc tgcgggcggc
      541 gaggccccca aagctgctga ggccgccgcg gccccggccg agagcgcggc ccctgccgcc
      601 ggggaggagc ccagcaagga ggaaggggaa cccaaaaaga ctgaggcgcc cgcagctcct
      661 gccgcccagg agaccaaaag tgacggggcc ccagcttcag actcaaaacc cggcagctcg
      721 gaggctgccc cctcttccaa ggagaccccc gcagccacgg aagcgcctag ttccacaccc
      781 aaggcccagg gccccgcagc ctctgcagaa gagcccaagc cggtggaggc cccggcagct
      841 aattccgacc aaaccgtaac cgtgaaagag tgacaaggac agcctatagg aaaaacaata
      901 ccacttaaaa caatctcctc tctctctctc tctctctctc tctatctctc tctctatctc
      961 ctctctctct ctcctctcct atctctcctc tctctctctc ctatactaac ttgtttcaaa
     1021 ttggaagtaa tgatatgtat tgcccaagga aaaatacagg atgttgtccc atcaagggag
     1081 ggagggggtg ggagaatcca aatagtattt ttgtggggaa atatctaata taccttcagt
     1141 caactttacc aagaagtcct ggatttccaa gatccgcgtc tgaaagtgca gtacatcgtt
     1201 tgtacctgaa actgccgcca catgcactcc tccaccgctg agagttgaat agcttttctt
     1261 ctgcaatggg agttgggagt gatgcgtttg attctgccca cagggcctgt gccaaggcaa
     1321 tcagatcttt atgagagcag tattttctgt gttttctttt taatttacag cctttcttat
     1381 tttgatattt ttttaatgtt gtggatgaat gccagctttc agacagagcc cacttagctt
     1441 gtccacatgg atctcaatgc caatcctcca ttcttcctct ccagatattt ttgggagtga
     1501 caaacattct ctcatcctac ttagcctacc tagatttctc atgacgagtt aatgcatgtc
     1561 cgtggttggg tgcacctgta gttctgttta ttggtcagtg gaaatgaaaa aaaaaaaaaa
     1621 aaaaagtctg cgttcattgc agttccagtt tctcttccat tctgtgtcac agacaccaac
     1681 acaccactca ttggaaaatg gaaaaaaaaa acaaaaaaaa aacaaaaaaa tgtacaatgg
     1741 atgcattgaa attatatgta attgtataaa tggtgcaaca gtaataaagt taaacaatta
     1801 aaaagaa
//
