LOCUS       NM_003658               1905 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens BARX homeobox 2 (BARX2), mRNA.
ACCESSION   NM_003658
VERSION     NM_003658.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1905)
  AUTHORS   Lu,Z., Peng,H., Li,R., Xu,X. and Peng,J.
  TITLE     BarH-like homeobox 2 represses the transcription of keratin 16 and
            affects Ras signaling pathway to suppress nasopharyngeal carcinoma
            progression
  JOURNAL   Bioengineered 13 (2), 3122-3136 (2022)
   PUBMED   35037835
  REMARK    GeneRIF: BarH-like homeobox 2 represses the transcription of
            keratin 16 and affects Ras signaling pathway to suppress
            nasopharyngeal carcinoma progression.
REFERENCE   2  (bases 1 to 1905)
  AUTHORS   Zhang,J., Zhang,T., Tang,B., Li,J. and Zha,Z.
  TITLE     The miR-187 induced bone reconstruction and healing in a mouse
            model of osteoporosis, and accelerated osteoblastic differentiation
            of human multipotent stromal cells by targeting BARX2
  JOURNAL   Pathol Res Pract 219, 153340 (2021)
   PUBMED   33550149
  REMARK    GeneRIF: The miR-187 induced bone reconstruction and healing in a
            mouse model of osteoporosis, and accelerated osteoblastic
            differentiation of human multipotent stromal cells by targeting
            BARX2.
REFERENCE   3  (bases 1 to 1905)
  AUTHORS   Ma,J., Xia,L.L., Yao,X.Q., Zheng,S.M., Li,S., Xu,L.S., Sha,W.H. and
            Li,Z.S.
  TITLE     BARX2 expression is downregulated by CpG island hypermethylation
            and is associated with suppressed cell proliferation and invasion
            of gastric cancer cells
  JOURNAL   Oncol Rep 43 (6), 1805-1818 (2020)
   PUBMED   32236603
  REMARK    GeneRIF: BARX2 expression is downregulated by CpG island
            hypermethylation and is associated with suppressed cell
            proliferation and invasion of gastric cancer cells.
REFERENCE   4  (bases 1 to 1905)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1905)
  AUTHORS   Chen,H., Zhang,M., Zhang,W., Li,Y., Zhu,J., Zhang,X., Zhao,L.,
            Zhu,S. and Chen,B.
  TITLE     Downregulation of BarH-like homeobox 2 promotes cell proliferation,
            migration and aerobic glycolysis through Wnt/beta-catenin
            signaling, and predicts a poor prognosis in non-small cell lung
            carcinoma
  JOURNAL   Thorac Cancer 9 (3), 390-399 (2018)
   PUBMED   29341468
  REMARK    GeneRIF: These findings reveal that Barx2 serving as a tumor
            suppressor gene could decrease cell proliferation, migration, and
            aerobic glycolysis through inhibiting the Wnt/beta-catenin
            signaling pathway, and predicts a good prognosis in non-small cell
            lung carcinoma
REFERENCE   6  (bases 1 to 1905)
  AUTHORS   Stevens,T.A., Iacovoni,J.S., Edelman,D.B. and Meech,R.
  TITLE     Identification of novel binding elements and gene targets for the
            homeodomain protein BARX2
  JOURNAL   J Biol Chem 279 (15), 14520-14530 (2004)
   PUBMED   14744868
  REMARK    GeneRIF: BARX2 can coordinate the expression of a network of genes
            that influence the growth of tumor cells
REFERENCE   7  (bases 1 to 1905)
  AUTHORS   Herring,B.P., Kriegel,A.M. and Hoggatt,A.M.
  TITLE     Identification of Barx2b, a serum response factor-associated
            homeodomain protein
  JOURNAL   J Biol Chem 276 (17), 14482-14489 (2001)
   PUBMED   11278942
REFERENCE   8  (bases 1 to 1905)
  AUTHORS   Krasner,A., Wallace,L., Thiagalingam,A., Jones,C., Lengauer,C.,
            Minahan,L., Ma,Y., Kalikin,L., Feinberg,A.P., Jabs,E.W.,
            Tunnacliffe,A., Baylin,S.B., Ball,D.W. and Nelkin,B.D.
  TITLE     Cloning and chromosomal localization of the human BARX2 homeobox
            protein gene
  JOURNAL   Gene 250 (1-2), 171-180 (2000)
   PUBMED   10854790
REFERENCE   9  (bases 1 to 1905)
  AUTHORS   Hjalt,T.A. and Murray,J.C.
  TITLE     The human BARX2 gene: genomic structure, chromosomal localization,
            and single nucleotide polymorphisms
  JOURNAL   Genomics 62 (3), 456-459 (1999)
   PUBMED   10644443
REFERENCE   10 (bases 1 to 1905)
  AUTHORS   Jones,F.S., Kioussi,C., Copertino,D.W., Kallunki,P., Holst,B.D. and
            Edelman,G.M.
  TITLE     Barx2, a new homeobox gene of the Bar class, is expressed in neural
            and craniofacial structures during development
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2632-2637 (1997)
   PUBMED   9122247
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003775.3 and BC111432.1.
            
            On May 17, 2019 this sequence version replaced NM_003658.4.
            
            Summary: This gene encodes a member of the homeobox transcription
            factor family. A highly related protein in mouse has been shown to
            influence cellular processes that control cell adhesion and
            remodeling of the actin cytoskeleton in myoblast fusion and
            chondrogenesis. The encoded protein may also play a role in cancer
            progression. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ243512.1, AF031924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281437.6/ ENSP00000281437.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AP003775.3         75771-75908
            139-169             AP003775.3         75909-75939
            170-1064            BC111432.1         1-895
            1065-1905           AP003775.3         151362-152202
FEATURES             Location/Qualifiers
     source          1..1905
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..1905
                     /gene="BARX2"
                     /note="BARX homeobox 2"
                     /db_xref="GeneID:8538"
                     /db_xref="HGNC:HGNC:956"
                     /db_xref="MIM:604823"
     exon            1..375
                     /gene="BARX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1028
                     /gene="BARX2"
                     /note="BarH-like homeobox 2"
                     /codon_start=1
                     /product="homeobox protein BarH-like 2"
                     /protein_id="NP_003649.2"
                     /db_xref="CCDS:CCDS8481.1"
                     /db_xref="GeneID:8538"
                     /db_xref="HGNC:HGNC:956"
                     /db_xref="MIM:604823"
                     /translation="MHCHAELRLSSPGQLKAARRRYKTFMIDEILSKETCDYFEKLSL
                     YSVCPSLVVRPKPLHSCTGSPSLRAYPLLSVITRQPTVISHLVPATPGIAQALSCHQV
                     TEAVSAEAPGGEALASSESETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQKYLST
                     PDRLDLAQSLGLTQLQVKTWYQNRRMKWKKMVLKGGQEAPTKPKGRPKKNSIPTSEEI
                     EAEEKMNSQAQGQEQLEPSQGQEELCEAQEPKARDVPLEMAEPPDPPQELPIPSSEPP
                     PLS"
     exon            376..676
                     /gene="BARX2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..761
                     /gene="BARX2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..1905
                     /gene="BARX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1887..1892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BARX2"
                     /note="hexamer: AATAAA"
     polyA_site      1905
                     /gene="BARX2"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtgggt ctagacgcgc ggcaggcgcg cccgctaccc gctctcctcc gcgcgccacc
       61 cgagccccgc cgcctcccca gctgccggga gcggggccca ggccccgccg tcgcgccagc
      121 cccgcggccc cagcgggccg ggcactcgca gccgcgctcg ggccggcgga cgctcgcgcc
      181 ggctcaccat gcactgccac gccgagctga ggctgagctc gcccggccag ctcaaagcag
      241 ccaggcggcg ctacaagact ttcatgatcg acgagatcct ctccaaggag acctgcgatt
      301 actttgagaa actttccctc tactccgtgt gcccgtcgct ggtcgtgcga cccaagcccc
      361 tgcattcctg tacgggctcc ccttccctgc gggcatatcc gctcctctcg gtgatcaccc
      421 gccagcccac tgtcatctcc cacctggtcc ctgccacccc gggaatcgcc caggcactgt
      481 cctgccacca ggtcaccgag gcggtctctg ctgaggcccc agggggcgag gccctagcca
      541 gcagcgagtc agagacggaa cagcccacgc cccgacagaa gaagccccgc cggagtcgca
      601 ccatcttcac cgagctgcag ctcatgggcc tggagaagaa attccagaag cagaagtatt
      661 tgtcaacccc agacaggttg gacttggctc agtctctggg actcactcag ctgcaggtga
      721 agacctggta tcagaatcgc aggatgaaat ggaagaaaat ggttcttaaa ggtggacagg
      781 aagcacccac aaaacccaaa ggtcgcccca agaagaactc catccccaca tcagaagaga
      841 ttgaagctga agagaagatg aacagccagg cccagggtca ggagcagctg gagccctctc
      901 aggggcagga ggagctctgt gaagcacagg aaccgaaagc acgtgatgtc cccttagaga
      961 tggcagagcc accagacccg ccccaggagt tgccaatacc ctcttcggaa cccccaccat
     1021 taagctaaag taaaaccctt ttgagggaag agggagactg gggagaaggg aaaagagaga
     1081 aggcagggag agtagggaga gaaaaccttc cagcagccca gtaaactgcg ggcgaagaga
     1141 tctacccgtc tccctccctc ccacagttac cattggcctt gtcatcgcaa gcatttgaca
     1201 aagacttgct tgtcttgggc ctgtcacctc ctgaaaggct gctttagctg tggatgccct
     1261 tgattaaggg agagagcgcc taggagctgc ctgccccagc tggggtgacg gctgtagggc
     1321 tgggtctatg ttgcaagccc tatatcctag catgcagtgg aaagtgctta gctctctccc
     1381 tcctgacctc tgggcagcca gtcatcaaag cagagagacg tggcggcatg tgggcagcat
     1441 gcccaggttc cttgctgact cagcacttat ttctgtagtt ttaaaaaaga atttaatgtt
     1501 tttggttgta tttttttggg ggggtgaggg tgggcaaaaa catgggggta gttctgagtt
     1561 gttagaaatg tttctgaatc aagtttgttt gaagacacgt gtgcctttgt acccattata
     1621 agatggtcat aagacccaag aactgataag ctttggtttt ttttttgttt tgttttgttt
     1681 tttgcttcat ttacccattc atgcctaggg ttccattatt ggaaccctaa gcttgtggga
     1741 gttatttcta tcctactgct caaggtcatc accaagatct gatttttcat aaaaaacatt
     1801 tgtgaccttc ggcataaatg ggttaaggtg ccatccctga aactgcaatg cagatatgtt
     1861 cagataactt ttatttttta attaaaaata aatctttcaa aagga
//
