LOCUS       NM_021570               1511 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens BARX homeobox 1 (BARX1), mRNA.
ACCESSION   NM_021570
VERSION     NM_021570.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1511)
  AUTHORS   Guan,X., Liang,J., Xiang,Y., Li,T. and Zhong,X.
  TITLE     BARX1 repressed FOXF1 expression and activated Wnt/beta-catenin
            signaling pathway to drive lung adenocarcinoma
  JOURNAL   Int J Biol Macromol 261 (Pt 2), 129717 (2024)
   PUBMED   38290639
  REMARK    GeneRIF: BARX1 repressed FOXF1 expression and activated
            Wnt/beta-catenin signaling pathway to drive lung adenocarcinoma.
REFERENCE   2  (bases 1 to 1511)
  AUTHORS   Zhang,T., Qiu,L., Cao,J., Li,Q., Zhang,L., An,G., Ni,J., Jia,H.,
            Li,S. and Li,K.
  TITLE     ZFP36 loss-mediated BARX1 stabilization promotes malignant
            phenotypes by transactivating master oncogenes in NSCLC
  JOURNAL   Cell Death Dis 14 (8), 527 (2023)
   PUBMED   37587140
  REMARK    GeneRIF: ZFP36 loss-mediated BARX1 stabilization promotes malignant
            phenotypes by transactivating master oncogenes in NSCLC.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1511)
  AUTHORS   Huang,X., Wang,Z., Zhang,J., Ni,X., Bai,G., Cao,J., Zhang,C.,
            Han,Z. and Liu,T.
  TITLE     BARX1 promotes osteosarcoma cell proliferation and invasion by
            regulating HSPA6 expression
  JOURNAL   J Orthop Surg Res 18 (1), 211 (2023)
   PUBMED   36927457
  REMARK    GeneRIF: BARX1 promotes osteosarcoma cell proliferation and
            invasion by regulating HSPA6 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1511)
  AUTHORS   Hemming,M.L., Coy,S., Lin,J.R., Andersen,J.L., Przybyl,J.,
            Mazzola,E., Abdelhamid Ahmed,A.H., van de Rijn,M., Sorger,P.K.,
            Armstrong,S.A., Demetri,G.D. and Santagata,S.
  TITLE     HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of
            Malignancy in Gastrointestinal Stromal Tumor
  JOURNAL   Clin Cancer Res 27 (6), 1706-1719 (2021)
   PUBMED   33451979
  REMARK    GeneRIF: HAND1 and BARX1 Act as Transcriptional and Anatomic
            Determinants of Malignancy in Gastrointestinal Stromal Tumor.
REFERENCE   5  (bases 1 to 1511)
  AUTHORS   Chang,C.A., Di Donato,N., Hackmann,K., Argiropoulos,B.,
            Ferreira,P., Innes,A.M. and Thomas,M.A.
  TITLE     Congenital hiatal hernia segregating with a duplication in
            9q22.31q22.32 in two families
  JOURNAL   Am J Med Genet A 182 (12), 3040-3047 (2020)
   PUBMED   33026187
  REMARK    GeneRIF: Congenital hiatal hernia segregating with a duplication in
            9q22.31q22.32 in two families.
REFERENCE   6  (bases 1 to 1511)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1511)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1511)
  AUTHORS   Krivicka-Uzkurele,B., Pilmane,M. and Akota,I.
  TITLE     Barx1, growth factors and apoptosis in facial tissue of children
            with clefts
  JOURNAL   Stomatologija 10 (2), 62-66 (2008)
   PUBMED   18708738
  REMARK    GeneRIF: Regional expression of barx1 was observed in epithelium
            before mixed dentition, while during mixed dentition gene appeared
            in hyaline cartilage. Expression of barx1 appears in cleft lip
            palate affected structures mainly in mixed dentition.
REFERENCE   9  (bases 1 to 1511)
  AUTHORS   Lowry,R.B., Gould,D.B., Walter,M.A. and Savage,P.R.
  TITLE     Absence of PITX2, BARX1, and FOXC1 mutations in De Hauwere syndrome
            (Axenfeld-Rieger anomaly, hydrocephaly, hearing loss): a 25-year
            follow up
  JOURNAL   Am J Med Genet A 143A (11), 1227-1230 (2007)
   PUBMED   17486624
  REMARK    GeneRIF: PITX2, BARX1, and FOXC1 mutations were absent in De
            Hauwere syndrome and suggest that De Hauwere syndrome is caused by
            a different gene.
REFERENCE   10 (bases 1 to 1511)
  AUTHORS   Gould,D.B. and Walter,M.A.
  TITLE     Cloning, characterization, localization, and mutational screening
            of the human BARX1 gene
  JOURNAL   Genomics 68 (3), 336-342 (2000)
   PUBMED   10995576
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357073.19, BC064363.1 and
            BC009458.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021570.3.
            
            Summary: This gene encodes a member of the Bar subclass of homeobox
            transcription factors. Studies of the mouse and chick homolog
            suggest the encoded protein may play a role in developing teeth and
            craniofacial mesenchyme of neural crest origin. The protein may
            also be associated with differentiation of stomach epithelia.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064363.1, AL555424.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253968.11/ ENSP00000253968.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL357073.19        75648-75676         c
            30-907              BC064363.1         46-923
            908-1511            BC009458.1         726-1329
FEATURES             Location/Qualifiers
     source          1..1511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32"
     gene            1..1511
                     /gene="BARX1"
                     /note="BARX homeobox 1"
                     /db_xref="GeneID:56033"
                     /db_xref="HGNC:HGNC:955"
                     /db_xref="MIM:603260"
     exon            1..432
                     /gene="BARX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..974
                     /gene="BARX1"
                     /note="BarH-like homeobox 1"
                     /codon_start=1
                     /product="homeobox protein BarH-like 1"
                     /protein_id="NP_067545.3"
                     /db_xref="CCDS:CCDS35070.2"
                     /db_xref="GeneID:56033"
                     /db_xref="HGNC:HGNC:955"
                     /db_xref="MIM:603260"
                     /translation="MQRPGEPGAARFGPPEGCADHRPHRYRSFMIEEILTEPPGPKGA
                     APAAAAAAAGELLKFGVQALLAARPFHSHLAVLKAEQAAVFKFPLAPLGCSGLSSALL
                     AAGPGLPGAAGAPHLPLELQLRGKLEAAGPGEPGTKAKKGRRSRTVFTELQLMGLEKR
                     FEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPK
                     KNSIPTSEQLTEQERAKDAEKPAEVPGEPSDRSRED"
     exon            433..724
                     /gene="BARX1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..809
                     /gene="BARX1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1511
                     /gene="BARX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1490..1495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BARX1"
                     /note="hexamer: AATAAA"
     polyA_site      1511
                     /gene="BARX1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcccgg gttcgaccgg ccgagccccg cgcgccccgc ccgcgccctg cgcctccgcc
       61 cggccggccg gcgggggagg gggcatgagc cggcgcccgc gcgccgcccc gagctgcggg
      121 ccggcctaga gccccgcgcg ggccccgcgc cggagccaag ccgtcgccgc cgccgccgcc
      181 aaaccgcggg cgcagcagtg ggcgccgcga tgcagcggcc gggggagccg ggcgccgcgc
      241 gcttcggccc gcccgagggc tgcgcggacc accggccgca ccgctatcgc agcttcatga
      301 ttgaggagat cctcacggag ccacccgggc ccaagggcgc cgcgcccgca gccgccgctg
      361 ccgcggcggg cgagctgctg aagttcggcg tgcaggcgct gctggcggcg cggcccttcc
      421 acagccacct ggccgtgctg aaggccgagc aggcggcggt gttcaagttc ccactggcgc
      481 cgctgggctg ttcagggctg agctctgcgt tgctggcggc agggcccggg ctgcccggcg
      541 ccgcgggtgc gccacacctg ccgctcgagt tgcagctccg cgggaagctg gaggcggcag
      601 gccctgggga gccaggcacc aaagccaaga aggggcgtcg gagccgcact gtgttcaccg
      661 agctgcagct gatgggcctg gagaaacgct tcgagaagca gaagtacctt tccacgccgg
      721 acagaataga tcttgctgag tccctgggcc tgagccagtt gcaggtgaag acgtggtacc
      781 agaatcggag gatgaagtgg aagaaaatag tgctgcaggg cggcggcctg gagtctccca
      841 ccaagcccaa ggggcggccc aagaagaact caattccaac gagcgagcag cttactgagc
      901 aggagcgcgc caaggatgca gagaaaccgg cggaggtgcc gggcgagccc agcgacagga
      961 gccgcgagga ctgagggcgg tatacggtgc ggggcctggg atgcccgcgc cacccgcagc
     1021 cccctcactc ggcggaaacc cgcgagccgg cccttccgcg tccaagaagt ttacttccta
     1081 agccttttta ttatgatctt gaatgcggac aattggggcc aaacgaggaa ggacacagac
     1141 ccaaaagcca gacccaggtc ccagcgcgct tctgggctct aacctgggag actcgcatcc
     1201 agcccggcgg aagctacagt ctctaccctg agctccgtgg cgcagagcgc tccacgcgta
     1261 ttcacgcccc gctcctcgcc tgcaccccca ccccgtctgg ggcctgccct cccggccggg
     1321 gagcctccag gcacacaccc gcttctggac gtcggggacc cagcggttgg gctcaggcca
     1381 caacggcctg agattgcccc ggggcaaccc gtcggctcgg cctggaggcc gggtccccga
     1441 tgtcgctggg gcccctaccc cctcttgcga agacggtgac tttttttcca ataaaatatt
     1501 ttatgacaca a
//
