LOCUS       NM_020063               2044 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens BarH like homeobox 2 (BARHL2), mRNA.
ACCESSION   NM_020063 XM_291583
VERSION     NM_020063.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2044)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2044)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 2044)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 2044)
  AUTHORS   Mo,Z., Li,S., Yang,X. and Xiang,M.
  TITLE     Role of the Barhl2 homeobox gene in the specification of
            glycinergic amacrine cells
  JOURNAL   Development 131 (7), 1607-1618 (2004)
   PUBMED   14998930
REFERENCE   5  (bases 1 to 2044)
  AUTHORS   Bulfone,A., Menguzzato,E., Broccoli,V., Marchitiello,A.,
            Gattuso,C., Mariani,M., Consalez,G.G., Martinez,S., Ballabio,A. and
            Banfi,S.
  TITLE     Barhl1, a gene belonging to a new subfamily of mammalian homeobox
            genes, is expressed in migrating neurons of the CNS
  JOURNAL   Hum Mol Genet 9 (9), 1443-1452 (2000)
   PUBMED   10814725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092805.2 and AY338397.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020063.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.136990.1,
                                           SRR3476690.626951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370445.5/ ENSP00000359474.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC092805.2         79472-79536         c
            66-1561             AY338397.1         1-1496
            1562-2044           AC092805.2         73773-74255         c
FEATURES             Location/Qualifiers
     source          1..2044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..2044
                     /gene="BARHL2"
                     /note="BarH like homeobox 2"
                     /db_xref="GeneID:343472"
                     /db_xref="HGNC:HGNC:954"
                     /db_xref="MIM:605212"
     exon            1..732
                     /gene="BARHL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1271
                     /gene="BARHL2"
                     /codon_start=1
                     /product="barH-like 2 homeobox protein"
                     /protein_id="NP_064447.1"
                     /db_xref="CCDS:CCDS730.1"
                     /db_xref="GeneID:343472"
                     /db_xref="HGNC:HGNC:954"
                     /db_xref="MIM:605212"
                     /translation="MTMEGASGSSFGIDTILSSASSGSPGMMNGDFRPLGEARTADFR
                     SQATPSPCSEIDTVGTAPSSPISVTMEPPEPHLVADATQHHHHLHHSQQPPPPAAAPT
                     QSLQPLPQQQQPLPPQQPPPPPPQQLGSAASAPRTSTSSFLIKDILGDSKPLAACAPY
                     STSVSSPHHTPKQESNAVHESFRPKLEQEDSKTKLDKREDSQSDIKCHGTKEEGDREI
                     TSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQV
                     KTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAA
                     AAMYSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLSSPIPGTPHPR"
     exon            733..958
                     /gene="BARHL2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..2044
                     /gene="BARHL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1969..1974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BARHL2"
                     /note="hexamer: AATAAA"
     polyA_site      1988
                     /gene="BARHL2"
                     /note="major polyA site"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BARHL2"
                     /note="hexamer: AATAAA"
     polyA_site      2044
                     /gene="BARHL2"
                     /note="major polyA site"
ORIGIN      
        1 agcggcggca acattgtttg gtgtttattt tgttttacga tcgatagctt tcttcgctgg
       61 ttcggggcgg ctgctgaacg gcggagtggc gtggacctca tgtagcaatg acaatggaag
      121 gggccagcgg gtcgagtttt ggaatagaca cgattttgtc cagtgccagt tcaggcagcc
      181 caggcatgat gaatggagat ttccgcccgc tcggtgaggc caggaccgcg gattttagga
      241 gtcaggccac cccatctccc tgttcggaga ttgataccgt agggacggcg ccttcttctc
      301 ctatctcagt caccatggag cccccggagc cgcatctggt agcagacgcg acccagcatc
      361 atcaccacct ccaccacagc cagcagccgc cgccgccggc cgcggccccg acgcaaagtt
      421 tgcagccttt gccccaacag cagcagccgc tgccgccaca gcagccgccg ccgccgcccc
      481 cccagcagct gggctcggcc gcctcggccc ccaggacttc cacgtcttct tttttaatta
      541 aggacatctt gggcgacagc aaacctctgg cggcatgtgc accctacagc accagcgtat
      601 cctctcccca ccacaccccg aagcaggaga gcaacgcagt gcacgagagc ttcaggccaa
      661 agctcgagca ggaggacagc aagaccaaac tcgacaagcg ggaggattcc cagagcgaca
      721 tcaaatgcca cgggacaaag gaggaaggag accgggagat tacgagtagc cgtgagagtc
      781 cccctgtgag agccaagaag cctcgaaaag caaggacagc tttttccgac caccagctca
      841 atcaactgga gcgtagcttt gagcggcaga agtacctgag cgtgcaggat cgcatggacc
      901 tggctgcagc gctcaacctc actgacaccc aagtcaagac ctggtaccag aaccgcagga
      961 ccaagtggaa gcggcagaca gcggtgggcc tggagttgct ggccgaggca gggaactact
     1021 cggcgctgca gaggatgttt ccatcgcctt atttctatca cccaagcctg ctgggcagca
     1081 tggacagcac tacggcggcg gcggctgccg ctgccatgta cagcagcatg taccggactc
     1141 ctccagcacc ccatccccag ctgcagcggc ccctggtgcc ccgtgtgctc atccacggcc
     1201 tagggcctgg gggacagcca gcccttaatc cattgtccag ccccatccca ggcaccccac
     1261 acccccggtg aaaacattgc agcgaaggca ctgcaatccc ttccccatat ccctgcccaa
     1321 cccggactgc tgcccgtcct ctccctgctc caggccacta ggcctccctt gcagccaact
     1381 ctggaaggca gaggagtaag agaggaagat gcttaccagt gggcagggga cccccaaaga
     1441 ggagccagcc ctctgctctc catctcccca cccctagaaa cagggctgga aatctccccc
     1501 acagcagtgt gactggtgaa aatgctgacc ccacacagag tgcaaccagt aagtgaaaac
     1561 atcaacaaaa acaaaacctc aaattctttt tcaaaaatga ctttagggac aagcaggagg
     1621 gagggagggg ggagggctaa ggagggaaga aagaagggca cggagcggaa acagcacagg
     1681 cagagtgaac tatatatgga cagcctcaag tgctgaggca aagggcgttg ccgaggacat
     1741 tccgtctgcc ccagagaaaa gaggagggta actgagaact ttgcactgat ttctcatgac
     1801 cttttttctt ttggaaaagt ggcatgctcc ataatatgaa aaaaatgtac atttgaaaga
     1861 ctgagtgata agtgatatat catatttatt atatgttgtc caaaaagagt cacttatata
     1921 cgttagtaaa aacatgattt ttcttttcat gtcttttcga ttcagtaaaa taaatgctta
     1981 gacaaaaata tagatttttt tgtgattgaa aattacaaaa ataaagttta tcttttttta
     2041 acaa
//
