LOCUS       NM_020064               1906 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens BarH like homeobox 1 (BARHL1), mRNA.
ACCESSION   NM_020064
VERSION     NM_020064.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Gu,Y., Chen,G. and Ning,X.
  TITLE     Homeobox Protein BarH-like 1 Promotes Gastric Cancer Progression by
            Activating Coiled-Coil Domain-Containing Protein 178
  JOURNAL   Dig Dis Sci 69 (4), 1182-1199 (2024)
   PUBMED   38358459
  REMARK    GeneRIF: Homeobox Protein BarH-like 1 Promotes Gastric Cancer
            Progression by Activating Coiled-Coil Domain-Containing Protein
            178.
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Barh,D., Garcia-Solano,M.E., Tiwari,S., Bhattacharya,A., Jain,N.,
            Torres-Moreno,D., Ferri,B., Silva,A., Azevedo,V., Ghosh,P.,
            Blum,K., Conesa-Zamora,P. and Perry,G.
  TITLE     BARHL1 Is Downregulated in Alzheimer's Disease and May Regulate
            Cognitive Functions through ESR1 and Multiple Pathways
  JOURNAL   Genes (Basel) 8 (10), 245 (2017)
   PUBMED   28956815
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   Poschl,J., Lorenz,A., Hartmann,W., von Bueren,A.O., Kool,M., Li,S.,
            Peraud,A., Tonn,J.C., Herms,J., Xiang,M., Rutkowski,S.,
            Kretzschmar,H.A. and Schuller,U.
  TITLE     Expression of BARHL1 in medulloblastoma is associated with
            prolonged survival in mice and humans
  JOURNAL   Oncogene 30 (47), 4721-4730 (2011)
   PUBMED   21602885
  REMARK    GeneRIF: expression of Barhl1 decelerates tumor growth both in
            human and in murine medulloblastomas.
REFERENCE   5  (bases 1 to 1906)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 1906)
  AUTHORS   Bulfone,A., Menguzzato,E., Broccoli,V., Marchitiello,A.,
            Gattuso,C., Mariani,M., Consalez,G.G., Martinez,S., Ballabio,A. and
            Banfi,S.
  TITLE     Barhl1, a gene belonging to a new subfamily of mammalian homeobox
            genes, is expressed in migrating neurons of the CNS
  JOURNAL   Hum Mol Genet 9 (9), 1443-1452 (2000)
   PUBMED   10814725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054797.1 and AF325688.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020064.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054797.1, AF325688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465402 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263610.7/ ENSP00000263610.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1789              AK054797.1         1-1789
            1790-1857           AF325688.1         1613-1680
            1858-1906           AK054797.1         1858-1906
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.13"
     gene            1..1906
                     /gene="BARHL1"
                     /note="BarH like homeobox 1"
                     /db_xref="GeneID:56751"
                     /db_xref="HGNC:HGNC:953"
                     /db_xref="MIM:605211"
     exon            1..658
                     /gene="BARHL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1176
                     /gene="BARHL1"
                     /codon_start=1
                     /product="barH-like 1 homeobox protein"
                     /protein_id="NP_064448.1"
                     /db_xref="CCDS:CCDS6950.1"
                     /db_xref="GeneID:56751"
                     /db_xref="HGNC:HGNC:953"
                     /db_xref="MIM:605211"
                     /translation="MEGSNGFGIDSILSHRAGSPALPKGDPLLGDCRSPLELSPRSES
                     SSDCSSPASPGRDCLETGTPRPGGASGPGLDSHLQPGQLSAPAQSRTVTSSFLIRDIL
                     ADCKPLAACAPYSSSGQPAAPEPGGRLAAKAAEDFRDKLDKSGSNASSDSEYKVKEEG
                     DREISSSRDSPPVRLKKPRKARTAFTDHQLAQLERSFERQKYLSVQDRMELAASLNLT
                     DTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYPQSLVSNLDPGAA
                     LYLYRGPSAPPPALQRPLVPRILIHGLQGASEPPPPLPPLAGVLPRAAQPR"
     exon            659..881
                     /gene="BARHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1906
                     /gene="BARHL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1887..1892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BARHL1"
                     /note="hexamer: AATAAA"
     polyA_site      1906
                     /gene="BARHL1"
                     /note="major polyA site"
ORIGIN      
        1 cttttggatc taatgcgcag aggaggttgg cccagagctc ccgggctccc ccaaggctga
       61 actccgtcca aggtgcccgc aggctccctg cccgccttcc ccatgccagc ccgcagctag
      121 gggcaggggc agcggcggct ggggttgggg gtgggtgggg agcttttggg gaggacaggt
      181 cgcagcttgg ctatggaagg ctccaatggc tttgggatcg actccattct ctcccaccgc
      241 gcgggcagcc ccgcccttcc caagggggac cccttgctcg gggactgccg ttcgcccctg
      301 gagctgagtc cacgctcaga gagcagcagc gactgctctt cgccagcctc tccaggaagg
      361 gactgtttgg agacggggac cccacggcct ggcggggcat ccggcccagg tttggactcc
      421 cacctgcagc ccgggcagct ctcagccccg gcccagtcgc gcaccgtcac ctcctccttt
      481 ctgatcaggg acatccttgc cgactgcaaa ccactcgcgg cctgtgcacc ctactctagc
      541 agcgggcagc cggcagcccc tgagcctggg ggccgccttg cggccaaggc cgcggaggac
      601 tttagagaca agctggacaa aagtggcagc aacgcctcat cggactctga gtataaagtg
      661 aaggaggagg gcgaccgcga gatctccagc tccagggaca gtcccccggt gcgcctgaaa
      721 aagccacgca aggcgcgcac ggccttcacc gaccatcagc tggcgcagct ggagcgcagc
      781 ttcgagcggc agaagtacct gagcgtgcag gaccgcatgg agctcgccgc ctcgctcaac
      841 ctcaccgaca cgcaggtcaa gacctggtac cagaaccgca ggactaaatg gaagcgacag
      901 acggccgtcg ggttggagct gctggcggag gcaggcaatt actcagcgct ccagcggatg
      961 ttcccgtcgc cttatttcta cccgcagagt ctggtttcca acctggaccc cggcgcggcg
     1021 ctctacctgt accgcggccc cagcgcgccg ccgcctgctc tccagagacc tctggtgccc
     1081 cgcatcctca tccacggact ccagggcgcc agcgagccgc ccccgccgct gccccccctg
     1141 gccggcgtcc tcccacgcgc cgcgcagcct cggtgaggcg cccgtcggct ccggggcctc
     1201 ctcccgcggg ctcggcgtgg ccccttccgc ccgcctttct gagggcgcag gttcgacgcc
     1261 ctttcccggg agggggccct gcccggccct ccctggcgcc ccagcccagt gccccccgaa
     1321 gggccaaatg ccaagtccac tgaggcccgg accccggact gcgtctcccc agcccccctc
     1381 ggcgtcctct ctcgcggccg ctctgtccgg gagccatccc cacccgccgg gtgtacatac
     1441 gcgtctctgc cactccccac ccccagcctc tgccggctcc cctaggcaac ccctttctcc
     1501 ccaggagcgg gtgcggctga ttcccaggct tcgctctctc ccacgcccct tctacgctcc
     1561 aggtggagaa cagcccctct ccccgcgccc ccgccaggga gagaagggga gtgcggagcc
     1621 ccgtctccct acccctcgag cacctgggcc agcggctgag ctgtacatac cgtgtgcaaa
     1681 gtgtatatga agttatttat tcgtgaccca tgagcccgtg accgtgtccg tggattagtg
     1741 agtctgtggc ctgtgccctc cccactccca ggcggggcag gaaggggcca agggggcttg
     1801 cccacccacc ccgaccccag cccccagcct cagccccggt ccgggggcag ccaggcctct
     1861 cgggttctct cttttttaaa tgtcgaaata aacttcttac aaatga
//
