LOCUS       NM_001386991            2398 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens BTG3 associated nuclear protein (BANP), transcript
            variant 31, mRNA.
ACCESSION   NM_001386991 XM_011523179
VERSION     NM_001386991.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2398)
  AUTHORS   Ren,J., Wang,J., Ren,Y., Zhang,Y., Wei,P., Wang,M., Zhang,Y.,
            Li,M., Yuan,C., Gong,H., Jiang,J. and Wang,Z.
  TITLE     Structural basis of DNA recognition by BEN domain proteins reveals
            a role for oligomerization in unmethylated DNA selection by BANP
  JOURNAL   Nucleic Acids Res 52 (18), 11349-11361 (2024)
   PUBMED   39225042
  REMARK    GeneRIF: Structural basis of DNA recognition by BEN domain proteins
            reveals a role for oligomerization in unmethylated DNA selection by
            BANP.
REFERENCE   2  (bases 1 to 2398)
  AUTHORS   Huang,Z., Zhang,R., Teng,Y., Guo,J., Zhang,H., Wang,L., Tang,L.V.,
            Shi,W., Wu,Q. and Xia,L.
  TITLE     Nuclear Matrix-associated Protein SMAR1 Attenuated Acute
            Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 +
            T Cells
  JOURNAL   Transplantation 108 (3), e23-e35 (2024)
   PUBMED   37817309
  REMARK    GeneRIF: Nuclear Matrix-associated Protein SMAR1 Attenuated Acute
            Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 +
            T Cells.
REFERENCE   3  (bases 1 to 2398)
  AUTHORS   Wang,X., Yao,L., Li,Z., Zhang,J., Ruan,M., Mulati,Y., Gan,Y. and
            Zhang,Q.
  TITLE     ZNF471 Interacts with BANP to Reduce Tumour Malignancy by
            Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by
            Aberrant Promoter Methylation in Renal Cell Carcinoma
  JOURNAL   Int J Biol Sci 20 (2), 643-663 (2024)
   PUBMED   38169650
  REMARK    GeneRIF: ZNF471 Interacts with BANP to Reduce Tumour Malignancy by
            Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by
            Aberrant Promoter Methylation in Renal Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2398)
  AUTHORS   Li,X., Zhao,C., Liu,W., Zhu,Q., Mu,L. and Ma,C.
  TITLE     BANP Participates in the Chronic Intermittent Hypoxia-Induced
            Senescence of Vascular Endothelial Cells by Promoting P53
            Phosphorylation and Nuclear Retention
  JOURNAL   Gerontology 70 (3), 302-317 (2024)
   PUBMED   38168028
  REMARK    GeneRIF: BANP Participates in the Chronic Intermittent
            Hypoxia-Induced Senescence of Vascular Endothelial Cells by
            Promoting P53 Phosphorylation and Nuclear Retention.
REFERENCE   5  (bases 1 to 2398)
  AUTHORS   Liu,K., Zhang,J., Xiao,Y., Yang,A., Song,X., Li,Y., Chen,Y.,
            Hughes,T.R. and Min,J.
  TITLE     Structural insights into DNA recognition by the BEN domain of the
            transcription factor BANP
  JOURNAL   J Biol Chem 299 (6), 104734 (2023)
   PUBMED   37086783
  REMARK    GeneRIF: Structural insights into DNA recognition by the BEN domain
            of the transcription factor BANP.
REFERENCE   6  (bases 1 to 2398)
  AUTHORS   Kaul-Ghanekar,R., Majumdar,S., Jalota,A., Gulati,N., Dubey,N.,
            Saha,B. and Chattopadhyay,S.
  TITLE     Abnormal V(D)J recombination of T cell receptor beta locus in SMAR1
            transgenic mice
  JOURNAL   J Biol Chem 280 (10), 9450-9459 (2005)
   PUBMED   15623522
  REMARK    GeneRIF: SMAR1 plays an important role in the regulation of T cell
            development as well as V(D)J recombination
REFERENCE   7  (bases 1 to 2398)
  AUTHORS   Kaul-Ghanekar,R., Jalota,A., Pavithra,L., Tucker,P. and
            Chattopadhyay,S.
  TITLE     SMAR1 and Cux/CDP modulate chromatin and act as negative regulators
            of the TCRbeta enhancer (Ebeta)
  JOURNAL   Nucleic Acids Res 32 (16), 4862-4875 (2004)
   PUBMED   15371550
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2398)
  AUTHORS   Kaul,R., Mukherjee,S., Ahmed,F., Bhat,M.K., Chhipa,R., Galande,S.
            and Chattopadhyay,S.
  TITLE     Direct interaction with and activation of p53 by SMAR1 retards
            cell-cycle progression at G2/M phase and delays tumor growth in
            mice
  JOURNAL   Int J Cancer 103 (5), 606-615 (2003)
   PUBMED   12494467
REFERENCE   9  (bases 1 to 2398)
  AUTHORS   Chattopadhyay,S., Kaul,R., Charest,A., Housman,D. and Chen,J.
  TITLE     SMAR1, a novel, alternatively spliced gene product, binds the
            Scaffold/Matrix-associated region at the T cell receptor beta locus
  JOURNAL   Genomics 68 (1), 93-96 (2000)
   PUBMED   10950932
  REMARK    GeneRIF: Identification of a novel mouse MAR-binding protein, named
            SMAR1, which shares homology with SATB1 and Cux in the MAR-binding
            domain/Cut repeat and also with the tetramerization domain of a B
            cell-specific MAR-binding protein, Bright.
REFERENCE   10 (bases 1 to 2398)
  AUTHORS   Birot,A., Duret,L., Bartholin,L., Santalucia,B., Tigaud,I.,
            Magaud,J. and Rouault,J.
  TITLE     Identification and molecular analysis of BANP
  JOURNAL   Gene 253 (2), 189-196 (2000)
   PUBMED   10940556
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127455.4 and AC134312.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 18, 2020 this sequence version replaced XM_011523179.3.
            
            Summary: This gene encodes a protein that binds to matrix
            attachment regions. The protein forms a complex with p53 and
            negatively regulates p53 transcription, and functions as a tumor
            suppressor and cell cycle regulator. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682872.1/ ENSP00000507916.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC127455.4         142264-142345       c
            83-220              AC127455.4         118594-118731       c
            221-312             AC127455.4         112652-112743       c
            313-512             AC127455.4         109520-109719       c
            513-629             AC134312.3         6355-6471
            630-805             AC134312.3         8150-8325
            806-1045            AC134312.3         20488-20727
            1046-1213           AC134312.3         29543-29710
            1214-1350           AC134312.3         35169-35305
            1351-1422           AC134312.3         37383-37454
            1423-1461           AC134312.3         40033-40071
            1462-1527           AC134312.3         67327-67392
            1528-1671           AC134312.3         74129-74272
            1672-2398           AC134312.3         78650-79376
FEATURES             Location/Qualifiers
     source          1..2398
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..2398
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /note="BTG3 associated nuclear protein"
                     /db_xref="GeneID:54971"
                     /db_xref="HGNC:HGNC:13450"
                     /db_xref="MIM:611564"
     exon            1..82
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..220
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1743
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /note="isoform p is encoded by transcript variant 31;
                     scaffold/matrix-associated region-1-binding protein; BEN
                     domain-containing protein 1"
                     /codon_start=1
                     /product="protein BANP isoform p"
                     /protein_id="NP_001373920.1"
                     /db_xref="CCDS:CCDS92203.1"
                     /db_xref="GeneID:54971"
                     /db_xref="HGNC:HGNC:13450"
                     /db_xref="MIM:611564"
                     /translation="MMSEHDLADVVQIAVEDLSPDHPVVLENHVVTDEDEPALKRQRL
                     EINCQDPSIKSFLYSINQTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQV
                     PMVAGSPLGATQTCNKVRCVVPQTTVILNNDRQNAIVAKMEDPLSNRAPDSLENVISN
                     AVPGRRQNTIVVKVPGQEDSHHEDGESGSEASDSVSSCGQAGSQSIGSNVTLITLNSE
                     EDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVS
                     NLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQ
                     SLAVKSFSRRTPNSSSYCPSEPMMSTPPPASELPQPQPQPQALHYALANAQQVQIHQI
                     GEDGQVQVIPQGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQLLEATRIPCLLAP
                     SVFKASSGQVLQGAQLIAVASSDPAAAGVDGSPLQGSDIQVQYVQLAPVSDHTAGAQT
                     AEALQPTLQPEMQLEHGAIQIQ"
     exon            221..312
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..512
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..629
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..805
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1045
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1213
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1350
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1422
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1461
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1527
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1671
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..2398
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2378..2383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /note="hexamer: AATAAA"
     polyA_site      2398
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /note="major polyA site"
ORIGIN      
        1 agagcggcgg cttctctcgc gaggacggac gccattatcg catctccccg acaaacacca
       61 cgagaattcc gcagcccaca cggtgaccaa aagccagccc cactgtgagt tgaactcttt
      121 cgtgttgacc ggccactctc cgtgctctgg atgatgtcgg aacacgacct ggccgatgtg
      181 gttcagattg cagtggaaga cctgagccct gaccacccag ttgttttgga gaatcatgta
      241 gtgacagatg aagacgaacc tgctttgaaa cgccagcgac tagaaatcaa ttgccaggat
      301 ccatctataa agtcattcct gtattccatc aaccagacaa tctgcttgcg gttggatagc
      361 attgaagcca aattgcaagc cctggaggct acttgtaaat ccttagaaga aaagctggat
      421 ctggtcacga acaagcagca cagccccatc caggtcccca tggtggccgg ctcccctctc
      481 ggggcaaccc agacgtgcaa caaagtgcga tgcgtcgtcc cccagactac agtaatactc
      541 aacaatgatc ggcagaacgc cattgtagcc aagatggaag accccttgag caacagggca
      601 ccggattccc tggaaaatgt cattagcaac gctgtgcctg ggcgtcggca gaacaccatt
      661 gtggtgaagg tgccgggcca agaagacagc caccacgagg acggggagag cggctcggag
      721 gccagcgact ctgtgtccag ctgtgggcag gcgggcagtc agagcatcgg gagcaacgtc
      781 acgctcatca ccctgaactc ggaagaggac taccccaatg gcacctggct gggcgacgag
      841 aacaaccccg agatgcgggt acgctgcgcc atcatcccct ccgacatgct gcacatcagc
      901 accaactgcc gcacggccga gaagatggcg ctcacgctgc tggactacct cttccaccgc
      961 gaggtgcagg ctgtgtccaa cctctcgggg cagggcaagc acgggaagaa gcagctggac
     1021 ccgctcacca tctacggcat ccggtgtcac cttttctata aatttggcat cacagaatcc
     1081 gactggtacc gaatcaagca gagcatcgac tccaagtgcc gcacggcgtg gcggcgcaag
     1141 cagcggggcc agagcctggc ggtcaagagc ttctcgcgga gaacgcccaa ctcgtcctcc
     1201 tactgccctt cagagccgat gatgagcacc ccacctcctg ccagcgagct cccgcagcca
     1261 cagccgcagc cgcaggccct gcactacgcg ctggccaacg cacagcaggt gcagatccac
     1321 cagatcggag aagacggaca ggtgcaagta atcccacagg gacacctcca catcgcccag
     1381 gtgccgcagg gggagcaagt ccagatcacg caggacagcg agggcaacct ccagatccat
     1441 cacgtggggc aggacggtca gcttctagag gccacccgca tcccctgcct cctggcccca
     1501 tccgtcttca aagccagcag tggccaggtg ctgcagggtg cacagctgat cgccgtggcc
     1561 tcctcggacc ccgcggcggc gggcgtggat gggtcgccac tccagggcag cgacatccag
     1621 gttcagtacg tgcagctggc gccagtgagt gaccacacgg ccggggcaca gacggccgaa
     1681 gccctgcagc ccacgctaca gccggagatg cagctcgagc acggggccat ccagattcag
     1741 tgagcggtgc ccatggcacc aggagcccct cgccggctcc gcctacggcc cggcccccac
     1801 gcgccctgct ctcacggcct cggcacaggc agcggctgca cgtgttctgc tgaagtgcgt
     1861 ctgaaggccg ctgcctccgc ggggaacagc atcctatcaa ctgaaagagc agccgccgcc
     1921 gcccccagcc ggagacccct ttcgtttgag tcctgctgtt ggtgtcggag cacgagggga
     1981 ggcacggtgc ggagagcgtc gcatatgcgc gggaaatcaa gaactatgat atttttctgt
     2041 ttaaacagct ttttttaatt tgctatggtg tttataacaa aaaagaaaat ttgaaaaaaa
     2101 aaatcccagg ggagtagcag gagccctttg ctgtgtgctc tgtccagtgt catgagacgg
     2161 gagccctttg ctgtgtgctc tgtccagtgt catgagacgg gagccctttg ctgtgtgctc
     2221 tgtccagtgt catgagacgg gagccctttg ctgtgtgctc tgtccagtgt catgaggcag
     2281 gtgtttgcaa agccagctct cggttccgat ggggtattgc tgacctactt ttctagggga
     2341 aatgctctta aacactgtaa ttatgcattt ctaatgaaat aaaatgtatt tatgacca
//
