LOCUS       NM_001384922            2591 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens BTG3 associated nuclear protein (BANP), transcript
            variant 13, mRNA.
ACCESSION   NM_001384922
VERSION     NM_001384922.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2591)
  AUTHORS   Ren,J., Wang,J., Ren,Y., Zhang,Y., Wei,P., Wang,M., Zhang,Y.,
            Li,M., Yuan,C., Gong,H., Jiang,J. and Wang,Z.
  TITLE     Structural basis of DNA recognition by BEN domain proteins reveals
            a role for oligomerization in unmethylated DNA selection by BANP
  JOURNAL   Nucleic Acids Res 52 (18), 11349-11361 (2024)
   PUBMED   39225042
  REMARK    GeneRIF: Structural basis of DNA recognition by BEN domain proteins
            reveals a role for oligomerization in unmethylated DNA selection by
            BANP.
REFERENCE   2  (bases 1 to 2591)
  AUTHORS   Huang,Z., Zhang,R., Teng,Y., Guo,J., Zhang,H., Wang,L., Tang,L.V.,
            Shi,W., Wu,Q. and Xia,L.
  TITLE     Nuclear Matrix-associated Protein SMAR1 Attenuated Acute
            Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 +
            T Cells
  JOURNAL   Transplantation 108 (3), e23-e35 (2024)
   PUBMED   37817309
  REMARK    GeneRIF: Nuclear Matrix-associated Protein SMAR1 Attenuated Acute
            Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 +
            T Cells.
REFERENCE   3  (bases 1 to 2591)
  AUTHORS   Wang,X., Yao,L., Li,Z., Zhang,J., Ruan,M., Mulati,Y., Gan,Y. and
            Zhang,Q.
  TITLE     ZNF471 Interacts with BANP to Reduce Tumour Malignancy by
            Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by
            Aberrant Promoter Methylation in Renal Cell Carcinoma
  JOURNAL   Int J Biol Sci 20 (2), 643-663 (2024)
   PUBMED   38169650
  REMARK    GeneRIF: ZNF471 Interacts with BANP to Reduce Tumour Malignancy by
            Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by
            Aberrant Promoter Methylation in Renal Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2591)
  AUTHORS   Li,X., Zhao,C., Liu,W., Zhu,Q., Mu,L. and Ma,C.
  TITLE     BANP Participates in the Chronic Intermittent Hypoxia-Induced
            Senescence of Vascular Endothelial Cells by Promoting P53
            Phosphorylation and Nuclear Retention
  JOURNAL   Gerontology 70 (3), 302-317 (2024)
   PUBMED   38168028
  REMARK    GeneRIF: BANP Participates in the Chronic Intermittent
            Hypoxia-Induced Senescence of Vascular Endothelial Cells by
            Promoting P53 Phosphorylation and Nuclear Retention.
REFERENCE   5  (bases 1 to 2591)
  AUTHORS   Liu,K., Zhang,J., Xiao,Y., Yang,A., Song,X., Li,Y., Chen,Y.,
            Hughes,T.R. and Min,J.
  TITLE     Structural insights into DNA recognition by the BEN domain of the
            transcription factor BANP
  JOURNAL   J Biol Chem 299 (6), 104734 (2023)
   PUBMED   37086783
  REMARK    GeneRIF: Structural insights into DNA recognition by the BEN domain
            of the transcription factor BANP.
REFERENCE   6  (bases 1 to 2591)
  AUTHORS   Kaul-Ghanekar,R., Majumdar,S., Jalota,A., Gulati,N., Dubey,N.,
            Saha,B. and Chattopadhyay,S.
  TITLE     Abnormal V(D)J recombination of T cell receptor beta locus in SMAR1
            transgenic mice
  JOURNAL   J Biol Chem 280 (10), 9450-9459 (2005)
   PUBMED   15623522
  REMARK    GeneRIF: SMAR1 plays an important role in the regulation of T cell
            development as well as V(D)J recombination
REFERENCE   7  (bases 1 to 2591)
  AUTHORS   Kaul-Ghanekar,R., Jalota,A., Pavithra,L., Tucker,P. and
            Chattopadhyay,S.
  TITLE     SMAR1 and Cux/CDP modulate chromatin and act as negative regulators
            of the TCRbeta enhancer (Ebeta)
  JOURNAL   Nucleic Acids Res 32 (16), 4862-4875 (2004)
   PUBMED   15371550
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2591)
  AUTHORS   Kaul,R., Mukherjee,S., Ahmed,F., Bhat,M.K., Chhipa,R., Galande,S.
            and Chattopadhyay,S.
  TITLE     Direct interaction with and activation of p53 by SMAR1 retards
            cell-cycle progression at G2/M phase and delays tumor growth in
            mice
  JOURNAL   Int J Cancer 103 (5), 606-615 (2003)
   PUBMED   12494467
REFERENCE   9  (bases 1 to 2591)
  AUTHORS   Chattopadhyay,S., Kaul,R., Charest,A., Housman,D. and Chen,J.
  TITLE     SMAR1, a novel, alternatively spliced gene product, binds the
            Scaffold/Matrix-associated region at the T cell receptor beta locus
  JOURNAL   Genomics 68 (1), 93-96 (2000)
   PUBMED   10950932
  REMARK    GeneRIF: Identification of a novel mouse MAR-binding protein, named
            SMAR1, which shares homology with SATB1 and Cux in the MAR-binding
            domain/Cut repeat and also with the tetramerization domain of a B
            cell-specific MAR-binding protein, Bright.
REFERENCE   10 (bases 1 to 2591)
  AUTHORS   Birot,A., Duret,L., Bartholin,L., Santalucia,B., Tigaud,I.,
            Magaud,J. and Rouault,J.
  TITLE     Identification and molecular analysis of BANP
  JOURNAL   Gene 253 (2), 189-196 (2000)
   PUBMED   10940556
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127455.4 and AC134312.3.
            
            Summary: This gene encodes a protein that binds to matrix
            attachment regions. The protein forms a complex with p53 and
            negatively regulates p53 transcription, and functions as a tumor
            suppressor and cell cycle regulator. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (13), as well as variants 5, 12,
            and 14, encodes isoform e.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1974397.1,
                                           SRR14038194.1939722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AC127455.4         142852-143318       c
            468-605             AC127455.4         118594-118731       c
            606-697             AC127455.4         112652-112743       c
            698-897             AC127455.4         109520-109719       c
            898-1073            AC134312.3         8150-8325
            1074-1313           AC134312.3         20488-20727
            1314-1481           AC134312.3         29543-29710
            1482-1618           AC134312.3         35169-35305
            1619-1681           AC134312.3         37392-37454
            1682-1720           AC134312.3         40033-40071
            1721-1864           AC134312.3         74129-74272
            1865-2591           AC134312.3         78650-79376
FEATURES             Location/Qualifiers
     source          1..2591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..2591
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /note="BTG3 associated nuclear protein"
                     /db_xref="GeneID:54971"
                     /db_xref="HGNC:HGNC:13450"
                     /db_xref="MIM:611564"
     exon            1..467
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..605
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             536..1936
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /note="isoform e is encoded by transcript variant 13;
                     scaffold/matrix-associated region-1-binding protein; BEN
                     domain-containing protein 1"
                     /codon_start=1
                     /product="protein BANP isoform e"
                     /protein_id="NP_001371851.1"
                     /db_xref="CCDS:CCDS54053.1"
                     /db_xref="GeneID:54971"
                     /db_xref="HGNC:HGNC:13450"
                     /db_xref="MIM:611564"
                     /translation="MMSEHDLADVVQIAVEDLSPDHPVVLENHVVTDEDEPALKRQRL
                     EINCQDPSIKSFLYSINQTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQV
                     PMVAGSPLGATQTCNKVRCAVPGRRQNTIVVKVPGQEDSHHEDGESGSEASDSVSSCG
                     QAGSQSIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAE
                     KMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRI
                     KQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPNSSSYCPSEPMMSTPPPASELPQPQPQ
                     PQALHYALANAQQVQIHQIGEDGQVQVGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQ
                     DGQVLQGAQLIAVASSDPAAAGVDGSPLQGSDIQVQYVQLAPVSDHTAGAQTAEALQP
                     TLQPEMQLEHGAIQIQ"
     exon            606..697
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..897
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1073
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1313
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1481
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1618
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1681
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1720
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1864
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2591
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2571..2576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /note="hexamer: AATAAA"
     polyA_site      2591
                     /gene="BANP"
                     /gene_synonym="BEND1; SMAR1; SMARBP1"
                     /note="major polyA site"
ORIGIN      
        1 agtctcgctc tgtcgccagg ctggagtgca gtggcgcgat ctcggctcac tgcaacctct
       61 gactcgcggg ctcaagcgat tctcctgcct cagcctcccg agtagttggg attacaaggc
      121 gcccgccacc acgcccggca taattttgta tttttagtag agacagggtt tcgccatgtt
      181 ggccaggctg gtcgcgaacc ctttacctca ggtgttccgc ccgccttggc ctcccacagg
      241 gctgagatta caggcgtgat ccaccgtgcc cggccgccat cacttattta tattatgtgt
      301 tacctatagg acttatctaa gaccataatc actgccgcgt gtgctaagtc ccgcgcgcgt
      361 gcactcaggc ccctctggat agacactggg gacccctgac cacttatgtc agggaaaacg
      421 ccaccaagcg ctccggaacc tcagggcagg acccgccgca gcagcaggtg accaaaagcc
      481 agccccactg tgagttgaac tctttcgtgt tgaccggcca ctctccgtgc tctggatgat
      541 gtcggaacac gacctggccg atgtggttca gattgcagtg gaagacctga gccctgacca
      601 cccagttgtt ttggagaatc atgtagtgac agatgaagac gaacctgctt tgaaacgcca
      661 gcgactagaa atcaattgcc aggatccatc tataaagtca ttcctgtatt ccatcaacca
      721 gacaatctgc ttgcggttgg atagcattga agccaaattg caagccctgg aggctacttg
      781 taaatcctta gaagaaaagc tggatctggt cacgaacaag cagcacagcc ccatccaggt
      841 ccccatggtg gccggctccc ctctcggggc aacccagacg tgcaacaaag tgcgatgcgc
      901 tgtgcctggg cgtcggcaga acaccattgt ggtgaaggtg ccgggccaag aagacagcca
      961 ccacgaggac ggggagagcg gctcggaggc cagcgactct gtgtccagct gtgggcaggc
     1021 gggcagtcag agcatcggga gcaacgtcac gctcatcacc ctgaactcgg aagaggacta
     1081 ccccaatggc acctggctgg gcgacgagaa caaccccgag atgcgggtac gctgcgccat
     1141 catcccctcc gacatgctgc acatcagcac caactgccgc acggccgaga agatggcgct
     1201 cacgctgctg gactacctct tccaccgcga ggtgcaggct gtgtccaacc tctcggggca
     1261 gggcaagcac gggaagaagc agctggaccc gctcaccatc tacggcatcc ggtgtcacct
     1321 tttctataaa tttggcatca cagaatccga ctggtaccga atcaagcaga gcatcgactc
     1381 caagtgccgc acggcgtggc ggcgcaagca gcggggccag agcctggcgg tcaagagctt
     1441 ctcgcggaga acgcccaact cgtcctccta ctgcccttca gagccgatga tgagcacccc
     1501 acctcctgcc agcgagctcc cgcagccaca gccgcagccg caggccctgc actacgcgct
     1561 ggccaacgca cagcaggtgc agatccacca gatcggagaa gacggacagg tgcaagtagg
     1621 acacctccac atcgcccagg tgccgcaggg ggagcaagtc cagatcacgc aggacagcga
     1681 gggcaacctc cagatccatc acgtggggca ggacggtcag gtgctgcagg gtgcacagct
     1741 gatcgccgtg gcctcctcgg accccgcggc ggcgggcgtg gatgggtcgc cactccaggg
     1801 cagcgacatc caggttcagt acgtgcagct ggcgccagtg agtgaccaca cggccggggc
     1861 acagacggcc gaagccctgc agcccacgct acagccggag atgcagctcg agcacggggc
     1921 catccagatt cagtgagcgg tgcccatggc accaggagcc cctcgccggc tccgcctacg
     1981 gcccggcccc cacgcgccct gctctcacgg cctcggcaca ggcagcggct gcacgtgttc
     2041 tgctgaagtg cgtctgaagg ccgctgcctc cgcggggaac agcatcctat caactgaaag
     2101 agcagccgcc gccgccccca gccggagacc cctttcgttt gagtcctgct gttggtgtcg
     2161 gagcacgagg ggaggcacgg tgcggagagc gtcgcatatg cgcgggaaat caagaactat
     2221 gatatttttc tgtttaaaca gcttttttta atttgctatg gtgtttataa caaaaaagaa
     2281 aatttgaaaa aaaaaatccc aggggagtag caggagccct ttgctgtgtg ctctgtccag
     2341 tgtcatgaga cgggagccct ttgctgtgtg ctctgtccag tgtcatgaga cgggagccct
     2401 ttgctgtgtg ctctgtccag tgtcatgaga cgggagccct ttgctgtgtg ctctgtccag
     2461 tgtcatgagg caggtgtttg caaagccagc tctcggttcc gatggggtat tgctgaccta
     2521 cttttctagg ggaaatgctc ttaaacactg taattatgca tttctaatga aataaaatgt
     2581 atttatgacc a
//
