LOCUS       NM_017935               3322 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens B cell scaffold protein with ankyrin repeats 1
            (BANK1), transcript variant 1, mRNA.
ACCESSION   NM_017935
VERSION     NM_017935.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3322)
  AUTHORS   Shu,Y., Ma,X., Chen,C., Wang,Y., Sun,X., Zhang,L., Lu,Z.,
            Petersen,F., Qiu,W. and Yu,X.
  TITLE     Myelin oligodendrocyte glycoprotein-associated disease is
            associated with BANK1, RNASET2 and TNIP1 polymorphisms
  JOURNAL   J Neuroimmunol 372, 577937 (2022)
   PUBMED   36054934
  REMARK    GeneRIF: Myelin oligodendrocyte glycoprotein-associated disease is
            associated with BANK1, RNASET2 and TNIP1 polymorphisms.
REFERENCE   2  (bases 1 to 3322)
  AUTHORS   Zhang,P., Zhai,J., Wang,K. and Wu,Y.
  TITLE     IKBKE and BANK1 Polymorphisms and Clinical Characteristics in
            Chinese Women with Systemic Lupus Erythematosus
  JOURNAL   Immunol Invest 51 (7), 2097-2107 (2022)
   PUBMED   35930382
  REMARK    GeneRIF: IKBKE and BANK1 Polymorphisms and Clinical Characteristics
            in Chinese Women with Systemic Lupus Erythematosus.
REFERENCE   3  (bases 1 to 3322)
  AUTHORS   Bolin,K., Imgenberg-Kreuz,J., Leonard,D., Sandling,J.K.,
            Alexsson,A., Pucholt,P., Haarhaus,M.L., Almlof,J.C., Nititham,J.,
            Jonsen,A., Sjowall,C., Bengtsson,A.A., Rantapaa-Dahlqvist,S.,
            Svenungsson,E., Gunnarsson,I., Syvanen,A.C., Lerang,K.,
            Troldborg,A., Voss,A., Molberg,O., Jacobsen,S., Criswell,L.,
            Ronnblom,L. and Nordmark,G.
  TITLE     Variants in BANK1 are associated with lupus nephritis of European
            ancestry
  JOURNAL   Genes Immun 22 (3), 194-202 (2021)
   PUBMED   34127828
  REMARK    GeneRIF: Variants in BANK1 are associated with lupus nephritis of
            European ancestry.
REFERENCE   4  (bases 1 to 3322)
  AUTHORS   Gomez Hernandez,G., Morell,M. and Alarcon-Riquelme,M.E.
  TITLE     The Role of BANK1 in B Cell Signaling and Disease
  JOURNAL   Cells 10 (5), 1184 (2021)
   PUBMED   34066164
  REMARK    GeneRIF: The Role of BANK1 in B Cell Signaling and Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3322)
  AUTHORS   Le Berre,L., Chesneau,M., Danger,R., Dubois,F., Chaussabel,D.,
            Garand,M. and Brouard,S.
  TITLE     Connection of BANK1, Tolerance, Regulatory B cells, and Apoptosis:
            Perspectives of a Reductionist Investigation
  JOURNAL   Front Immunol 12, 589786 (2021)
   PUBMED   33815360
  REMARK    GeneRIF: Connection of BANK1, Tolerance, Regulatory B cells, and
            Apoptosis: Perspectives of a Reductionist Investigation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3322)
  AUTHORS   Fung,E.Y., Smyth,D.J., Howson,J.M., Cooper,J.D., Walker,N.M.,
            Stevens,H., Wicker,L.S. and Todd,J.A.
  TITLE     Analysis of 17 autoimmune disease-associated variants in type 1
            diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
  JOURNAL   Genes Immun 10 (2), 188-191 (2009)
   PUBMED   19110536
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3322)
  AUTHORS   Orozco,G., Abelson,A.K., Gonzalez-Gay,M.A., Balsa,A.,
            Pascual-Salcedo,D., Garcia,A., Fernandez-Gutierrez,B.,
            Petersson,I., Pons-Estel,B., Eimon,A., Paira,S., Scherbarth,H.R.,
            Alarcon-Riquelme,M. and Martin,J.
  TITLE     Study of functional variants of the BANK1 gene in rheumatoid
            arthritis
  JOURNAL   Arthritis Rheum 60 (2), 372-379 (2009)
   PUBMED   19180476
  REMARK    GeneRIF: These results suggest that BANK1 SNPs and haplotypes may
            contribute to rheumatoid arthritis susceptibility with a low risk.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3322)
  AUTHORS   Kozyrev,S.V., Abelson,A.K., Wojcik,J., Zaghlool,A., Linga
            Reddy,M.V., Sanchez,E., Gunnarsson,I., Svenungsson,E., Sturfelt,G.,
            Jonsen,A., Truedsson,L., Pons-Estel,B.A., Witte,T., D'Alfonso,S.,
            Barizzone,N., Danieli,M.G., Gutierrez,C., Suarez,A., Junker,P.,
            Laustrup,H., Gonzalez-Escribano,M.F., Martin,J., Abderrahim,H. and
            Alarcon-Riquelme,M.E.
  TITLE     Functional variants in the B-cell gene BANK1 are associated with
            systemic lupus erythematosus
  JOURNAL   Nat Genet 40 (2), 211-216 (2008)
   PUBMED   18204447
  REMARK    GeneRIF: Functional variants in the B-cell gene BANK1 are
            assoicated with systemic lupus erythematosus.
            GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
            Erratum:[Nat Genet. 2008 Apr;40(4):484. Barrizzone, Nadia
            [corrected to Barizzone, Nadia]]
REFERENCE   9  (bases 1 to 3322)
  AUTHORS   Yokoyama,K., Su Ih,I.H., Tezuka,T., Yasuda,T., Mikoshiba,K.,
            Tarakhovsky,A. and Yamamoto,T.
  TITLE     BANK regulates BCR-induced calcium mobilization by promoting
            tyrosine phosphorylation of IP(3) receptor
  JOURNAL   EMBO J 21 (1-2), 83-92 (2002)
   PUBMED   11782428
REFERENCE   10 (bases 1 to 3322)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109928.4, AP002075.3 and
            AC095062.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017935.4.
            
            Summary: The protein encoded by this gene is a B-cell-specific
            scaffold protein that functions in B-cell receptor-induced calcium
            mobilization from intracellular stores. This protein can also
            promote Lyn-mediated tyrosine phosphorylation of inositol
            1,4,5-trisphosphate receptors. Polymorphisms in this gene are
            associated with susceptibility to systemic lupus erythematosus.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032241.1, SRR1660805.240231.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322953.9/ ENSP00000320509.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AC109928.4         3513-3733
            222-620             AC109928.4         42591-42989
            621-775             AC109928.4         67818-67972
            776-914             AC109928.4         75309-75447
            915-1054            AC109928.4         83288-83427
            1055-1160           AC109928.4         108088-108193
            1161-1357           AP002075.3         98365-98561         c
            1358-1436           AC095062.3         6955-7033
            1437-1745           AC095062.3         10642-10950
            1746-2051           AC095062.3         15401-15706
            2052-2120           AC095062.3         29280-29348
            2121-2299           AC095062.3         45652-45830
            2300-2363           AC095062.3         48516-48579
            2364-2393           AC095062.3         56716-56745
            2394-2449           AC095062.3         57786-57841
            2450-2514           AC095062.3         59125-59189
            2515-3322           AC095062.3         59446-60253
FEATURES             Location/Qualifiers
     source          1..3322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..3322
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /note="B cell scaffold protein with ankyrin repeats 1"
                     /db_xref="GeneID:55024"
                     /db_xref="HGNC:HGNC:18233"
                     /db_xref="MIM:610292"
     exon            1..221
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2509
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /note="isoform 1 is encoded by transcript variant 1;
                     B-cell scaffold protein with ankyrin repeats"
                     /codon_start=1
                     /product="B-cell scaffold protein with ankyrin repeats
                     isoform 1"
                     /protein_id="NP_060405.5"
                     /db_xref="CCDS:CCDS34038.1"
                     /db_xref="GeneID:55024"
                     /db_xref="HGNC:HGNC:18233"
                     /db_xref="MIM:610292"
                     /translation="MLPAAPGKGLGSPDPAPCGPAPPGNTKDIIMIYEEDAEEWALYL
                     TEVFLHVVKREAILLYRLENFSFRHLELLNLTSYKCKLLILSNSLLRDLTPKKCQFLE
                     KILHSPKSVVTLLCGVKSSDQLYELLNISQSRWEISTEQEPEDYISVIQSIIFKDSED
                     YFEVNIPTDLRAKHSGEISERKEIEELSEASRNTIPLAVVLPTEIPCENPGEIFIILR
                     DEVIGDTVEVEFTSSNKRIRTRPALWNKKVWCMKALEFPAGSVHVNVYCDGIVKATTK
                     IKYYPTAKAKECLFRMADSGESLCQNSIEELDGVLTSIFKHEIPYYEFQSLQTEICSQ
                     NKYTHFKELPTLLHCAAKFGLKNLAIHLLQCSGATWASKMKNMEGSDPAHIAERHGHK
                     ELKKIFEDFSIQEIDINNEQENDYEEDIASFSTYIPSTQNPAFHHESRKTYGQSADGA
                     EANEMEGEGKQNGSGMETKHSPLEVGSESSEDQYDDLYVFIPGADPENNSQEPLMSSR
                     PPLPPPRPVANAFQLERPHFTLPGTMVEGQMERSQNWGHPGVRQETGDEPKGEKEKKE
                     EEKEQEEEEDPYTFAEIDDSEYDMILANLSIKKKTGSRSFIINRPPAPTPRPTSIPPK
                     EETTPYIAQVFQQKTARRQSDDDKFCGLPKKQDRARIESPAFSTLRGCLTDGQEELIL
                     LQEKVKNGKMSMDEALEKFKHWQMGKSGLEMIQQEKLRQLRDCIIGKRPEEENVYNKL
                     TIVHHPGGKETAHNENKFYNVHFSNKLPARPQVEKEFGFCCKKDH"
     exon            222..620
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            621..775
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            776..914
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1054
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1160
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1357
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1436
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1745
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..2051
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2120
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2299
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2363
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2393
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2449
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2514
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..3322
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3227..3232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /note="hexamer: AATAAA"
     polyA_site      3249
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /note="major polyA site"
     regulatory      3287..3292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BANK1"
                     /gene_synonym="BANK"
                     /note="hexamer: AATAAA"
     polyA_site      3322
                     /gene="BANK1"
                     /gene_synonym="BANK"
ORIGIN      
        1 gagacctggc cgcagcctcc gcgggtggca agcgggctgg ggagagccga gggccaaagg
       61 aagagaaaat cgcggggagt ctctggccgg gagagtccag gtagcgctcg gcgggcagca
      121 gtgcgcaggc ccctcggctt caaccgccac aatgctgcca gcagcgccag gcaaggggct
      181 tgggagcccg gaccccgccc cctgcggccc agcgccccca ggaaatacaa aagatataat
      241 aatgatatat gaagaagatg ctgaggaatg ggctctgtac ttgacagaag tatttttaca
      301 tgttgtgaaa agggaagcca tcctgttata tcgcttggag aatttctctt ttcggcattt
      361 ggagttgctg aacttaacgt cttacaaatg taaacttttg atattatcaa atagcctgct
      421 tagagaccta actccaaaga aatgtcagtt tctggaaaag atacttcatt caccaaaaag
      481 tgtagttact ttgctttgtg gagtgaagag ttcagatcag ctctatgaat tactaaatat
      541 ctctcaaagc agatgggaga tctcaactga acaggaacct gaagactaca tctctgtaat
      601 ccagagtatc atattcaaag attctgaaga ctactttgag gtcaacattc caacagacct
      661 acgagcaaaa cattctgggg aaataagtga gagaaaggaa attgaagaac tatcagaagc
      721 ttcaagaaac accataccac tagcagtggt gcttcccact gaaattccat gtgagaatcc
      781 tggtgaaata ttcataattt tgagagatga agtaattggt gatactgtag aggttgaatt
      841 tacatcaagt aataagcgca ttagaacacg gccagccctt tggaataaga aagtctggtg
      901 catgaaagct ttagagtttc ctgctggttc agtccatgtc aatgtctact gtgatggaat
      961 cgttaaagct acaaccaaaa ttaagtacta cccaacagca aaggcaaagg aatgcctatt
     1021 cagaatggca gattcaggag agagtttgtg ccagaatagc attgaagaac ttgatggtgt
     1081 ccttacatcc atattcaaac atgagatacc atattatgag ttccagtctc ttcaaactga
     1141 aatttgttct caaaacaaat atactcattt caaagaactt ccaactcttc tccactgtgc
     1201 agcaaaattt ggcttaaaga acctggctat tcatttgctt caatgttcag gagcaacctg
     1261 ggcatctaag atgaaaaata tggagggttc agaccccgca catattgctg aaaggcatgg
     1321 tcacaaagaa ctcaagaaaa tcttcgaaga cttttcaatc caagaaattg acataaataa
     1381 tgagcaagaa aatgattatg aagaggatat tgcctcattt tccacatata ttccttccac
     1441 acagaaccca gcatttcatc atgaaagcag gaagacatac gggcagagtg cagatggagc
     1501 tgaggcaaat gaaatggaag gggaaggaaa acagaatgga tcaggcatgg agaccaaaca
     1561 cagcccacta gaggttggca gtgagagttc tgaagaccag tatgatgact tgtatgtgtt
     1621 cattcctggt gctgatccag aaaataattc acaagagcca ctcatgagca gcagacctcc
     1681 tctccccccg ccgcgacctg tagctaatgc cttccaactg gaaagacctc acttcacctt
     1741 accagggaca atggtggaag gccaaatgga aagaagtcaa aactggggtc atcctggtgt
     1801 tagacaagaa acaggagatg aacccaaagg agaaaaagag aagaaagaag aggaaaaaga
     1861 gcaggaggag gaagaagacc catatacttt tgctgagatt gatgacagtg aatatgacat
     1921 gatattggcc aatctgagta taaagaaaaa aactgggagt cggtctttca ttataaatag
     1981 acctcctgcc cccacacccc gacccacaag tatacctcca aaagaggaaa ctacacctta
     2041 catagctcaa gtgtttcaac aaaagacagc cagaagacaa tctgatgatg acaagttctg
     2101 tggtcttcct aagaaacaag acagagctcg gatagagagt ccagcctttt ctactctcag
     2161 gggctgtcta actgatggtc aggaagaact catcctcctg caggagaaag taaagaatgg
     2221 gaaaatgtct atggatgaag ctctggagaa atttaaacac tggcagatgg gaaaaagtgg
     2281 cctggaaatg attcagcagg agaaattacg acaactacga gactgcatta ttgggaaaag
     2341 gccagaagaa gaaaatgtct ataataaact caccattgtg caccatccag gtggtaagga
     2401 aactgcccac aatgaaaata agttttataa tgtacacttc agcaataagc ttcctgctcg
     2461 accccaagtt gaaaaggaat ttggtttctg ttgcaagaaa gatcattaaa gaaggttatt
     2521 ataatgaaac tcacgaatct acggacattt tgctttcagg gtgaagcaag cttgaatttg
     2581 gattgcctgc tctctttaaa gcgaattcat actatgacag cagaaacaaa acttcagatt
     2641 tcagaatttg ttattggcaa aatttattct cattatacct gcttcatatg ggtatattac
     2701 tattaaaaca gaataccata gagtaattgc attatttgaa aattctctca ttttacaatg
     2761 cacttcacca atgaaacagc taatttccat tttgaaaatt aaaagaaaac agcacagaga
     2821 agttaaatgc ggtgtagcaa agttatgggg tctgcttgag ggcactaacc tcaacagatt
     2881 attcctcctc tccttagaat aaccatgaaa atacaaattt acttagcaca tttttgcttt
     2941 ttaagtagct ggttcatttt ctgaatttct cacattcaga gttccagtca ttattgttac
     3001 atcatgtttg cagaaacctt gtcttattta gtgtctattt gcatataacc ctgaaaacat
     3061 tattatttga aaacttttct atatctcaaa ttaatataca ttttcataac ctacctttgt
     3121 attaagactt gcaattttat caatctatta tttcttagaa acaatttact agcttagaat
     3181 agaaagcaat gttatcgtca tataattttc atgtacaaat gccacaaata aattgaatgt
     3241 ttaaagctat gtctgagttt ttaaagtaaa tttataagaa ttagccaata aaattgcttc
     3301 tcggcctttt ggctaagatc aa
//
