LOCUS       NM_178477                589 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens BANF family member 2 (BANF2), transcript variant 1,
            mRNA.
ACCESSION   NM_178477
VERSION     NM_178477.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 589)
  AUTHORS   Huang,C., Gong,H., Mu,B., Lan,X., Yang,C., Tan,J., Liu,W., Zou,Y.,
            Li,L., Feng,B., He,X., Luo,Q. and Chen,Z.
  TITLE     BAF-L Modulates Histone-to-Protamine Transition during
            Spermiogenesis
  JOURNAL   Int J Mol Sci 23 (4), 1985 (2022)
   PUBMED   35216101
  REMARK    GeneRIF: BAF-L Modulates Histone-to-Protamine Transition during
            Spermiogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 589)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 589)
  AUTHORS   Elkhatib,R.A., Paci,M., Boissier,R., Longepied,G., Auguste,Y.,
            Achard,V., Bourgeois,P., Levy,N., Branger,N., Mitchell,M.J. and
            Metzler-Guillemain,C.
  TITLE     LEM-domain proteins are lost during human spermiogenesis but BAF
            and BAF-L persist
  JOURNAL   Reproduction 154 (4), 387-401 (2017)
   PUBMED   28684548
  REMARK    GeneRIF: BAF and BAF-L might contribute to the shaping of the
            spermatozoon nucleus and, after fertilisation, its transition to
            the male pronucleus.
REFERENCE   4  (bases 1 to 589)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 589)
  AUTHORS   Tifft,K.E., Segura-Totten,M., Lee,K.K. and Wilson,K.L.
  TITLE     Barrier-to-autointegration factor-like (BAF-L): a proposed
            regulator of BAF
  JOURNAL   Exp Cell Res 312 (4), 478-487 (2006)
   PUBMED   16337940
REFERENCE   6  (bases 1 to 589)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054871.1, AA394107.1, BC062735.1 and AW022487.1.
            
            On May 21, 2020 this sequence version replaced NM_178477.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript but encodes the shorter isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI075928.1, BC062735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246090.6/ ENSP00000246090.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BC054871.1         23-83
            62-73               AA394107.1         44-55
            74-262              BC062735.1         83-271
            263-578             AW022487.1         50-365
            579-589             AA394107.1         396-406
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.1"
     gene            1..589
                     /gene="BANF2"
                     /gene_synonym="BAF-L; BAF2; BAFL; C20orf179"
                     /note="BANF family member 2"
                     /db_xref="GeneID:140836"
                     /db_xref="HGNC:HGNC:16172"
     exon            1..90
                     /gene="BANF2"
                     /gene_synonym="BAF-L; BAF2; BAFL; C20orf179"
                     /inference="alignment:Splign:2.1.0"
     exon            91..253
                     /gene="BANF2"
                     /gene_synonym="BAF-L; BAF2; BAFL; C20orf179"
                     /inference="alignment:Splign:2.1.0"
     exon            254..382
                     /gene="BANF2"
                     /gene_synonym="BAF-L; BAF2; BAFL; C20orf179"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..529
                     /gene="BANF2"
                     /gene_synonym="BAF-L; BAF2; BAFL; C20orf179"
                     /note="isoform 1 is encoded by transcript variant 1;
                     barrier-to-autointegration factor-like protein; testis
                     secretory sperm-binding protein Li 212a; barrier to
                     autointegration factor 2"
                     /codon_start=1
                     /product="barrier-to-autointegration factor-like protein
                     isoform 1"
                     /protein_id="NP_848572.3"
                     /db_xref="CCDS:CCDS13129.1"
                     /db_xref="GeneID:140836"
                     /db_xref="HGNC:HGNC:16172"
                     /translation="MDNMSPRLRAFLSEPIGEKDVCWVDGISHELAINLVTKGINKAY
                     ILLGQFLLMHKNEAEFQRWLICCFGATECEAQQTSHCLKEWCACFL"
     exon            383..589
                     /gene="BANF2"
                     /gene_synonym="BAF-L; BAF2; BAFL; C20orf179"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      589
                     /gene="BANF2"
                     /gene_synonym="BAF-L; BAF2; BAFL; C20orf179"
                     /note="major polyA site"
ORIGIN      
        1 aagacataag ctgaacctct ggcctgcagt tccagatcca aggtgactga gacaaactgc
       61 cagctgccac tggcttatca ggagcacctg aatctgctga cacatcaagg ccacttttct
      121 taggagcccc ctgacttcca aaatcagtgc ctttggattc atctcttccg ggagagttca
      181 gtgtcttctg aaatgttaca aaacgtcctt cagagcaaga aggcgtacac gaggagctcg
      241 actctgtaga aaggagatgg acaacatgtc tcccaggctg agagccttcc tctccgaacc
      301 cattggagaa aaggatgtct gctgggtgga tggcatcagc catgagctcg cgatcaattt
      361 ggtcaccaaa ggtatcaata aggcctacat cctgctggga caattccttc tgatgcacaa
      421 gaatgaagcc gagtttcaga ggtggctcat ttgctgtttt ggtgccactg agtgtgaggc
      481 ccagcagact tctcactgcc tcaaggagtg gtgtgcctgc ttcctgtaga cacaaacctc
      541 attgctgccc cccaccaccc tctggggaaa atgacgcctt ctccaccta
//
