LOCUS       NM_003860                731 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  Homo sapiens barrier to autointegration nuclear assembly factor 1
            (BANF1), transcript variant 1, mRNA.
ACCESSION   NM_003860
VERSION     NM_003860.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 731)
  AUTHORS   Harb,O.A., Elfeky,M.A., Alabiad,M.A., Hemeda,R., Allam,A.S., El
            Hawary,A.T., Elbaz,M., Sharaf,A.L., Gertallah,L.M., Abdelaziz,A.M.,
            Shalaby,A.M., Alorini,M., Yahia,A.I.O. and Negm,M.
  TITLE     PYCR1, BANF1, and STARD8 Expression in Gastric Carcinoma: A
            Clinicopathologic, Prognostic, and Immunohistochemical Study
  JOURNAL   Appl Immunohistochem Mol Morphol 32 (2), 102-110 (2024)
   PUBMED   37982568
  REMARK    GeneRIF: PYCR1, BANF1, and STARD8 Expression in Gastric Carcinoma:
            A Clinicopathologic, Prognostic, and Immunohistochemical Study.
REFERENCE   2  (bases 1 to 731)
  AUTHORS   Xu,Y., Wang,X., Yuan,W., Zhang,L., Chen,W. and Hu,K.
  TITLE     Identification of BANF1 as a novel prognostic biomarker in gastric
            cancer and validation via in-vitro and in-vivo experiments
  JOURNAL   Aging (Albany NY) 16 (2), 1808-1828 (2024)
   PUBMED   38261746
  REMARK    GeneRIF: Identification of BANF1 as a novel prognostic biomarker in
            gastric cancer and validation via in-vitro and in-vivo experiments.
REFERENCE   3  (bases 1 to 731)
  AUTHORS   Chick,B.Y. and Hargreaves,D.C.
  TITLE     RNA polymerase II promoter-proximal pausing promotes BAF chromatin
            binding and remodeling
  JOURNAL   Nat Genet 56 (1), 19-20 (2024)
   PUBMED   38129539
  REMARK    GeneRIF: RNA polymerase II promoter-proximal pausing promotes BAF
            chromatin binding and remodeling.
REFERENCE   4  (bases 1 to 731)
  AUTHORS   Zhou,L., Zhu,L., Wu,X., Hu,S., Zhang,S., Ning,M., Yu,J. and Chen,M.
  TITLE     Decreased TMIGD1 aggravates colitis and intestinal barrier
            dysfunction via the BANF1-NF-kappaB pathway in Crohn's disease
  JOURNAL   BMC Med 21 (1), 287 (2023)
   PUBMED   37542259
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 731)
  AUTHORS   Broussard,G., Ni,G., Zhang,Z., Li,Q., Cano,P., Dittmer,D.P. and
            Damania,B.
  TITLE     Barrier-to-autointegration factor 1 promotes gammaherpesvirus
            reactivation from latency
  JOURNAL   Nat Commun 14 (1), 434 (2023)
   PUBMED   36746947
  REMARK    GeneRIF: Barrier-to-autointegration factor 1 promotes
            gammaherpesvirus reactivation from latency.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 731)
  AUTHORS   Cai,M., Huang,Y., Zheng,R., Wei,S.Q., Ghirlando,R., Lee,M.S.,
            Craigie,R., Gronenborn,A.M. and Clore,G.M.
  TITLE     Solution structure of the cellular factor BAF responsible for
            protecting retroviral DNA from autointegration
  JOURNAL   Nat Struct Biol 5 (10), 903-909 (1998)
   PUBMED   9783751
REFERENCE   7  (bases 1 to 731)
  AUTHORS   Lynch,R.A., Piper,M., Bankier,A., Bhugra,B., Surti,U., Liu,J.,
            Buckler,A., Dear,P.H. and Menon,A.G.
  TITLE     Genomic and functional map of the chromosome 14 t(12;14) breakpoint
            cluster region in uterine leiomyoma
  JOURNAL   Genomics 52 (1), 17-26 (1998)
   PUBMED   9740667
REFERENCE   8  (bases 1 to 731)
  AUTHORS   Dear,P.H., Bankier,A.T. and Piper,M.B.
  TITLE     A high-resolution metric HAPPY map of human chromosome 14
  JOURNAL   Genomics 48 (2), 232-241 (1998)
   PUBMED   9521877
REFERENCE   9  (bases 1 to 731)
  AUTHORS   Lee,M.S. and Craigie,R.
  TITLE     A previously unidentified host protein protects retroviral DNA from
            autointegration
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1528-1533 (1998)
   PUBMED   9465049
REFERENCE   10 (bases 1 to 731)
  AUTHORS   Lee,M.S. and Craigie,R.
  TITLE     Protection of retroviral DNA from autointegration: involvement of a
            cellular factor
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9823-9827 (1994)
   PUBMED   7937898
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005942.1, BC008705.1 and
            AP006287.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003860.3.
            
            Summary: The protein encoded by this gene was first identified by
            its ability to protect retroviruses from intramolecular integration
            and therefore promote intermolecular integration into the host cell
            genome. The protein forms a homodimer which localizes to both the
            nucleus and cytoplasm and is specifically associated with
            chromosomes during mitosis. This protein binds to double stranded
            DNA in a non-specific manner and also binds to LEM-domain
            containing proteins of the nuclear envelope. This protein is
            thought to facilitate nuclear reassembly by binding with both DNA
            and inner nuclear membrane proteins and thereby recruit chromatin
            to the nuclear periphery. Alternative splicing results in multiple
            transcript variants encoding the same protein.[provided by RefSeq,
            Jan 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.263062.1,
                                           SRR1163658.467813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312175.7/ ENSP00000310275.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-726               BC005942.1         4-729
            727-728             BC008705.1         716-717
            729-731             AP006287.2         119398-119400
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..731
                     /gene="BANF1"
                     /gene_synonym="BAF; BCRP1; D14S1460; NGPS"
                     /note="barrier to autointegration nuclear assembly factor
                     1"
                     /db_xref="GeneID:8815"
                     /db_xref="HGNC:HGNC:17397"
                     /db_xref="MIM:603811"
     exon            1..68
                     /gene="BANF1"
                     /gene_synonym="BAF; BCRP1; D14S1460; NGPS"
                     /inference="alignment:Splign:2.1.0"
     exon            69..207
                     /gene="BANF1"
                     /gene_synonym="BAF; BCRP1; D14S1460; NGPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..354
                     /gene="BANF1"
                     /gene_synonym="BAF; BCRP1; D14S1460; NGPS"
                     /note="breakpoint cluster region protein 1; barrier to
                     autointegration factor 1; BAF nuclear assembly factor 1"
                     /codon_start=1
                     /product="barrier-to-autointegration factor"
                     /protein_id="NP_003851.1"
                     /db_xref="CCDS:CCDS8125.1"
                     /db_xref="GeneID:8815"
                     /db_xref="HGNC:HGNC:17397"
                     /db_xref="MIM:603811"
                     /translation="MTTSQKHRDFVAEPMGEKPVGSLAGIGEVLGKKLEERGFDKAYV
                     VLGQFLVLKKDEDLFREWLKDTCGANAKQSRDCFGCLREWCDAFL"
     exon            208..731
                     /gene="BANF1"
                     /gene_synonym="BAF; BCRP1; D14S1460; NGPS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      709..714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BANF1"
                     /gene_synonym="BAF; BCRP1; D14S1460; NGPS"
                     /note="hexamer: AATAAA"
     polyA_site      731
                     /gene="BANF1"
                     /gene_synonym="BAF; BCRP1; D14S1460; NGPS"
                     /note="major polyA site"
ORIGIN      
        1 agtggcttga ggtatccgca ggagcggccg ggtggcggga ggaaccgtta cgggaactga
       61 agttgcggat taagcctgat caagatgaca acctcccaaa agcaccgaga cttcgtggca
      121 gagcccatgg gggagaagcc agtggggagc ctggctggga ttggtgaagt cctgggcaag
      181 aagctggagg aaaggggttt tgacaaggcc tatgttgtcc ttggccagtt tctggtgcta
      241 aagaaagatg aagacctctt ccgggaatgg ctgaaagaca cttgtggcgc caacgccaag
      301 cagtcccggg actgcttcgg atgccttcga gagtggtgcg acgccttctt gtgatgctct
      361 ctgggaagct ctcaatcccc agccctcatc cagagtttgc agccgagtag ggactcctcc
      421 cctgtcctct acgaaggaaa agattgctat tgtcgtactc acctccgacg tactccgggg
      481 tcttttggga gttttctccc ctaaccattt caactttttt ttggattctc gctcttgcat
      541 gcctcccccg tcctttttcc cttgccagtt ccctggtgac agttaccagc tttcctgaat
      601 ggattcccgg ccccatccct cacccccacc ctcactttca atccgtttga taccatttgg
      661 ctcctttttt ggcagaacag tcactgtcct tgtaaagttt tttagatcaa taaagtcagt
      721 ggctttcatg a
//
