LOCUS       NM_012342               1691 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens BMP and activin membrane bound inhibitor (BAMBI),
            mRNA.
ACCESSION   NM_012342
VERSION     NM_012342.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1691)
  AUTHORS   Monshizadeh,K., Tajamolian,M., Anbari,F., Mehrjardi,M.Y.V.,
            Kalantar,S.M. and Dehghani,M.
  TITLE     The association of RBX1 and BAMBI gene expression with oocyte
            maturation in PCOS women
  JOURNAL   BMC Med Genomics 17 (1), 24 (2024)
   PUBMED   38238750
  REMARK    GeneRIF: The association of RBX1 and BAMBI gene expression with
            oocyte maturation in PCOS women.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1691)
  AUTHORS   Wang,L., Si,W., Yu,X., Piffko,A., Dou,X., Ding,X., Bugno,J.,
            Yang,K., Wen,C., Zhang,L., Chen,D., Huang,X., Wang,J., Arina,A.,
            Pitroda,S., Chmura,S.J., He,C., Liang,H.L. and Weichselbaum,R.
  TITLE     Epitranscriptional regulation of TGF-beta pseudoreceptor BAMBI by
            m6A/YTHDF2 drives extrinsic radioresistance
  JOURNAL   J Clin Invest 133 (24), e172919 (2023)
   PUBMED   38099498
  REMARK    GeneRIF: Epitranscriptional regulation of TGF-beta pseudoreceptor
            BAMBI by m6A/YTHDF2 drives extrinsic radioresistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1691)
  AUTHORS   Ehnert,S., Rinderknecht,H., Liu,C., Voss,M., Konrad,F.M.,
            Eisler,W., Alexander,D., Ngamsri,K.C., Histing,T., Rollmann,M.F.
            and Nussler,A.K.
  TITLE     Increased Levels of BAMBI Inhibit Canonical TGF-beta Signaling in
            Chronic Wound Tissues
  JOURNAL   Cells 12 (16), 2095 (2023)
   PUBMED   37626905
  REMARK    GeneRIF: Increased Levels of BAMBI Inhibit Canonical TGF-beta
            Signaling in Chronic Wound Tissues.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1691)
  AUTHORS   Zhi,Y., Gao,Q., Wang,Z., Dong,Y., Guan,Y., Yuan,J. and Zhang,Z.
  TITLE     Circular RNA circSP5 promotes liver metastasis of colorectal cancer
            via SP5-mediated BAMBI transcription
  JOURNAL   Funct Integr Genomics 23 (3), 275 (2023)
   PUBMED   37596430
  REMARK    GeneRIF: Circular RNA circSP5 promotes liver metastasis of
            colorectal cancer via SP5-mediated BAMBI transcription.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1691)
  AUTHORS   Gao,H., Fan,H. and Xie,H.
  TITLE     The regulatory effect of the YY1/miR-HCC2/BAMBI axis on the
            stemness of liver cancer cells
  JOURNAL   Int J Oncol 62 (5) (2023)
   PUBMED   36999621
  REMARK    GeneRIF: The regulatory effect of the YY1/miR-HCC2/BAMBI axis on
            the stemness of liver cancer cells.
REFERENCE   6  (bases 1 to 1691)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 1691)
  AUTHORS   Sekiya,T., Adachi,S., Kohu,K., Yamada,T., Higuchi,O., Furukawa,Y.,
            Nakamura,Y., Nakamura,T., Tashiro,K., Kuhara,S., Ohwada,S. and
            Akiyama,T.
  TITLE     Identification of BMP and activin membrane-bound inhibitor (BAMBI),
            an inhibitor of transforming growth factor-beta signaling, as a
            target of the beta-catenin pathway in colorectal tumor cells
  JOURNAL   J Biol Chem 279 (8), 6840-6846 (2004)
   PUBMED   14660579
  REMARK    GeneRIF: beta-catenin interferes with transforming growth
            factor-beta-mediated growth arrest by inducing the expression of
            BAMBI
REFERENCE   8  (bases 1 to 1691)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1691)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   10 (bases 1 to 1691)
  AUTHORS   Degen,W.G., Weterman,M.A., van Groningen,J.J., Cornelissen,I.M.,
            Lemmers,J.P., Agterbos,M.A., Geurts van Kessel,A., Swart,G.W. and
            Bloemers,H.P.
  TITLE     Expression of nma, a novel gene, inversely correlates with the
            metastatic potential of human melanoma cell lines and xenografts
  JOURNAL   Int J Cancer 65 (4), 460-465 (1996)
   PUBMED   8621228
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ640107.1, U23070.1 and
            AI680996.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012342.2.
            
            Summary: This gene encodes a transmembrane glycoprotein related to
            the type I receptors of the transforming growth factor-beta
            (TGF-beta) family, whose members play important roles in signal
            transduction in many developmental and pathological processes. The
            encoded protein however is a pseudoreceptor, lacking an
            intracellular serine/threonine kinase domain required for
            signaling. Similar proteins in frog, mouse and zebrafish function
            as negative regulators of TGF-beta, which has led to the suggestion
            that the encoded protein may function to limit the signaling range
            of the TGF-beta family during early embryogenesis. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223065.1, U23070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375533.6/ ENSP00000364683.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               BQ640107.1         180-498
            320-1526            U23070.1           315-1521
            1527-1691           AI680996.1         16-180              c
FEATURES             Location/Qualifiers
     source          1..1691
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.1"
     gene            1..1691
                     /gene="BAMBI"
                     /gene_synonym="NMA"
                     /note="BMP and activin membrane bound inhibitor"
                     /db_xref="GeneID:25805"
                     /db_xref="HGNC:HGNC:30251"
                     /db_xref="MIM:604444"
     exon            1..453
                     /gene="BAMBI"
                     /gene_synonym="NMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1160
                     /gene="BAMBI"
                     /gene_synonym="NMA"
                     /note="non-metastatic gene A protein; putative
                     transmembrane protein NMA; BMP and activin membrane-bound
                     inhibitor homolog"
                     /codon_start=1
                     /product="BMP and activin membrane-bound inhibitor homolog
                     precursor"
                     /protein_id="NP_036474.1"
                     /db_xref="CCDS:CCDS7162.1"
                     /db_xref="GeneID:25805"
                     /db_xref="HGNC:HGNC:30251"
                     /db_xref="MIM:604444"
                     /translation="MDRHSSYIFIWLQLELCAMAVLLTKGEIRCYCDAAHCVATGYMC
                     KSELSACFSRLLDPQNSNSPLTHGCLDSLASTTDICQAKQARNHSGTTIPTLECCHED
                     MCNYRGLHDVLSPPRGEASGQGNRYQHDGSRNLITKVQELTSSKELWFRAAVIAVPIA
                     GGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHHSKKGQVAKLDLECMVP
                     VSGHENCCLTCDKMRQADLSNDKILSLVHWGMYSGHGKLEFV"
     exon            454..741
                     /gene="BAMBI"
                     /gene_synonym="NMA"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1691
                     /gene="BAMBI"
                     /gene_synonym="NMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1444..1449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAMBI"
                     /gene_synonym="NMA"
                     /note="hexamer: AATAAA"
     polyA_site      1464
                     /gene="BAMBI"
                     /gene_synonym="NMA"
                     /note="major polyA site"
     regulatory      1507..1512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAMBI"
                     /gene_synonym="NMA"
                     /note="hexamer: AATATA"
     polyA_site      1528
                     /gene="BAMBI"
                     /gene_synonym="NMA"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAMBI"
                     /gene_synonym="NMA"
                     /note="hexamer: AATAAT"
     polyA_site      1627
                     /gene="BAMBI"
                     /gene_synonym="NMA"
     regulatory      1667..1672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAMBI"
                     /gene_synonym="NMA"
                     /note="hexamer: AACAAG"
     polyA_site      1691
                     /gene="BAMBI"
                     /gene_synonym="NMA"
ORIGIN      
        1 gggctggcgc gggcgggagc tgcggcggat acccttgcgt gctgtggaga ccctactctc
       61 ttcgctgaga acggccgcta gcggggactg aaggccggga gcccactccc gacccggggc
      121 tagcgtgcgt ccctagagtc gagcggggca agggagccag tggccgccga cgggggaccg
      181 ggaaactttt ctgggctcct gggcgcgccc tgtagccgcg ctccatgctc cggcagcggc
      241 ccgaaaccca gccccgccgc tgacggcgcc cgccgctccg ggcagggccc atgccctgcg
      301 cgctccgggg gtcgtaggct gccgccgagc cggggctccg gaagccggcg ggggcgccgc
      361 ggccgtgcgg ggcgtcaatg gatcgccact ccagctacat cttcatctgg ctgcagctgg
      421 agctctgcgc catggccgtg ctgctcacca aaggtgaaat tcgatgctac tgtgatgctg
      481 cccactgtgt agccactggt tatatgtgta aatctgagct cagcgcctgc ttctctagac
      541 ttcttgatcc tcagaactca aattccccac tcacccatgg ctgcctggac tctcttgcaa
      601 gcacgacaga catctgccaa gccaaacagg cccgaaacca ctctggcacc accataccca
      661 cattggaatg ctgtcatgaa gacatgtgca attacagagg gctgcacgat gttctctctc
      721 ctcccagggg tgaggcctca ggacaaggaa acaggtatca gcatgatggt agcagaaacc
      781 ttatcaccaa ggtgcaggag ctgacttctt ccaaagagtt gtggttccgg gcagcggtca
      841 ttgccgtgcc cattgctgga gggctgattt tagtgttgct tattatgttg gccctgagga
      901 tgcttcgaag tgaaaataag aggctgcagg atcagcggca acagatgctc tcccgtttgc
      961 actacagctt tcacggacac cattccaaaa aggggcaggt tgcaaagtta gacttggaat
     1021 gcatggtgcc ggtcagtggg cacgagaact gctgtctgac ctgtgataaa atgagacaag
     1081 cagacctcag caacgataag atcctctcgc ttgttcactg gggcatgtac agtgggcacg
     1141 ggaagctgga attcgtatga cggagtctta tctgaactac acttactgaa cagcttgaag
     1201 gccttttgag ttctgctgga caggagcact ttatctgaag acaaactcat ttaatcatct
     1261 ttgagagaca aaatgacctc tgcaaacaga atcttggata tttcttctga aggattattt
     1321 gcacagactt aaatacagtt aaatgtgtta tttgctttta aaattataaa aagcaaagag
     1381 aagactttgt acacactgtc accagggtta tttgcatcca agggagctgg aattgagtac
     1441 ctaaataaac aaaaatgtgc cctatgtaag cttctacatc ttgatttatt gtaaagattt
     1501 aaaagaaata tatatatttt gtctgaaatt taatagtgtc tttcataaat ttaactggga
     1561 aacgtgagac agtacatgtt aattatacaa atggccattt gctgttaata atttgttctc
     1621 aactctagga tgtggcttgg tttttttttt tctcttttct tttttaaaca agaccaagat
     1681 cttgcttatt c
//
