LOCUS       NM_001188               2170 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens BCL2 antagonist/killer 1 (BAK1), mRNA.
ACCESSION   NM_001188
VERSION     NM_001188.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2170)
  AUTHORS   Guan,Z., Li,H., Zhang,C., Huang,Z., Ye,M., Zhang,Y., Li,S. and
            Peng,K.
  TITLE     RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis
            to activate pathogenic NLRP3 pyroptosis
  JOURNAL   PLoS Pathog 20 (8), e1012387 (2024)
   PUBMED   39213434
  REMARK    GeneRIF: RVFV virulence factor NSs triggers the mitochondrial
            MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2170)
  AUTHORS   Dadsena,S., Cuevas Arenas,R., Vieira,G., Brodesser,S., Melo,M.N.
            and Garcia-Saez,A.J.
  TITLE     Lipid unsaturation promotes BAX and BAK pore activity during
            apoptosis
  JOURNAL   Nat Commun 15 (1), 4700 (2024)
   PUBMED   38830851
  REMARK    GeneRIF: Lipid unsaturation promotes BAX and BAK pore activity
            during apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2170)
  AUTHORS   Miller,M.S., Cowan,A.D., Brouwer,J.M., Smyth,S.T., Peng,L.,
            Wardak,A.Z., Uren,R.T., Luo,C., Roy,M.J., Shah,S., Tan,Z.,
            Reid,G.E., Colman,P.M. and Czabotar,P.E.
  TITLE     Sequence differences between BAX and BAK core domains manifest as
            differences in their interactions with lipids
  JOURNAL   FEBS J 291 (11), 2335-2353 (2024)
   PUBMED   38088212
  REMARK    GeneRIF: Sequence differences between BAX and BAK core domains
            manifest as differences in their interactions with lipids.
REFERENCE   4  (bases 1 to 2170)
  AUTHORS   Schweighofer,S.V., Jans,D.C., Keller-Findeisen,J., Folmeg,A.,
            Ilgen,P., Bates,M. and Jakobs,S.
  TITLE     Endogenous BAX and BAK form mosaic rings of variable size and
            composition on apoptotic mitochondria
  JOURNAL   Cell Death Differ 31 (4), 469-478 (2024)
   PUBMED   38503846
  REMARK    GeneRIF: Endogenous BAX and BAK form mosaic rings of variable size
            and composition on apoptotic mitochondria.
REFERENCE   5  (bases 1 to 2170)
  AUTHORS   Sovilj,D., Kelemen,C.D., Dvorakova,S., Zobalova,R., Raabova,H.,
            Kriska,J., Hermanova,Z., Knotek,T., Anderova,M., Klener,P.,
            Filimonenko,V., Neuzil,J. and Andera,L.
  TITLE     Cell-specific modulation of mitochondrial respiration and
            metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak
  JOURNAL   Apoptosis 29 (3-4), 424-438 (2024)
   PUBMED   38001340
  REMARK    GeneRIF: Cell-specific modulation of mitochondrial respiration and
            metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak.
REFERENCE   6  (bases 1 to 2170)
  AUTHORS   Sattler,M., Liang,H., Nettesheim,D., Meadows,R.P., Harlan,J.E.,
            Eberstadt,M., Yoon,H.S., Shuker,S.B., Chang,B.S., Minn,A.J.,
            Thompson,C.B. and Fesik,S.W.
  TITLE     Structure of Bcl-xL-Bak peptide complex: recognition between
            regulators of apoptosis
  JOURNAL   Science 275 (5302), 983-986 (1997)
   PUBMED   9020082
REFERENCE   7  (bases 1 to 2170)
  AUTHORS   Chittenden,T., Flemington,C., Houghton,A.B., Ebb,R.G., Gallo,G.J.,
            Elangovan,B., Chinnadurai,G. and Lutz,R.J.
  TITLE     A conserved domain in Bak, distinct from BH1 and BH2, mediates cell
            death and protein binding functions
  JOURNAL   EMBO J 14 (22), 5589-5596 (1995)
   PUBMED   8521816
REFERENCE   8  (bases 1 to 2170)
  AUTHORS   Kiefer,M.C., Brauer,M.J., Powers,V.C., Wu,J.J., Umansky,S.R.,
            Tomei,L.D. and Barr,P.J.
  TITLE     Modulation of apoptosis by the widely distributed Bcl-2 homologue
            Bak
  JOURNAL   Nature 374 (6524), 736-739 (1995)
   PUBMED   7715731
REFERENCE   9  (bases 1 to 2170)
  AUTHORS   Chittenden,T., Harrington,E.A., O'Connor,R., Flemington,C.,
            Lutz,R.J., Evan,G.I. and Guild,B.C.
  TITLE     Induction of apoptosis by the Bcl-2 homologue Bak
  JOURNAL   Nature 374 (6524), 733-736 (1995)
   PUBMED   7715730
REFERENCE   10 (bases 1 to 2170)
  AUTHORS   Farrow,S.N., White,J.H., Martinou,I., Raven,T., Pun,K.T.,
            Grinham,C.J., Martinou,J.C. and Brown,R.
  TITLE     Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K
  JOURNAL   Nature 374 (6524), 731-733 (1995)
   PUBMED   7715729
  REMARK    Erratum:[Nature 1995 Jun 1;375(6530):431]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB142221.1, BC004431.1,
            Z93017.6 and BM855203.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001188.3.
            
            Summary: The protein encoded by this gene belongs to the BCL2
            protein family. BCL2 family members form oligomers or heterodimers
            and act as anti- or pro-apoptotic regulators that are involved in a
            wide variety of cellular activities. This protein localizes to
            mitochondria, and functions to induce apoptosis. It interacts with
            and accelerates the opening of the mitochondrial voltage-dependent
            anion channel, which leads to a loss in membrane potential and the
            release of cytochrome c. This protein also interacts with the tumor
            suppressor P53 after exposure to cell stress. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004431.1, U23765.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374467.4/ ENSP00000363591.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                CB142221.1         18-89
            73-991              BC004431.1         1-919
            992-1948            Z93017.6           80204-81160         c
            1949-2170           BM855203.1         1-222
FEATURES             Location/Qualifiers
     source          1..2170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..2170
                     /gene="BAK1"
                     /gene_synonym="BAK; BAK-LIKE; BCL2L7; CDN1"
                     /note="BCL2 antagonist/killer 1"
                     /db_xref="GeneID:578"
                     /db_xref="HGNC:HGNC:949"
                     /db_xref="MIM:600516"
     exon            1..252
                     /gene="BAK1"
                     /gene_synonym="BAK; BAK-LIKE; BCL2L7; CDN1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..353
                     /gene="BAK1"
                     /gene_synonym="BAK; BAK-LIKE; BCL2L7; CDN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..919
                     /gene="BAK1"
                     /gene_synonym="BAK; BAK-LIKE; BCL2L7; CDN1"
                     /note="pro-apoptotic protein BAK; apoptosis regulator BAK;
                     BCL2-like 7 protein; bcl2-L-7; bcl-2-like protein 7"
                     /codon_start=1
                     /product="bcl-2 homologous antagonist/killer"
                     /protein_id="NP_001179.1"
                     /db_xref="CCDS:CCDS4781.1"
                     /db_xref="GeneID:578"
                     /db_xref="HGNC:HGNC:949"
                     /db_xref="MIM:600516"
                     /translation="MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQ
                     QEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQP
                     TAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVD
                     FMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS"
     exon            354..489
                     /gene="BAK1"
                     /gene_synonym="BAK; BAK-LIKE; BCL2L7; CDN1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..633
                     /gene="BAK1"
                     /gene_synonym="BAK; BAK-LIKE; BCL2L7; CDN1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..814
                     /gene="BAK1"
                     /gene_synonym="BAK; BAK-LIKE; BCL2L7; CDN1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..2170
                     /gene="BAK1"
                     /gene_synonym="BAK; BAK-LIKE; BCL2L7; CDN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2149..2154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAK1"
                     /gene_synonym="BAK; BAK-LIKE; BCL2L7; CDN1"
                     /note="hexamer: AATAAA"
     polyA_site      2170
                     /gene="BAK1"
                     /gene_synonym="BAK; BAK-LIKE; BCL2L7; CDN1"
                     /note="major polyA site"
ORIGIN      
        1 acagagcaac ttcctctaga gggagctgat tggagccggg tgccgctggc acctctatga
       61 tcactggagt ctcgcgggtc cctcgggctg cacagggaca agtaaaggct acatccagat
      121 gccgggaatg cactgacgcc cattcctgga aactgggctc ccactcagcc cctgggagca
      181 gcagccgcca gcccctcggg acctccatct ccaccctgct gagccacccg ggttgggcca
      241 ggatcccggc aggctgatcc cgtcctccac tgagacctga aaaatggctt cggggcaagg
      301 cccaggtcct cccaggcagg agtgcggaga gcctgccctg ccctctgctt ctgaggagca
      361 ggtagcccag gacacagagg aggttttccg cagctacgtt ttttaccgcc atcagcagga
      421 acaggaggct gaaggggtgg ctgcccctgc cgacccagag atggtcacct tacctctgca
      481 acctagcagc accatggggc aggtgggacg gcagctcgcc atcatcgggg acgacatcaa
      541 ccgacgctat gactcagagt tccagaccat gttgcagcac ctgcagccca cggcagagaa
      601 tgcctatgag tacttcacca agattgccac cagcctgttt gagagtggca tcaattgggg
      661 ccgtgtggtg gctcttctgg gcttcggcta ccgtctggcc ctacacgtct accagcatgg
      721 cctgactggc ttcctaggcc aggtgacccg cttcgtggtc gacttcatgc tgcatcactg
      781 cattgcccgg tggattgcac agaggggtgg ctgggtggca gccctgaact tgggcaatgg
      841 tcccatcctg aacgtgctgg tggttctggg tgtggttctg ttgggccagt ttgtggtacg
      901 aagattcttc aaatcatgac tcccaagggt gccctttggg gtcccggttc agacccctgc
      961 ctggacttaa gcgaagtctt tgccttctct gttcccttgc aggggtcccc cctcaagagt
     1021 acagaagctt tagcaagtgt gcactccagc ttcggagggc ccctgcgtgg gggccagtca
     1081 ggctgcagag gcacctcaac attgcatggt gctagtgggc cctctctctg ggcccagggg
     1141 ctgtggccgt ctcctccctc agctctctgg gacctcctta gccctgtctg ctaggcgctg
     1201 gggagactga taacttgggg aggcaagaga ctgggagcca cttctcccca gaaagtgttt
     1261 aacggtttta gctttttata atacccttgt gagagcccat tcccaccatt ctacctgagg
     1321 ccaggacgtc tggggtgtgg ggattggtgg gtctatgttc cccaggattc agctattctg
     1381 gaagatcagc accctaagag atgggactag gacctgagcc tggtcctggc cgtccctaag
     1441 catgtgtccc aggagcagga cctactagga gaggggggcc aaggtcctgc tcaactctac
     1501 ccctgctccc attcctccct ccggccatac tgcctttgca gttggactct cagggattct
     1561 gggcttgggg tgtggggtgg ggtggagtcg cagaccagag ctgtctgaac tcacgtgtca
     1621 gaagcctcca agcctgcctc ccaaggtcct ctcagttctc tcccttcctc tctccttata
     1681 gacacttgct cccaacccat tcactacagg tgaaggctct cacccccatc cctgggggcc
     1741 ttgggtgagt ggcctgctaa ggctcctcct tgcccagact acagggctta ggacttggtt
     1801 tgttatatca gggaaaagga gtagggagtt catctggagg gttctaagtg ggagaaggac
     1861 tatcaacacc actaggaatc ccagaggtgg gatcctccct catggctctg gcacagtgta
     1921 atccaggggt gtagatgggg gaactgtgaa tacttgaact ctgttccccc accctccatg
     1981 ctcctcacct gtctaggtct cctcagggtg gggggtgaca gtgccttctc tattgggcac
     2041 agcctagggt cttgggggtc aggggggaga agttcttgat tcagccaaat gcagggaggg
     2101 gaggcagatg gagcccatag gccaccccct atcctctgag tgtttggaaa taaactgtgc
     2161 aatcccctca
//
