LOCUS       NM_025045               2149 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens BAR/IMD domain containing adaptor protein 2 like 2
            (BAIAP2L2), mRNA.
ACCESSION   NM_025045
VERSION     NM_025045.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2149)
  AUTHORS   Wei,H., Yang,J., Chen,X., Liu,M., Zhang,H., Sun,W., Wang,Y. and
            Zhou,Y.
  TITLE     BAIAP2L2 is a novel prognostic biomarker related to migration and
            invasion of HCC and associated with cuprotosis
  JOURNAL   Sci Rep 13 (1), 8692 (2023)
   PUBMED   37248248
  REMARK    GeneRIF: BAIAP2L2 is a novel prognostic biomarker related to
            migration and invasion of HCC and associated with cuprotosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2149)
  AUTHORS   Tholen,L.E., Schigt,H., Kleuskens,S.G.E., Bos,C., Spruijt,C.G.,
            Willemsen,B., Vermeulen,M., Hoenderop,J.G.J. and de Baaij,J.H.F.
  TITLE     HNF1beta-associated cyst development and electrolyte disturbances
            are not explained by BAIAP2L2 expression
  JOURNAL   FASEB J 37 (1), e22696 (2023)
   PUBMED   36520027
  REMARK    GeneRIF: HNF1beta-associated cyst development and electrolyte
            disturbances are not explained by BAIAP2L2 expression.
REFERENCE   3  (bases 1 to 2149)
  AUTHORS   Song,Y., Zhuang,G., Li,J. and Zhang,M.
  TITLE     BAIAP2L2 facilitates the malignancy of prostate cancer (PCa) via
            VEGF and apoptosis signaling pathways
  JOURNAL   Genes Genomics 43 (4), 421-432 (2021)
   PUBMED   33646530
  REMARK    GeneRIF: BAIAP2L2 facilitates the malignancy of prostate cancer
            (PCa) via VEGF and apoptosis signaling pathways.
REFERENCE   4  (bases 1 to 2149)
  AUTHORS   Liu,J., Shangguan,Y., Sun,J., Cong,W. and Xie,Y.
  TITLE     BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR
            and Wnt3a/beta-catenin signaling pathways
  JOURNAL   Biomed Pharmacother 129, 110414 (2020)
   PUBMED   32570120
  REMARK    GeneRIF: BAIAP2L2 promotes the progression of gastric cancer via
            AKT/mTOR and Wnt3a/beta-catenin signaling pathways.
REFERENCE   5  (bases 1 to 2149)
  AUTHORS   Xu,L., Du,H., Zhang,Q., Wang,C., Yan,L., Tian,G. and Fu,X.
  TITLE     BAI1-associated protein 2-like 2 is a potential biomarker in lung
            cancer
  JOURNAL   Oncol Rep 41 (2), 1304-1312 (2019)
   PUBMED   30483805
  REMARK    GeneRIF: these findings revealed BAIAP2L2 as a novel biomarker and
            potential therapeutic target for lung cancer
REFERENCE   6  (bases 1 to 2149)
  AUTHORS   Pykalainen,A., Boczkowska,M., Zhao,H., Saarikangas,J., Rebowski,G.,
            Jansen,M., Hakanen,J., Koskela,E.V., Peranen,J., Vihinen,H.,
            Jokitalo,E., Salminen,M., Ikonen,E., Dominguez,R. and
            Lappalainen,P.
  TITLE     Pinkbar is an epithelial-specific BAR domain protein that generates
            planar membrane structures
  JOURNAL   Nat Struct Mol Biol 18 (8), 902-907 (2011)
   PUBMED   21743456
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2149)
  AUTHORS   Veltman,D.M., Auciello,G., Spence,H.J., Machesky,L.M.,
            Rappoport,J.Z. and Insall,R.H.
  TITLE     Functional analysis of Dictyostelium IBARa reveals a conserved role
            of the I-BAR domain in endocytosis
  JOURNAL   Biochem J 436 (1), 45-52 (2011)
   PUBMED   21401524
REFERENCE   8  (bases 1 to 2149)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 2149)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022322.1, AY358164.1,
            KF457452.1 and AW007403.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_025045.5.
            
            Summary: The protein encoded by this gene binds phosphoinositides
            and promotes the formation of planar or curved membrane structures.
            The encoded protein is found in RAB13-positive vesicles and at
            intercellular contacts with the plasma membrane. [provided by
            RefSeq, Dec 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358164.1, DRR138516.981299.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381669.8/ ENSP00000371085.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL022322.1         25326-25340         c
            16-182              AY358164.1         1-167
            183-183             KF457452.1         127-127             c
            184-210             AL022322.1         25131-25157         c
            211-2042            AY358164.1         196-2027
            2043-2149           AW007403.1         20-126              c
FEATURES             Location/Qualifiers
     source          1..2149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2149
                     /gene="BAIAP2L2"
                     /note="BAR/IMD domain containing adaptor protein 2 like 2"
                     /db_xref="GeneID:80115"
                     /db_xref="HGNC:HGNC:26203"
                     /db_xref="MIM:617536"
     exon            1..210
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1749
                     /gene="BAIAP2L2"
                     /note="brain-specific angiogenesis inhibitor 1-associated
                     protein 2-like protein 2; BAI1-associated protein 2-like
                     protein 2; pinkbar; planar intestinal- and kidney-specific
                     BAR domain protein; BAI1 associated protein 2 like 2"
                     /codon_start=1
                     /product="BAR/IMD domain-containing adapter protein 2-like
                     2"
                     /protein_id="NP_079321.3"
                     /db_xref="CCDS:CCDS43018.1"
                     /db_xref="GeneID:80115"
                     /db_xref="HGNC:HGNC:26203"
                     /db_xref="MIM:617536"
                     /translation="MAPEMDQFYRSTMAIYKSIMEQFNPALENLVYLGNNYLRAFHAL
                     SEAAEVYFSAIQKIGERALQSPTSQILGEILVQMSDTQRHLNSDLEVVVQTFHGGLLQ
                     HMEKNTKLDMQFIKDSRQHYELEYRHRAANLEKCMSELWRMERKRDKNVREMKESVNR
                     LHAQMQAFVSESQRAAELEEKRRYRFLAEKHLLLSNTFLQFFGRARGMLQNRVLLWKE
                     QSEASRSPSRAHSPGLLGPALGPPYPSGRLTPTCLDMPPRPLGEFSSPRSRHGSGSYG
                     TEPDARPASQLEPDRRSLPRTPSASSLYSGSAQSSRSNSFGERPGGGGGARRVRALVS
                     HSEGANHTLLRFSAGDVVEVLVPEAQNGWLYGKLEGSSASGWFPEAYVKALEEGPVNP
                     MTPVTPMTSMTSMSPMTPMNPGNELPSRSYPLRGSHSLDDLLDRPGNSIAPSEYWDGQ
                     SRSRTPSRVPSRAPSPAPPPLPSSRRSSMGSTAVATDVKKLMSSEQYPPQELFPRGTN
                     PFATVKLRPTITNDRSAPLIR"
     exon            211..286
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            287..373
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..435
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..507
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..624
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..771
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..924
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1060
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1277
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1418
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1626
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1673
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..2149
                     /gene="BAIAP2L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2129..2134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAIAP2L2"
                     /note="hexamer: AATAAA"
     polyA_site      2149
                     /gene="BAIAP2L2"
                     /note="major polyA site"
ORIGIN      
        1 gccactcctc tgaggcaggc ctccatctcc aggtccctct ccgaggcttc ctcgctgcca
       61 gctgagtcgt gggcacctga gggactacct accactgctc ccggctgtgc catcgccacc
      121 agctcccagc ctcctgctca gacccgggac agcccctcca tggcccccga gatggaccag
      181 ttctacaggt ccaccatggc catctacaag agcatcatgg agcagtttaa ccccgccctg
      241 gagaacctgg tgtacctggg caacaactac ctgcgtgcct tccacgctct gtccgaggcg
      301 gccgaggtct acttcagtgc catccagaag attggggagc gtgccctgca gagccccacc
      361 tcacagattc tgggggagat cttggtgcag atgtctgaca cccagcggca cttgaactct
      421 gacctggagg tggtggtgca gacattccat ggaggcctgc tgcagcacat ggagaagaac
      481 accaagctgg acatgcagtt catcaaagac agccgccagc actatgagct cgagtaccgc
      541 caccgagcgg ccaacctgga gaagtgcatg tctgagctgt ggcgcatgga gcgcaagaga
      601 gacaagaacg tgcgggagat gaaggagagt gtgaaccggc tgcacgcaca gatgcaggcc
      661 ttcgtgtctg agagtcagcg ggcggctgaa ttggaagaga agcggcgcta tcgcttccta
      721 gcagagaagc acctgctact ttccaacacc ttcctgcagt tcttcggccg ggcccggggg
      781 atgctccaga accgcgtgct gctgtggaag gagcagtctg aggccagccg cagcccgtcg
      841 cgcgcccact cccccggcct gctgggcccc gcgctggggc cgccctaccc ctcgggccgc
      901 ctgacgccca cctgcctgga catgcccccg aggcccctgg gagagttcag ctccccccgc
      961 agccggcacg gctccggctc ctacggcacc gagcccgacg cgaggcccgc gtcccagcta
     1021 gagccagacc gtcgctccct gccccgcacg ccgtcggcct cctcgctcta cagcggcagc
     1081 gcccaaagct cgcgctccaa ctcctttggc gagcgcccgg gcggcggcgg gggcgccagg
     1141 agagtccgcg ccctggtctc ccactcggag ggcgccaacc acacgctgct gcgcttctcc
     1201 gctggggacg tggtggaggt gttggtgccc gaggcccaga acggctggct ctacggcaag
     1261 ctggagggct cgtccgcgag cggttggttc cccgaggcgt acgtgaaggc tctggaggag
     1321 gggcccgtga atcccatgac ccccgtgacc cccatgacct ccatgacctc catgtccccc
     1381 atgacaccca tgaaccccgg gaacgagctg ccttccaggt cctacccact ccggggcagc
     1441 cacagcctcg atgacctcct ggaccggccg ggcaactcca tagcaccctc ggagtactgg
     1501 gatggccagt cccgctcccg caccccaagc cgggtgccaa gccgtgcccc cagccctgca
     1561 cctccaccct tgcccagcag ccgccgcagc agcatgggca gcacagcagt tgccactgac
     1621 gtcaagaaac tgatgtcctc agagcagtac ccaccacagg agctcttccc gaggggcaca
     1681 aatccttttg ccactgtcaa gcttcgtccc accatcacca atgaccgctc agcacccctc
     1741 atccgctgag gcggggtccg aggtcgtacc ccacagtgca cctgcccagg ggctgttcag
     1801 agctggcaat ggcagcgaca gcagcaacag cagcagatcc aagaagcggg tccctgagac
     1861 ggggggtggc tgccctcccc agaccacccc ggcagcctga gcagctccaa agcactggct
     1921 tggggtccga gaccttcaaa gtaaagcagg cggaatgggg ggacaggaca atttctcccc
     1981 ctccaggggc tccaggactc tccctggggg gcccacctct tgccccctaa cctctttccc
     2041 ccttttctgc ccccgtgggg aggagcccct tgtacctgct ccgtgcccaa cacatgccct
     2101 ctctgtacat cttttgtaaa tgatgagaaa taaaggaagt ggacgcaaa
//
