LOCUS       NP_079321                529 aa            linear   PRI 28-APR-2025
DEFINITION  BAR/IMD domain-containing adapter protein 2-like 2 [Homo sapiens].
ACCESSION   NP_079321
VERSION     NP_079321.3
DBSOURCE    REFSEQ: accession NM_025045.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 529)
  AUTHORS   Wei,H., Yang,J., Chen,X., Liu,M., Zhang,H., Sun,W., Wang,Y. and
            Zhou,Y.
  TITLE     BAIAP2L2 is a novel prognostic biomarker related to migration and
            invasion of HCC and associated with cuprotosis
  JOURNAL   Sci Rep 13 (1), 8692 (2023)
   PUBMED   37248248
  REMARK    GeneRIF: BAIAP2L2 is a novel prognostic biomarker related to
            migration and invasion of HCC and associated with cuprotosis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 529)
  AUTHORS   Tholen,L.E., Schigt,H., Kleuskens,S.G.E., Bos,C., Spruijt,C.G.,
            Willemsen,B., Vermeulen,M., Hoenderop,J.G.J. and de Baaij,J.H.F.
  TITLE     HNF1beta-associated cyst development and electrolyte disturbances
            are not explained by BAIAP2L2 expression
  JOURNAL   FASEB J 37 (1), e22696 (2023)
   PUBMED   36520027
  REMARK    GeneRIF: HNF1beta-associated cyst development and electrolyte
            disturbances are not explained by BAIAP2L2 expression.
REFERENCE   3  (residues 1 to 529)
  AUTHORS   Song,Y., Zhuang,G., Li,J. and Zhang,M.
  TITLE     BAIAP2L2 facilitates the malignancy of prostate cancer (PCa) via
            VEGF and apoptosis signaling pathways
  JOURNAL   Genes Genomics 43 (4), 421-432 (2021)
   PUBMED   33646530
  REMARK    GeneRIF: BAIAP2L2 facilitates the malignancy of prostate cancer
            (PCa) via VEGF and apoptosis signaling pathways.
REFERENCE   4  (residues 1 to 529)
  AUTHORS   Liu,J., Shangguan,Y., Sun,J., Cong,W. and Xie,Y.
  TITLE     BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR
            and Wnt3a/beta-catenin signaling pathways
  JOURNAL   Biomed Pharmacother 129, 110414 (2020)
   PUBMED   32570120
  REMARK    GeneRIF: BAIAP2L2 promotes the progression of gastric cancer via
            AKT/mTOR and Wnt3a/beta-catenin signaling pathways.
REFERENCE   5  (residues 1 to 529)
  AUTHORS   Xu,L., Du,H., Zhang,Q., Wang,C., Yan,L., Tian,G. and Fu,X.
  TITLE     BAI1-associated protein 2-like 2 is a potential biomarker in lung
            cancer
  JOURNAL   Oncol Rep 41 (2), 1304-1312 (2019)
   PUBMED   30483805
  REMARK    GeneRIF: these findings revealed BAIAP2L2 as a novel biomarker and
            potential therapeutic target for lung cancer
REFERENCE   6  (residues 1 to 529)
  AUTHORS   Pykalainen,A., Boczkowska,M., Zhao,H., Saarikangas,J., Rebowski,G.,
            Jansen,M., Hakanen,J., Koskela,E.V., Peranen,J., Vihinen,H.,
            Jokitalo,E., Salminen,M., Ikonen,E., Dominguez,R. and
            Lappalainen,P.
  TITLE     Pinkbar is an epithelial-specific BAR domain protein that generates
            planar membrane structures
  JOURNAL   Nat Struct Mol Biol 18 (8), 902-907 (2011)
   PUBMED   21743456
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 529)
  AUTHORS   Veltman,D.M., Auciello,G., Spence,H.J., Machesky,L.M.,
            Rappoport,J.Z. and Insall,R.H.
  TITLE     Functional analysis of Dictyostelium IBARa reveals a conserved role
            of the I-BAR domain in endocytosis
  JOURNAL   Biochem J 436 (1), 45-52 (2011)
   PUBMED   21401524
REFERENCE   8  (residues 1 to 529)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (residues 1 to 529)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022322.1, AY358164.1,
            KF457452.1 and AW007403.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 26, 2006 this sequence version replaced NP_079321.2.
            
            Summary: The protein encoded by this gene binds phosphoinositides
            and promotes the formation of planar or curved membrane structures.
            The encoded protein is found in RAB13-positive vesicles and at
            intercellular contacts with the plasma membrane. [provided by
            RefSeq, Dec 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358164.1, DRR138516.981299.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381669.8/ ENSP00000371085.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     Protein         1..529
                     /product="BAR/IMD domain-containing adapter protein 2-like
                     2"
                     /note="brain-specific angiogenesis inhibitor 1-associated
                     protein 2-like protein 2; BAI1-associated protein 2-like
                     protein 2; pinkbar; planar intestinal- and kidney-specific
                     BAR domain protein; BAI1 associated protein 2 like 2"
                     /calculated_mol_wt=58856
     Region          6..220
                     /region_name="I-BAR_IMD_BAIAP2L2"
                     /note="Inverse (I)-BAR, also known as the IRSp53/MIM
                     homology Domain (IMD), of Brain-specific Angiogenesis
                     Inhibitor 1-Associated Protein 2-Like 2; cd07644"
                     /db_xref="CDD:153328"
     Site            order(14..15,23,26..27,30,33..34,37,40..41,43..44,48,
                     50..51,54..55,57..58,61..62,71,75,82,85,174,177..178,
                     180..181,184..185,187..188,191..192,195,198..199,202,206,
                     209,216..217,219..220)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153328"
     Region          221..327
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXY1.1)"
     Site            231
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80Y61; propagated from
                     UniProtKB/Swiss-Prot (Q6UXY1.1)"
     Site            272
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80Y61; propagated from
                     UniProtKB/Swiss-Prot (Q6UXY1.1)"
     Site            302
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80Y61; propagated from
                     UniProtKB/Swiss-Prot (Q6UXY1.1)"
     Region          331..385
                     /region_name="SH3_BAIAP2L2"
                     /note="Src Homology 3 domain of Brain-specific
                     Angiogenesis Inhibitor 1-Associated Protein 2-Like 2;
                     cd11914"
                     /db_xref="CDD:212847"
     Site            order(332..333,335,342..343,355..356,361..363,365,
                     375..376,378..381)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212847"
     Region          403..510
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXY1.1)"
     Site            478
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80Y61; propagated from
                     UniProtKB/Swiss-Prot (Q6UXY1.1)"
     Site            481
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80Y61; propagated from
                     UniProtKB/Swiss-Prot (Q6UXY1.1)"
     Region          <513..528
                     /region_name="WH2"
                     /note="Wiskott-Aldrich Syndrome Homology (WASP) region 2
                     (WH2 motif), and similar proteins; cl41728"
                     /db_xref="CDD:425359"
     CDS             1..529
                     /gene="BAIAP2L2"
                     /coded_by="NM_025045.6:160..1749"
                     /db_xref="CCDS:CCDS43018.1"
                     /db_xref="GeneID:80115"
                     /db_xref="HGNC:HGNC:26203"
                     /db_xref="MIM:617536"
ORIGIN      
        1 mapemdqfyr stmaiyksim eqfnpalenl vylgnnylra fhalseaaev yfsaiqkige
       61 ralqsptsqi lgeilvqmsd tqrhlnsdle vvvqtfhggl lqhmekntkl dmqfikdsrq
      121 hyeleyrhra anlekcmsel wrmerkrdkn vremkesvnr lhaqmqafvs esqraaelee
      181 krryrflaek hlllsntflq ffgrargmlq nrvllwkeqs easrspsrah spgllgpalg
      241 ppypsgrltp tcldmpprpl gefssprsrh gsgsygtepd arpasqlepd rrslprtpsa
      301 sslysgsaqs srsnsfgerp gggggarrvr alvshsegan htllrfsagd vvevlvpeaq
      361 ngwlygkleg ssasgwfpea yvkaleegpv npmtpvtpmt smtsmspmtp mnpgnelpsr
      421 syplrgshsl ddlldrpgns iapseywdgq srsrtpsrvp srapspappp lpssrrssmg
      481 stavatdvkk lmsseqyppq elfprgtnpf atvklrptit ndrsaplir
//
