LOCUS       NM_018842               3645 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens BAR/IMD domain containing adaptor protein 2 like 1
            (BAIAP2L1), mRNA.
ACCESSION   NM_018842
VERSION     NM_018842.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3645)
  AUTHORS   Xie,J., Lu,Z.N., Bai,S.H., Cui,X.F., Lian,H.Y., Xie,C.Y., Wang,N.,
            Wang,L. and Han,Z.G.
  TITLE     Heterochromatin formation and remodeling by IRTKS condensates
            counteract cellular senescence
  JOURNAL   EMBO J 43 (20), 4542-4577 (2024)
   PUBMED   39192031
  REMARK    GeneRIF: Heterochromatin formation and remodeling by IRTKS
            condensates counteract cellular senescence.
REFERENCE   2  (bases 1 to 3645)
  AUTHORS   Zhang,Y., Yi,F., Zhang,X., Song,J., Cai,J., Lai,J. and Song,F.
  TITLE     IRTKS contributes to the malignant progression of cervical cancer
            cells
  JOURNAL   Med Oncol 41 (7), 174 (2024)
   PUBMED   38869721
  REMARK    GeneRIF: IRTKS contributes to the malignant progression of cervical
            cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3645)
  AUTHORS   Deng,N., Zhang,X. and Zhang,Y.
  TITLE     BAIAP2L1 accelerates breast cancer progression and chemoresistance
            by activating AKT signaling through binding with ribosomal protein
            L3
  JOURNAL   Cancer Sci 114 (3), 764-780 (2023)
   PUBMED   36308067
  REMARK    GeneRIF: BAIAP2L1 accelerates breast cancer progression and
            chemoresistance by activating AKT signaling through binding with
            ribosomal protein L3.
REFERENCE   4  (bases 1 to 3645)
  AUTHORS   Lu,Y., Zhou,X.Y., Zhou,C.L., Liu,J., Yong,T., Fan,Y. and Wang,C.
  TITLE     Insulin receptor tyrosine kinase substrate (IRTKS) promotes the
            tumorigenesis of pancreatic cancer via PI3K/AKT signaling
  JOURNAL   Hum Cell 35 (6), 1885-1899 (2022)
   PUBMED   36057038
  REMARK    GeneRIF: Insulin receptor tyrosine kinase substrate (IRTKS)
            promotes the tumorigenesis of pancreatic cancer via PI3K/AKT
            signaling.
REFERENCE   5  (bases 1 to 3645)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3645)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 3645)
  AUTHORS   Scita,G., Confalonieri,S., Lappalainen,P. and Suetsugu,S.
  TITLE     IRSp53: crossing the road of membrane and actin dynamics in the
            formation of membrane protrusions
  JOURNAL   Trends Cell Biol 18 (2), 52-60 (2008)
   PUBMED   18215522
  REMARK    Review article
REFERENCE   8  (bases 1 to 3645)
  AUTHORS   Galligan,C.L., Baig,E., Bykerk,V., Keystone,E.C. and Fish,E.N.
  TITLE     Distinctive gene expression signatures in rheumatoid arthritis
            synovial tissue fibroblast cells: correlates with disease activity
  JOURNAL   Genes Immun 8 (6), 480-491 (2007)
   PUBMED   17568789
REFERENCE   9  (bases 1 to 3645)
  AUTHORS   Millard,T.H., Dawson,J. and Machesky,L.M.
  TITLE     Characterisation of IRTKS, a novel IRSp53/MIM family actin
            regulator with distinct filament bundling properties
  JOURNAL   J Cell Sci 120 (Pt 9), 1663-1672 (2007)
   PUBMED   17430976
  REMARK    GeneRIF: Study characterised IRTKS, which has widespread tissue
            distribution, is a substrate for the insulin receptor and binds
            Rac, and expression of IRTKS induces clusters of short actin
            bundles rather than filopodia-like protrusions.
REFERENCE   10 (bases 1 to 3645)
  AUTHORS   Yamagishi,A., Masuda,M., Ohki,T., Onishi,H. and Mochizuki,N.
  TITLE     A novel actin bundling/filopodium-forming domain conserved in
            insulin receptor tyrosine kinase substrate p53 and missing in
            metastasis protein
  JOURNAL   J Biol Chem 279 (15), 14929-14936 (2004)
   PUBMED   14752106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI560834.1, DA442866.1,
            BC013888.2, AK074419.1 and BM977002.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018842.4.
            
            Summary: This gene encodes a member of the IMD (IRSp53/MIM homology
            domain) family. Members of this family can be subdivided in two
            groups, the IRSp53-like and MIM-like, based on the presence or
            absence of the SH3 (Src homology 3) domain. The protein encoded by
            this gene contains a conserved IMD, also known as F-actin bundling
            domain, at the N-terminus, and a canonical SH3 domain near the
            C-terminus, so it belongs to the IRSp53-like group. This protein is
            the substrate for insulin receptor tyrosine kinase and binds to the
            small GTPase Rac. It is involved in signal transduction pathways
            that link deformation of the plasma membrane and remodeling of the
            actin cytoskeleton. It also promotes actin assembly and membrane
            protrusions when overexpressed in mammalian cells, and is essential
            to the formation of a potent actin assembly complex during EHEC
            (Enterohemorrhagic Escherichia coli) pedestal formation. [provided
            by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.72776.1, AF119666.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000005260.9/ ENSP00000005260.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BI560834.1         31-55
            26-54               DA442866.1         39-67
            55-2052             BC013888.2         33-2030
            2053-3249           AK074419.1         672-1868
            3250-3645           BM977002.1         13-408              c
FEATURES             Location/Qualifiers
     source          1..3645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3-q22.1"
     gene            1..3645
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /note="BAR/IMD domain containing adaptor protein 2 like 1"
                     /db_xref="GeneID:55971"
                     /db_xref="HGNC:HGNC:21649"
                     /db_xref="MIM:611877"
     exon            1..289
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1774
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /note="insulin receptor tyrosine kinase substrate;
                     brain-specific angiogenesis inhibitor 1-associated protein
                     2-like protein 1; BAI1-associated protein 2-like protein
                     1; BAI1 associated protein 2 like 1"
                     /codon_start=1
                     /product="BAR/IMD domain-containing adapter protein 2-like
                     1"
                     /protein_id="NP_061330.2"
                     /db_xref="CCDS:CCDS34687.1"
                     /db_xref="GeneID:55971"
                     /db_xref="HGNC:HGNC:21649"
                     /db_xref="MIM:611877"
                     /translation="MSRGPEEVNRLTESTYRNVMEQFNPGLRNLINLGKNYEKAVNAM
                     ILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIH
                     ELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKE
                     IEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELL
                     NSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDT
                     LSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPSLQRSVSVAT
                     GLNMMKKQKVKTIFPHTAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWF
                     PSSYTKLLEENETEAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYLECLSMGAAAD
                     RRADSARTTSTFKAPASKPETAAPNDANGTAKPPFLSGENPFATVKLRPTVTNDRSAP
                     IIR"
     exon            290..365
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            366..452
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            453..514
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            515..586
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            587..724
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            725..877
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1045
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1193
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1401
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1479
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1660
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1698
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..3645
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2030..2035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /note="hexamer: AGTAAA"
     polyA_site      2052
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
     regulatory      3624..3629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /note="hexamer: AATAAA"
     polyA_site      3645
                     /gene="BAIAP2L1"
                     /gene_synonym="IRTKS"
                     /note="major polyA site"
ORIGIN      
        1 ctctggcggc gtccggccgc ttctcctctg ctcctcgaag aaggccaggg cggcgctgcc
       61 gcaagttttg acattttcgc agcggagacg cgcgcgggca ctctcgggcc gacggctgcg
      121 gcggcggccg accctccaga gccccttagt cgcgccccgg ccctcccgct gcccggagtc
      181 cggcggccac gaggcccagc cgcgtcctcc cgcgcttgct cgcccggcgg ccgcagccat
      241 gtcccggggg cccgaggagg tgaaccggct cacggagagc acctaccgga atgttatgga
      301 acagttcaat cctgggctgc gaaatttaat aaacctgggg aaaaattatg agaaagctgt
      361 aaacgctatg atcctggcag gaaaagccta ctacgatgga gtggccaaga tcggtgagat
      421 tgccactggg tcccccgtgt caactgaact gggacatgtc ctcatagaga tttcaagtac
      481 ccacaagaaa ctcaacgaga gtcttgatga aaattttaaa aaattccaca aagagattat
      541 ccatgagctg gagaagaaga tagaacttga cgtgaaatat atgaacgcaa ctctaaaaag
      601 ataccaaaca gaacacaaga ataaattaga gtctttggag aaatcccaag ctgagttgaa
      661 gaagatcaga aggaaaagcc aaggaagccg aaacgcactc aaatatgaac acaaagaaat
      721 tgagtatgtg gagaccgtta cttctcgtca gagtgaaatc cagaaattca ttgcagatgg
      781 ttgcaaagag gctctgcttg aagagaagag gcgcttctgc tttctggttg ataagcactg
      841 tggctttgca aaccacatac attattatca cttacagtct gcagaactac tgaattccaa
      901 gctgcctcgg tggcaggaga cctgtgttga tgccatcaaa gtgccagaga aaatcatgaa
      961 tatgatcgaa gaaataaaga ccccagcctc tacccccgtg tctggaactc ctcaggcttc
     1021 acccatgatc gagagaagca atgtggttag gaaagattac gacacccttt ctaaatgctc
     1081 accaaagatg ccccccgctc cttcaggcag agcatatacc agtcccttga tcgatatgtt
     1141 taataaccca gccacggctg ccccgaattc acaaagggta aataattcaa caggtacttc
     1201 cgaagatccc agtttacagc gatcagtttc ggttgcaacg ggactgaaca tgatgaagaa
     1261 gcagaaagtg aagaccatct tcccgcacac tgcgggctcc aacaagacct tactcagctt
     1321 tgcacaggga gatgtcatca cgctgctcat ccccgaggag aaggatggct ggctctatgg
     1381 agaacacgac gtgtccaagg cgaggggttg gttcccgtcg tcgtacacga agttgctgga
     1441 agaaaatgag acagaagcag tgaccgtgcc cacgccaagc cccacaccag tgagaagcat
     1501 cagcaccgtg aacttgtctg agaatagcag tgttgtcatc cccccacccg actacttgga
     1561 atgcttgtcc atgggggcag ctgccgacag gagagcagat tcggccagga cgacatccac
     1621 ctttaaggcc ccagcgtcca agcccgagac cgcggctcct aacgatgcca acgggactgc
     1681 aaagccgcct tttctcagcg gagaaaaccc ctttgccact gtgaaactcc gcccgactgt
     1741 gacgaatgat cgctcggcac ccatcattcg atgagaggac agccaaggac tctcccgggc
     1801 ctctccggtt ctcccttgcg gaatgatggg cgcatcctgt ctgccacgtg ctgacggtcg
     1861 ggaagcttca gtggagaggc ctaactctaa tgtcgcctgc ttaagcaaat catgcttctc
     1921 tgtttcacgt agttgggttg acaagtttct gcctttaaga taaatgagta atagtctaat
     1981 gaccagctca gccatttaaa atattttctt cctattctgt tcaagaaaca gtaaacttgg
     2041 tttcaatctt tactgtattt tttaaatgaa ttttttcctt aataacagcc agaataaggg
     2101 atagtctatg ctttcaggac tggctttctg cacctgatat gaatgagacc agttttattt
     2161 tataaagcat gtgctcttaa tagcattatg tctaaagaag atatcacgta agtttgcatc
     2221 ttagcatgca aatcataatt ttaagcaata taaattatga aaatactata taaatgtaat
     2281 ttaacttaaa atgtttaagt gtagagcttc cagagatgga gaaaccccca ccctccctcc
     2341 aaccacgcca gagctgtaga gtgctaagac gctttgcctg cccttatcac agccacacgt
     2401 agcactcgac gaaatctcct ccgagagctc cttttcttgg tagttaggag tcgccaacgg
     2461 attcgctgca cacggcccat ccaggacaca ggcctgggcg tcggagtcac ggctccttgt
     2521 gttctcactc agctagttgg ccaaagctgc atccattacc agtacactca aactgctcgg
     2581 ggtcctggtt tctccgtgtt tgaatcaggt acagactctc aaaggatacg tgtaaagcca
     2641 ggatgacctc tggtgcctgg agaagggcgg gtttttcagc ctagcagcca tgatgccctc
     2701 ggaacctggc cctatggtat ggatgtgagg actacgcact ggctgccctg agcccggggc
     2761 tggaaatcat ctttggctgc caaggatctg gacctatttt ggagtggaga gtcatggtta
     2821 aaattcccag cccggcccag gtacgggaat cccagcattt tgtgaggccg aggcaggggg
     2881 atcacctgag gtcaggagtc tctactaaaa atacaaaaat tagacaggtg tggtggtggg
     2941 cgccactcag gaggctgagg caggagaatc acttgaaccc gggaggcaga ggttgcagtg
     3001 agccagatca tgctgctgca ctccagcccg gccgctcacc gtgtgtgttg ctgggtgctg
     3061 gggctgtgac ttatcccctc tcctttagcc ttgccataag tgtagtatcc tatgaggctg
     3121 agattgggaa aggttacatg caggtaagcc agtggacgtg gccgatgctt caggctcctt
     3181 ccagccaggt ccagcagtgt taccatctgc ttctcctggg aggacaaacc aggcaccccc
     3241 accatgaagg ggctgcaggc accatgaact atgttaacaa ccccagtctg tactacagaa
     3301 agggctgcag ccacatgaga attcagtcca cacaagcccc atggccgtgt tccccacttc
     3361 agccacaggg ctcagggagc cccatctggc gctaagggga actgctgggg tgtgggtgac
     3421 acctggcctt tggcgttctg ccttggggag gtttctggtt ttgttacggg gtggaagaat
     3481 aggacctggg ggtctcggat gcaacctgca gaccccgtgg ctcacccaac cccaggttct
     3541 gcctcccaga ccagaacggg catggcctgg tccttggcac cgaggtgcct gctctgtaaa
     3601 tatcaaggga ttacaacttt aataataaag cagaacttga aaaca
//
