LOCUS       NM_001144888            3304 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens BAR/IMD domain containing adaptor protein 2 (BAIAP2),
            transcript variant 4, mRNA.
ACCESSION   NM_001144888
VERSION     NM_001144888.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3304)
  AUTHORS   Picas,L., Andre-Arpin,C., Comunale,F., Bousquet,H., Tsai,F.C.,
            Rico,F., Maiuri,P., Pernier,J., Bodin,S., Nicot,A.S., Laporte,J.,
            Bassereau,P., Goud,B., Gauthier-Rouviere,C. and Miserey,S.
  TITLE     BIN1 regulates actin-membrane interactions during IRSp53-dependent
            filopodia formation
  JOURNAL   Commun Biol 7 (1), 549 (2024)
   PUBMED   38724689
  REMARK    GeneRIF: BIN1 regulates actin-membrane interactions during
            IRSp53-dependent filopodia formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3304)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 3304)
  AUTHORS   Mukherjee,A., Ron,J.E., Hu,H.T., Nishimura,T., Hanawa-Suetsugu,K.,
            Behkam,B., Mimori-Kiyosue,Y., Gov,N.S., Suetsugu,S. and Nain,A.S.
  TITLE     Actin Filaments Couple the Protrusive Tips to the Nucleus through
            the I-BAR Domain Protein IRSp53 during the Migration of Cells on 1D
            Fibers
  JOURNAL   Adv Sci (Weinh) 10 (7), e2207368 (2023)
   PUBMED   36698307
  REMARK    GeneRIF: Actin Filaments Couple the Protrusive Tips to the Nucleus
            through the I-BAR Domain Protein IRSp53 during the Migration of
            Cells on 1D Fibers.
REFERENCE   4  (bases 1 to 3304)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   5  (bases 1 to 3304)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3304)
  AUTHORS   Miyahara,A., Okamura-Oho,Y., Miyashita,T., Hoshika,A. and Yamada,M.
  TITLE     Genomic structure and alternative splicing of the insulin receptor
            tyrosine kinase substrate of 53-kDa protein
  JOURNAL   J Hum Genet 48 (8), 410-414 (2003)
   PUBMED   12884081
REFERENCE   7  (bases 1 to 3304)
  AUTHORS   Fujiwara,T., Mammoto,A., Kim,Y. and Takai,Y.
  TITLE     Rho small G-protein-dependent binding of mDia to an Src homology 3
            domain-containing IRSp53/BAIAP2
  JOURNAL   Biochem Biophys Res Commun 271 (3), 626-629 (2000)
   PUBMED   10814512
REFERENCE   8  (bases 1 to 3304)
  AUTHORS   Abbott,M.A., Wells,D.G. and Fallon,J.R.
  TITLE     The insulin receptor tyrosine kinase substrate p58/53 and the
            insulin receptor are components of CNS synapses
  JOURNAL   J Neurosci 19 (17), 7300-7308 (1999)
   PUBMED   10460236
REFERENCE   9  (bases 1 to 3304)
  AUTHORS   Okamura-Oho,Y., Miyashita,T., Ohmi,K. and Yamada,M.
  TITLE     Dentatorubral-pallidoluysian atrophy protein interacts through a
            proline-rich region near polyglutamine with the SH3 domain of an
            insulin receptor tyrosine kinase substrate
  JOURNAL   Hum Mol Genet 8 (6), 947-957 (1999)
   PUBMED   10332026
REFERENCE   10 (bases 1 to 3304)
  AUTHORS   Oda,K., Shiratsuchi,T., Nishimori,H., Inazawa,J., Yoshikawa,H.,
            Taketani,Y., Nakamura,Y. and Tokino,T.
  TITLE     Identification of BAIAP2 (BAI-associated protein 2), a novel human
            homologue of hamster IRSp53, whose SH3 domain interacts with the
            cytoplasmic domain of BAI1
  JOURNAL   Cytogenet Cell Genet 84 (1-2), 75-82 (1999)
   PUBMED   10343108
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB153324.1, BC002495.2 and
            AC115099.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001144888.1.
            
            Summary: The protein encoded by this gene has been identified as a
            brain-specific angiogenesis inhibitor (BAI1)-binding protein. This
            adaptor protein links membrane bound G-proteins to cytoplasmic
            effector proteins. This protein functions as an insulin receptor
            tyrosine kinase substrate and suggests a role for insulin in the
            central nervous system. It also associates with a downstream
            effector of Rho small G proteins, which is associated with the
            formation of stress fibers and cytokinesis. This protein is
            involved in lamellipodia and filopodia formation in motile cells
            and may affect neuronal growth-cone guidance. This protein has also
            been identified as interacting with the
            dentatorubral-pallidoluysian atrophy gene, which is associated with
            an autosomal dominant neurodegenerative disease. Alternative
            splicing results in multiple transcript variants encoding distinct
            isoforms.[provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (4) shares identical sequence with
            variants 1, 2 and 3, but diverges after amino acid 511 resulting in
            a distinct 23 amino acid sequence at the C-terminus. This
            transcript variant encodes isoform 4 and is alternatively referred
            to as variant M.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225612.1, SRR7410570.636458.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428708.7/ ENSP00000401022.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CB153324.1         30-50
            22-2095             BC002495.2         1-2074
            2096-3304           AC115099.6         103600-104808
FEATURES             Location/Qualifiers
     source          1..3304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3304
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /note="BAR/IMD domain containing adaptor protein 2"
                     /db_xref="GeneID:10458"
                     /db_xref="HGNC:HGNC:947"
                     /db_xref="MIM:605475"
     exon            1..158
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1709
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /note="isoform 4 is encoded by transcript variant 4;
                     brain-specific angiogenesis inhibitor 1-associated protein
                     2; insulin receptor substrate p53/p58; fas
                     ligand-associated factor 3; WASP and MIM like; IRS-58;
                     IRSp53/58; BAR/IMD domain-containing adapter protein 2;
                     insulin receptor substrate protein of 53 kDa; insulin
                     receptor substrate of 53 kDa; BAI1 associated protein 2"
                     /codon_start=1
                     /product="BAR/IMD domain-containing adapter protein 2
                     isoform 4"
                     /protein_id="NP_001138360.1"
                     /db_xref="CCDS:CCDS45806.1"
                     /db_xref="GeneID:10458"
                     /db_xref="HGNC:HGNC:947"
                     /db_xref="MIM:605475"
                     /translation="MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAG
                     VTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELL
                     TQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDK
                     ELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKEL
                     LAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVISDPIPGAKP
                     LPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLS
                     DSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNST
                     LLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQG
                     KSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGAR
                     SMSRNPFAHVQLKPTVTNDRSAPLLS"
     exon            159..234
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            235..321
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            322..383
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            384..455
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            456..593
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            594..746
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            747..968
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1170
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1372
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1441
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1604
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1639
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..3304
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2075..2080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /note="hexamer: AATAAA"
     polyA_site      2095
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /note="major polyA site"
     regulatory      3274..3279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
                     /note="hexamer: AATAAA"
     polyA_site      3304
                     /gene="BAIAP2"
                     /gene_synonym="BAP2; FLAF3; IRSP53; WAML"
ORIGIN      
        1 gtggttcggg tccgctttcg tctccgtcct gctgccgtta ccgccgctgc tgccgccgct
       61 tgcgtccccc gctccggtct gtggtgcagc cgggacccag gaccatgtct ctgtctcgct
      121 cagaggagat gcaccggctc acggaaaatg tctataagac catcatggag cagttcaacc
      181 ctagcctccg gaacttcatc gccatgggga agaattacga gaaggcactg gcaggtgtga
      241 cgtatgcagc caaaggctac tttgacgccc tggtgaagat gggggagctg gccagcgaga
      301 gccagggctc caaagaactc ggagacgttc tcttccagat ggctgaagtc cacaggcaga
      361 tccagaatca gctggaagaa atgctgaagt cttttcacaa cgagctgctt acgcagctgg
      421 agcagaaggt ggagctggac tccaggtatc tgagtgctgc gctgaagaaa taccagactg
      481 agcaaaggag caaaggcgac gccctggaca agtgtcaggc tgagctgaag aagcttcgga
      541 agaagagcca gggcagcaag aatcctcaga agtactcgga caaggagctg cagtacatcg
      601 acgccatcag caacaagcag ggcgagctgg agaattacgt gtccgacggc tacaagaccg
      661 cactgacaga ggagcgcagg cgcttctgct tcctggtgga gaagcagtgc gccgtggcca
      721 agaactccgc ggcctaccac tccaagggca aggagctgct ggcgcagaag ctgccgctgt
      781 ggcaacaggc ctgtgccgac cccagcaaga tcccggagcg cgcggtgcag ctcatgcagc
      841 aggtggccag caacggcgcc accctcccca gcgccctgtc ggcctccaag tccaacctgg
      901 tcatttccga ccccattccg ggggccaagc ccctgccggt gccccccgag ctggcaccgt
      961 tcgtggggcg gatgtctgcc caggagagca cacccatcat gaacggcgtc acaggcccgg
     1021 atggcgagga ctacagcccg tgggctgacc gcaaggctgc ccagcccaaa tccctgtctc
     1081 ctccgcagtc tcagagcaag ctcagcgact cctactccaa cacactcccc gtgcgcaaga
     1141 gcgtgacccc aaaaaacagc tatgccacca ccgagaacaa gactctgcct cgctcgagct
     1201 ccatggcagc cggcctggag cgcaatggcc gtatgcgggt gaaggccatc ttctcccacg
     1261 ctgctgggga caacagcacc ctcctgagct tcaaggaggg tgacctcatt accctgctgg
     1321 tgcctgaggc ccgcgatggc tggcactacg gagagagtga gaagaccaag atgcggggct
     1381 ggtttccctt ctcctacacc cgggtcttgg acagcgatgg cagtgacagg ctgcacatga
     1441 gcctgcagca agggaagagc agcagcacgg gcaacctcct ggacaaggac gacctggcca
     1501 tcccaccccc cgattacggc gccgcctccc gggccttccc cgcccagacg gccagcggct
     1561 tcaagcagag gccctacagt gtggccgtgc ccgccttctc ccagggcctg gatgactatg
     1621 gagcgcggtc catgagcagg aatccctttg cccacgtcca gctgaagccg acagtgacca
     1681 acgacaggtc tgcccccctc ctcagctgat ggccacatct gcagtgctgc ccatctggtg
     1741 gcttcccccg cccttcccat gtagcctgtt ctgtcatcat ctgtgcgttc ctgtgtagag
     1801 aacatccagg ccccggctgc ctggtcttgc cccacttgag tctggcctgg actggatccc
     1861 agctgttcta ggcagggccg ggcagagtgg ggcgcaggcc cctgaagggc gagacccagt
     1921 ggctgggctg cccagggctg aggggccgcc tcttgagggt acacgcctct ggtcacatgg
     1981 ccatggagcc ttgggtaccc ctgagttaag ggaggacatt tggccagctg gtggctggga
     2041 ggggagcctg gctgccctgc tgcttctcct gcctaataaa caggcttctc ctgcaccagg
     2101 tgtgatctgt ccgcccaagg gccagaaggc cgggagcacg gggatgggag cgcccgcacc
     2161 ctggctggaa gatgaacttc ccgtaagcac gtaattccct gcaggtccgg cagctacacc
     2221 tggagtgtgg ggcctggtcc ctccccatgc ccctcggtgg ggctctcctg ggcccctcac
     2281 tcccactggc aatgtcacaa gggcctcccc aggcccctcc tgcctcgggc aggccccagc
     2341 cctcctcctt acccaacctc ccatccagaa ccttgctgcc agggcctccc agctcgctcc
     2401 tgcggccaaa ggccagctgt caggtgctat gcggggtcac cagcagagtg cccgctggca
     2461 ggtgggggct tccccgcttc cggggtctgc cccaggactc ctgggtggac ctcccccccc
     2521 cacctccgct gactcctgca ggcactgggg agctctgctg gaattggggg ttttaaaact
     2581 tcattagcag atttgtgctc ttccatactg tttgtttgtt tgttaggtga aatacagtgt
     2641 ggtgagctgc actggtgaca acagccctta cctggctggg gaggtgtctc cagcagagct
     2701 cactcccgcc tacagccact cacaccccgg ggacaggaag ctgtagagtt ggcgggccag
     2761 gagggcagtt gagagctggc cagcggaggg tgcagggaag cccagctgtg ctcaactctc
     2821 ctgcctccgc cttccaccct gggcccaggg acagacagac attgccctca gaagggcagg
     2881 gaggaggctg tcctggagag gcctgtaggt ccattcttca cccgtcccta ccaggccaac
     2941 tcggcctgca ggaagggaga cctgcagggc gctacccctg cgcccccaca cacagtaggg
     3001 ccagaacacc atcccctcca ccggggtgtg ccgaggacag tggggaggag aggagagggg
     3061 cagcttcctc ctggccccag gaagggctgg catcgggttc ctggcacagc ccctcctgtc
     3121 caggacttta tcatcggcag acctcagaag acaacacaca aaggtttctt ttgtcttagc
     3181 ttcatttctc ttaaaaaaca aggaacaaga aaacattgca ccagcgttct aagcctcaaa
     3241 caaaacacaa aacaaatccc cctgcgaagc aacaataaac tttacatctc tttggcaaca
     3301 ataa
//
