LOCUS       NM_014952               4779 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens bromo adjacent homology domain containing 1 (BAHD1),
            transcript variant 1, mRNA.
ACCESSION   NM_014952
VERSION     NM_014952.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4779)
  AUTHORS   Yang,Z.Y., Yin,S.P., Ren,Q., Lu,D.W., Tang,T., Li,Y., Sun,Y.Z.,
            Mo,H.B., Yin,T.J., Yi,Z.Y., Zhu,J.P., Zhang,F. and Chen,H.
  TITLE     BAHD1 serves as a critical regulator of breast cancer cell
            proliferation and invasion
  JOURNAL   Breast Cancer 29 (3), 516-530 (2022)
   PUBMED   35048286
  REMARK    GeneRIF: BAHD1 serves as a critical regulator of breast cancer cell
            proliferation and invasion.
            Erratum:[Breast Cancer. 2022 Nov;29(6):1140. doi:
            10.1007/s12282-022-01402-9.. PMID: 36112339]
REFERENCE   2  (bases 1 to 4779)
  AUTHORS   Fan,H., Guo,Y., Tsai,Y.H., Storey,A.J., Kim,A., Gong,W.,
            Edmondson,R.D., Mackintosh,S.G., Li,H., Byrum,S.D., Tackett,A.J.,
            Cai,L. and Wang,G.G.
  TITLE     A conserved BAH module within mammalian BAHD1 connects H3K27me3 to
            Polycomb gene silencing
  JOURNAL   Nucleic Acids Res 49 (8), 4441-4455 (2021)
   PUBMED   33823544
  REMARK    GeneRIF: A conserved BAH module within mammalian BAHD1 connects
            H3K27me3 to Polycomb gene silencing.
REFERENCE   3  (bases 1 to 4779)
  AUTHORS   Xu,P., Scott,D.C., Xu,B., Yao,Y., Feng,R., Cheng,L., Mayberry,K.,
            Wang,Y.D., Bi,W., Palmer,L.E., King,M.T., Wang,H., Li,Y., Fan,Y.,
            Alpi,A.F., Li,C., Peng,J., Papizan,J., Pruett-Miller,S.M.,
            Spallek,R., Bassermann,F., Cheng,Y., Schulman,B.A. and Weiss,M.J.
  TITLE     FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent
            transcriptional repression in erythropoiesis
  JOURNAL   Blood 137 (2), 155-167 (2021)
   PUBMED   33156908
  REMARK    GeneRIF: FBXO11-mediated proteolysis of BAHD1 relieves
            PRC2-dependent transcriptional repression in erythropoiesis.
REFERENCE   4  (bases 1 to 4779)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4779)
  AUTHORS   Pourpre,R., Naudon,L., Meziane,H., Lakisic,G., Jouneau,L.,
            Varet,H., Legendre,R., Wendling,O., Selloum,M., Proux,C.,
            Coppee,J.Y., Herault,Y. and Bierne,H.
  TITLE     BAHD1 haploinsufficiency results in anxiety-like phenotypes in male
            mice
  JOURNAL   PLoS One 15 (5), e0232789 (2020)
   PUBMED   32407325
  REMARK    GeneRIF: The effect of partial BAHD1 deficiency on behavior was
            then evaluated on Bahd1 heterozygous male mice, which have no
            lethal or metabolic phenotypes. Bahd1+/- mice showed anxiety-like
            behavior and reduced prepulse inhibition (PPI) of the startle
            response.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4779)
  AUTHORS   Zhu,H., Wan,X., Li,J., Han,L., Bo,X., Chen,W., Lu,C., Shen,Z.,
            Xu,C., Chen,L., Yu,C. and Xu,G.
  TITLE     Computational Prediction and Validation of BAHD1 as a Novel
            Molecule for Ulcerative Colitis
  JOURNAL   Sci Rep 5, 12227 (2015)
   PUBMED   26183847
  REMARK    GeneRIF: computational approaches leveraging public gene expression
            data can be used to infer potential genes or proteins for diseases,
            and BAHD1 might act as an indispensable factor in regulating the
            cellular inflammatory response in UC.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4779)
  AUTHORS   Lebreton,A., Job,V., Ragon,M., Le Monnier,A., Dessen,A., Cossart,P.
            and Bierne,H.
  TITLE     Structural basis for the inhibition of the chromatin repressor
            BAHD1 by the bacterial nucleomodulin LntA
  JOURNAL   mBio 5 (1), e00775-e00713 (2014)
   PUBMED   24449750
  REMARK    GeneRIF: Authors identified a dilysine motif (K180/K181) in the
            elbow region of Listeria monocytogenes LntA and a central
            proline-rich region in human BAHD1 as crucial for the direct
            LntA-BAHD1 interaction.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4779)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   9  (bases 1 to 4779)
  AUTHORS   Lebreton,A., Lakisic,G., Job,V., Fritsch,L., Tham,T.N., Camejo,A.,
            Mattei,P.J., Regnault,B., Nahori,M.A., Cabanes,D., Gautreau,A.,
            Ait-Si-Ali,S., Dessen,A., Cossart,P. and Bierne,H.
  TITLE     A bacterial protein targets the BAHD1 chromatin complex to
            stimulate type III interferon response
  JOURNAL   Science 331 (6022), 1319-1321 (2011)
   PUBMED   21252314
  REMARK    GeneRIF: findings show a Listeria virulence factor, lmo0438/lntA,
            could target the chromatin repressor BAHD1 in host cell nucleus to
            activate interferon-stimulated genes; LntA-BAHD1 interplay may
            modulate IFN-lambda-mediated immune response to control host
            colonization
REFERENCE   10 (bases 1 to 4779)
  AUTHORS   Bierne,H., Tham,T.N., Batsche,E., Dumay,A., Leguillou,M.,
            Kerneis-Golsteyn,S., Regnault,B., Seeler,J.S., Muchardt,C.,
            Feunteun,J. and Cossart,P.
  TITLE     Human BAHD1 promotes heterochromatic gene silencing
  JOURNAL   Proc Natl Acad Sci U S A 106 (33), 13826-13831 (2009)
   PUBMED   19666599
  REMARK    GeneRIF: BAHD1 acts as a silencer by recruiting at specific
            promoters a set of proteins that coordinate heterochromatin
            assembly
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013356.8, HY041603.1, BC022782.2, AB023162.1 and BU740533.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014952.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022782.2, SRR9304715.349738.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000416165.6/ ENSP00000396976.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AC013356.8         126675-126872
            199-259             HY041603.1         4-64
            260-873             BC022782.2         1-614
            874-1221            AB023162.1         803-1150
            1222-1222           AC013356.8         145078-145078
            1223-4776           BC022782.2         964-4517
            4777-4779           BU740533.1         25-27               c
FEATURES             Location/Qualifiers
     source          1..4779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4779
                     /gene="BAHD1"
                     /note="bromo adjacent homology domain containing 1"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
     exon            1..316
                     /gene="BAHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..1762
                     /gene="BAHD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..2673
                     /gene="BAHD1"
                     /note="isoform a is encoded by transcript variant 1; bromo
                     adjacent homology domain-containing 1 protein; BAH
                     domain-containing protein 1"
                     /codon_start=1
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform a"
                     /protein_id="NP_055767.3"
                     /db_xref="CCDS:CCDS10058.1"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
                     /translation="MTHTRRKSLPMLSSGLTGRREPLQMEDSNMEQGVEGVEPGMPES
                     PGHLTGRRKNYPLRKRPLVPEKPKACKVLLTRLENVAGPRSADEADELPPDLPKPPSP
                     APSSEDPGLAQPRKRRLASLNAEALNNLLLEREDTSSLAGTRRSRAGDPHRSRDRDRA
                     TGGWSSSKKRPRLGDLGGGSRDLSPEPAPDEGPRRDGDPAPKRLASLNAAAFLKLSQE
                     RELPLRLPRAHAEVDGRSTEPPAPKAPRPKWPKVNGKNYPKAWQGASSGEAAGPPGWQ
                     GCPDEPWPSATPCGPSVQPSHQPLSKALESPLGLRPHLPLLMGGQAALKPEPGRPGEE
                     SPAPKQELHQPSFPTPQLSPLPMPGNPADYNGLCVGPELTALGSFYLYCGQEGLQCGG
                     YSPCPMLPEGKLSPVAAPHEEGLLLAPSSVPSGTPFQHPPWGSSRYCSSEDTGVNGYS
                     ICGVLPLSVTHAGTTCGGCPYKMPFAAEGCRSLGQLEFPLPEAGHPASPAHPLLGCPV
                     PSVPPAAEPVPHLQTPTSEPQTVARACPQSAKPPSGSKSGLRTGSSCRHTARSKAARR
                     PSHPKQPRVQRPRPRRRRRRRTNGWVPVGAACEKAVYVLDEPEPAIRKSYQAVERHGE
                     TIRVRDTVLLKSGPRKTSTPYVAKISALWENPESGELMMSLLWYYRPEHLQGGRSPSM
                     HEPLQNEVFASRHQDQNSVACIEEKCYVLTFAEYCRFCAMAKRRGEGLPSRKTALVPP
                     SADYSTPPHRTVPEDTDPELVFLCRHVYDFRHGRILKNPQ"
     exon            1763..2145
                     /gene="BAHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2305
                     /gene="BAHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2382
                     /gene="BAHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2483
                     /gene="BAHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..4779
                     /gene="BAHD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4744..4749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAHD1"
                     /note="hexamer: AATAAA"
     polyA_site      4779
                     /gene="BAHD1"
                     /note="major polyA site"
ORIGIN      
        1 gagtttgtgg gggaaccgcg agcggcgtag cggatcccgg agcccggccc ccgccgcccg
       61 cccgtccggc tgcctgcccc gcccgtccgg cccccgccgt ccgcccgccc cggccaggcg
      121 cgcccgcccc ccccgacggc cccgcccggc cgcggtcccc gctccgcccg cccggccccg
      181 gcccccagga ggaggcgctg acgcagcagc gtggagcccg ggaattgagc gcccccgggg
      241 ggttccagcc gccggattcc agcccggccg gggcctgcgg gcgcccagag ccgcgccgtc
      301 cgcgccgccc gttctggttg gaagtactcc atgacacaca ctcggagaaa gtcccttccc
      361 atgctgagtt cgggcctcac tggccgccga gagcccctgc agatggaaga cagcaacatg
      421 gagcaggggg ttgagggtgt ggagccaggc atgcccgaga gcccaggtca cctcacaggg
      481 cgccgcaaga attacccact tcgtaagcgc ccattggttc ctgagaagcc caaggcctgc
      541 aaagtgctgc tgactcgcct ggagaatgtg gccggtcccc ggagtgcaga tgaggctgat
      601 gagctaccgc ctgacctgcc caagcccccc agcccggccc catccagtga agaccctggc
      661 cttgcccagc cccgcaagcg gcgcctggcc tccctcaatg ctgaagctct caataacctg
      721 ctgctggagc gagaggacac cagcagcctg gcaggcaccc gccgcagtcg agcaggggat
      781 ccccaccgca gccgtgaccg tgatcgtgct actgggggct ggtcctcctc caagaagcgg
      841 ccccggctgg gggaccttgg aggaggaagt cgggacctgt ctccagagcc agcacccgat
      901 gaaggtcccc gccgagatgg agacccagct cccaagagac tggctagcct gaacgcagct
      961 gctttcctaa aactgagcca ggagcgggag ctacccctgc ggctgcctcg tgcccatgca
     1021 gaagtagatg ggcgctccac tgagccccca gcacccaagg ccccgaggcc aaagtggccc
     1081 aaggtcaatg gcaagaacta tcccaaggct tggcaggggg ccagctctgg ggaggctgca
     1141 ggcccacctg gctggcaagg ctgccctgat gaaccatggc catctgcaac tccttgtggg
     1201 ccatccgtcc agccatctca tcagcccctg agcaaggctc tggagagccc tttggggctg
     1261 cgccctcacc tgcccctgct gatgggtgga caggcggctc tgaagccgga gcctgggcgc
     1321 ccaggcgagg agtcacctgc ccctaagcag gaactgcatc agccctcttt ccccacacct
     1381 cagctgtcgc cgctgccgat gcctggcaac cccgccgact acaatggcct gtgtgttggg
     1441 cctgagctca ctgcactagg cagcttctac ctgtactgtg gccaagaggg gctgcagtgt
     1501 gggggctact cgccctgccc catgcttcct gagggcaagc tgtccccagt ggctgcacct
     1561 cacgaggagg ggctcctctt agctccgagc tcagtgccct caggcacccc tttccagcac
     1621 cctccctggg gctcctctcg ctactgctct agcgaggaca ctggagtgaa tggctacagc
     1681 atctgcggag tgttgcccct gtctgttacc cacgctggca ctacctgtgg cggctgccca
     1741 tacaaaatgc cttttgcagc agaaggctgc agatccctgg gccagttgga atttcctctc
     1801 ccggaagctg gccacccagc ctcacccgcc cacccactcc tggggtgccc tgtacccagt
     1861 gtgccacctg cagcagagcc cgtcccccat cttcagacac ccacctcgga gccccagaca
     1921 gtagcccgtg cgtgccctca gagcgccaaa cctcccagcg gttctaagtc aggtctgcgc
     1981 acaggctcca gctgcaggca cactgcaagg agcaaggctg cccgcaggcc tagccacccc
     2041 aagcagccac gtgtccagcg cccacgccct cgccgccgcc gtcgccgccg cactaatggc
     2101 tgggtacctg ttggggctgc gtgtgagaag gctgtgtatg tcttggatga gccggagcca
     2161 gccatccgaa agagctacca ggcggtagag cggcatgggg agacaatccg agtccgggac
     2221 accgtccttc tcaaatcagg cccacgaaag acctccacac cttatgtggc caagatctct
     2281 gccctctggg agaaccccga gtcaggagag ctgatgatga gcctcctgtg gtattacaga
     2341 cctgagcact tacagggagg ccgcagtccc agcatgcacg agcccttgca gaatgaagtg
     2401 tttgcatcgc gacatcagga ccagaacagt gtggcctgca ttgaggagaa gtgctatgtg
     2461 ctgacttttg ccgagtactg caggttctgt gccatggcca agcgccgagg tgaaggcctc
     2521 cccagccgaa agacagcact ggttcccccc tctgcagact attccacccc accccaccgc
     2581 acagtgccag aggacacgga ccctgagctg gtgttccttt gccgccatgt ctatgacttc
     2641 cgccacgggc gcatccttaa gaacccccag tagcctcctc atgcccatgc tggggctacc
     2701 catgggcaag tggggctcgg ggtagggggc actgcttgaa gcacagcact tggttagggg
     2761 gccacagagg cctaagtttg ctggcctgtg gttttcttgg gggggagggc aggggcccct
     2821 gtgggttctg ggctccaggg gagggagctg gggaggccag ggtataagaa aagcatcaga
     2881 actctcagct tggcccaagg taccttctgt ggttcccctg ggtggagatt tccgaaaagt
     2941 agtcttctct gaggctgggc caagcctgag ggaaatgggg ccctaggagg gtgggggcgg
     3001 gaaggagggg caaggtcttt caggaaccag acccaacagg cccttctgta gcctccccct
     3061 tgccctcaaa gggggagtgg gggccagctt tacctcaccc actgtgaccc gccgcttccc
     3121 cttcagcctg ggaccaggct ttcctagatc ccagcacagc tctgagcttg ttcctttgag
     3181 gcatagagag ccagagtctg gcttccagag cattgacttc ctcttcctag acttgaggcc
     3241 ttttctctgg ctttcctcct ttgccctgca gtagcaactg gtgctgggac aagttgaccc
     3301 acctctcaca gtcatgggtg tggcccactt gtgggagtct cctgtccacc tcccagagac
     3361 ggccacccag cgggtctggc ttcccagaaa gttaactgat gattgtgggg tttgtcatat
     3421 ctgggaggga agatgggtgc tgggagaggg ttgggggcag ggggcaagga aaattgctac
     3481 ctgatttgtt gaagattttt cctcttgcct tacacatgga ggttccagga aacctcttgc
     3541 agaacttcac acgtgattct tcaagccaca cccacctgaa atcaaaccaa aggagtgctg
     3601 tggctcccct tgccctgcca ccctttccct agtcttttgt agattgcact aatttacatc
     3661 ctagcaagaa tcaacactgt atcagtccac ggacctgctg agctgcagcc acttgctcta
     3721 ggagctaagg acttgcattt tcagtttgtt cctgttgccc agaggccctg ttctcacctc
     3781 atgctgctcc ccagagtaga ctaacaggct cagtcccctg ttgtccttgt ggagactagg
     3841 ccttggccct ggccctgaga ctctgtgagg gggctggagc agcctggtta tttcctatct
     3901 gtaccaaaga ggagtatggt gggagaggga gtggagtgca gtgtggcttg ggcctggtgc
     3961 tgggaacctg ctagctgagc acttccacaa gggcataccc ctgggggcag gggctggggc
     4021 tgagaactgc agccctgggt cttcccttag ggaggaaggg cagatgaacc cagcaggctt
     4081 aggaggtggc actgggtgag gacagctggg caggggctgc agagggaggt ggaaatgaac
     4141 cctgagggct cccccaactt gccatgccct gtcccttagt agatgagttg ctcctgattg
     4201 gtcattgggt ttgggtgagg cctggaggct tcagaggtga atttatgctt gggaagcctg
     4261 atcccaaacc tgaagggaag ggacttggat ctccttatat tgaataagct gtttggagga
     4321 aggtgtctgt ctgggaggat ggggcagtaa atgaggttgg cagagtggca gtgggggctc
     4381 tgcagagcca gccttggagc ctgctcattc tgggcccttg ctgccaagga gcccagcctc
     4441 acctagcagg aaaggagatg aaggccctcc tcccaggagg tagggtcttg gctgccccga
     4501 acttaaatgc ttttgaaatc tcttagatgt ggaaatattt tttcgaacct gaaaatgcag
     4561 ctggtagaat ttcaatggaa gcataatcca tgtaaaatat attttagttg atattttgta
     4621 aaatgcactt tttgtgtgtg ttgatcctgg tttcccagat ctgtatttca gtgtttacaa
     4681 gggaggaagg acctttcctc acctcccttt tgacagagat tagaagtact tctttaagaa
     4741 aaaaataaat ttgagaaatt gtattgattt agaaaagga
//
