LOCUS       NM_001015048            4684 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens BAG cochaperone 5 (BAG5), transcript variant 3, mRNA.
ACCESSION   NM_001015048
VERSION     NM_001015048.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4684)
  AUTHORS   Bracho-Valdes,I., Cervantes-Villagrana,R.D., Beltran-Navarro,Y.M.,
            Olguin-Olguin,A., Escobar-Islas,E., Carretero-Ortega,J.,
            Olivares-Reyes,J.A., Reyes-Cruz,G., Gutkind,J.S. and
            Vazquez-Prado,J.
  TITLE     Akt Is Controlled by Bag5 through a Monoubiquitination to
            Polyubiquitination Switch
  JOURNAL   Int J Mol Sci 24 (24), 17531 (2023)
   PUBMED   38139359
  REMARK    GeneRIF: Akt Is Controlled by Bag5 through a Monoubiquitination to
            Polyubiquitination Switch.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4684)
  AUTHORS   Hakui,H., Kioka,H., Miyashita,Y., Nishimura,S., Matsuoka,K.,
            Kato,H., Tsukamoto,O., Kuramoto,Y., Takuwa,A., Takahashi,Y.,
            Saito,S., Ohta,K., Asanuma,H., Fu,H.Y., Shinomiya,H., Yamada,N.,
            Ohtani,T., Sawa,Y., Kitakaze,M., Takashima,S., Sakata,Y. and
            Asano,Y.
  TITLE     Loss-of-function mutations in the co-chaperone protein BAG5 cause
            dilated cardiomyopathy requiring heart transplantation
  JOURNAL   Sci Transl Med 14 (628), eabf3274 (2022)
   PUBMED   35044787
REFERENCE   3  (bases 1 to 4684)
  AUTHORS   Wang,J.M., Gao,Q., Zhang,Q., Hao,L., Jiang,J.Y., Huyan,L.Y.,
            Liu,B.Q., Yan,J., Li,C. and Wang,H.Q.
  TITLE     Implication of BAG5 downregulation in metabolic reprogramming of
            cisplatin-resistant ovarian cancer cells via mTORC2 signaling
            pathway
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (9), 119076 (2021)
   PUBMED   34126157
  REMARK    GeneRIF: Implication of BAG5 downregulation in metabolic
            reprogramming of cisplatin-resistant ovarian cancer cells via
            mTORC2 signaling pathway.
REFERENCE   4  (bases 1 to 4684)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4684)
  AUTHORS   Yan,F., Fan,B., Wang,J., Wei,W., Tang,Q., Lu,L., Luo,Z., Pu,J. and
            Yang,S.S.
  TITLE     Circ_0008305-mediated miR-660/BAG5 axis contributes to
            hepatocellular carcinoma tumorigenesis
  JOURNAL   Cancer Med 10 (3), 833-842 (2021)
   PUBMED   33481351
  REMARK    GeneRIF: Circ_0008305-mediated miR-660/BAG5 axis contributes to
            hepatocellular carcinoma tumorigenesis.
REFERENCE   6  (bases 1 to 4684)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4684)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
  REMARK    GeneRIF: Bcl-2-associated athanogene 5 (BAG5) is a negative
            regulator of both Hsp70 and parkin function that sensitizes
            dopaminergic neurons to injury-induced death.
REFERENCE   8  (bases 1 to 4684)
  AUTHORS   Takayama,S., Xie,Z. and Reed,J.C.
  TITLE     An evolutionarily conserved family of Hsp70/Hsc70 molecular
            chaperone regulators
  JOURNAL   J Biol Chem 274 (2), 781-786 (1999)
   PUBMED   9873016
REFERENCE   9  (bases 1 to 4684)
  AUTHORS   Hohfeld,J. and Jentsch,S.
  TITLE     GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic
            protein BAG-1
  JOURNAL   EMBO J 16 (20), 6209-6216 (1997)
   PUBMED   9321400
  REMARK    Erratum:[EMBO J 1998 Feb 2;17(3):847]
REFERENCE   10 (bases 1 to 4684)
  AUTHORS   Takayama,S., Sato,T., Krajewski,S., Kochel,K., Irie,S., Millan,J.A.
            and Reed,J.C.
  TITLE     Cloning and functional analysis of BAG-1: a novel Bcl-2-binding
            protein with anti-cell death activity
  JOURNAL   Cell 80 (2), 279-284 (1995)
   PUBMED   7834747
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF941752.1, AL139300.6 and
            CA424706.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001015048.2.
            
            Summary: The protein encoded by this gene is a member of the
            BAG1-related protein family. BAG1 is an anti-apoptotic protein that
            functions through interactions with a variety of cell apoptosis and
            growth related proteins including BCL-2, Raf-protein kinase,
            steroid hormone receptors, growth factor receptors and members of
            the heat shock protein 70 kDa family. This protein contains a BAG
            domain near the C-terminus, which could bind and inhibit the
            chaperone activity of Hsc70/Hsp70. Three transcript variants
            encoding two different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding region compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2 and 3
            both encode the same isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020680.1, SRR11853567.9724.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000299204.6/
                                                  ENSP00000299204.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               BF941752.1         158-354
            198-4683            AL139300.6         120297-124782
            4684-4684           CA424706.1         26-26               c
FEATURES             Location/Qualifiers
     source          1..4684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..4684
                     /gene="BAG5"
                     /gene_synonym="BAG-5; CMD2F"
                     /note="BAG cochaperone 5"
                     /db_xref="GeneID:9529"
                     /db_xref="HGNC:HGNC:941"
                     /db_xref="MIM:603885"
     exon            1..42
                     /gene="BAG5"
                     /gene_synonym="BAG-5; CMD2F"
                     /inference="alignment:Splign:2.1.0"
     exon            43..4684
                     /gene="BAG5"
                     /gene_synonym="BAG-5; CMD2F"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1414
                     /gene="BAG5"
                     /gene_synonym="BAG-5; CMD2F"
                     /note="bcl-2-associated athanogene 5; BCL2 associated
                     athanogene 5"
                     /codon_start=1
                     /product="BAG family molecular chaperone regulator 5"
                     /protein_id="NP_001015048.1"
                     /db_xref="CCDS:CCDS9982.1"
                     /db_xref="GeneID:9529"
                     /db_xref="HGNC:HGNC:941"
                     /db_xref="MIM:603885"
                     /translation="MDMGNQHPSISRLQEIQKEVKSVEQQVIGFSGLSDDKNYKKLER
                     ILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNANHPHRIEIQNIFEEAQ
                     SLVREKIVPFYNGGNCVTDEFEEGIQDIILRLTHVKTGGKISLRKARYHTLTKICAVQ
                     EIIEDCMKKQPSLPLSEDAHPSVAKINFVMCEVNKARGVLIALLMGVNNNETCRHLSC
                     VLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEEEADTTKAFDLRQNHSI
                     LKIEKVLKRMREIKNELLQAQNPSELYLSSKTELQGLIGQLDEVSLEKNPCIREARRR
                     AVIEVQTLITYIDLKEALEKRKLFACEEHPSHKAVWNVLGNLSEIQGEVLSFDGNRTD
                     KNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVRLAQNILSYLDLKSDEWEY"
     regulatory      4065..4070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAG5"
                     /gene_synonym="BAG-5; CMD2F"
                     /note="hexamer: AGTAAA"
     polyA_site      4086
                     /gene="BAG5"
                     /gene_synonym="BAG-5; CMD2F"
                     /note="major polyA site"
     regulatory      4106..4111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAG5"
                     /gene_synonym="BAG-5; CMD2F"
                     /note="hexamer: ATTAAA"
     polyA_site      4138
                     /gene="BAG5"
                     /gene_synonym="BAG-5; CMD2F"
                     /note="major polyA site"
     regulatory      4654..4659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAG5"
                     /gene_synonym="BAG-5; CMD2F"
                     /note="hexamer: AATAAA"
     polyA_site      4684
                     /gene="BAG5"
                     /gene_synonym="BAG-5; CMD2F"
ORIGIN      
        1 gaagcgtcgg cgacgcatcg cgcgatggcg cgggcgggac agtgcttgtg aaactgaaca
       61 caacaaaagt atggatatgg gaaaccaaca tccttctatt agtaggcttc aggaaatcca
      121 aaaggaagta aaaagtgtag aacagcaagt tatcggcttc agtggtctgt cagatgacaa
      181 gaattacaag aaactggaga ggattctaac aaaacagctt tttgaaatag actctgtaga
      241 tactgaagga aaaggagata ttcagcaagc taggaagcgg gcagcacagg agacagaacg
      301 tcttctcaaa gagttggagc agaatgcaaa ccacccacac cggattgaaa tacagaacat
      361 ttttgaggaa gcccagtccc tcgtgagaga gaaaattgtg ccattttata atggaggcaa
      421 ctgcgtaact gatgagtttg aagaaggcat ccaagatatc attctgaggc tgacacatgt
      481 taaaactgga ggaaaaatct ccttgcggaa agcaaggtat cacactttaa ccaaaatctg
      541 tgcggtgcaa gagataatcg aagactgcat gaaaaagcag ccttccctgc cgctttccga
      601 ggatgcacat ccttccgttg ccaaaatcaa cttcgtgatg tgtgaggtga acaaggcccg
      661 aggggtcctg attgcacttc tgatgggtgt gaacaacaat gagacctgca ggcacttatc
      721 ctgtgtgctc tcggggctga tcgctgacct ggatgctcta gatgtgtgcg gccggacaga
      781 aatcagaaat tatcggaggg aggtagtaga agatatcaac aaattattga aatatctgga
      841 tttggaagag gaagcagaca caactaaagc atttgacctg agacagaatc attccatttt
      901 aaaaatagaa aaggtcctca agagaatgag agaaataaaa aatgaacttc tccaagcaca
      961 aaacccttct gaattgtacc tgagctccaa aacagaattg cagggtttaa ttggacagtt
     1021 ggatgaggta agtcttgaaa aaaacccctg catccgggaa gccaggagaa gagcagtgat
     1081 cgaggtgcaa actctgatca catatattga cttgaaggag gcccttgaga aaagaaagct
     1141 gtttgcttgt gaggagcacc catcccataa agccgtctgg aacgtccttg gaaacttgtc
     1201 tgagatccag ggagaagttc tttcatttga tggaaatcga accgataaga actacatccg
     1261 gctggaagag ctgctcacca agcagctgct agccctggat gctgttgatc cgcagggaga
     1321 agagaagtgt aaggctgcca ggaaacaagc tgtgaggctt gcgcagaata ttctcagcta
     1381 tctcgacctg aaatctgatg aatgggagta ctgaaatacc agagatctca cttttgatac
     1441 tgttttgcac ttcatatgtg cttctatgta tagagagctt tcagttcatt gatttatacg
     1501 tgcatatttc agtctcagta tttatgattg aagcaaattc tattcagtat ctgctgcttt
     1561 tgatgttgca agacaaatat cattacagca cgttaacttt tccattcgga tcattatctg
     1621 tatgatgtgg tgtggtttgt ttggtttgtc cttttttttg cgtttttaat cagaaaacaa
     1681 aatagaggca gcttttgtag attttaaatg ggttgtgcaa gcattaaaat gcaggtcttt
     1741 cagaatctag aactaggcat aaccttacat aatactagga aaattatgag aaaggggaaa
     1801 tttttggtta aataagagta aggttcaaac acaagcagta catgttctgt ttcattatgc
     1861 tcgatagaag gctttttttt cacttataag gcctgattgg tcctacccag cttaacgggg
     1921 tggggttttt ttgtttgttc agacagtctg ttcttttgta aacattttta gttggaaaaa
     1981 cagcatctgc attttcccca tcctctacgt tttagagagg aatcttgttt ttgtgtgcaa
     2041 cataagaaaa ttatgaaaac taatagccaa aaaacctttg agattgcatt aaagagaagg
     2101 gataaaggac cagcaataat accttgtaag ttgcttttgt ttgtaaaatc tgagcttata
     2161 gttttcctta gtgagtaaat tcataaggat gggaacattt aaattaagtt aatgggcctt
     2221 taaaaaaaaa aaaaggaaac actcatacct gtagttggag gatgaatact ggagacgggt
     2281 taccaatgtc aggttatact aaaactaaat cagaaagtct gaatgtagca cataatggtt
     2341 ctcttctgtt gtccaaggct gtaaaatgga cagccttgtc acacctcccc ggtgctgttt
     2401 tacaacgtga gggtagacgc tgtcagtaac ccagagggac caggccttcc taggttttct
     2461 aggcagtcag ctgttaacca ctcacttagt aaatgtcata actacacctg ctccaggacc
     2521 aatcagtgaa acctgctcgg aattaaaggc ttcctctggg tgcctgctga acaactgagc
     2581 tcatgtcatg ggcatgtggt ggtttctctg ttgcctgaaa gagccattaa agtcagtcgt
     2641 gcgtgaagca tctctcttct aaaggatgtg tatttccata aatgctttct gaggatccgg
     2701 tacaaaatga tttcccaaag ttctgaagtg ccttgagaac atgtgggtcc gagtgttata
     2761 acagactcct cccccgggtc accttttgcc tggtcatcct gttagagtac atctttggaa
     2821 atccagggta atattctctt tcagagatgc tcattgtgta actctgtgta gggagatagt
     2881 cactttaaac agctcaaagt agctagctaa aggagtagcc ttaaatacct aaaagatgac
     2941 agaagcatag cccttaacaa atcttcagct tgtctctcag tatttcccaa tcatgaaaat
     3001 cccttgctat gtctttccta ctagaaatgt tctagaatcg ctggacggtg gggtcagagg
     3061 gcagtcggta tttaggccgt gagcttccca tactactgca ggtccaactc ctggcaaccg
     3121 cgggctcaag gcaggtcatt ggaatccacg ttttggccac agtagttgta ggattgcttt
     3181 tctgtatcat aattttagaa tgctcttaaa atcttgagga agagttttta ttttttattt
     3241 atttttgaga tggagtctct gttgcccagg ctgcagtgca gtggtgccat ctcagctcac
     3301 tgcaacctcc acctcccagg ttcaagcgat tctcctgcct cagccacctg agtagctggg
     3361 agtacaggca tgtggcacca tgcctggcta atttttgtat ttttaataga gttgagattt
     3421 caccatgatg gtcaggctgg tctcgaactc ctgacctcgt gatccgcccg cctcggcccc
     3481 ccaaagtgct gggattaacg ggtgtgagcc acggcgccca gcccaggaag agtttttaaa
     3541 ttagagctct gtttaattat accactggga aatcatggtt acgcttcagg catattcttc
     3601 cccagagtac tacttacatt ttaaatttca ttttgtaaag ttaaatgtca gcattccctt
     3661 taaaagtgtc cattgttctt tgaaagtaga cgtttcagtc attcttttca aacaagtgtt
     3721 tgtgtacctt ttgccaagct gtgggcatcg tgtgtgagta cagggtgctc agctcttcca
     3781 ccgtcatttt gaattgttca catgggtaat tggtcatgga aatgatcaga ttgaccttga
     3841 ttgactgtca ggcatggctt tgtttctggt ttcaatctgt tctcgttcct tgtaccggat
     3901 tattctactc ctgcaatgaa ccctgttgac accggattta gctcttgtcg gccttcgtgg
     3961 ggagctgttt gtgttaatat gagctactgc atgtaattct taaactgggc ttgtcacatt
     4021 gtattgtatt tttgtgatct gtaatgaaaa gaatctgtac tgcaagtaaa acctactccc
     4081 caaaaatgtg tggctttggg tctgcattaa acgctgtagt ccatgttcat gccaaaaatg
     4141 gctgggaacg tttgctttat ttacattcag tcagcgttgc tttcagatca cactttatcc
     4201 acacaggaaa gccagtcagc ctataatgaa gtagttatta aaataaatgt aatgaatatg
     4261 tctacaaagt atagtttagt ggtttatttt gctaaaatgc acatatattt gatataattt
     4321 agtttgagaa gttcagctag tttttctcct ttgtttgact ttgtcaattt ctatctggtt
     4381 tttaagggtc tgagcttagc ttgtgcatgc aaggttttgg gtttttttat tttttttttg
     4441 agcacagctt ttcacctttt aatttgttgg gtatttttct cttaataaga gaaatattgg
     4501 ccatcgattt ttacatataa tacaagtgtg tttttccagt acattggttc ctgtcccctc
     4561 tctgtgaact gtttgagtat tggaacagta tgtcttcaat aattcaatgt tactttgaga
     4621 tacatgtgtt aatataccct tagttattct tgaaataaaa ccagtctctt acgcttgcag
     4681 tgga
//
