LOCUS       NM_004874               4197 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens BAG cochaperone 4 (BAG4), transcript variant 1, mRNA.
ACCESSION   NM_004874
VERSION     NM_004874.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4197)
  AUTHORS   Bao,F., An,S., Yang,Y. and Xu,T.R.
  TITLE     SODD Promotes Lung Cancer Tumorigenesis by Activating the PDK1/AKT
            and RAF/MEK/ERK Signaling
  JOURNAL   Genes (Basel) 14 (4), 829 (2023)
   PUBMED   37107587
  REMARK    GeneRIF: SODD Promotes Lung Cancer Tumorigenesis by Activating the
            PDK1/AKT and RAF/MEK/ERK Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4197)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 4197)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4197)
  AUTHORS   Jiang,L., Chen,Y., Min,G., Wang,J., Chen,W., Wang,H., Wang,X. and
            Yao,N.
  TITLE     Bcl2-associated athanogene 4 promotes the invasion and metastasis
            of gastric cancer cells by activating the PI3K/AKT/NF-kappaB/ZEB1
            axis
  JOURNAL   Cancer Lett 520, 409-421 (2021)
   PUBMED   34419501
  REMARK    GeneRIF: Bcl2-associated athanogene 4 promotes the invasion and
            metastasis of gastric cancer cells by activating the
            PI3K/AKT/NF-kappaB/ZEB1 axis.
REFERENCE   5  (bases 1 to 4197)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4197)
  AUTHORS   Eichholtz-Wirth,H. and Sagan,D.
  TITLE     Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible
            for radioresistance in human HT-R15 cells
  JOURNAL   Anticancer Res 22 (1A), 235-240 (2002)
   PUBMED   12017295
  REMARK    GeneRIF: Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is
            responsible for radioresistance in human HT-R15 cells.
REFERENCE   7  (bases 1 to 4197)
  AUTHORS   Antoku,K., Maser,R.S., Scully,W.J. Jr., Delach,S.M. and
            Johnson,D.E.
  TITLE     Isolation of Bcl-2 binding proteins that exhibit homology with
            BAG-1 and suppressor of death domains protein
  JOURNAL   Biochem Biophys Res Commun 286 (5), 1003-1010 (2001)
   PUBMED   11527400
REFERENCE   8  (bases 1 to 4197)
  AUTHORS   Frisch,S.M.
  TITLE     Evidence for a function of death-receptor-related,
            death-domain-containing proteins in anoikis
  JOURNAL   Curr Biol 9 (18), 1047-1049 (1999)
   PUBMED   10508612
REFERENCE   9  (bases 1 to 4197)
  AUTHORS   Jiang,Y., Woronicz,J.D., Liu,W. and Goeddel,D.V.
  TITLE     Prevention of constitutive TNF receptor 1 signaling by silencer of
            death domains
  JOURNAL   Science 283 (5401), 543-546 (1999)
   PUBMED   9915703
  REMARK    Erratum:[Science 1999 Mar 19;283(5409):1852]
REFERENCE   10 (bases 1 to 4197)
  AUTHORS   Takayama,S., Xie,Z. and Reed,J.C.
  TITLE     An evolutionarily conserved family of Hsp70/Hsc70 molecular
            chaperone regulators
  JOURNAL   J Biol Chem 274 (2), 781-786 (1999)
   PUBMED   9873016
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF095194.2, AC084024.17 and
            BM683128.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004874.3.
            
            Summary: The protein encoded by this gene is a member of the
            BAG1-related protein family. BAG1 is an anti-apoptotic protein that
            functions through interactions with a variety of cell apoptosis and
            growth related proteins including BCL-2, Raf-protein kinase,
            steroid hormone receptors, growth factor receptors and members of
            the heat shock protein 70 kDa family. This protein contains a BAG
            domain near the C-terminus, which could bind and inhibit the
            chaperone activity of Hsc70/Hsp70. This protein was found to be
            associated with the death domain of tumor necrosis factor receptor
            type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively
            regulates downstream cell death signaling. The regulatory role of
            this protein in cell death was demonstrated in epithelial cells
            which undergo apoptosis while integrin mediated matrix contacts are
            lost. Alternatively spliced transcript variants encoding distinct
            isoforms have been identified. [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.40234.1, BC038505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287322.5/ ENSP00000287322.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1445              AF095194.2         28-1472
            1446-3725           AC084024.17        96207-98486
            3726-4197           BM683128.1         15-486              c
FEATURES             Location/Qualifiers
     source          1..4197
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..4197
                     /gene="BAG4"
                     /gene_synonym="BAG-4; SODD"
                     /note="BAG cochaperone 4"
                     /db_xref="GeneID:9530"
                     /db_xref="HGNC:HGNC:940"
                     /db_xref="MIM:603884"
     exon            1..285
                     /gene="BAG4"
                     /gene_synonym="BAG-4; SODD"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1389
                     /gene="BAG4"
                     /gene_synonym="BAG-4; SODD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     silencer of death domains; BAG family molecular chaperone
                     regulator 4; bcl-2-associated athanogene 4; BCL2
                     associated athanogene 4"
                     /codon_start=1
                     /product="BAG family molecular chaperone regulator 4
                     isoform 1"
                     /protein_id="NP_004865.1"
                     /db_xref="CCDS:CCDS6104.1"
                     /db_xref="GeneID:9530"
                     /db_xref="HGNC:HGNC:940"
                     /db_xref="MIM:603884"
                     /translation="MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPP
                     QPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNY
                     WNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGY
                     TQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLP
                     HYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTS
                     PWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDL
                     LDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQY
                     LEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILE
                     KLEKKGL"
     exon            286..393
                     /gene="BAG4"
                     /gene_synonym="BAG-4; SODD"
                     /inference="alignment:Splign:2.1.0"
     exon            394..648
                     /gene="BAG4"
                     /gene_synonym="BAG-4; SODD"
                     /inference="alignment:Splign:2.1.0"
     exon            649..903
                     /gene="BAG4"
                     /gene_synonym="BAG-4; SODD"
                     /inference="alignment:Splign:2.1.0"
     exon            904..4197
                     /gene="BAG4"
                     /gene_synonym="BAG-4; SODD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4163..4168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAG4"
                     /gene_synonym="BAG-4; SODD"
                     /note="hexamer: AATAAA"
     polyA_site      4197
                     /gene="BAG4"
                     /gene_synonym="BAG-4; SODD"
                     /note="major polyA site"
ORIGIN      
        1 agggcagcgg atcccatgtc ggccctgagg cgctcgggct acggccccag tgacggtccg
       61 tcctacggcc gctactacgg gcctgggggt ggagatgtgc cggtacaccc acctccaccc
      121 ttatatcctc ttcgccctga acctccccag cctcccattt cctggcgggt gcgcgggggc
      181 ggcccggcgg agaccacctg gctgggagaa ggcggaggag gcgatggcta ctatccctcg
      241 ggaggcgcct ggccagagcc tggtcgagcc ggaggaagcc accaggagca gccaccatat
      301 cctagctaca attctaacta ttggaattct actgcgagat ctagggctcc ttacccaagt
      361 acatatcctg taagaccaga attgcaaggc cagagtttga attcttatac aaatggagcg
      421 tatggtccaa catacccccc aggccctggg gcaaatactg cctcatactc aggggcttat
      481 tatgcacctg gttatactca gaccagttac tccacagaag ttccaagtac ttaccgttca
      541 tctggcaaca gcccaactcc agtctctcgt tggatctatc cccagcagga ctgtcagact
      601 gaagcacccc ctcttagggg gcaggttcca ggatatccgc cttcacagaa ccctggaatg
      661 accctgcccc attatcctta tggagatggt aatcgtagtg ttccacaatc aggaccgact
      721 gtacgaccac aagaagatgc gtgggcttct cctggtgctt atggaatggg tggccgttat
      781 ccctggcctt catcagcgcc ctcagcacca cccggcaatc tctacatgac tgaaagtact
      841 tcaccatggc ctagcagtgg ctctccccag tcaccccctt cacccccagt ccagcagccc
      901 aaggattctt cataccccta tagccaatca gatcaaagca tgaaccggca caactttcct
      961 tgcagtgtcc atcagtacga atcctcgggg acagtgaaca atgatgattc agatcttttg
     1021 gattcccaag tccagtatag tgctgagcct cagctgtatg gtaatgccac cagtgaccat
     1081 cccaacaatc aagatcaaag tagcagtctt cctgaagaat gtgtaccttc agatgaaagt
     1141 actcctccga gtattaaaaa aatcatacat gtgctggaga aggtccagta tcttgaacaa
     1201 gaagtagaag aatttgtagg aaaaaagaca gacaaagcat actggcttct ggaagaaatg
     1261 ctaaccaagg aacttttgga actggattca gttgaaactg ggggccagga ctctgtacgg
     1321 caggccagaa aagaggctgt ttgtaagatt caggccatac tggaaaaatt agaaaaaaaa
     1381 ggattatgaa aggatttaga acaaagtgga agcctgttac taacttgacc aaagaacact
     1441 tgatttggtt aattaccctc tttttgaaat gcctgttgat gacaagaagc aatacattcc
     1501 agctttcctt tgattttata cttgaaaaac tggcaaagga atggaagaat attttagtca
     1561 tgagttgttt tcagttttca gacgaatgaa tgtaatagga aactatggag ttaccaatat
     1621 tgccaagtag actcactcct taaaaaattt atggatatct acaagctgct tcttaccagc
     1681 aggagggaaa cacacttcac acaacaggct tatcagaaac ctaccagatg aaactggata
     1741 taatctgaga caaacaggat gtgttttttt aaacatctgg atatcttgtc acatttttgt
     1801 acattgtgac tgctttcaac atatacttca tgtgtaatta tagcttagac tttagccttc
     1861 ttggacttct gttttgtttt gttatttgca gtttacaaat atagtattat tctctacttc
     1921 ttggtacatt ttgtagtaat atgtttaata taattattca agagactata ttgacagcca
     1981 gatagtatgg cagttctgaa aaaatttata tcttttcacc acttgaatat actgcaatgt
     2041 gtagtgagta aattgtctcc ctttttctat agatcattag gttagagttt ttttcttctt
     2101 tttttttttt tttttttttt accacttctg ctgttcatgg tagtagtgga aggtaaattt
     2161 ggaaatggca ttgacataaa atgaaaatgt ttacggacac ttttcttttt tgctttttta
     2221 ttgtatttgg ataaagatcc acttaaaagt tatctgtttt ttcctgtttt tttttttttt
     2281 ccccaaagtg tagttatgtt ttcactattg ctgcttctat agagggcatt gtgatagaga
     2341 gttacagatg aaacattaaa tgccacagtg agtagaaata attactacaa aaagtaataa
     2401 atatgattac ttggtaatat cattctccat ctaaaatact agtttcacct gtgagcagat
     2461 ttcagctcag tttatagtta aaaacaatga gggtaaaatg ggattcatgc tcagggaatg
     2521 aatcagccat agttagagtg ggaaattatt attttcttca tttaaaggta gattttatgt
     2581 ttatttccct aaattgcata agataaaatt gtctgtttaa taaaaagaca tttattacca
     2641 ttattaacag tcattttaga gccaaattta agaaaaggat attgaaaggg tctttattgg
     2701 ccttgtttgg gtaactctat gctgttagat agaagagact taggtaaata actttttatg
     2761 tctgaggtga gtacacaata ttggttcttg gaaaaatagc tgtttcttca taagataccc
     2821 aagtgataat tttttttccc ctagactgtc aggcctatga gtaaatacta aatctattag
     2881 ctgtccccac tcataaacca aaccaaacca atacaaacag atgaggagag gaaatgtagt
     2941 aaaaatactg gctgggtctt atgattggga tgagtgattt tataagataa tatggtgata
     3001 attttattct aggattttat ttttggccta atataggaat gtttaaaaaa ggcttttcta
     3061 tgaaaattag aaatttatac ttgaaattaa aagtctagaa gggggaggac cttaaagcta
     3121 agctaccagt aagacaatga ataattcaga agagaacact attcttttac tgactgagtg
     3181 cccaagatgc caatttccat gaagtcttga tttatatata tgtacacatg ttatgcacat
     3241 acatgtttgt tttctaacag ttatttttta agcttttgag ataattttag acttacagaa
     3301 gagttgtaaa agtagtagag ttcttgtata ctctgcaccc accttgccct tatgttaaca
     3361 tcttacgtaa caatagaaca tttgtcaaaa ttaagaaatt aaccttgata taatactaac
     3421 taaagtagaa agtttaaaaa gtagagattt tagtcttttc actaatgtcc ttttactgtt
     3481 ccaagaccca gccttgcatt tagctatcat gcctacgtcc tgtcttccag tctgtgacag
     3541 tgtatcataa caggggatac ctgatgttgt aatgtatttc tggtgttgtt aaccttgatc
     3601 actatgctaa ggtggtgtct gctaggattc gctactgtaa acttactgtg ttttccttgt
     3661 aattattgaa tatttgctgg agatacccgg agactatgca aatgtcccgt ttctgcttaa
     3721 acttttgctc attttactat ccattggcag atcttgcttg tggcagttac tactgtggtg
     3781 ttctaatggt gattttctat ttctctcaat ccttctacat ttattattgg aattcttctg
     3841 taaggaagag ttgtcagttc tggatttata tttttaacta taataagata ttcaggataa
     3901 gtatagattt agaacttaaa gatgttaaat catgttaaaa ttattccaaa taccaatatc
     3961 aaagaaaact aagttggtaa tctatctcag aaaatatatg aacttaagaa ggaaaatagt
     4021 atttatgatt tgtagaattg gttcaacttt tgacttaata ctgactttgg actgaattca
     4081 aagttttctt gaaatttcac atctggactt tttaaagtgt ctacatttat attactttgg
     4141 ggatcatttt gtcaaagtct tgaataaagt tacccagtcc tggcatgata aacacaa
//
