LOCUS       NM_004281               2561 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens BAG cochaperone 3 (BAG3), mRNA.
ACCESSION   NM_004281
VERSION     NM_004281.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2561)
  AUTHORS   Qu,H.Q., Wang,J.F., Rosa-Campos,A., Hakonarson,H. and Feldman,A.M.
  TITLE     The Role of BAG3 Protein Interactions in Cardiomyopathies
  JOURNAL   Int J Mol Sci 25 (20), 11308 (2024)
   PUBMED   39457090
  REMARK    GeneRIF: The Role of BAG3 Protein Interactions in Cardiomyopathies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2561)
  AUTHORS   Zhang,C., Xu,H., Tang,Q., Duan,Y., Xia,H., Huang,H., Ye,D. and
            Bi,F.
  TITLE     CaMKII suppresses proteotoxicity by phosphorylating BAG3 in
            response to proteasomal dysfunction
  JOURNAL   EMBO Rep 25 (10), 4488-4514 (2024)
   PUBMED   39261742
  REMARK    GeneRIF: CaMKII suppresses proteotoxicity by phosphorylating BAG3
            in response to proteasomal dysfunction.
REFERENCE   3  (bases 1 to 2561)
  AUTHORS   Zamotina,M.A., Muranova,L.K., Zabolotskii,A.I., Tyurin-Kuzmin,P.A.,
            Kulebyakin,K.Y. and Gusev,N.B.
  TITLE     Universal Adapter Protein Bag3 and Small Heat Shock Proteins
  JOURNAL   Biochemistry (Mosc) 89 (9), 1535-1545 (2024)
   PUBMED   39418513
  REMARK    GeneRIF: Universal Adapter Protein Bag3 and Small Heat Shock
            Proteins.
            Review article
REFERENCE   4  (bases 1 to 2561)
  AUTHORS   Perez-Bermejo,J.A., Judge,L.M., Jensen,C.L., Wu,K., Watry,H.L.,
            Truong,A., Ho,J.J., Carter,M., Runyon,W.V., Kaake,R.M.,
            Pulido,E.H., Mandegar,M.A., Swaney,D.L., So,P.L., Krogan,N.J. and
            Conklin,B.R.
  TITLE     Functional analysis of a common BAG3 allele associated with
            protection from heart failure
  JOURNAL   Nat Cardiovasc Res 2 (7), 615-628 (2023)
   PUBMED   39195919
  REMARK    GeneRIF: Functional analysis of a common BAG3 allele associated
            with protection from heart failure.
REFERENCE   5  (bases 1 to 2561)
  AUTHORS   Liao,Q., Ozawa,F., Friess,H., Zimmermann,A., Takayama,S.,
            Reed,J.C., Kleeff,J. and Buchler,M.W.
  TITLE     The anti-apoptotic protein BAG-3 is overexpressed in pancreatic
            cancer and induced by heat stress in pancreatic cancer cell lines
  JOURNAL   FEBS Lett 503 (2-3), 151-157 (2001)
   PUBMED   11513873
REFERENCE   6  (bases 1 to 2561)
  AUTHORS   Doong,H., Price,J., Kim,Y.S., Gasbarre,C., Probst,J., Liotta,L.A.,
            Blanchette,J., Rizzo,K. and Kohn,E.
  TITLE     CAIR-1/BAG-3 forms an EGF-regulated ternary complex with
            phospholipase C-gamma and Hsp70/Hsc70
  JOURNAL   Oncogene 19 (38), 4385-4395 (2000)
   PUBMED   10980614
REFERENCE   7  (bases 1 to 2561)
  AUTHORS   Lee,J.H., Takahashi,T., Yasuhara,N., Inazawa,J., Kamada,S. and
            Tsujimoto,Y.
  TITLE     Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in
            preventing cell death
  JOURNAL   Oncogene 18 (46), 6183-6190 (1999)
   PUBMED   10597216
REFERENCE   8  (bases 1 to 2561)
  AUTHORS   Takayama,S., Xie,Z. and Reed,J.C.
  TITLE     An evolutionarily conserved family of Hsp70/Hsc70 molecular
            chaperone regulators
  JOURNAL   J Biol Chem 274 (2), 781-786 (1999)
   PUBMED   9873016
REFERENCE   9  (bases 1 to 2561)
  AUTHORS   Selcen,D. and Engel,A.G.
  TITLE     Myofibrillar Myopathy - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301672
REFERENCE   10 (bases 1 to 2561)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF071218.2 and BC006418.1.
            
            On Dec 4, 2019 this sequence version replaced NM_004281.3.
            
            Summary: BAG proteins compete with Hip for binding to the
            Hsc70/Hsp70 ATPase domain and promote substrate release. All the
            BAG proteins have an approximately 45-amino acid BAG domain near
            the C terminus but differ markedly in their N-terminal regions. The
            protein encoded by this gene contains a WW domain in the N-terminal
            region and a BAG domain in the C-terminal region. The BAG domains
            of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase
            domain in vitro and in mammalian cells. All 3 proteins bind with
            high affinity to the ATPase domain of Hsc70 and inhibit its
            chaperone activity in a Hip-repressible manner. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006418.1, AK222800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369085.8/ ENSP00000358081.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1591              AF071218.2         11-1601
            1592-2561           BC006418.1         1580-2549
FEATURES             Location/Qualifiers
     source          1..2561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..2561
                     /gene="BAG3"
                     /gene_synonym="BAG-3; BIS; CAIR-1; CMD1HH; CMT2JJ; HMND15;
                     MFM6"
                     /note="BAG cochaperone 3"
                     /db_xref="GeneID:9531"
                     /db_xref="HGNC:HGNC:939"
                     /db_xref="MIM:603883"
     exon            1..476
                     /gene="BAG3"
                     /gene_synonym="BAG-3; BIS; CAIR-1; CMD1HH; CMT2JJ; HMND15;
                     MFM6"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..2024
                     /gene="BAG3"
                     /gene_synonym="BAG-3; BIS; CAIR-1; CMD1HH; CMT2JJ; HMND15;
                     MFM6"
                     /note="BCL2-binding athanogene 3; docking protein CAIR-1;
                     bcl-2-binding protein Bis; BCL2 associated athanogene 3;
                     Bcl-2-binding protein BIS transcript 2"
                     /codon_start=1
                     /product="BAG family molecular chaperone regulator 3"
                     /protein_id="NP_004272.2"
                     /db_xref="CCDS:CCDS7615.1"
                     /db_xref="GeneID:9531"
                     /db_xref="HGNC:HGNC:939"
                     /db_xref="MIM:603883"
                     /translation="MSAATHSPMMQVASGNGDRDPLPPGWEIKIDPQTGWPFFVDHNS
                     RTTTWNDPRVPSEGPKETPSSANGPSREGSRLPPAREGHPVYPQLRPGYIPIPVLHEG
                     AENRQVHPFHVYPQPGMQRFRTEAAAAAPQRSQSPLRGMPETTQPDKQCGQVAAAAAA
                     QPPASHGPERSQSPAASDCSSSSSSASLPSSGRSSLGSHQLPRGYISIPVIHEQNVTR
                     PAAQPSFHQAQKTHYPAQQGEYQTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASSR
                     EGSPARSSTPLHSPSPIRVHTVVDRPQQPMTHRETAPVSQPENKPESKPGPVGPELPP
                     GHIPIQVIRKEVDSKPVSQKPPPPSEKVEVKVPPAPVPCPPPSPGPSAVPSSPKSVAT
                     EERAAPSTAPAEATPPKPGEAEAPPKHPGVLKVEAILEKVQGLEQAVDNFEGKKTDKK
                     YLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVY
                     ELQPSNLEADQPLQAIMEMGAVAADKGKKNAGNAEDPHTETQQPEATAAATSNPSSMT
                     DTPGNPAAP"
     exon            477..803
                     /gene="BAG3"
                     /gene_synonym="BAG-3; BIS; CAIR-1; CMD1HH; CMT2JJ; HMND15;
                     MFM6"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1205
                     /gene="BAG3"
                     /gene_synonym="BAG-3; BIS; CAIR-1; CMD1HH; CMT2JJ; HMND15;
                     MFM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..2561
                     /gene="BAG3"
                     /gene_synonym="BAG-3; BIS; CAIR-1; CMD1HH; CMT2JJ; HMND15;
                     MFM6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2545..2550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BAG3"
                     /gene_synonym="BAG-3; BIS; CAIR-1; CMD1HH; CMT2JJ; HMND15;
                     MFM6"
                     /note="hexamer: AATAAT"
     polyA_site      2561
                     /gene="BAG3"
                     /gene_synonym="BAG-3; BIS; CAIR-1; CMD1HH; CMT2JJ; HMND15;
                     MFM6"
                     /note="major polyA site"
ORIGIN      
        1 gcatccaacc ccgggccgcg gccaacttct ctggactgga ccagaagttt ctagccggcc
       61 agttgctacc tccctttatc tcctccttcc cctctggcag cgaggaggct atttccagac
      121 acttccaccc ctctctggcc acgtcacccc cgcctttaat tcataaaggt gcccggcgcc
      181 ggcttcccgg acacgtcggc ggcggagagg ggcccacggc ggcggcccgg ccagagactc
      241 ggcgcccgga gccagcgccc cgcacccgcg ccccagcggg cagaccccaa cccagcatga
      301 gcgccgccac ccactcgccc atgatgcagg tggcgtccgg caacggtgac cgcgaccctt
      361 tgccccccgg atgggagatc aagatcgacc cgcagaccgg ctggcccttc ttcgtggacc
      421 acaacagccg caccactacg tggaacgacc cgcgcgtgcc ctctgagggc cccaaggaga
      481 ctccatcctc tgccaatggc ccttcccggg agggctctag gctgccgcct gctagggaag
      541 gccaccctgt gtacccccag ctccgaccag gctacattcc cattcctgtg ctccatgaag
      601 gcgctgagaa ccggcaggtg caccctttcc atgtctatcc ccagcctggg atgcagcgat
      661 tccgaactga ggcggcagca gcggctcctc agaggtccca gtcacctctg cggggcatgc
      721 cagaaaccac tcagccagat aaacagtgtg gacaggtggc agcggcggcg gcagcccagc
      781 ccccagcctc ccacggacct gagcggtccc agtctccagc tgcctctgac tgctcatcct
      841 catcctcctc ggccagcctg ccttcctccg gcaggagcag cctgggcagt caccagctcc
      901 cgcgggggta catctccatt ccggtgatac acgagcagaa cgttacccgg ccagcagccc
      961 agccctcctt ccaccaagcc cagaagacgc actacccagc gcagcagggg gagtaccaga
     1021 cccaccagcc tgtgtaccac aagatccagg gggatgactg ggagccccgg cccctgcggg
     1081 cggcatcccc gttcaggtca tctgtccagg gtgcatcgag ccgggagggc tcaccagcca
     1141 ggagcagcac gccactccac tccccctcgc ccatccgtgt gcacaccgtg gtcgacaggc
     1201 ctcagcagcc catgacccat cgagaaactg cacctgtttc ccagcctgaa aacaaaccag
     1261 aaagtaagcc aggcccagtt ggaccagaac tccctcctgg acacatccca attcaagtga
     1321 tccgcaaaga ggtggattct aaacctgttt cccagaagcc cccacctccc tctgagaagg
     1381 tagaggtgaa agttccccct gctccagttc cttgtcctcc tcccagccct ggcccttctg
     1441 ctgtcccctc ttcccccaag agtgtggcta cagaagagag ggcagccccc agcactgccc
     1501 ctgcagaagc tacacctcca aaaccaggag aagccgaggc tcccccaaaa catccaggag
     1561 tgctgaaagt ggaagccatc ctggagaagg tacaggggct ggagcaggct gtagacaact
     1621 ttgaaggcaa gaagactgac aaaaagtacc tgatgatcga agagtatttg accaaagagc
     1681 tgctggccct ggattcagtg gaccccgagg gacgagccga tgtgcgtcag gccaggagag
     1741 acggtgtcag gaaggttcag accatcttgg aaaaacttga acagaaagcc attgatgtcc
     1801 caggtcaagt ccaggtctat gaactccagc ccagcaacct tgaagcagat cagccactgc
     1861 aggcaatcat ggagatgggt gccgtggcag cagacaaggg caagaaaaat gctggaaatg
     1921 cagaagatcc ccacacagaa acccagcagc cagaagccac agcagcagcg acttcaaacc
     1981 ccagcagcat gacagacacc cctggtaacc cagcagcacc gtagcctctg ccctgtaaaa
     2041 atcagactcg gaaccgatgt gtgctttagg gaattttaag ttgcatgcat ttcagagact
     2101 ttaagtcagt tggtttttat tagctgcttg gtatgcagta acttgggtgg aggcaaaaca
     2161 ctaataaaag ggctaaaaag gaaaatgatg cttttcttct atattcttac tctgtacaaa
     2221 taaagaagtt gcttgttgtt tgagaagttt aaccccgttg cttgttgttc tgcagccctg
     2281 tctacttggg cacccccacc acctgttagc tgtggttgtg cactgtcttt tgtagctctg
     2341 gactggaggg gtagatgggg agtcaattac ccatcacata aatatgaaac atttatcaga
     2401 aatgttgcca ttttaatgag atgattttct tcatctcata attaaaatac ctgactttag
     2461 agagagtaaa atgtgccagg agccatagga atatctgtat gttggatgac tttaatgcta
     2521 cattttaaaa aaagaaaata aagtaataat ataactcaaa a
//
