LOCUS       NM_021813               9215 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens BTB domain and CNC homolog 2 (BACH2), transcript
            variant 1, mRNA.
ACCESSION   NM_021813
VERSION     NM_021813.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9215)
  AUTHORS   Li,X., Gao,H., Liu,L., Yang,Y., Sun,S. and Liu,Y.
  TITLE     Genetic polymorphisms of BACH2, a key gene regulating Th2 immune
            response, increasing risk of allergic rhinitis
  JOURNAL   Gene 926, 148624 (2024)
   PUBMED   38824974
  REMARK    GeneRIF: Genetic polymorphisms of BACH2, a key gene regulating Th2
            immune response, increasing risk of allergic rhinitis.
REFERENCE   2  (bases 1 to 9215)
  AUTHORS   Thakore,P.I., Schnell,A., Huang,L., Zhao,M., Hou,Y., Christian,E.,
            Zaghouani,S., Wang,C., Singh,V., Singaraju,A., Krishnan,R.K.,
            Kozoriz,D., Ma,S., Sankar,V., Notarbartolo,S., Buenrostro,J.D.,
            Sallusto,F., Patsopoulos,N.A., Rozenblatt-Rosen,O., Kuchroo,V.K.
            and Regev,A.
  TITLE     BACH2 regulates diversification of regulatory and proinflammatory
            chromatin states in TH17 cells
  JOURNAL   Nat Immunol 25 (8), 1395-1410 (2024)
   PUBMED   39009838
  REMARK    GeneRIF: BACH2 regulates diversification of regulatory and
            proinflammatory chromatin states in TH17 cells.
REFERENCE   3  (bases 1 to 9215)
  AUTHORS   Poch,T., Bahn,J., Casar,C., Krause,J., Evangelakos,I., Gilladi,H.,
            Kunzmann,L.K., Laschtowitz,A., Iuso,N., Schafer,A.M., Liebig,L.A.,
            Steinmann,S., Sebode,M., Folseraas,T., Engesaeter,L.K.,
            Karlsen,T.H., Franke,A., Hubner,N., Schlein,C., Galun,E., Huber,S.,
            Lohse,A.W., Gagliani,N., Schwinge,D. and Schramm,C.
  TITLE     Intergenic risk variant rs56258221 skews the fate of naive CD4+ T
            cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
  JOURNAL   Cell Rep Med 5 (7), 101620 (2024)
   PUBMED   38901430
  REMARK    GeneRIF: Intergenic risk variant rs56258221 skews the fate of naive
            CD4[+] T cells via miR4464-BACH2 interplay in primary sclerosing
            cholangitis.
REFERENCE   4  (bases 1 to 9215)
  AUTHORS   Weng,X., Zheng,M., Liu,Y. and Lou,G.
  TITLE     The role of Bach2 in regulating CD8 + T cell development and
            function
  JOURNAL   Cell Commun Signal 22 (1), 169 (2024)
   PUBMED   38459508
  REMARK    GeneRIF: The role of Bach2 in regulating CD8 + T cell development
            and function.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9215)
  AUTHORS   Long,D., Yang,B., Yang,M., Xiong,F., Zhu,X., Tan,Y. and Wu,H.
  TITLE     Bach2 in CD4+ T cells from SLE patients modulates B-cell
            differentiation and IgG production
  JOURNAL   Eur J Immunol 53 (4), e2250109 (2023)
   PUBMED   36781170
  REMARK    GeneRIF: Bach2 in CD4[+] T cells from SLE patients modulates B-cell
            differentiation and IgG production.
REFERENCE   6  (bases 1 to 9215)
  AUTHORS   Vieira,S.A., Deininger,M.W., Sorour,A., Sinclair,P., Foroni,L.,
            Goldman,J.M. and Melo,J.V.
  TITLE     Transcription factor BACH2 is transcriptionally regulated by the
            BCR/ABL oncogene
  JOURNAL   Genes Chromosomes Cancer 32 (4), 353-363 (2001)
   PUBMED   11746976
  REMARK    GeneRIF: BACH2 is transcriptionally regulated by the BCR/ABL
            oncogene.
REFERENCE   7  (bases 1 to 9215)
  AUTHORS   Sasaki,S., Ito,E., Toki,T., Maekawa,T., Kanezaki,R., Umenai,T.,
            Muto,A., Nagai,H., Kinoshita,T., Yamamoto,M., Inazawa,J.,
            Taketo,M.M., Nakahata,T., Igarashi,K. and Yokoyama,M.
  TITLE     Cloning and expression of human B cell-specific transcription
            factor BACH2 mapped to chromosome 6q15
  JOURNAL   Oncogene 19 (33), 3739-3749 (2000)
   PUBMED   10949928
REFERENCE   8  (bases 1 to 9215)
  AUTHORS   Hoshino,H., Kobayashi,A., Yoshida,M., Kudo,N., Oyake,T.,
            Motohashi,H., Hayashi,N., Yamamoto,M. and Igarashi,K.
  TITLE     Oxidative stress abolishes leptomycin B-sensitive nuclear export of
            transcription repressor Bach2 that counteracts activation of Maf
            recognition element
  JOURNAL   J Biol Chem 275 (20), 15370-15376 (2000)
   PUBMED   10809773
REFERENCE   9  (bases 1 to 9215)
  AUTHORS   Kobayashi,A., Yamagiwa,H., Hoshino,H., Muto,A., Sato,K., Morita,M.,
            Hayashi,N., Yamamoto,M. and Igarashi,K.
  TITLE     A combinatorial code for gene expression generated by transcription
            factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ
            domain
  JOURNAL   Mol Cell Biol 20 (5), 1733-1746 (2000)
   PUBMED   10669750
REFERENCE   10 (bases 1 to 9215)
  AUTHORS   Oyake,T., Itoh,K., Motohashi,H., Hayashi,N., Hoshino,H.,
            Nishizawa,M., Yamamoto,M. and Igarashi,K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB240991.1, AJ271878.1, AI524722.1, AB208889.1, AL353692.14 and
            CN261405.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021813.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ271878.1, DRR138518.59113.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257749.9/ ENSP00000257749.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               DB240991.1         70-170
            102-367             AJ271878.1         1-266
            368-534             AI524722.1         267-433
            535-2314            AJ271878.1         434-2213
            2315-3710           AB208889.1         1846-3241
            3711-8666           AL353692.14        122522-127477       c
            8667-9215           CN261405.1         6-554
FEATURES             Location/Qualifiers
     source          1..9215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..9215
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /note="BTB domain and CNC homolog 2"
                     /db_xref="GeneID:60468"
                     /db_xref="HGNC:HGNC:14078"
                     /db_xref="MIM:605394"
     exon            1..364
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /inference="alignment:Splign:2.1.0"
     exon            365..457
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /inference="alignment:Splign:2.1.0"
     exon            458..535
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /inference="alignment:Splign:2.1.0"
     exon            536..648
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /inference="alignment:Splign:2.1.0"
     exon            649..797
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1052
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /inference="alignment:Splign:2.1.0"
     CDS             810..3335
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /note="BTB and CNC homolog 2; BTB and CNC homology 1,
                     basic leucine zipper transcription factor 2"
                     /codon_start=1
                     /product="transcription regulator protein BACH2"
                     /protein_id="NP_068585.1"
                     /db_xref="CCDS:CCDS5026.1"
                     /db_xref="GeneID:60468"
                     /db_xref="HGNC:HGNC:14078"
                     /db_xref="MIM:605394"
                     /translation="MSVDEKPDSPMYVYESTVHCTNILLGLNDQRKKDILCDVTLIVE
                     RKEFRAHRAVLAACSEYFWQALVGQTKNDLVVSLPEEVTARGFGPLLQFAYTAKLLLS
                     RENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNSEDGLFVCRKDAACQRPHEDCENSA
                     GEEEDEEEETMDSETAKMACPRDQMLPEPISFEAAAIPVAEKEEALLPEPDVPTDTKE
                     SSEKDALTQYPRYKKYQLACTKNVYNASSHSTSGFASTFREDNSSNSLKPGLARGQIK
                     SEPPSEENEEESITLCLSGDEPDAKDRAGDVEMDRKQPSPAPTPTAPAGAACLERSRS
                     VASPSCLRSLFSITKSVELSGLPSTSQQHFARSPACPFDKGITQGDLKTDYTPFTGNY
                     GQPHVGQKEVSNFTMGSPLRGPGLEALCKQEGELDRRSVIFSSSACDQVSTSVHSYSG
                     VSSLDKDLSEPVPKGLWVGAGQSLPSSQAYSHGGLMADHLPGRMRPNTSCPVPIKVCP
                     RSPPLETRTRTSSSCSSYSYAEDGSGGSPCSLPLCEFSSSPCSQGARFLATEHQEPGL
                     MGDGMYNQVRPQIKCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQITD
                     LPRNDFQMMIKMHKLTSEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLV
                     CEKEKLLSERNQLKACMGELLDNFSCLSQEVCRDIQSPEQIQALHRYCPVLRPMDLPT
                     ASSINPAPLGAEQNIAASQCAVGENVPCCLEPGAAPPGPPWAPSNTSENCTSGRRLEG
                     TDPGTFSERGPPLEPRSQTVTVDFCQEMTDKCTTDEQPRKDYT"
     exon            1053..2645
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2852
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..9215
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7627..7632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /note="hexamer: AATAAA"
     polyA_site      7645
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /note="major polyA site"
     regulatory      9183..9188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /note="hexamer: AATAAA"
     polyA_site      9215
                     /gene="BACH2"
                     /gene_synonym="BTBD25; IMD60"
                     /note="major polyA site"
ORIGIN      
        1 aaacagcgcc gagccgccgc cgcctcagca gcagcagcag cagcagcagc ggcagcagcg
       61 gccgtgcacg cccgggctgc ggtcgcacag cgctaacgtg agcggccgcc gccctcgcca
      121 ccccgcctgc ccactcccgc cgccgccccg ctctcgcttt ccccccggcc tcccctcgcc
      181 ccttcccctc ccccttcccg gcgcactcgg ggggctggga acgagctgcc atgtgatgcg
      241 cgtcccctcc gcgagctttc ggtgacccac gaactgccca cctcgccggc tgccgggagg
      301 gggctgcgag ccgggaagac gcggggaaga ggaggcggaa aaggacgcaa agttctccgg
      361 cgagcgcgtt cgttcacata gctcccagtt ttaacatttc gccacctact gaagacatca
      421 tttgggacca agctgatgag cccttgaagc acagcagata agagtgttgc tgttgatcat
      481 ctttgcctgg gaagttgaat gataaagcca gaagaaagca tgctttctga tcatttgcag
      541 ctgtctgctt cagaaagtga gggctccagg aatgaggaga atcttcaaga acttcctcgc
      601 actgtgacat gtctgatccc ttgctcccat ccctgcagca tgaacaaggt ggacactcac
      661 tgacctgtca caaggttgcc ccacaaaact ttggggtcca tgtctgaatg gattgccaga
      721 gccttctcat ctctcccttc gcccagttcc ctgcatccta agactcgaag gcagcacagg
      781 acctggaaaa attacatggt gtgaacggca tgtctgtgga tgagaagcct gactccccca
      841 tgtatgtgta tgagtccaca gtccactgca ccaacatcct cctgggcctc aatgaccagc
      901 ggaaaaagga tattctctgt gacgtgactt tgatcgtgga gaggaaggag ttccgggccc
      961 accgggctgt gctggccgca tgcagtgaat atttttggca ggcgctggtt ggacagacaa
     1021 aaaatgattt ggtggtcagc ttgcctgagg aggtcacagc caggggcttt gggccgctgt
     1081 tacagtttgc ctacactgcc aagctgttac tcagcagaga aaacatccgc gaggtcatcc
     1141 gctgtgctga gttcctgcgc atgcacaacc tggaggactc ctgcttcagc ttcctgcaga
     1201 cccagctcct gaacagtgag gatggcctgt ttgtgtgccg gaaggatgct gcgtgccagc
     1261 gcccacacga ggactgcgag aactctgcag gagaggagga ggatgaagag gaggagacga
     1321 tggattcaga gacggccaag atggcttgcc ccagggacca gatgcttcca gagcccatca
     1381 gctttgaggc cgccgccatc cccgtagcag agaaggaaga agccctgctg cccgagcctg
     1441 acgtgcccac agacaccaag gagagctcag aaaaggacgc gttaacgcag taccccagat
     1501 acaagaaata ccagcttgca tgtaccaaga atgtctataa tgcatcatca cacagtacct
     1561 caggttttgc aagcacattc cgggaagata actctagcaa cagcctcaag ccggggcttg
     1621 ccagggggca gattaaaagt gagccgccca gtgaagagaa tgaggaagag agcatcacgc
     1681 tctgcctgtc tggagatgag cctgacgcca aggacagagc gggggatgtc gagatggacc
     1741 ggaaacagcc cagccctgcc cctaccccca cggccccagc tggggccgcc tgcctggaga
     1801 gatccaggag cgtggcctcg ccctcctgct taaggtctct gttcagcata acgaaaagtg
     1861 tggagctgtc tggcctgccc agtacatctc agcagcactt tgccaggagt ccagcctgcc
     1921 cttttgacaa ggggatcact cagggtgacc ttaaaactga ctacacccct ttcacaggga
     1981 attatggaca gccccacgtg ggccagaagg aggtgtccaa cttcaccatg gggtcgcccc
     2041 tcagggggcc tgggttggag gctctctgta aacaggaggg agagctggac cggaggagcg
     2101 tgatcttctc ctccagcgct tgtgaccaag tgagcacctc ggtgcattct tattctgggg
     2161 tgagcagttt ggacaaagac ctctctgagc cggtgccaaa gggtctgtgg gtgggagccg
     2221 gccagtccct ccccagctcg caggcctact cccacggtgg gctgatggcc gaccacttgc
     2281 caggaaggat gcggcccaac accagctgcc cggtaccaat caaagtctgc cctcgctcac
     2341 cccccttgga gaccaggacc aggacttcca gctcctgctc ttcctattcc tacgcggagg
     2401 acgggagcgg gggctcaccc tgcagcctcc ctctctgtga gttctcctcc tcgccctgtt
     2461 cccagggagc cagattcctt gccacagaac atcaggaacc aggcctgatg ggagatggaa
     2521 tgtacaacca agtgcggccc caaattaaat gtgagcagtc ttatggaacc aactccagtg
     2581 acgaatccgg atcgttctcg gaagcagaca gtgagtcgtg tcctgtgcag gacaggggcc
     2641 aggaggtaaa acttcctttt cctgtagatc aaatcacaga tcttccaagg aacgatttcc
     2701 agatgatgat taaaatgcac aagctaacct cagaacagtt agagtttatt catgatgtcc
     2761 gacggcgcag caagaaccgc atcgcggccc agcgctgccg caaaaggaaa ctggactgta
     2821 ttcagaattt agaatgtgaa atccgcaaat tggtgtgtga gaaagagaaa ctgttgtcag
     2881 agaggaatca actgaaagca tgcatggggg aactgttgga caacttctcc tgcctttccc
     2941 aggaagtttg ccgagacatc cagagccccg agcagatcca ggccctgcat cggtattgcc
     3001 ctgtcctcag acccatggac ttgcccacgg cctccagtat taaccctgcg cccttgggtg
     3061 ctgagcagaa cattgcggcc tcccaatgcg cagtggggga aaacgtgccc tgctgcttgg
     3121 agccaggcgc ggctcccccc ggacccccct gggcacccag caacacctcc gagaattgta
     3181 cctctgggag gagactagaa ggcactgacc cgggaacctt ctcagagaga ggacctcctc
     3241 ttgaacccag gagccaaaca gtgaccgtgg acttctgcca ggaaatgact gataagtgta
     3301 caactgacga acagcccagg aaagattata cctagtgact cggctctgcc tcccagtccg
     3361 cacacctctc ccatccaggc gttcttcagt cagcctgtgg cactgttcat ctgctgtccc
     3421 gaagaaaccg agaacacatt tggtgcacac tacagcggtc ttagcagcaa tactgttccg
     3481 aagtatcctc tcctcttctc gagcaggagt gatagttacc ttcacaatgg tgctacccct
     3541 tgcccaggca aggaaagaca gcagtgatga cactgtctgt ctgtggctca atttcagtct
     3601 tcacagggat agactacaac acctctaggc cccaaccacg gatttttttt ctcagtggcc
     3661 catgtcacaa accctatctc aggaatttct tctgaatgtt caattttttt cattgaagac
     3721 agcttctata cacatcaaag ttttatagct agactgtaca tattatatat aatatatata
     3781 taaaatatat atatatatat atatatatcc atatgcaaaa gtcctgcatg cctcaacttt
     3841 ctcatcctaa aactggaaac ttatttctca tttagaaaca ggttccaaca ttcctcttct
     3901 tttgtctctg atgctagaac tagtttggta actgttaaca tggtcatttt tcttgcttca
     3961 cagttcaatt ttcaattcgt acttatttat ggacaaaatt cagtgttgga agctttttcc
     4021 caaggtttta tttcagattt ctttttcgtt tggtttggtt ttggcacctc caagtggtgt
     4081 catttgagca ttgtaggttt gttttttgtt tgtttggggg gttttgtttg tttttgtttt
     4141 tgtttttgtt ttccttgcag atactgtaca gtaatggtca actttgccac ttgcactgag
     4201 ttttgggtca aacctatttt cttaaatgaa gttgtaactt cggtataact caagtatact
     4261 gtatattctt tgcttttagt taaaaaagta aaacatttta gctaattaaa aagcactcag
     4321 gtgataatta tgtaggaaaa acaatcttgc caaataatga attcatccta ggatgtgtag
     4381 acaataatct gcttgaatat ttttatattt cacctcctcc ccacctttcc ctaagcaaag
     4441 tttaaacgca gatagagagt tcagagttga tgctggatgt tcagattcct aagtggggag
     4501 agagtttgga catctcactc aaaagtacat cagaaaaaca ggaatccgtg attttatacc
     4561 agaactcagc aggcattggc tcctagaaat caagttagaa agttttcacc cagggagtaa
     4621 gtcccattca tttcaacacg tcctgaggcc tcggcttgct cttggaagtg ttgtgcagta
     4681 ggacctgctc ccctgaagga cggggccaac cagccactgg ctttcctgcc caggcttggc
     4741 ctcccaggac atctggcctg aggggatttg aatcacagcc ccgaaggtcc tgccttcacc
     4801 ccattgggag agagcagggc atcctggcat ctgcgatcca tccctgacac aggctgacac
     4861 attctttctc ctttccttct ccaaaggctt ggagttttct tctgaggttt ttctgccagt
     4921 gtcttgtctg aaggcagact tcattctgag gctttggaca agctatcacc gggaaccctc
     4981 cctgtcccct tcccgaatca cacacatacc ctaccctcac ctgatgataa ttttctcttc
     5041 ttgctgcaaa actggttggc ttgcaaccca gagagagcag cttcccttgg ctctggggcc
     5101 gtgttggccc cagccacgtt tacaggaagg tgtgccccag aggaggagga atcagctccc
     5161 tcgctccagt ggccttgggt ccgggtctca ctgagcagcc cgagggccac tccagcccgg
     5221 ctggggaaga gagtcctgaa cggtttgatg tggggatggg gtggtgggca gtggggaata
     5281 gatggttgac tttgtttctt tatttgtgcc attgtttgga caatattaaa gctgcatgta
     5341 aaaggggaaa ttagtatatg atgtaggcta aaagtgaaat catagtaaca tatgttttag
     5401 tattattaac ttttttctgt acaaatatta gcactaaatg tttaaatatg tatgaatgcc
     5461 agaaatttgt cagttcatgc agtaggataa aaaaaaaaaa aaaaaaaaaa aaaaggcttt
     5521 tctttttaaa cagttccact tttaaaacct gcctctgggt ttttgttttt tcttgtttgt
     5581 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtct gaaacagatc
     5641 ttgataaagc tctgtgttgg agctgctggt ttttgttatg gttgttggaa tttcttggcc
     5701 tactaggaca gttctgtgct tcaccatgag gtttgccttt gtggaaaact ggtgacagtg
     5761 agaatataaa ctcaatgtga atcacgtgat acttcgcagg cgtgtgttac agtggagtca
     5821 gctgacagta ttttgctttt taactctatt gttgcctttc caagtgacct ctcctcttct
     5881 tttaaaaaaa gaacactttc tgctcatatc ataaccaggt ccaacccagc ttcttggcat
     5941 gaggtttacc ctggtaacaa ctcatgtgca actggtagtc ttgaccacat tccatccatt
     6001 tcctcaggtt tctgtggttc agtagcccag acctgtttgg cagccatttc tagcaggggc
     6061 ggggcctctt tatttctctc caccctaact cagacctcac cttcctccca cccacccctg
     6121 ccttgctttt cttcctcttc ccccaaccta acttctgcca tgggaactgg ttaaaaacac
     6181 tgctctaaaa accatcttcc aatttcatag agatttctca caagttattt cattcataat
     6241 ccaccatgaa cagtgactag cttcgtgcag ttgttcatgt gatgtgtgtg tgtcttttcc
     6301 tattcagaac tatgtgcttg tcaaaattat ttctgggttg attcaaaggg aggacttgct
     6361 ggggaccaga atccaaacgg cctcaagtgg aattttaaaa cctagcctgt ctcttttccc
     6421 tgggatccct ctgtcaaccc cacgcctttt aggaaaaaga aaagtgagtg aacagcaagg
     6481 aagagtgttt gcacagtaca gtaacatttg gttgttctta aggctctttt cttacaaaaa
     6541 taagagaccc tccaaccacg ggctgtttag gaggatgcct gcttgggtct ccaaatggct
     6601 ggggtaggaa tggttgttgg ggcagagcca gtggaggtga gtgaccctga gactaatgaa
     6661 catcccacct aaatccagtc ctccccttgg atctgccttt gtcctgcttg tgtatccagg
     6721 caacctcttt tcaagttggt caggctttgg acaggtgagt gatttgctgt atgtgtttgt
     6781 ttctctgcgt tacctggggg tgccttgatt aaaatcgaac tttattacat actgattctg
     6841 gaacaaaaca gttagaaaaa ctttaaaaaa aaaaaaaccg acaaagttac gaggccatcc
     6901 tgctatttat cttctgagtt cccagcaatg actcaggcat cagagatgat gctgcagtgg
     6961 aaaacctgac tctgtgtgtc tgcaactgaa tgttgtgcga gtaatttatt aactgtcttt
     7021 ctaaaggttt gctgctttta agatgcacta taattcggga tgtaatcctt acattgcttt
     7081 tccaaggaag ggaacaaaag tctagtgatt agtatgccaa ctgccactac tccttcaaaa
     7141 ggagccagga ccagcgacaa gactcatgag aggactggct aaagtgaagt gtgcacagtg
     7201 tgaagtttaa tgctgttgtc aagaggccta aacccacatt ttctctttta atattttatg
     7261 attgccatca aagaagaaga aaaagaagga acagacaaag gtttgaaaat gataagcctg
     7321 ttaagacacc aaaaactcct gtcccgtgaa gctgcttgac atcctgtgga gtagcataat
     7381 cctctcaaaa tgaggaagag ctgcctgcaa agctttctca agtccctatt tggctaccta
     7441 cttctctaca ttatgcccca tttaaactag gagctgtctt agaaatgact tcaaactgct
     7501 tcactattgc ttacagttta ggaggagtct cagatccaga aggagcaaga atcaagtttg
     7561 gtcctcaaat gactgtaaat agactaaaga acaaggtgtt ttttgttttt gtttttgttt
     7621 tctaagaata aagctgttcg ttgtatcatg agttagtgtt tcttccccaa actgaagact
     7681 gtgttggaag tgcaatttct ggtgagtcag tccacaatac aatgccctgt gtggagttgg
     7741 tattcataca ggaaatctgt gtgcacgagg cattgtgtgt tgaaagtgta tgtttatagt
     7801 actgcctgag ccatctcatg accccagcgt ccaaaaccga tgctgtagaa cagaacatat
     7861 ctgtacacaa atagtgtgtg caaatagcat ttgtacatag aaaagtctca ttgtggcaga
     7921 ttgagcataa attattcaac tgacggtgca aaaacattac ttgcaaagaa aagtttatag
     7981 tattttccta cactccaccc tgggagatga tatttctatc aaatgaatat cagtgcattt
     8041 taaatgtaat atgaaaacga tgctgccatt ttgtgaagaa tacccacttg gttgcagagg
     8101 ccaactttca tagctttgat ttaatgttgt gacacggtgt atgcattttg ctgtcaagca
     8161 atggataaac agctctgact ttcattctca ttccagttta ttgacctcag ataaaacact
     8221 ggcccttctt agaagcagaa gtgtgcacca agaccattca tttcaggtag actcacattc
     8281 agtgccaagt gctcccatgg gaataatcag acgcatatgt tgcgaaagag tgaagggact
     8341 tggacaaaga ggggttttcc tacagatgga tgctcagtct tctaccaaaa catgtttgga
     8401 ggcagaacta tgacctcccc ttaagtccta acaatgtatt ttgtgtgtgc aaatcctggg
     8461 atgcccgttt cacgctctga cataaagaca tggcacctct agtgagtgat caggaagatt
     8521 ccatatgcat ttgggagctt caggtgcttg ttagacacag tgagccattc aaggcaagca
     8581 ccacctttgc tagtgaggcc aagagagcct gtgacaattt gacaatttgt tccagaacca
     8641 gtctgatgca agtgcacctc taatatatgc cttacaaact ccagaggcca tattcaaaac
     8701 agggtcttct cagtgtatgc aaggggctgc agcccctctt ctcttcctcc ccaggttgaa
     8761 caatacggac agttttcaca catatctacc tgtataaccc tctgtacctc tcataactgg
     8821 tcaacgactg taacaggtta catcaggtgt ttttctacat actttttaca cagattctat
     8881 gcgattaatg taatttaatt caatgcatca ttttattgta ctagttctta ggcttgtcct
     8941 tatttttttc taagtgattg tggtttttct cgtggttttt attgtaaaaa atgaaaggct
     9001 gttgatgctt attctctgta actaagaatt tttacctttt gggggaaaaa agcattgcta
     9061 tgaactaatg aattgaaact tcatttactc attgtaaata cactattgtg caaaaaaagt
     9121 tttcactcaa ttgaattgct agtgttaact gaattttgtc tagacaccat ttctgttgat
     9181 gaaataaaga catatcatta tgcattgtaa actga
//
