LOCUS       NM_001186               5618 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens BTB domain and CNC homolog 1 (BACH1), transcript
            variant 2, mRNA.
ACCESSION   NM_001186
VERSION     NM_001186.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5618)
  AUTHORS   Chen,Y., Zeng,Z. and Chen,J.
  TITLE     Role of BACH1 in multiple myeloma
  JOURNAL   Hematology 29 (1), 2352687 (2024)
   PUBMED   38767507
  REMARK    GeneRIF: Role of BACH1 in multiple myeloma.
REFERENCE   2  (bases 1 to 5618)
  AUTHORS   Xiao,S., Li,G., Tan,M., Liu,W. and Li,W.
  TITLE     Loss of BACH1 improves osteogenic differentiation in
            glucocorticoid-induced hBMSCs through restoring autophagy
  JOURNAL   BMC Musculoskelet Disord 25 (1), 665 (2024)
   PUBMED   39182017
  REMARK    GeneRIF: Loss of BACH1 improves osteogenic differentiation in
            glucocorticoid-induced hBMSCs through restoring autophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5618)
  AUTHORS   Dennis,M., Hurley,A., Bray,N., Cordero,C., Ilagan,J., Mertz,T.M.
            and Roberts,S.A.
  TITLE     Her2 amplification, Rel-A, and Bach1 can influence APOBEC3A
            expression in breast cancer cells
  JOURNAL   PLoS Genet 20 (5), e1011293 (2024)
   PUBMED   38805570
  REMARK    GeneRIF: Her2 amplification, Rel-A, and Bach1 can influence
            APOBEC3A expression in breast cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5618)
  AUTHORS   Liu,L., Matsumoto,M., Watanabe-Matsui,M., Nakagawa,T., Nagasawa,Y.,
            Pang,J., Callens,B.K.K., Muto,A., Ochiai,K., Takekawa,H., Alam,M.,
            Nishizawa,H., Shirouzu,M., Shima,H., Nakayama,K. and Igarashi,K.
  TITLE     TANK Binding Kinase 1 Promotes BACH1 Degradation through Both
            Phosphorylation-Dependent and -Independent Mechanisms without
            Relying on Heme and FBXO22
  JOURNAL   Int J Mol Sci 25 (8), 4141 (2024)
   PUBMED   38673728
  REMARK    GeneRIF: TANK Binding Kinase 1 Promotes BACH1 Degradation through
            Both Phosphorylation-Dependent and -Independent Mechanisms without
            Relying on Heme and FBXO22.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5618)
  AUTHORS   Kanezaki,R., Toki,T., Yokoyama,M., Yomogida,K., Sugiyama,K.,
            Yamamoto,M., Igarashi,K. and Ito,E.
  TITLE     Transcription factor BACH1 is recruited to the nucleus by its novel
            alternative spliced isoform
  JOURNAL   J Biol Chem 276 (10), 7278-7284 (2001)
   PUBMED   11069897
REFERENCE   6  (bases 1 to 5618)
  AUTHORS   Kobayashi,A., Yamagiwa,H., Hoshino,H., Muto,A., Sato,K., Morita,M.,
            Hayashi,N., Yamamoto,M. and Igarashi,K.
  TITLE     A combinatorial code for gene expression generated by transcription
            factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ
            domain
  JOURNAL   Mol Cell Biol 20 (5), 1733-1746 (2000)
   PUBMED   10669750
REFERENCE   7  (bases 1 to 5618)
  AUTHORS   Blouin,J.L., Duriaux Sail,G., Guipponi,M., Rossier,C.,
            Pappasavas,M.P. and Antonarakis,S.E.
  TITLE     Isolation of the human BACH1 transcription regulator gene, which
            maps to chromosome 21q22.1
  JOURNAL   Hum Genet 102 (3), 282-288 (1998)
   PUBMED   9544839
REFERENCE   8  (bases 1 to 5618)
  AUTHORS   Ohira,M., Seki,N., Nagase,T., Ishikawa,K., Nomura,N. and Ohara,O.
  TITLE     Characterization of a human homolog (BACH1) of the mouse Bach1 gene
            encoding a BTB-basic leucine zipper transcription factor and its
            mapping to chromosome 21q22.1
  JOURNAL   Genomics 47 (2), 300-306 (1998)
   PUBMED   9479503
REFERENCE   9  (bases 1 to 5618)
  AUTHORS   Oyake,T., Itoh,K., Motohashi,H., Hayashi,N., Hoshino,H.,
            Nishizawa,M., Yamamoto,M. and Igarashi,K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
REFERENCE   10 (bases 1 to 5618)
  AUTHORS   Rehfuss,R.P., Walton,K.M., Loriaux,M.M. and Goodman,R.H.
  TITLE     The cAMP-regulated enhancer-binding protein ATF-1 activates
            transcription in response to cAMP-dependent protein kinase A
  JOURNAL   J Biol Chem 266 (28), 18431-18434 (1991)
   PUBMED   1655749
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC063307.1, AF124731.2 and
            AI336948.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001186.3.
            
            Summary: This gene encodes a transcription factor that belongs to
            the cap'n'collar type of basic region leucine zipper factor family
            (CNC-bZip). The encoded protein contains broad complex, tramtrack,
            bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is
            atypical of CNC-bZip family members. These BTB/POZ domains
            facilitate protein-protein interactions and formation of homo-
            and/or hetero-oligomers. When this encoded protein forms a
            heterodimer with MafK, it functions as a repressor of Maf
            recognition element (MARE) and transcription is repressed. Multiple
            alternatively spliced transcript variants have been identified for
            this gene. [provided by RefSeq, May 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063307.1, SRR1660809.206118.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286800.8/ ENSP00000286800.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3492              BC063307.1         1-3492
            3493-5067           AF124731.2         101162-102736
            5068-5618           AI336948.1         2-552               c
FEATURES             Location/Qualifiers
     source          1..5618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.3"
     gene            1..5618
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
                     /note="BTB domain and CNC homolog 1"
                     /db_xref="GeneID:571"
                     /db_xref="HGNC:HGNC:935"
                     /db_xref="MIM:602751"
     exon            1..32
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
                     /inference="alignment:Splign:2.1.0"
     exon            33..326
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2303
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
                     /note="basic region leucine zipper transcriptional
                     regulator BACH1; BTB and CNC homology 1, basic leucine
                     zipper transcription factor 1"
                     /codon_start=1
                     /product="transcription regulator protein BACH1"
                     /protein_id="NP_001177.1"
                     /db_xref="CCDS:CCDS13585.1"
                     /db_xref="GeneID:571"
                     /db_xref="HGNC:HGNC:935"
                     /db_xref="MIM:602751"
                     /translation="MSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQR
                     FRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKEN
                     VDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLL
                     DQRDLETDEVEEFLENKNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAAL
                     ALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGGVPECRDLQVM
                     LKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGD
                     LNFAGMQNTTVLTEKPLSGTDVQEKTFGESQDLPLKSDLGTREDSSVASSDRSSVERE
                     VAEHLAKGFWSDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESPEPGQ
                     RTFTTLSSVNCPFISTLSTEGCSSNLEIGNDDYVSEPQQEPCPYACVISLGDDSETDT
                     EGDSESCSAREQECEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRRRSK
                     NRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLCQKV
                     CKEAALSQEQIQILAKYSAADCPLSFLISEKDKSTPDGELALPSIFSLSDRPPAVLPP
                     CARGNSEPGYARGQESQQMSTATSEQAGPAEQCRQSGGISDFCQQMTDKCTTDE"
     exon            327..1661
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1868
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..5618
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5431..5436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
                     /note="hexamer: AATAAA"
     polyA_site      5459
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
     regulatory      5587..5592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
                     /note="hexamer: AATAAA"
     polyA_site      5618
                     /gene="BACH1"
                     /gene_synonym="BACH-1; BTBD24"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtcgg gccgcgccgc gcctcagctc tggttgatga taattagaag catgctttcc
       61 actgaacttc ccgacaacat ttgttatgca gaatgtctct gagtgagaac tcggtttttg
      121 cctatgaatc ttctgtgcat agcaccaatg ttttactcag ccttaatgac cagcggaaga
      181 aagatgtgct gtgcgatgtc accatctttg tggagggaca gcggttccgc gctcaccggt
      241 ccgtgctggc ggcatgcagc agttacttcc actcaagaat cgtaggccag gctgatggag
      301 agctgaacat tactcttcca gaagaggtga cagttaaagg atttgaacct ttaattcagt
      361 ttgcctacac tgctaaactg attttaagta aagagaatgt ggatgaagtg tgcaaatgtg
      421 tggagttttt aagtgtacat aatattgagg aatcctgctt tcagtttctg aaatttaagt
      481 ttttggactc cactgcagac cagcaagaat gcccaagaaa aaaatgcttt tcatcacact
      541 gtcagaaaac agaccttaaa ctttcacttt tggaccagag ggatctagaa actgatgaag
      601 tggaggaatt tctggaaaat aaaaatgttc agactcctca gtgtaaactc cgcaggtatc
      661 aaggaaatgc aaaagcctca cctcctctac aagacagtgc cagtcagaca tatgagtcca
      721 tgtgcttaga gaaggatgct gctctggcct tgccttcttt atgccccaaa tacagaaaat
      781 tccaaaaagc atttggaact gacagagtcc gtactgggga atctagtgtc aaagacattc
      841 atgcttctgt tcagccaaat gaaaggtctg aaaatgaatg cctgggagga gtcccggagt
      901 gtagagattt gcaggtgatg ttaaaatgtg acgaaagtaa attagcaatg gaacctgaag
      961 aaacgaagaa agatcctgct tctcagtgcc caactgaaaa atcagaagtg actcctttcc
     1021 cccacaattc ttccatagac cctcatggac tttattcttt gtctctttta cacacatatg
     1081 accaatatgg tgacttgaat tttgctggta tgcaaaacac aacagtgtta acagaaaagc
     1141 ctttgtcagg tacagacgtc caagaaaaaa catttggtga aagtcaggat ttacctttga
     1201 aatccgactt gggcaccagg gaagatagta gtgttgcatc tagtgatagg agtagtgtgg
     1261 agcgagaagt ggcagaacac ctagcaaaag gcttctggag tgacatttgc agcacggaca
     1321 ctccttgcca aatgcagtta tcacctgctg tggccaaaga tggctcagaa cagatctcac
     1381 agaaacggtc tgagtgtccg tggttaggta tcaggattag tgagagccca gaaccaggtc
     1441 aaaggacttt cacaacatta agttctgtca actgcccttt tataagtact ctgagtactg
     1501 aaggctgttc aagcaatttg gaaattggaa acgatgatta tgtttcagaa ccccagcaag
     1561 aaccttgccc atatgcttgt gtcattagct tgggagacga ctctgagacg gacaccgaag
     1621 gagacagtga atcctgttca gccagagaac aagaatgtga ggtaaaactg ccattcaatg
     1681 cacaacggat aatttcactg tctcgaaatg attttcagtc cttgttgaaa atgcacaagc
     1741 ttactccaga acagctggat tgtatccatg atattcgaag aagaagtaaa aacagaattg
     1801 ctgcacagcg ctgtcgcaag agaaaacttg actgtataca gaatcttgaa tcagaaattg
     1861 agaagctgca aagtgaaaag gagagcttgt tgaaggaaag agatcacatt ttgtcaactc
     1921 tgggtgagac aaagcagaac ctaactggac tttgccagaa agtttgtaaa gaagcagctc
     1981 tgagtcaaga acaaatacag atactcgcca agtactcagc tgcagattgc ccactttcat
     2041 ttttaatttc tgaaaaagat aaaagtactc ctgatggtga actggcgtta ccatcaattt
     2101 tcagtttatc tgaccggcct ccagcagtgc tgcctccctg tgccagagga aacagtgagc
     2161 ctggctacgc gcgagggcag gagtcccagc agatgtccac agccacctct gagcaagctg
     2221 ggcctgcgga acagtgtcgt cagagtggtg ggatctcaga tttctgtcag cagatgactg
     2281 ataaatgtac tactgatgag taaacttgca ttcacttcct tcaaaccatc taattttctc
     2341 ctgaagtttt ggcagcgtct tgaaagccta atatgaccat ctgttgctca acaatactgt
     2401 ttttttcctt tagtagttta ccataaggga atttccttta agtcaaccat gatttctcct
     2461 tgatttctac aagagacaaa gaaatgattt tgcctcctgg atatcagaaa aatccatgtg
     2521 aaaatgtagt aaacctttaa aactcatgtt ttaaagaata ataactctag taataactct
     2581 tcctgctatt cagaataagt aggagaatga aaactgcagc atatcagaca gcaatttaac
     2641 agcttgaaac atctacagat agttcctact aaaagaagtg gcctgcagaa gtttaataat
     2701 ttgacttttt tctaatattt tagtttgaaa gaaaatttct tcccaagcaa tgctaataga
     2761 gttctattct tagaagcagg gtgtcagcta ctgggaatat ttttgtagag ctgcattgtg
     2821 aaaaaaagat ggtcttacct gaatcttagg gctttgttct tcggctccta aaatcaggct
     2881 ttaagctaca ttgggaagat ttagtaaata ggcaagtggt tggcctaaga cgggggctgc
     2941 ttctcctctt cagtatggac tctagaaagt ctggctacat gaatagattt aagtgtcact
     3001 ttccctccct gccccccgct tcagtctcta ccatatctgg tcccatcatg gacttcctat
     3061 ttcctggcat ttttgtccct ttggaagaag aaataggact cagaatacag tggcatgagt
     3121 gattacactg gcagcattat ctcaggctcc ctagaatctg gagagcttac caacatgtaa
     3181 agctgttcat ttttccaccg tgggtcacca atgccagaaa accagacatc acggggaaag
     3241 aatgttgctt actttttacc aggagtgcag ttcatttttt tcaccctgtt tttgaagtcg
     3301 tattattcac ttgtaaaaat gattgtaaca gataaaaaat gtatctgcag caactctgca
     3361 ggtttgtgaa ataggatgaa actcaatctt tttctattgt gggtttgcat ttgaaaagca
     3421 ggttgaatcc ttgctctctt ctccaaattt ggtgtggtat aaagacacac aaatcatttt
     3481 aacttggaca tttaaagatc agtcttagtg tttgttcagt cctgttacaa aatagataac
     3541 tgagcaccta tcgcataaca ttttgcggtg gcttttagcc atgctggggt tagatgtgtt
     3601 tgagagtcaa atgaaagcta tggatcttct cagcaattaa aaaaaatgca tatattcaca
     3661 ttcacagaaa cattggcaga acccagtttt aatggtacag aggagtagtt tatagtgttg
     3721 atttcaccaa aatcagaggg ctgaaagaga cacttctata gactgcatcc tgagcctagt
     3781 gcagggcttg tctagctaat gtgggcagcc accacccact gtgtatgaac aagtctgaag
     3841 caagttggcc ttgcccttga gagtatatgg ggaccagtct tcatgtcttg gagtaatttg
     3901 tcaaatgtta ccctttttga tcagggtgta gggggaggat attgctagta tattttcagt
     3961 ggtttgtatg ttctctctgt cactgactta tttgtaagag aaaattagtt ggacttgttt
     4021 attttctagt agcttttata agtacactca agaatttgtc agggagaata attctgatag
     4081 tgcatcccat actgcaaaag aatttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta
     4141 tgtgtatgta tacatatata tctctccata taggtatttc tttgatactt gtaattttaa
     4201 atttcagctt cacgatataa aataatataa gaacttctgg tttacaaaat gtaaaatctt
     4261 aagccaatgg aacccttgat ttcctacctc agtgtacacc caactattgg ttgtatcagt
     4321 ttgtgtatgt gcaaatgtca aataatcttt tgctttaatt gctactgtac ttgctttgaa
     4381 agattaccta ctattttatg ataaaatgta gttgtctcca gagcttaaat ataatttgta
     4441 aagcacttgg tttaaatttc tctctaccta taaacagttt agcattaagg gtttctatta
     4501 atgacacaga attattggcc aagtgtaatt tcttaaaatt tagcattact ttaaatagcc
     4561 agcatgtaat acaagtaact acactacctc atatctacat gattttcaag ttgtaatgca
     4621 gatggacaga taaaaaagat tttacgtttg tcttttggcc ataagtggga aagttttctg
     4681 tatattgcat agcattacac atttatgcct attttaacat taacttctaa agaagttttt
     4741 tctaagaaaa tgtttcaagg caatattttt tttgaggctg ccgaagacaa atgacaggat
     4801 tatgagtata cagtgtatgc cttttccttc atgcagaatt ttgaaatgtt ttcagtttgt
     4861 atattgcata ttcacatgat cattgttcac tattttatga actggccttc tcaatgtttg
     4921 atgatttttt aaaagctgtt atgttgaatt cagtaaaata acattacctt attttttttc
     4981 ttattcaaat tctggaacta tagcaaataa ttcgttaaat tgtcatattc aaaacaaatg
     5041 tggatacagt cttggttctc catctgtaat tttttttaac agtttgctat agcttactgc
     5101 ttaactaatt ttaaataagg aaataagtat gttagatgca gtagacgata caggttgcat
     5161 gtggacactc agtcacatta acaacttggg aaaaaaatgg caatgttacg gtgaattctc
     5221 aggtgaactt ttttcagtta taaaacatct attttgaatc tgtaaatatt ttaaatgttt
     5281 tattaaggca tgtaataaac tattctttga aacttgttgg gtagaatgaa aattaaagcc
     5341 ataatggtag aagatggcat actgattata aaagaagcag aaaaacattg atttttttat
     5401 atctttcata atataatttt ctaacaatgc aataaaacca ctaaactttt gtgtccatat
     5461 tttactgaga ccatgtttca ttaaaagcat agtttcatag tatttaattt acatttctcc
     5521 ctaatgttct tacccaaatg tacctgaact aaaaaatgtt agatgttggt gataagttga
     5581 cagttaaata aaattctcta aaattgcttc taattgaa
//
