LOCUS       NM_004776               4722 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens beta-1,4-galactosyltransferase 5 (B4GALT5), mRNA.
ACCESSION   NM_004776
VERSION     NM_004776.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4722)
  AUTHORS   Wu,Y., Zhao,B., Chen,X., Geng,X. and Zhang,Z.
  TITLE     Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia
            progression through modulating B4GALT5 expression and PI3K/AKT
            signaling pathway
  JOURNAL   Int J Lab Hematol 44 (2), 320-332 (2022)
   PUBMED   34709725
  REMARK    GeneRIF: Circ_0009910 sponges miR-491-5p to promote acute myeloid
            leukemia progression through modulating B4GALT5 expression and
            PI3K/AKT signaling pathway.
REFERENCE   2  (bases 1 to 4722)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4722)
  AUTHORS   Sun,G., Cao,Y., Dai,X., Li,M. and Guo,J.
  TITLE     Hsc70 Interacts with beta4GalT5 to Regulate the Growth of Gliomas
  JOURNAL   Neuromolecular Med 21 (1), 33-41 (2019)
   PUBMED   30607818
  REMARK    GeneRIF: Hsc70 Interacts with beta4GalT5 to Regulate the Growth of
            Gliomas.
REFERENCE   4  (bases 1 to 4722)
  AUTHORS   Chatterjee,S.B., Hou,J., Bandaru,V.V.R., Pezhouh,M.K., Syed Rifat
            Mannan,A.A. and Sharma,R.
  TITLE     Lactosylceramide synthase beta-1,4-GalT-V: A novel target for the
            diagnosis and therapy of human colorectal cancer
  JOURNAL   Biochem Biophys Res Commun 508 (2), 380-386 (2019)
   PUBMED   30502090
  REMARK    GeneRIF: beta-1,4-GalT-V gene/protein expression is specifically
            increased in colorectal cancer, compared to visibly normal tissue.
            Furthermore, we observed a marked increase in its enzymatic
            activity, and its product lactosylceramide. beta-1,4-GalT-V may
            serve as a diagnostic and therapeutic biomarker for the progression
            of colorectal cancer.
REFERENCE   5  (bases 1 to 4722)
  AUTHORS   Li,S.F., Zhu,C.S., Wang,Y.M., Xie,X.X., Xiao,L.L., Zhang,Z.C.,
            Tang,Q.Q. and Li,X.
  TITLE     Downregulation of beta1,4-galactosyltransferase 5 improves insulin
            resistance by promoting adipocyte commitment and reducing
            inflammation
  JOURNAL   Cell Death Dis 9 (2), 196 (2018)
   PUBMED   29415997
  REMARK    GeneRIF: Results demonstrated B4GalT5 downregulation improved
            insulin resistance by promoting adipogenic commitment and
            decreasing M1 macrophage infiltration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4722)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 4722)
  AUTHORS   Amado,M., Almeida,R., Schwientek,T. and Clausen,H.
  TITLE     Identification and characterization of large galactosyltransferase
            gene families: galactosyltransferases for all functions
  JOURNAL   Biochim Biophys Acta 1473 (1), 35-53 (1999)
   PUBMED   10580128
  REMARK    Review article
REFERENCE   8  (bases 1 to 4722)
  AUTHORS   Lo,N.W., Shaper,J.H., Pevsner,J. and Shaper,N.L.
  TITLE     The expanding beta 4-galactosyltransferase gene family: messages
            from the databanks
  JOURNAL   Glycobiology 8 (5), 517-526 (1998)
   PUBMED   9597550
REFERENCE   9  (bases 1 to 4722)
  AUTHORS   Sato,T., Aoki,N., Matsuda,T. and Furukawa,K.
  TITLE     Differential effect of alpha-lactalbumin on
            beta-1,4-galactosyltransferase IV activities
  JOURNAL   Biochem Biophys Res Commun 244 (3), 637-641 (1998)
   PUBMED   9535717
REFERENCE   10 (bases 1 to 4722)
  AUTHORS   Sato,T., Furukawa,K., Bakker,H., Van den Eijnden,D.H. and Van
            Die,I.
  TITLE     Molecular cloning of a human cDNA encoding
            beta-1,4-galactosyltransferase with 37% identity to mammalian
            UDP-Gal:GlcNAc beta-1,4-galactosyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 472-477 (1998)
   PUBMED   9435216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR000345.1, BC104987.1, AL035683.9 and BG939833.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004776.3.
            
            Summary: This gene is one of seven beta-1,4-galactosyltransferase
            (beta4GalT) genes. They encode type II membrane-bound glycoproteins
            that appear to have exclusive specificity for the donor substrate
            UDP-galactose; all transfer galactose in a beta1,4 linkage to
            similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a
            distinct function in the biosynthesis of different glycoconjugates
            and saccharide structures. As type II membrane proteins, they have
            an N-terminal hydrophobic signal sequence that directs the protein
            to the Golgi apparatus and which then remains uncleaved to function
            as a transmembrane anchor. By sequence similarity, the beta4GalTs
            form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and
            beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function
            of the enzyme encoded by this gene is not clear. This gene was
            previously designated as B4GALT4 but was renamed to B4GALT5. In the
            literature it is also referred to as beta4GalT2. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF038663.1, AB004550.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371711.4/ ENSP00000360776.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               DR000345.1         15-169
            156-1642            BC104987.1         1-1487
            1643-4229           AL035683.9         41534-44120         c
            4230-4722           BG939833.1         16-508              c
FEATURES             Location/Qualifiers
     source          1..4722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..4722
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /note="beta-1,4-galactosyltransferase 5"
                     /db_xref="GeneID:9334"
                     /db_xref="HGNC:HGNC:928"
                     /db_xref="MIM:604016"
     exon            1..303
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1355
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /EC_number="2.4.1.274"
                     /note="beta-1,4-GalT IV; beta4-GalT IV; UDP-Gal:betaGlcNAc
                     beta 1,4-galactosyltransferase, polypeptide 5;
                     beta-1.4-galactosyltransferase V; beta-1,4-GalT II;
                     beta-1,4-GalTase 5; UDP-Gal:beta-GlcNAc
                     beta-1,4-galactosyltransferase 5;
                     UDP-galactose:beta-N-acetylglucosamine
                     beta-1,4-galactosyltransferase 5; lacCer synthase;
                     lactosylceramide synthase; glucosylceramide
                     beta-1,4-galactosyltransferase"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 5"
                     /protein_id="NP_004767.1"
                     /db_xref="CCDS:CCDS13420.1"
                     /db_xref="GeneID:9334"
                     /db_xref="HGNC:HGNC:928"
                     /db_xref="MIM:604016"
                     /translation="MRARRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLF
                     MMQAQGILIRDNVRTIGAQVYEQVLRSAYAKRNSSVNDSDYPLDLNHSETFLQTTTFL
                     PEDFTYFANHTCPERLPSMKGPIDINMSEIGMDYIHELFSKDPTIKLGGHWKPSDCMP
                     RWKVAILIPFRNRHEHLPVLFRHLLPMLQRQRLQFAFYVVEQVGTQPFNRAMLFNVGF
                     QEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVS
                     GLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGE
                     VQFLGRYALLRKSKERQGLDGLNNLNYFANITYDALYKNITVNLTPELAQVNEY"
     exon            304..438
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /inference="alignment:Splign:2.1.0"
     exon            439..552
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /inference="alignment:Splign:2.1.0"
     exon            553..677
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /inference="alignment:Splign:2.1.0"
     exon            678..794
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /inference="alignment:Splign:2.1.0"
     exon            795..982
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1105
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1207
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..4722
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4702..4707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /note="hexamer: AATACA"
     polyA_site      4722
                     /gene="B4GALT5"
                     /gene_synonym="B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5;
                     beta4GalT-V; gt-V"
                     /note="major polyA site"
ORIGIN      
        1 atgtggcccg gcccgcgacg gccggcggct gggagcggcg aggcggcggc ggcggcgagt
       61 ggcggcccgc gaggcccggg aggcggtggc cgaggcccag gcggtggcgg cggcggccca
      121 ggaggcggcg gacggggagc tgcgggagca ggcccggcct ggctctctag cggccgcctg
      181 gctgcagcat gcgcgcccgc cgggggctgc tgcggctgcc gcgccgctcg ctgctcgccg
      241 cgctcttctt cttttctctc tcgtcctcgc tgctgtactt cgtctatgtg gcgcccggca
      301 tagtgaacac ctacctcttc atgatgcaag cccaaggcat tctgatccgg gacaacgtga
      361 gaacaatcgg tgctcaggtt tatgagcagg tgcttcggag tgcttatgcc aagaggaaca
      421 gcagtgtaaa tgactcagat tatcctcttg acttgaacca cagtgaaacc ttcctgcaaa
      481 ctacaacatt tcttcctgaa gacttcacct actttgcaaa ccatacctgc cctgaaagac
      541 tcccttccat gaagggccca atagacataa acatgagtga aattggaatg gattacattc
      601 atgaactctt ctccaaagac ccaaccatca agctcggagg tcactggaag ccttctgatt
      661 gcatgcctcg gtggaaggtg gcgatcctta tccccttccg gaaccgccac gagcacctcc
      721 cagtcctgtt cagacacctg cttcccatgc tccagcgcca gcgcttgcag tttgcatttt
      781 atgtggttga acaagttggt acccaaccct ttaatcgagc catgcttttc aacgttggct
      841 ttcaagaggc aatgaaagac ttggattggg actgtttgat ttttcatgat gtagatcaca
      901 taccggaaag tgatcgcaac tattatggat gtggacagat gccgaggcat tttgcaacca
      961 aattggataa gtatatgtat ctgcttcctt ataccgagtt ctttggcgga gtgagtggct
     1021 taacagtgga acaatttcgg aaaatcaatg gctttcctaa tgctttctgg ggttggggtg
     1081 gagaagatga cgacctctgg aacagagtac agaatgcagg ctattctgtg agccggccag
     1141 agggtgacac aggaaagtac aagtccattc ctcatcacca tcgaggagaa gtccagtttc
     1201 ttggaaggta tgctctgctg aggaagtcaa aagaacggca agggctggat ggcctcaaca
     1261 acctgaacta ctttgcaaac atcacatacg acgccttgta taaaaacata actgtcaacc
     1321 tgacacccga gctggctcag gtgaacgagt actgagagga gagaatgtac gtttgcttta
     1381 cccaccgcca ccaagaaagc agtccgatga gatttttttt tggagggggg agggtctaca
     1441 cagcaagaga acagaaatac tgtgtctcat gaaggatcac agagttcagg gggaaaatgt
     1501 gacagcacac gcacaaacgc cttcactgga tcagccgctg gaactgaggg agtgagcttg
     1561 gggacttcct tcgtcagcac tggctttctg ttttcacaag acagacgtct gtcccgctgc
     1621 tctctcccca tctcctaccc cacatcctgt cttagccgca gtctccagaa cccatgatga
     1681 actgtgatct gccgtggtcc tgccgtggtc ctgccgtgga gcctgtccct acacatgacc
     1741 ttggagcctc ttggccttca gagcagaggc aaacccacca cagggcagct gcgttttagg
     1801 aagagcaaat gaaactccac accattcttc tagatctctg gtgttctctt tggtttcatt
     1861 tttttaaaaa attaccttct ttgggtgggg attgagggtg gaggggaggg tgtttgggaa
     1921 agataaatag acataaatat ataacaatca cttcttgaag aagtataatt gtaaataagc
     1981 catgtaaaat gcctttttaa aatttaattt tctagctggc tccaattcaa attgaggatt
     2041 tatgtattag gccacttact tggttggcaa gtgcaggaac tcagttaaaa tgcagttgaa
     2101 gaatgtcatc tcccgaattg ctgtcacttt ggcgagggag tggatatagg gcatgtcaca
     2161 aaagaacaaa ataacccgac ctttattgct gggagctggc ttctgtccct ttcttccccc
     2221 ccccacgagt cttgcccttg acttctgctc tggattcact cttccctgtc ggccgcgcat
     2281 gtgctcatcc cactctccgc taagcgggag gctgctgtta gagcaggctg cttcctgcct
     2341 aaagcaggcc cttcggggct cgctgcacac acatctctgg ctctccaggc ttcgtgttct
     2401 gtcttttcat cagcatggcg gggcgggggg cggggggcgg gggtgtgtat gggaatccct
     2461 ccccctctta ctttttctct tgtggaactt ggccacagtt tctgaacaat gtgcctacat
     2521 taccagctgg cttcagtgat tcctctgtgt ccctttttgg tttctggaaa gattctttgt
     2581 caacattagt aactgataca tagaaccaag gagcactcaa atagggagcc aggagccagg
     2641 gagctggtga cacttgtgtg ctgtggggca gctgggatcc aggtaagacc ggattgaagc
     2701 tttgaaatta gactaacaaa gctccagaca gcaagagccc aggtgcactg ctcacacccc
     2761 cacctgcatt ttgaagtcat attatttttt gttttgtttt ttaagacggt ctggctctgt
     2821 cgcctaagct ggagtgtggt ggcacgatca cagctcactg cagcctccat ctcctaggct
     2881 caagccattt tcccacctca gcctcccgag tagctgggac tacaggtgca caccaccaca
     2941 cctggctaat tttttgtatt tttagtagag acaggggttt cttccatgtt gcccaggctg
     3001 gtctcgaact cctggactca agcaatccgc ccaccttgac ttcccaaagt gctgggatta
     3061 tgggcgggtg tgagccattg cgcccagcct tgaagtcatg ttctaaattg tatttgaatt
     3121 tgtgcctctt tgtttttccc caaaccaaag ccctcaaatt gtagtctctg tcggcttctg
     3181 cagaattctg gaaaatgcca gttttcctcc cccgcccttg ttttccataa aacatattta
     3241 tatattgtga tgaggagtac tttctgaaga gtacttcgta ttttttttta attgccttgt
     3301 ttgccttcaa cttccttgat tttcatagtt tacatgggtg tgtgtagggg tgtgtgtgtg
     3361 tatgtgtgtg ggttagggct tttttcgttg catgtgatgg ttctgtggac atatgatccc
     3421 cacaaactgt gggagtgatt ggccaggcct tgttttgttt gtttgtttgt ttgtgttttt
     3481 gttcttttga agaatagagt ggtatttaga aaataaattg cattgcaaag ctcttatcgg
     3541 ctcatatgag agagcaggtt cctgcccttg aaaatgccgg taagctatag catatgtttt
     3601 ttaagactta agcatttcat gctttaaaat accttcacaa gtgaacatta cacacagaag
     3661 ttcatttggt tttcctttgt tttatggtgc atatagcaat aaagaccccc ctccaccctg
     3721 caacccccat cccccaccgg gcctttgtcc ctgccttggc ttttctcccc ttctcattct
     3781 cctctcccct ttcctcactg aaggctgtga gttgctttca atgtgacaac actatgatgt
     3841 catttggaag gatttgccag gacagactga ttctgagtcc tgggtgccgt atgtgtatgc
     3901 ggcagtgttg tcaggcgatc ttgtttgaag ctctatgttg ccataattac catcaagtac
     3961 acactgttgg caaaaggcta acacctgact ttagaaaatg ctgatttgag aacaaaagga
     4021 aaggtctttt ttcactgctt aaagtggggt cactttgata cctttgcggt catgtctgtg
     4081 tctgatgagt gtagaatctc tggatgtgca ctgtcagtca tgtgtccacc aggcctcgaa
     4141 tatcatatgg gaaatgtcat agttaaaaac gtacagccag gcccgtgtgc tgttaatagt
     4201 gtgaaattgt catgttaaaa aaaaaaacag gaaccaaatg tgaccttgtg catatattgg
     4261 tagctgaaaa tcttcaaggc tactgatggg tggcccctta atcttgtctt tgattgctgt
     4321 gtgcagggaa aggtgtcccc gtttgttcat gctgttttgg ggggtggggg ggtatttgca
     4381 agaatactca ttttgacata ataggtcctc ttgtcagaga tcctctacca cagacattaa
     4441 tagctgagca ggagccacat ggattgattg tatccactca ccattgacga tggcattgag
     4501 cgtagctagc ttatttccat cactacgtgt ttttgagctt gctcttacgt tttaagaggt
     4561 gccaggggta catttttgca ctgaaatcta aagatgtttt aaaaaacact tttcacaaaa
     4621 atagtccttt gtcattacat tatttactca tgtgtttgta catttttgta tgttaattta
     4681 tgaatgattt tttcagtaaa aaatacatat tcaagaacca aa
//
