LOCUS       NM_173593               5493 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens beta-1,4-N-acetyl-galactosaminyltransferase 3
            (B4GALNT3), mRNA.
ACCESSION   NM_173593
VERSION     NM_173593.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5493)
  AUTHORS   Tokoro,Y., Nagae,M., Nakano,M., Harduin-Lepers,A. and Kizuka,Y.
  TITLE     LacdiNAc synthase B4GALNT3 has a unique PA14 domain and suppresses
            N-glycan capping
  JOURNAL   J Biol Chem 300 (7), 107450 (2024)
   PUBMED   38844136
  REMARK    GeneRIF: LacdiNAc synthase B4GALNT3 has a unique PA14 domain and
            suppresses N-glycan capping.
REFERENCE   2  (bases 1 to 5493)
  AUTHORS   Costa,V., Esposito,R., Ziviello,C., Sepe,R., Bim,L.V.,
            Cacciola,N.A., Decaussin-Petrucci,M., Pallante,P., Fusco,A. and
            Ciccodicola,A.
  TITLE     New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary
            thyroid carcinoma
  JOURNAL   Oncotarget 6 (13), 11242-11251 (2015)
   PUBMED   25803323
  REMARK    GeneRIF: Identify a new chimeric transcript generated by the fusion
            of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression
            papillary thyroid carcinoma.
REFERENCE   3  (bases 1 to 5493)
  AUTHORS   Che,M.I., Huang,J., Hung,J.S., Lin,Y.C., Huang,M.J., Lai,H.S.,
            Hsu,W.M., Liang,J.T. and Huang,M.C.
  TITLE     beta1, 4-N-acetylgalactosaminyltransferase III modulates cancer
            stemness through EGFR signaling pathway in colon cancer cells
  JOURNAL   Oncotarget 5 (11), 3673-3684 (2014)
   PUBMED   25003232
  REMARK    GeneRIF: Data suggest B4GALNT3 regulates cancer stemness and the
            invasive properties of colon cancer cells through modifying EGFR
            glycosylation and signaling.
REFERENCE   4  (bases 1 to 5493)
  AUTHORS   Fiete,D., Beranek,M. and Baenziger,J.U.
  TITLE     Peptide-specific transfer of N-acetylgalactosamine to O-linked
            glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl
            transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4
  JOURNAL   J Biol Chem 287 (34), 29204-29212 (2012)
   PUBMED   22722940
  REMARK    GeneRIF: Peptide-specific transfer of N-acetylgalactosamine to
            O-linked glycans by the glycosyltransferases
            beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and
            beta4GalNAc-T4.
REFERENCE   5  (bases 1 to 5493)
  AUTHORS   Fiete,D., Beranek,M. and Baenziger,J.U.
  TITLE     Molecular basis for protein-specific transfer of
            N-acetylgalactosamine to N-linked glycans by the
            glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3
            (beta4GalNAc-T3) and beta4GalNAc-T4
  JOURNAL   J Biol Chem 287 (34), 29194-29203 (2012)
   PUBMED   22722937
  REMARK    GeneRIF: Molecular basis for protein-specific transfer of
            N-acetylgalactosamine to N-linked glycans by the
            glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3
            (beta4GalNAc-T3) and beta4GalNAc-T4.
REFERENCE   6  (bases 1 to 5493)
  AUTHORS   Arking,D.E., Reinier,K., Post,W., Jui,J., Hilton,G., O'Connor,A.,
            Prineas,R.J., Boerwinkle,E., Psaty,B.M., Tomaselli,G.F., Rea,T.,
            Sotoodehnia,N., Siscovick,D.S., Burke,G.L., Marban,E.,
            Spooner,P.M., Chakravarti,A. and Chugh,S.S.
  TITLE     Genome-wide association study identifies GPC5 as a novel genetic
            locus protective against sudden cardiac arrest
  JOURNAL   PLoS One 5 (3), e9879 (2010)
   PUBMED   20360844
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5493)
  AUTHORS   Miller,E., Fiete,D., Blake,N.M., Beranek,M., Oates,E.L., Mi,Y.,
            Roseman,D.S. and Baenziger,J.U.
  TITLE     A necessary and sufficient determinant for protein-selective
            glycosylation in vivo
  JOURNAL   J Biol Chem 283 (4), 1985-1991 (2008)
   PUBMED   18048353
  REMARK    GeneRIF: betaGT3 and betaGT4, that are able to transfer GalNAc to
            GlcNAc in beta1,4-linkage display the necessary glycoprotein
            specificity in vivo.
REFERENCE   8  (bases 1 to 5493)
  AUTHORS   Huang,J., Liang,J.T., Huang,H.C., Shen,T.L., Chen,H.Y., Lin,N.Y.,
            Che,M.I., Lin,W.C. and Huang,M.C.
  TITLE     Beta1,4-N-acetylgalactosaminyltransferase III enhances malignant
            phenotypes of colon cancer cells
  JOURNAL   Mol Cancer Res 5 (6), 543-552 (2007)
   PUBMED   17579116
  REMARK    GeneRIF: up-regulation of beta4GalNAc-T3 may play a critical role
            in promoting tumor malignanc
REFERENCE   9  (bases 1 to 5493)
  AUTHORS   Ikehara,Y., Sato,T., Niwa,T., Nakamura,S., Gotoh,M., Ikehara,S.K.,
            Kiyohara,K., Aoki,C., Iwai,T., Nakanishi,H., Hirabayashi,J.,
            Tatematsu,M. and Narimatsu,H.
  TITLE     Apical Golgi localization of N,N'-diacetyllactosediamine synthase,
            beta4GalNAc-T3, is responsible for LacdiNAc expression on gastric
            mucosa
  JOURNAL   Glycobiology 16 (9), 777-785 (2006)
   PUBMED   16728562
  REMARK    GeneRIF: supra-nuclear expression of beta4GalNAc-T3 is essential
            for the formation of LacdiNAc on the surface mucous cells and that
            LacdiNAc and beta4GalNAc-T3 are novel differentiation markers of
            surface mucous cells in the gastric mucosa.
REFERENCE   10 (bases 1 to 5493)
  AUTHORS   Sato,T., Gotoh,M., Kiyohara,K., Kameyama,A., Kubota,T., Kikuchi,N.,
            Ishizuka,Y., Iwasaki,H., Togayachi,A., Kudo,T., Ohkura,T.,
            Nakanishi,H. and Narimatsu,H.
  TITLE     Molecular cloning and characterization of a novel human beta
            1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible
            for the synthesis of N,N'-diacetyllactosediamine, galNAc beta
            1-4GlcNAc
  JOURNAL   J Biol Chem 278 (48), 47534-47544 (2003)
   PUBMED   12966086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005844.8, AB089940.1, CN400443.1, AK093503.1, AK131277.1 and
            AC006205.9.
            
            On May 17, 2019 this sequence version replaced NM_173593.3.
            
            Summary: B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto
            glucosyl residues to form N,N-prime-diacetyllactosediamine
            (LacdiNAc, or LDN), a unique terminal structure of cell surface
            N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by
            OMIM, Aug 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB089940.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266383.10/ ENSP00000266383.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               AC005844.8         111673-112110
            439-629             AB089940.1         1-191
            630-1145            CN400443.1         99-614
            1146-1669           AB089940.1         708-1231
            1670-1708           AK093503.1         954-992
            1709-2186           AB089940.1         1271-1748
            2187-2498           AK093503.1         1474-1785
            2499-3435           AB089940.1         2061-2997
            3436-3876           AK131277.1         2389-2829
            3877-5493           AC006205.9         48071-49687         c
FEATURES             Location/Qualifiers
     source          1..5493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..5493
                     /gene="B4GALNT3"
                     /note="beta-1,4-N-acetyl-galactosaminyltransferase 3"
                     /db_xref="GeneID:283358"
                     /db_xref="HGNC:HGNC:24137"
                     /db_xref="MIM:612220"
     exon            1..607
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..3435
                     /gene="B4GALNT3"
                     /EC_number="2.4.1.244"
                     /note="Beta4GalNAc-T3; NGalNAc-T2;
                     N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-
                     acetylgalactosaminyltransferase; B4GalNAcT3;
                     N-acetyl-beta-glucosaminyl-glycoprotein
                     4-beta-N-acetylgalactosaminyltransferase 2;
                     beta-1,4-N-acetyl-galactosaminyl transferase 3;
                     beta4GalNAcT3; beta-1,4-N-acetylgalactosaminyltransferase
                     III"
                     /codon_start=1
                     /product="beta-1,4-N-acetylgalactosaminyltransferase 3"
                     /protein_id="NP_775864.3"
                     /db_xref="CCDS:CCDS8504.1"
                     /db_xref="GeneID:283358"
                     /db_xref="HGNC:HGNC:24137"
                     /db_xref="MIM:612220"
                     /translation="MGSPRAARPPLLLRPVKLLRRRFRLLLALAVVSVGLWTLYLELV
                     ASAQVGGNPLNRRYGSWRELAKALASRNIPAVDPHLQFYHPQRLSLEDHDIDQGVSSN
                     SSYLKWNKPVPWLSEFRGRANLHVFEDWCGSSIQQLRRNLHFPLYPHIRTTLRKLAVS
                     PKWTNYGLRIFGYLHPFTDGKIQFAIAADDNAEFWLSLDDQVSGLQLLASVGKTGKEW
                     TAPGEFGKFRSQISKPVSLSASHRYYFEVLHKQNEEGTDHVEVAWRRNDPGAKFTIID
                     SLSLSLFTNETFLQMDEVGHIPQTAASHVDSSNALPRDEQPPADMLRPDPRDTLYRVP
                     LIPKSHLRHVLPDCPYKPSYLVDGLPLQRYQGLRFVHLSFVYPNDYTRLSHMETHNKC
                     FYQENAYYQDRFSFQEYIKIDQPEKQGLEQPGFEENLLEESQYGEVAEETPASNNQNA
                     RMLEGRQTPASTLEQDATDYRLRSLRKLLAQPREGLLAPFSKRNSTASFPGRTSHIPV
                     QQPEKRKQKPSPEPSQDSPHSDKWPPGHPVKNLPQMRGPRPRPAGDSPRKTQWLNQVE
                     SYIAEQRRGDRMRPQAPGRGWHGEEEVVAAAGQEGQVEGEEEGEEEEEEEDMSEVFEY
                     VPVFDPVVNWDQTFSARNLDFQALRTDWIDLSCNTSGNLLLPEQEALEVTRVFLKKLN
                     QRSRGRYQLQRIVNVEKRQDQLRGGRYLLELELLEQGQRVVRLSEYVSARGWQGIDPA
                     GGEEVEARNLQGLVWDPHNRRRQVLNTRAQEPKLCWPQGFSWSHRAVVHFVVPVKNQA
                     RWVQQFIKDMENLFQVTGDPHFNIVITDYSSEDMDVEMALKRSKLRSYQYVKLSGNFE
                     RSAGLQAGIDLVKDPHSIIFLCDLHIHFPAGVIDAIRKHCVEGKMAFAPMVMRLHCGA
                     TPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWELLDRILQAGLDVE
                     RLSLRNFFHHFHSKRGMWSRRQMKTL"
     exon            608..711
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..789
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            790..885
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            886..976
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1077
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1145
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1224
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1291
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1435
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1545
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1646
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1708
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..2498
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2818
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2972
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3045
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3199
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3326
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..5493
                     /gene="B4GALNT3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggttccgcg agcaggagag cccagagccc ggagcccggt ccggggctgg cgggggcgcg
       61 ggcggaggca ggcgggcggg cgccggggaa gcctccttct gggcagcgag tgagggcggg
      121 cgcgcaggga gggagggcgg cagcgagcct gcgacgggag aggcgtgggg aggagagccc
      181 ggcgcggaac acacgcgcgg aggaggagcc gggctcggct cccggagaga cctgctgggc
      241 gcccgcgcag cccggagacc cctcgcgccc ggagcatgag cccgagcccc gccggagagc
      301 ggccgggaga gacggcctcg gcgcagccct gagacgctgg gccgggacgc ggggcgccct
      361 gggcgcgggg cccggccggg gggcggcggc tcggggggtt ggagcccgcg ctggcggcgg
      421 ccgcctcggc gcagcgccat ggggagcccc cgggccgcgc ggcccccgct gctcctgcgc
      481 ccggtgaagc tgctgcggag gcgcttccgg ctgctgctgg cgctcgccgt ggtgtctgtg
      541 gggctctgga ctctgtatct ggaactggtg gcgtcggccc aggtcggcgg gaaccccctg
      601 aaccggaggt acggcagctg gagagaactg gccaaggctc tggccagcag gaacattcca
      661 gctgtggatc cacacctcca gttctaccat ccccagaggc tgagcctcga ggaccacgac
      721 attgaccaag gggtgagcag taacagcagc tacttgaagt ggaacaagcc tgtcccctgg
      781 ctctcagagt tccggggccg tgccaacctg catgtgtttg aagactggtg tggcagctct
      841 atccagcagc tcaggaggaa cctgcatttc ccactgtacc cccatattcg cacaaccctg
      901 aggaagcttg ctgtgtcccc caaatggacc aactatggcc tccgcatctt tggctacctg
      961 caccccttta ctgatgggaa aatccagttt gccattgctg cagatgacaa cgcggagttc
     1021 tggctgagcc tcgatgacca ggtctcaggc ctccagctgc tggccagtgt gggcaagact
     1081 ggaaaggagt ggaccgcccc gggagagttt gggaaatttc ggagccaaat ttccaagccg
     1141 gtgagcctgt cagcctccca caggtactac ttcgaggtgc tgcacaagca gaatgaggag
     1201 ggcaccgacc acgtggaagt tgcatggcga cggaacgacc ctggagccaa gttcaccatc
     1261 attgactccc tctccctgtc cctcttcaca aatgagacgt tcctacagat ggatgaggtg
     1321 ggccacatcc cacagacagc agccagccac gtggactcct ccaacgctct tcccagggat
     1381 gagcagccgc ccgctgacat gcttcggcct gacccccggg acaccctcta tcgagtgcct
     1441 ctgatcccca agtcgcatct ccgccacgtc ctgcctgact gtccctacaa acccagctat
     1501 ctggtggatg ggcttcctct gcagcgctac cagggactcc ggtttgttca tctgtctttt
     1561 gtttacccca atgactatac ccgcctgagc cacatggaga cccacaataa atgtttctac
     1621 caggaaaacg cctactacca agaccggttc agctttcagg agtacatcaa gattgaccag
     1681 cctgagaagc aggggctgga gcagccaggt tttgaggaaa accttctaga agagtcccag
     1741 tatggggaag tggcagagga gacccctgcc tccaacaacc agaatgccag gatgcttgag
     1801 ggaagacaga cacctgcctc caccctggag caagatgcca ctgactaccg cctccgaagc
     1861 ctgcggaaac tcctggctca gccccgggag ggcctgctgg cccccttctc caagcggaac
     1921 tccacagcgt ccttcccagg gaggaccagc cacattccag tgcagcagcc agagaagagg
     1981 aagcaaaaac ccagccctga gcccagccaa gattcacctc attccgacaa gtggcctcct
     2041 gggcaccctg tgaagaacct gcctcagatg agggggccca ggcccaggcc cgctggtgac
     2101 agccccagga agactcagtg gctgaaccag gtggagtcgt acatcgcaga gcagagacgg
     2161 ggtgacagga tgcggcctca ggcccctgga aggggctggc atggggagga ggaagtggtg
     2221 gcggccgcag gccaggaagg acaagtggag ggagaggaag agggggaaga agaggaggag
     2281 gaagaggata tgagtgaggt gttcgagtac gtacctgtgt ttgacccggt agtaaactgg
     2341 gaccagacct tcagtgcccg gaatctcgac ttccaagccc tgaggactga ctggatcgat
     2401 ctgagctgta acacatctgg caacctgctg cttccagagc aggaagctct ggaggtcacg
     2461 cgagtcttct tgaagaagct caaccagagg agccggggga ggtaccagct acagcgcatt
     2521 gtgaacgtgg aaaagcgtca ggaccagcta cgtgggggtc gctacctcct ggagcttgaa
     2581 ctgttggaac aaggccagcg cgtggtgcgg ctctcggagt atgtgtctgc acgaggctgg
     2641 cagggcatcg atccagctgg tggggaggag gtcgaggccc ggaacctgca aggcctggtc
     2701 tgggacccac acaaccgtag gagacaggtc ctgaataccc gggcccaaga gcccaagctg
     2761 tgctggcctc agggtttctc ctggagtcac cgagccgtgg tccacttcgt cgtgcctgtg
     2821 aagaaccagg cacgctgggt acagcaattc atcaaagaca tggaaaacct gttccaggtc
     2881 accggtgacc cacacttcaa catcgtcatc actgactata gcagtgagga catggatgtt
     2941 gagatggcac tgaagaggtc caagctgcgg agctaccagt acgtgaagct aagtggaaac
     3001 tttgaacgct cagctggact tcaggctggc atagacctcg tgaaggaccc gcacagcatc
     3061 atcttcctct gtgacctcca catccacttc ccagctggag tcatcgatgc cattcggaag
     3121 cactgtgtgg agggaaagat ggcctttgcc cccatggtga tgaggctgca ttgtggggcc
     3181 accccccagt ggcctgaggg ctactgggag gtgaatgggt tcgggctgct tggcatctac
     3241 aagtctgacc tggacaggat tgggggcatg aacaccaagg agttccgaga ccgctggggc
     3301 ggggaagact gggagctgct ggacaggata ctccaagcgg gcctggacgt ggagcgtctc
     3361 tccctcagga atttcttcca tcatttccat tccaagcgag gcatgtggag ccgtcgccag
     3421 atgaagacgc tgtagccgga gggtgtccgc ggggcccagc actccccgct ctggactagc
     3481 agtggctccc cagggccctg ctactgttca gggatgggga gtggggtgac ggctggaccc
     3541 caagaggcct cgaagctgac ggcccactcc acctggagct gtcccctcac agaggcaggt
     3601 tccggggctc ctgtctctgc ctcctgggcc ttcagaaggg aggactttga gagagaggcc
     3661 aggagggacc acttgctcag tcgagaacgg gaagagctcc tgagaaggac gggtcaggaa
     3721 ggagagatct gactgagcga caccatcctc atccatgaag gtgcacgccc acatccccca
     3781 agcgctcctc acgccaagcg ctgaccacca gaccctcttc tagtggacat attttattgg
     3841 ggggcgggga ttttaaaaac agaaaaccga aactgctgtc cagagcgggg gtgaggttgt
     3901 gcactgaggg actgtcccca cgtgcaggcc tcccgcccac tcctatgtcc cttgggcgtt
     3961 gtccctggcc gcgggactgg tcccacgtgg ggcaggtctc tgctccaccc caggctcgtg
     4021 ccttccagag acacacatct cccagtagcc accaaacagc tggccactga ttagggcatt
     4081 aacttcctcc ggatggctca cgtcagacca gaagcacaga acgggctgtt tctggtgctt
     4141 gggcattggg aggtggggag ctggcgggca gggggcttgc cactccctgg cactggacat
     4201 tgaggcctgc agaacaggca gggtgatgaa ggcaggggag agaagccctt tcccttaccg
     4261 gcgtgcctgt gggtaaggcc tcccgagagg acatggagaa gaggtaaaga ggatgtggac
     4321 atatctgtca atttccttag gcaagaagcg ggtgggggct ggacagaaag ggacgaaaag
     4381 ggaagtggaa gctgtgagcc tcacagtcca gctccactgc agacctgccc ttctgcaggg
     4441 agagccctgg ccacccggcc ttgagtggaa gaagaggaaa gggtgtacgg gggcaaaacc
     4501 ctggacaggg agcaggataa gaagggggcg ggatgagagg tttggggagg tgaggacatt
     4561 gccctgagat atcccctgga ggcagggaga ggagtggggg caggaggaac tgaagagggg
     4621 ggcagtttca gggaaaatag cccttagcct ttttagtcga tgccaccctt tctgtcacct
     4681 ggagaccttg tacttctctt gcactaataa ccccggtgct tttgtggctg ggggtttttc
     4741 tgttgctgct gctgcctcca ccactgctgt gaattcaccc atggtgcatt ggacactgga
     4801 tcttgaactc cagagtctgt ttagggaggt gagcacaggg ctgggggagg tgcggcgggg
     4861 cccagaagac caggccactg agcccgcgct ccaggctgtg acggtccaaa ccacggcact
     4921 ggagctgcag ggtctgccta gtgggctctg cattccccga gagcacgagt ttggcacatg
     4981 ggagaatgga gcccgtggag aaccttctgg ggggtcgggg agaatccctg cctcccttta
     5041 aggaatcatg aaggacagag acttttgaga ttgtggctta ggaaggccat acctgctccc
     5101 tgggctgtgg ctttttctgg tccctgctga ggccgactgg cccctggaga aggatggtgg
     5161 ggcataggct agggctgcag ttggccagtg gggctgccag tttctttctg ggaccactct
     5221 cgtcctcggg cattgcactg gaaggctgga accagcccaa actgcccacc tgcttcactt
     5281 ccaatgacta ggagccagcc cagcctcctg ccctgcccac acccctgcgc cctgggccag
     5341 tgccttgcgt ttgatgttac ctccacacca tctgccttaa gaggaagggc cgggcaaggc
     5401 ccctactccc tagagaaatg tcttgggtag gagagggtgt gggatggtgg gaggggaagc
     5461 attaaataca gcaacttctt agaaaaaaaa aaa
//
