LOCUS       NM_001009905            2985 bp    mRNA    linear   PRI 14-APR-2024
DEFINITION  Homo sapiens UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase like 1 (B3GNTL1),
            transcript variant 1, mRNA.
ACCESSION   NM_001009905 NM_194288
VERSION     NM_001009905.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2985)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 2985)
  AUTHORS   Zheng,H., Li,Y., Ji,C., Li,J., Zhang,J., Yin,G., Xu,J., Ye,X.,
            Wu,M., Zou,X., Gu,S., Xie,Y. and Mao,Y.
  TITLE     Characterization of a cDNA encoding a protein with limited
            similarity to beta1, 3-N-acetylglucosaminyltransferase
  JOURNAL   Mol Biol Rep 31 (3), 171-175 (2004)
   PUBMED   15560372
  REMARK    GeneRIF: beta3-GnTL1 is similar to beta1,
            3-N-acetylglucosaminyltransferase
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130371.4.
            
            On Jan 13, 2021 this sequence version replaced NM_001009905.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY634364.1, AY304503.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320865.4/ ENSP00000319979.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC130371.4         51808-51841
            35-151              AC130371.4         54793-54909
            152-251             AC130371.4         55008-55107
            252-316             AC130371.4         68479-68543
            317-382             AC130371.4         89059-89124
            383-478             AC130371.4         98368-98463
            479-574             AC130371.4         137832-137927
            575-699             AC130371.4         142397-142521
            700-835             AC130371.4         146084-146219
            836-904             AC130371.4         146329-146397
            905-979             AC130371.4         146809-146883
            980-1084            AC130371.4         156595-156699
            1085-2985           AC130371.4         159529-161429
FEATURES             Location/Qualifiers
     source          1..2985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2985
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase like 1"
                     /db_xref="GeneID:146712"
                     /db_xref="HGNC:HGNC:21727"
                     /db_xref="MIM:615337"
     exon            1..34
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1060
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /EC_number="2.4.1.-"
                     /note="isoform a is encoded by transcript variant 1;
                     UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 8;
                     UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase-like protein 1;
                     BGnT-like protein 1; beta3Gn-T-like protein 1;
                     queuosine-tRNA galactosyltransferase;
                     beta1,3-N-acetylglucosaminyltransferase-like protein 1;
                     beta-1,3-Gn-T8"
                     /codon_start=1
                     /product="queuosine-tRNA galactosyltransferase isoform a"
                     /protein_id="NP_001009905.2"
                     /db_xref="CCDS:CCDS32778.2"
                     /db_xref="GeneID:146712"
                     /db_xref="HGNC:HGNC:21727"
                     /db_xref="MIM:615337"
                     /translation="MQAHVSIILPVHNAEPWLDECLRSVLQQDFEGTMELSVFNDASK
                     DKSGAIIEKWRVKLEDSGVHVIIGGHDSPSPRGVGYAKNQAVAQSSGSYLCFLDSDDV
                     MMPQRVRLQHEAAVQHPSSIIGCRVRRDPPNSTERYTRWINQLTPEQLLTQVFTSNGP
                     TVIMPTWFCSRAWFSHVGPFNEGGQGVPEDLLFFYEHLRKGGGVIRVDQSLLLYRHHP
                     QAATHCVLETTIWTHRVRFLEEQALPRWAAFTIWNAGKQGRRLYRSLTAGSQRKVVAF
                     CDVDENKIRKGFYCHEDSQERPKPRIPILHFRAARPPFVICVKLDLTGGAFEDNLRSL
                     HLQEGQDFLHFS"
     exon            35..151
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            152..251
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            252..316
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            317..382
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            383..478
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            479..574
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            575..699
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            700..835
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            836..904
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            905..979
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1084
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..2985
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1318..1323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /note="hexamer: AATAAA"
     polyA_site      1343
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /note="major polyA site"
     regulatory      2960..2965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
                     /note="hexamer: AATAAA"
     polyA_site      2978
                     /gene="B3GNTL1"
                     /gene_synonym="3-Gn-T8; B3GNT8; beta-1; beta3Gn-T8;
                     beta3GnTL1; BGnT-8; QTGAL"
ORIGIN      
        1 gtccgaggag agccaggcca tgcaggccca cgtgtctatt atcctcccag tccacaacgc
       61 tgaaccgtgg ctggacgaat gtttgaggtc tgttttgcaa caggactttg aaggtaccat
      121 ggagctgtct gttttcaatg atgccagtaa ggacaagtct ggggctatca ttgaaaaatg
      181 gagagtgaag ctggaagatt ctggtgtcca cgtgatcatt ggggggcacg attctccctc
      241 tcctagaggc gtcggatacg ctaaaaatca agcagttgcc cagagctcag ggtcttacct
      301 ttgctttttg gattcggatg acgtcatgat gccccagcgg gtgaggctgc aacacgaggc
      361 tgccgttcag cacccgtcga gcatcattgg ttgcagagtg aggagagatc cccctaactc
      421 caccgaacga tacacacgtt ggatcaacca gctgacgccg gagcagctcc taacccaggt
      481 tttcacctca aatggcccca cggtgatcat gcccacctgg ttctgctcgc gagcgtggtt
      541 ctcccacgtg ggccccttta acgagggagg tcagggcgtc ccggaggacc tgctgttctt
      601 ctacgagcac ctcaggaagg gcggcggcgt catccgcgtg gaccagagtc tcctgctgta
      661 tcgccaccac ccacaggcgg ccacgcactg cgtcctcgag acgaccatct ggacccaccg
      721 cgtccgcttc ctggaagagc aggccctgcc ccgctgggcg gccttcacca tctggaacgc
      781 tggcaagcag gggcgccggc tgtaccgcag cttgactgcc ggcagccagc gcaaggtggt
      841 ggcattctgt gacgtggacg agaacaagat caggaaaggc ttctattgcc acgaggactc
      901 tcaggaaaga cccaagcccc gaatccccat cctgcacttc cgagccgccc ggccaccctt
      961 cgtcatctgc gtgaagctgg acctcacagg gggcgccttt gaggacaacc tgaggtcact
     1021 gcacttgcag gagggccagg acttccttca cttcagctga cggacccatg gcagctgctc
     1081 ccagtgcatc ccaggccagc aggagctttg tgagctgcag gcatggcgat ggtgcgcctg
     1141 ttccacaccc agcaggcgca accagagtct cgtgtgtgcc gaccacagga gccaagcctt
     1201 ttccactgtg tggactcatg tggccaaggc taggcctggt cacccaggac cctcaccacg
     1261 tgaccccagc caatcgggac agttcaagga ggaggagacc cctattacac aggttggaat
     1321 aaaatattta aatctcgtaa aaatgtaacc caaggctctt ttagggtata aagaccattg
     1381 gccaccaggt caaacacaac aacagtagtg tgttaacccc acactcctgt gtggccaggt
     1441 cgtcacacac atcccgtgaa gagctgtctg ctaaacacac agcacggact gtcacagtcc
     1501 tggtcttgtg gtcctggtga cctcacaagc ctcacagatg cggtggcacc tcccagttct
     1561 cggcctgccc atgttcctgt gtccaggccc catccccacc tgagagcagg ccagggagcc
     1621 accctaatct acaccacgca catggcaccc ctgggctcct cacataggga aagggttgct
     1681 cacccaagcc cttgggcctc tgagtggcca cacctggggc tgctttggtg ctgctggccg
     1741 tggttctgca cctcaagccc tatgagcaca gcacaggtcc cagagatggg tgtgggttgc
     1801 taccacagtg aaatttttat acacgttccc ctcaccagct ttgggatgga tcagcacgag
     1861 ctcagacaca gagacaaagg tagcctcctg ccctttgcct aaaaacccaa gtgtggactc
     1921 tgcccaggct ctcctaagac agtgtaatta tttcaagaat ggtatttatt tccgacatta
     1981 ctgtagaggc acacattgga ctctgacgat tccccttgca gcagacattt gtgaagctgc
     2041 tggtcggcac acccatcaat cagtgactcc tgcactgcag aggggccaca tgcacgatgc
     2101 tcacgtgtgc acagggggga ggacagcacc cccaccaggc agacgggccc agaaacagca
     2161 tctgcccagc actccagacc atgcctgcca ccagggcttc tcagttctct agcatttgaa
     2221 cctctgattt aacattcatc tctctccaag actgggtggg gcactgcctg tggccagacg
     2281 tctcccacag cagggacagc accaggcaag aagggggcct ggtctccagg caggaggagt
     2341 gcagcccacc tcccctctgg ctgacccctg ggcagtgagc ctttccatca cccctacaca
     2401 catcaggctc agagacaaaa ggcaggaact tcttggtaca tgattttata ggaagcacat
     2461 ttgtgttcaa gtgaaggcag aggcgtccac cccaagtcac cagagcgcag gtgcagagag
     2521 gaaaagctgt cagctagtgc cagcctccaa gggccagcgc tacccttcaa cagctggagg
     2581 caccactgtg cgaggctttc cacaccggcc tccctcagga acaagacatc ctcaccaggc
     2641 aggggtgagg tatgggctcc aggactggct tcagcaggca ccaggctgaa gaagagacaa
     2701 gacaagctca ggctggtcag ctccaacaca caccattccc agccagggga ccctcacccc
     2761 tctgggccct gtgtggggac tgacacggtt cctgcaggaa accatttgtg ccgtttccca
     2821 cacacccggc agcctgagct atgtggctga caggtgctca tgactaacgt gtcctcggaa
     2881 gggcacccca tctggggagc gggaagggag gttcactgca ctgctcttaa cctgcattca
     2941 cacgtttgaa atttttccta ataaaaatgt aaaaagcaca tttaa
//
