LOCUS       NM_001385648            1543 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 8 (B3GNT8), transcript
            variant 1, mRNA.
ACCESSION   NM_001385648 XM_011526934
VERSION     NM_001385648.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1543)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1543)
  AUTHORS   Perez,A.G., Andrade-Da-Costa,J., De Souza,W.F., De Souza
            Ferreira,M., Boroni,M., De Oliveira,I.M., Freire-Neto,C.A.,
            Fernandes,P.V., De Lanna,C.A., Souza-Santos,P.T., Morgado-Diaz,J.A.
            and De-Freitas-Junior,J.C.M.
  TITLE     N-glycosylation and receptor tyrosine kinase signaling affect
            claudin-3 levels in colorectal cancer cells
  JOURNAL   Oncol Rep 44 (4), 1649-1661 (2020)
   PUBMED   32945502
  REMARK    GeneRIF: Nglycosylation and receptor tyrosine kinase signaling
            affect claudin3 levels in colorectal cancer cells.
REFERENCE   3  (bases 1 to 1543)
  AUTHORS   Shen,L., Dong,X., Wang,Y., Qiu,L., Peng,F. and Luo,Z.
  TITLE     beta3GnT8 regulates oxaliplatin resistance by altering integrin
            beta1 glycosylation in colon cancer cells
  JOURNAL   Oncol Rep 39 (4), 2006-2014 (2018)
   PUBMED   29393491
  REMARK    GeneRIF: These results revealed that b3GnT8 may play a key role in
            the development of oxaliplatin resistance in colon cancer cells
            possibly through the alteration of the glycosylation of integrin
            beta1. These findings may be valuable for overcoming drug
            resistance in colon cancer
REFERENCE   4  (bases 1 to 1543)
  AUTHORS   Jiang,Z., Liu,Z., Zou,S., Ni,J., Shen,L., Zhou,Y., Hua,D. and Wu,S.
  TITLE     Transcription factor c-jun regulates beta3Gn-T8 expression in
            gastric cancer cell line SGC-7901
  JOURNAL   Oncol Rep 36 (3), 1353-1360 (2016)
   PUBMED   27459970
  REMARK    GeneRIF: Cjun plays a significant role in regulating the expression
            of beta3GnT8 in the SGC7901 cell line.
REFERENCE   5  (bases 1 to 1543)
  AUTHORS   Shen,L., Yu,M., Xu,X., Gao,L., Ni,J., Luo,Z. and Wu,S.
  TITLE     Knockdown of beta3GnT8 reverses 5-fluorouracil resistance in human
            colorectal cancer cells via inhibition the biosynthesis of
            polylactosamine-type N-glycans
  JOURNAL   Int J Oncol 45 (6), 2560-2568 (2014)
   PUBMED   25269761
  REMARK    GeneRIF: In conclusion, the alteration of b3GnT8 in colorectal
            cancer cells correlates with tumor sensitivity to the
            chemotherapeutic drug and has significant implication for the
            development of new treatment strategies.
REFERENCE   6  (bases 1 to 1543)
  AUTHORS   Liu,Z., Shen,L., Xu,L., Sun,X., Zhou,J. and Wu,S.
  TITLE     Down-regulation of beta-1,3-N-acetylglucosaminyltransferase-8 by
            siRNA inhibits the growth of human gastric cancer
  JOURNAL   Mol Med Rep 4 (3), 497-503 (2011)
   PUBMED   21468598
  REMARK    GeneRIF: The down-regulation of beta3Gn-T8 caused significant
            inhibition of tumor cell growth in vitro.
REFERENCE   7  (bases 1 to 1543)
  AUTHORS   Shen,L., Liu,Z., Tu,Y., Xu,L., Sun,X. and Wu,S.
  TITLE     Regulation of MMP-2 expression and activity by
            beta-1,3-N-acetylglucosaminyltransferase-8 in AGS gastric cancer
            cells
  JOURNAL   Mol Biol Rep 38 (3), 1541-1550 (2011)
   PUBMED   20963502
  REMARK    GeneRIF: These results reveal a new mechanism by which beta3Gn-T8
            can regulate MMP-2 and TIMP-2.
REFERENCE   8  (bases 1 to 1543)
  AUTHORS   Seko,A. and Yamashita,K.
  TITLE     Activation of beta1,3-N-acetylglucosaminyltransferase-2
            (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in
            increasing poly-N-acetyllactosamine chains in differentiated HL-60
            cells
  JOURNAL   J Biol Chem 283 (48), 33094-33100 (2008)
   PUBMED   18826941
  REMARK    GeneRIF: up-regulation of beta3Gn-T8 in differentiated cells
            increases poly-N-acetyllactosamine chains by activating intrinsic
            beta3Gn-T2.
REFERENCE   9  (bases 1 to 1543)
  AUTHORS   Ishida,H., Togayachi,A., Sakai,T., Iwai,T., Hiruma,T., Sato,T.,
            Okubo,R., Inaba,N., Kudo,T., Gotoh,M., Shoda,J., Tanaka,N. and
            Narimatsu,H.
  TITLE     A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which
            synthesizes poly-N-acetyllactosamine, is dramatically upregulated
            in colon cancer
  JOURNAL   FEBS Lett 579 (1), 71-78 (2005)
   PUBMED   15620693
  REMARK    GeneRIF: The cloning of a novel
            beta1,3-N-acetylglucosaminyltransferase that is upregulated in a
            human colon cancer cell line.
REFERENCE   10 (bases 1 to 1543)
  AUTHORS   Huang,C., Zhou,J., Wu,S., Shan,Y., Teng,S. and Yu,L.
  TITLE     Cloning and tissue distribution of the human B3GALT7 gene, a member
            of the beta1,3-Glycosyltransferase family
  JOURNAL   Glycoconj J 21 (5), 267-273 (2004)
   PUBMED   15486459
  REMARK    GeneRIF: highly expressed in lung, throat and ileum, whereas the
            expression level was low in tongue, breast, uteri, testis. In
            addition, it was also demonstrated that B3GALT7 is differentially
            transcribed in human tumor cell lines.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011462.4.
            
            On Jan 5, 2021 this sequence version replaced NM_001385648.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3917574.1, AY277592.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149876, SAMEA2150585
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000691102.1/ ENSP00000510371.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC011462.4         3588-3678
            92-1543             AC011462.4         4152-5603
FEATURES             Location/Qualifiers
     source          1..1543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1543
                     /gene="B3GNT8"
                     /gene_synonym="B3GALT7; beta3Gn-T8; BGALT15"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 8"
                     /db_xref="GeneID:374907"
                     /db_xref="HGNC:HGNC:24139"
                     /db_xref="MIM:615357"
     exon            1..91
                     /gene="B3GNT8"
                     /gene_synonym="B3GALT7; beta3Gn-T8; BGALT15"
                     /inference="alignment:Splign:2.1.0"
     exon            92..1543
                     /gene="B3GNT8"
                     /gene_synonym="B3GALT7; beta3Gn-T8; BGALT15"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1317
                     /gene="B3GNT8"
                     /gene_synonym="B3GALT7; beta3Gn-T8; BGALT15"
                     /note="UDP-Gal:betaGal beta 1,3-galactosyltransferase
                     polypeptide 7; beta galactosyltransferase BGALT15;
                     beta1,3-N-acetylglucosaminyltransferase 8; BGnT-8;
                     beta-1,3-Gn-T8; beta-1,3-N-acetylglucosaminyltransferase
                     8"
                     /codon_start=1
                     /product="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 8"
                     /protein_id="NP_001372577.1"
                     /db_xref="CCDS:CCDS12582.1"
                     /db_xref="GeneID:374907"
                     /db_xref="HGNC:HGNC:24139"
                     /db_xref="MIM:615357"
                     /translation="MRCPKCLLCLSALLTLLGLKVYIEWTSESRLSKAYPSPRGTPPS
                     PTPANPEPTLPANLSTRLGQTIPLPFAYWNQQQWRLGSLPSGDSTETGGCQAWGAAAA
                     TEIPDFASYPKDLRRFLLSAACRSFPQWLPGGGGSQVSSCSDTDVPYLLLAVKSEPGR
                     FAERQAVRETWGSPAPGIRLLFLLGSPVGEAGPDLDSLVAWESRRYSDLLLWDFLDVP
                     FNQTLKDLLLLAWLGRHCPTVSFVLRAQDDAFVHTPALLAHLRALPPASARSLYLGEV
                     FTQAMPLRKPGGPFYVPESFFEGGYPAYASGGGYVIAGRLAPWLLRAAARVAPFPFED
                     VYTGLCIRALGLVPQAHPGFLTAWPADRTADHCAFRNLLLVRPLGPQASIRLWKQLQD
                     PRLQC"
     polyA_site      1543
                     /gene="B3GNT8"
                     /gene_synonym="B3GALT7; beta3Gn-T8; BGALT15"
                     /note="major polyA site"
ORIGIN      
        1 aacacagggg ctggggcagg cagatcagag ggagctgagg gaggcctgac ctgaggccgg
       61 cacccggagc tggcgggagc cagacccaga gctcccgcgg ccgccccttc cctgggccgg
      121 gtcatgcgct gccccaagtg ccttctctgc ctgtcagcac tgctcacact cctgggcctc
      181 aaagtgtaca tcgagtggac atccgagtcc cggctcagca aggcctaccc cagccctcgg
      241 ggcaccccgc caagccccac gccagccaac cctgagccca ccctacctgc caacctctcc
      301 acccgcctgg gccagactat cccgctgccc tttgcttact ggaaccagca gcagtggcgg
      361 ctggggtccc tgcccagtgg ggacagcact gaaacggggg gctgccaggc ttggggggcc
      421 gccgccgcca ccgagatccc tgacttcgcc tcctacccca aggacctccg ccgcttcttg
      481 ctgtcagcag cctgccggag cttcccacag tggctgcctg gaggtggtgg cagccaagtc
      541 tccagctgct cagatactga tgtcccctac ctgctgttgg ccgtcaagtc agaaccaggg
      601 cgctttgcag aacgacaggc cgtgagagag acgtggggca gtccagctcc agggatccgg
      661 ctgctcttcc tgctagggtc tccggtgggt gaggcggggc ctgacctaga ctcactagtg
      721 gcctgggaga gccgtcgcta cagtgacctg ctgctctggg acttcctcga cgtcccattc
      781 aaccagacgc tcaaagacct gctgctgctg gcctggctgg gccgccactg ccccaccgtg
      841 agttttgtct tgcgagctca ggacgatgcc tttgtacaca cccctgccct gctggctcac
      901 ctgcgggccc tgccacctgc ctcggcccga agcctctacc tgggtgaggt ctttacccag
      961 gccatgcctc tccggaagcc aggaggaccc ttctatgtgc ccgagtcctt cttcgaaggt
     1021 ggctacccag cctatgcaag cgggggtggc tacgtcattg ccgggcgcct ggcaccctgg
     1081 ctgctgcggg cggcagcccg tgtggcaccc ttcccctttg aggacgtcta cactggcctt
     1141 tgcatccgag ccctgggcct ggtgccccag gcccacccag gcttcctcac agcctggcca
     1201 gcagaccgca ctgcggacca ctgtgctttc cgcaacctgc tgctggtacg gcccctgggc
     1261 ccccaggcca gcattcggct ctggaaacaa ctgcaagacc caaggctcca gtgctgactc
     1321 tcattgggga gggcggaggt gctgacctgg cctgggcctc tggggccggc ccctggctca
     1381 gcccctcctt ccaggtcttg atgggaggga ggagggccca gaagctggac aacttaagcc
     1441 actccttggc ctcccccagc caggggcctg ggcaggaaag atggggtggt ggactgtttt
     1501 tgcctacttt ttgtttttga aaaacatgca ctccccactc tga
//
