LOCUS       NM_145236               3539 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7), mRNA.
ACCESSION   NM_145236
VERSION     NM_145236.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3539)
  AUTHORS   Wang,X., Wang,Y., Chen,X., He,Y., Zhou,X., Jiao,S., Zhu,Z., Wu,C.
            and Bao,J.
  TITLE     Identification of glycogene-based prognostic signature and
            validation of B3GNT7 as a potential biomarker and therapeutic
            target in breast cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (19), 16957-16969 (2023)
   PUBMED   37740763
  REMARK    GeneRIF: Identification of glycogene-based prognostic signature and
            validation of B3GNT7 as a potential biomarker and therapeutic
            target in breast cancer.
REFERENCE   2  (bases 1 to 3539)
  AUTHORS   Carroll,D.J., Burns,M.W.N., Mottram,L., Propheter,D.C., Boucher,A.,
            Lessen,G.M., Kumar,A., Malaker,S.A., Xing,C., Hooper,L.V., Yrlid,U.
            and Kohler,J.J.
  TITLE     Interleukin-22 regulates B3GNT7 expression to induce fucosylation
            of glycoproteins in intestinal epithelial cells
  JOURNAL   J Biol Chem 298 (2), 101463 (2022)
   PUBMED   34864058
  REMARK    GeneRIF: Interleukin-22 regulates B3GNT7 expression to induce
            fucosylation of glycoproteins in intestinal epithelial cells.
REFERENCE   3  (bases 1 to 3539)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3539)
  AUTHORS   Lu,C.H., Wu,W.Y., Lai,Y.J., Yang,C.M. and Yu,L.C.
  TITLE     Suppression of B3GNT7 gene expression in colon adenocarcinoma and
            its potential effect in the metastasis of colon cancer cells
  JOURNAL   Glycobiology 24 (4), 359-367 (2014)
   PUBMED   24418929
  REMARK    GeneRIF: The nude mice xenograft model demonstrated that ectopic
            expression of the B3GNT7 gene in colon cancer cells diminished the
            migration capability and the liver-metastasis potential,
            respectively, of colon cancer cells.
REFERENCE   5  (bases 1 to 3539)
  AUTHORS   den Hoed,M., Eijgelsheim,M., Esko,T., Brundel,B.J., Peal,D.S.,
            Evans,D.M., Nolte,I.M., Segre,A.V., Holm,H., Handsaker,R.E.,
            Westra,H.J., Johnson,T., Isaacs,A., Yang,J., Lundby,A., Zhao,J.H.,
            Kim,Y.J., Go,M.J., Almgren,P., Bochud,M., Boucher,G.,
            Cornelis,M.C., Gudbjartsson,D., Hadley,D., van der Harst,P.,
            Hayward,C., den Heijer,M., Igl,W., Jackson,A.U., Kutalik,Z.,
            Luan,J., Kemp,J.P., Kristiansson,K., Ladenvall,C., Lorentzon,M.,
            Montasser,M.E., Njajou,O.T., O'Reilly,P.F., Padmanabhan,S., St
            Pourcain,B., Rankinen,T., Salo,P., Tanaka,T., Timpson,N.J.,
            Vitart,V., Waite,L., Wheeler,W., Zhang,W., Draisma,H.H.,
            Feitosa,M.F., Kerr,K.F., Lind,P.A., Mihailov,E., Onland-Moret,N.C.,
            Song,C., Weedon,M.N., Xie,W., Yengo,L., Absher,D., Albert,C.M.,
            Alonso,A., Arking,D.E., de Bakker,P.I., Balkau,B., Barlassina,C.,
            Benaglio,P., Bis,J.C., Bouatia-Naji,N., Brage,S., Chanock,S.J.,
            Chines,P.S., Chung,M., Darbar,D., Dina,C., Dorr,M., Elliott,P.,
            Felix,S.B., Fischer,K., Fuchsberger,C., de Geus,E.J., Goyette,P.,
            Gudnason,V., Harris,T.B., Hartikainen,A.L., Havulinna,A.S.,
            Heckbert,S.R., Hicks,A.A., Hofman,A., Holewijn,S.,
            Hoogstra-Berends,F., Hottenga,J.J., Jensen,M.K., Johansson,A.,
            Junttila,J., Kaab,S., Kanon,B., Ketkar,S., Khaw,K.T., Knowles,J.W.,
            Kooner,A.S., Kors,J.A., Kumari,M., Milani,L., Laiho,P.,
            Lakatta,E.G., Langenberg,C., Leusink,M., Liu,Y., Luben,R.N.,
            Lunetta,K.L., Lynch,S.N., Markus,M.R., Marques-Vidal,P., Mateo
            Leach,I., McArdle,W.L., McCarroll,S.A., Medland,S.E., Miller,K.A.,
            Montgomery,G.W., Morrison,A.C., Muller-Nurasyid,M., Navarro,P.,
            Nelis,M., O'Connell,J.R., O'Donnell,C.J., Ong,K.K., Newman,A.B.,
            Peters,A., Polasek,O., Pouta,A., Pramstaller,P.P., Psaty,B.M.,
            Rao,D.C., Ring,S.M., Rossin,E.J., Rudan,D., Sanna,S., Scott,R.A.,
            Sehmi,J.S., Sharp,S., Shin,J.T., Singleton,A.B., Smith,A.V.,
            Soranzo,N., Spector,T.D., Stewart,C., Stringham,H.M., Tarasov,K.V.,
            Uitterlinden,A.G., Vandenput,L., Hwang,S.J., Whitfield,J.B.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilson,J.F., Witteman,J.C.,
            Wong,A., Wong,Q., Jamshidi,Y., Zitting,P., Boer,J.M., Boomsma,D.I.,
            Borecki,I.B., van Duijn,C.M., Ekelund,U., Forouhi,N.G., Froguel,P.,
            Hingorani,A., Ingelsson,E., Kivimaki,M., Kronmal,R.A., Kuh,D.,
            Lind,L., Martin,N.G., Oostra,B.A., Pedersen,N.L., Quertermous,T.,
            Rotter,J.I., van der Schouw,Y.T., Verschuren,W.M., Walker,M.,
            Albanes,D., Arnar,D.O., Assimes,T.L., Bandinelli,S., Boehnke,M., de
            Boer,R.A., Bouchard,C., Caulfield,W.L., Chambers,J.C., Curhan,G.,
            Cusi,D., Eriksson,J., Ferrucci,L., van Gilst,W.H., Glorioso,N., de
            Graaf,J., Groop,L., Gyllensten,U., Hsueh,W.C., Hu,F.B.,
            Huikuri,H.V., Hunter,D.J., Iribarren,C., Isomaa,B., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kiemeney,L.A., van der Klauw,M.M.,
            Kooner,J.S., Kraft,P., Iacoviello,L., Lehtimaki,T., Lokki,M.L.,
            Mitchell,B.D., Navis,G., Nieminen,M.S., Ohlsson,C., Poulter,N.R.,
            Qi,L., Raitakari,O.T., Rimm,E.B., Rioux,J.D., Rizzi,F., Rudan,I.,
            Salomaa,V., Sever,P.S., Shields,D.C., Shuldiner,A.R., Sinisalo,J.,
            Stanton,A.V., Stolk,R.P., Strachan,D.P., Tardif,J.C.,
            Thorsteinsdottir,U., Tuomilehto,J., van Veldhuisen,D.J.,
            Virtamo,J., Viikari,J., Vollenweider,P., Waeber,G., Widen,E.,
            Cho,Y.S., Olsen,J.V., Visscher,P.M., Willer,C., Franke,L.,
            Erdmann,J., Thompson,J.R., Pfeufer,A., Sotoodehnia,N.,
            Newton-Cheh,C., Ellinor,P.T., Stricker,B.H., Metspalu,A.,
            Perola,M., Beckmann,J.S., Smith,G.D., Stefansson,K., Wareham,N.J.,
            Munroe,P.B., Sibon,O.C., Milan,D.J., Snieder,H., Samani,N.J. and
            Loos,R.J.
  CONSRTM   Global BPgen Consortium; CARDIoGRAM Consortium; PR GWAS Consortium;
            QRS GWAS Consortium; QT-IGC Consortium; CHARGE-AF Consortium
  TITLE     Identification of heart rate-associated loci and their effects on
            cardiac conduction and rhythm disorders
  JOURNAL   Nat Genet 45 (6), 621-631 (2013)
   PUBMED   23583979
REFERENCE   6  (bases 1 to 3539)
  AUTHORS   Kitayama,K., Hayashida,Y., Nishida,K. and Akama,T.O.
  TITLE     Enzymes responsible for synthesis of corneal keratan sulfate
            glycosaminoglycans
  JOURNAL   J Biol Chem 282 (41), 30085-30096 (2007)
   PUBMED   17690104
  REMARK    GeneRIF: sulfated keratan sulfate is produced by beta3GNT7,
            beta4GalT4, CGn6ST, and KSG6ST
REFERENCE   7  (bases 1 to 3539)
  AUTHORS   Seko,A. and Yamashita,K.
  TITLE     beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts
            efficiently on keratan sulfate-related glycans
  JOURNAL   FEBS Lett 556 (1-3), 216-220 (2004)
   PUBMED   14706853
REFERENCE   8  (bases 1 to 3539)
  AUTHORS   Kataoka,K. and Huh,N.H.
  TITLE     A novel beta1,3-N-acetylglucosaminyltransferase involved in
            invasion of cancer cells as assayed in vitro
  JOURNAL   Biochem Biophys Res Commun 294 (4), 843-848 (2002)
   PUBMED   12061784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF502430.1, AK126207.1, AC017104.8 and AK000770.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145236.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB224859.1, AK126207.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287590.6/ ENSP00000287590.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1348              AF502430.1         87-1434
            1349-2495           AK126207.1         1331-2477
            2496-3373           AC017104.8         8648-9525
            3374-3539           AK000770.1         1703-1868
FEATURES             Location/Qualifiers
     source          1..3539
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..3539
                     /gene="B3GNT7"
                     /gene_synonym="beta3GnT7"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 7"
                     /db_xref="GeneID:93010"
                     /db_xref="HGNC:HGNC:18811"
                     /db_xref="MIM:615313"
     exon            1..105
                     /gene="B3GNT7"
                     /gene_synonym="beta3GnT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1300
                     /gene="B3GNT7"
                     /gene_synonym="beta3GnT7"
                     /note="beta 1,3-N-acetylglucosaminyltransferase 7; BGnT-7;
                     beta3Gn-T7; beta-1,3-Gn-T7"
                     /codon_start=1
                     /product="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 7"
                     /protein_id="NP_660279.1"
                     /db_xref="CCDS:CCDS46540.1"
                     /db_xref="GeneID:93010"
                     /db_xref="HGNC:HGNC:18811"
                     /db_xref="MIM:615313"
                     /translation="MSLWKKTVYRSLCLALALLVAVTVFQRSLTPGQFLQEPPPPTLE
                     PQKAQKPNGQLVNPNNFWKNPKDVAAPTPMASQGPQAWDVTTTNCSANINLTHQPWFQ
                     VLEPQFRQFLFYRHCRYFPMLLNHPEKCRGDVYLLVVVKSVITQHDRREAIRQTWGRE
                     RQSAGGGRGAVRTLFLLGTASKQEERTHYQQLLAYEDRLYGDILQWGFLDTFFNLTLK
                     EIHFLKWLDIYCPHVPFIFKGDDDVFVNPTNLLEFLADRQPQENLFVGDVLQHARPIR
                     RKDNKYYIPGALYGKASYPPYAGGGGFLMAGSLARRLHHACDTLELYPIDDVFLGMCL
                     EVLGVQPTAHEGFKTFGISRNRNSRMNKEPCFFRAMLVVHKLLPPELLAMWGLVHSNL
                     TCSRKLQVL"
     exon            106..3539
                     /gene="B3GNT7"
                     /gene_synonym="beta3GnT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3516..3521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GNT7"
                     /gene_synonym="beta3GnT7"
                     /note="hexamer: AATAAA"
     polyA_site      3539
                     /gene="B3GNT7"
                     /gene_synonym="beta3GnT7"
                     /note="major polyA site"
ORIGIN      
        1 ctccgtcccc acccgcccgc cgtcccgccg gcccgagccg tggcgcccag agctgcgagc
       61 cgctcgcccc tccgccgctc cggcccgggc cgccatgtcg ctgtggaaga aaaccgtcta
      121 ccggagtctg tgcctggccc tggccctgct cgtggccgtg acggtgttcc aacgcagtct
      181 cacccctggt cagtttctgc aggagcctcc gccacccacc ctggagccac agaaggccca
      241 gaagccaaat ggacagctgg tgaaccccaa caacttctgg aagaacccga aagatgtggc
      301 tgcgcccacg cccatggcct ctcaggggcc ccaggcctgg gacgtgacca ccactaactg
      361 ctcagccaat atcaacttga cccaccagcc ctggttccag gtcctggagc cgcagttccg
      421 gcagtttctc ttctaccgcc actgccgcta cttccccatg ctgctgaacc acccggagaa
      481 gtgcaggggc gatgtctacc tgctggtggt tgtcaagtcg gtcatcacgc agcacgaccg
      541 ccgcgaggcc atccgccaga cctggggccg cgagcggcag tccgcgggtg ggggccgagg
      601 cgccgtgcgc accctcttcc tgctgggcac ggcctccaag caggaggagc gcacgcacta
      661 ccagcagctg ctggcctacg aagaccgcct ctacggcgac atcctgcagt ggggctttct
      721 cgacaccttc ttcaacctga ccctcaagga gatccacttc ctcaagtggc tggacatcta
      781 ctgcccccac gtccccttca ttttcaaagg cgacgatgac gtcttcgtca accccaccaa
      841 cctgctagaa tttctggctg accggcagcc acaggaaaac ctgttcgtgg gcgatgtcct
      901 gcagcacgct cggcccattc gcaggaaaga caacaaatac tacatcccgg gggccctgta
      961 cggcaaggcc agctatccgc cgtatgcagg cggcggtggc ttcctcatgg ccggcagcct
     1021 ggcccggcgc ctgcaccatg cctgcgacac cctggagctc tacccgatcg acgacgtctt
     1081 tctgggcatg tgcctggagg tgctgggcgt gcagcccacg gcccacgagg gcttcaagac
     1141 tttcggcatc tcccggaacc gcaacagccg catgaacaag gagccgtgct ttttccgcgc
     1201 catgctcgtg gtgcacaagc tgctgccccc tgagctgctc gccatgtggg ggctggtgca
     1261 cagcaatctc acctgctccc gcaagctcca ggtgctctga ccccagccgg gctactagga
     1321 caggccaggg cacttgctcc tgagccccca tggtattggg gctggagcca cagtgcccag
     1381 gcctagcctt tggtccccaa ggggaggtgg agggttgagg cctacgtgcc actgggtgtg
     1441 gtggggtgca ggtagccaga aagggacctc cctgtgtgga taattctagg aaactgaggc
     1501 ccaggaacgg ttggagctgc ccagtctgga ggccctctct gaggagcgag gcgccaggcc
     1561 ctggcagccc tcctgacctg ggtccgttgc tggccccctc agatgtggtg ggaggtcctg
     1621 gtgacctctg gaggaacgct gtgctcaggt acctgggcta ggcctggcct gatgggtctg
     1681 tggccgcccc tcgtcttcac agggaagagt cttctgtgaa atgcctcagt ctccccagag
     1741 gccgggcggc cctggcagga gaaactcaac cctgtgcggg ctcacaggca ccccccagtc
     1801 cacaccctgg tctcctggga gagagggccc agccggctct ccgcagcccc aggcctgcct
     1861 ggagacgggc cgcctctgcc acagggcctc cactcctggc tgtgtcctgt aaggtctgga
     1921 agggcgaccg ctctgactac ctcagcgccc ctcagaatct ccctggggct gcagccctac
     1981 cccaccccga cacagggcag aagagcagcg ctcctggccc cccgaagtcc cagagctgct
     2041 gacccccacc ccaggcaagt ctctcccgca gcccccacac ccccaggcct ggctccctgg
     2101 ctggaaagca gccggtttgg ccctggaagt ggacattcct ctattactgt gaagttttat
     2161 ttatgaagaa tttggaggga gaaggctcca ggcttcagga gggggtggtg tcctccctgg
     2221 ccctcctccc ttccctcccc tcattccagc tgcctgccct cagcaccccc aggcccctca
     2281 cagcccagcc ccctccagag ccctgcccca ccgcaccctg cttctccagg gcctagcaga
     2341 ccagcatctg ccccggtgaa gggatggatc agctgtgggg gtgggtgcag aaggttgcca
     2401 cctcctacct cagcgggagt cacctaggaa agatggaggg attgacacta ttttctcaat
     2461 aaaatgggac tttttttttt tttttttttt ttttttggtg tgaaacttcc tgttcccagc
     2521 tgcatcagag agcctgtctg gggccaaggt tgccagagat ttctgaagac acagcttgtt
     2581 ccttgttctt ggctggtggg tgcacaagga cttctggaag ggatttagac ggggctgagt
     2641 gctaggatta aagtggggat gggagtacgg caacagaaaa acctgggagc tagcaatgca
     2701 cccagccctt gactgtgccc tggtggacag ccgagctgtg gctctagcgt gagccagtgc
     2761 cttcctgtcc ctgccaaggg tgaggccaga gttggccccg aggctaatgt ttcagtgggt
     2821 gagattaggt cggccgtaca gaggccggtg ggctccctga catcccttcc aggcaacctg
     2881 aaagcactga aatagcttat ggccctgtgc cagggacctt ggcccaagct gctgacctcc
     2941 agggtgggga gggagctacc cccaggagaa gagtcactca gacagcagta tgagcaagcc
     3001 agccagcagc tccgtgcctg cacccagctc aggggaatcc cagggggttc agatgcccag
     3061 gaaggaaaag gggacagcgc tactgctatg gaatgagacc accacttctc ctgttgtcct
     3121 tcccagcttc tccccaacct ccccttttcc ctagtttata agacaggaga aaagggagaa
     3181 agcaaaaagc tggaaagaaa cagaagtaag ataaatagct agacgacctt ggcgccacca
     3241 cctggccctg gtggttaaaa tgataataat attaacccct gaccaaaacg actggtgtta
     3301 tctgtaaatc ccagacattg tgtgagaaag caccgtaaaa ctttttgtcc tattagctga
     3361 tgtgtgtagc ccccagtcac gttcctcacg cttacttgat ctattatgac cctttcacgt
     3421 ggacccctta gagttgtaag ctcttaaaag ggctaggaat ttctttttcg gggagctcgg
     3481 ctcttaagac gcgagtctgc cgacgctccc ggccgaataa aaacctcttc cttctttaa
//
