LOCUS       NM_138706               2503 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 6 (B3GNT6), mRNA.
ACCESSION   NM_138706
VERSION     NM_138706.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2503)
  AUTHORS   Xiao,S., Yang,C., Zhang,Y. and Lai,C.
  TITLE     Downregulation of B3GNT6 is a predictor of poor outcomes in
            patients with colorectal cancer
  JOURNAL   World J Surg Oncol 20 (1), 110 (2022)
   PUBMED   35387659
  REMARK    GeneRIF: Downregulation of B3GNT6 is a predictor of poor outcomes
            in patients with colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2503)
  AUTHORS   Doi,N., Ino,Y., Angata,K., Shimada,K., Narimatsu,H. and Hiraoka,N.
  TITLE     Clinicopathological significance of core 3 O-glycan synthetic
            enzyme, beta1,3-N-acetylglucosaminyltransferase 6 in pancreatic
            ductal adenocarcinoma
  JOURNAL   PLoS One 15 (11), e0242851 (2020)
   PUBMED   33253272
  REMARK    GeneRIF: Clinicopathological significance of core 3 O-glycan
            synthetic enzyme, beta1,3-N-acetylglucosaminyltransferase 6 in
            pancreatic ductal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2503)
  AUTHORS   Cherian,R.M., Jin,C., Liu,J., Karlsson,N.G. and Holgersson,J.
  TITLE     A Panel of Recombinant Mucins Carrying a Repertoire of Sialylated
            O-Glycans Based on Different Core Chains for Studies of Glycan
            Binding Proteins
  JOURNAL   Biomolecules 5 (3), 1810-1831 (2015)
   PUBMED   26274979
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2503)
  AUTHORS   Bisognin,A., Pizzini,S., Perilli,L., Esposito,G., Mocellin,S.,
            Nitti,D., Zanovello,P., Bortoluzzi,S. and Mandruzzato,S.
  TITLE     An integrative framework identifies alternative splicing events in
            colorectal cancer development
  JOURNAL   Mol Oncol 8 (1), 129-141 (2014)
   PUBMED   24189147
REFERENCE   5  (bases 1 to 2503)
  AUTHORS   Lee,S.H., Hatakeyama,S., Yu,S.Y., Bao,X., Ohyama,C., Khoo,K.H.,
            Fukuda,M.N. and Fukuda,M.
  TITLE     Core3 O-glycan synthase suppresses tumor formation and metastasis
            of prostate carcinoma PC3 and LNCaP cells through down-regulation
            of alpha2beta1 integrin complex
  JOURNAL   J Biol Chem 284 (25), 17157-17169 (2009)
   PUBMED   19395705
  REMARK    GeneRIF: alpha2beta1 integrin acquired core3 O-glycans in cells
            expressing core3 synthase with decreased maturation of beta1
            integrin, leading to decreased levels of the alpha2beta1 integrin
            complex
REFERENCE   6  (bases 1 to 2503)
  AUTHORS   Iwai,T., Kudo,T., Kawamoto,R., Kubota,T., Togayachi,A., Hiruma,T.,
            Okada,T., Kawamoto,T., Morozumi,K. and Narimatsu,H.
  TITLE     Core 3 synthase is down-regulated in colon carcinoma and profoundly
            suppresses the metastatic potential of carcinoma cells
  JOURNAL   Proc Natl Acad Sci U S A 102 (12), 4572-4577 (2005)
   PUBMED   15755813
  REMARK    GeneRIF: expression was markedly down-regulated in gastric and
            colorectal carcinomas
REFERENCE   7  (bases 1 to 2503)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   8  (bases 1 to 2503)
  AUTHORS   Iwai,T., Inaba,N., Naundorf,A., Zhang,Y., Gotoh,M., Iwasaki,H.,
            Kudo,T., Togayachi,A., Ishizuka,Y., Nakanishi,H. and Narimatsu,H.
  TITLE     Molecular cloning and characterization of a novel
            UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase
            (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of
            O-glycans
  JOURNAL   J Biol Chem 277 (15), 12802-12809 (2002)
   PUBMED   11821425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA439499.1, BC103908.1,
            CD636501.1, AK127544.1 and BC025357.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_138706.4.
            
            Summary: The protein encoded by this gene is a
            beta-1,3-N-acetylglucosaminyltransferase that adds an
            N-acetylglucosamine moiety to N-acetylgalactosamine-modified serine
            or threonine. The encoded enzyme is responsible for creating the
            core 3 structure of O-glycans, which are important components of
            mucin-type glycoproteins. [provided by RefSeq, Dec 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292773.1, AK172863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000622824.1/ ENSP00000484640.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               DA439499.1         58-413
            357-1070            BC103908.1         313-1026
            1071-1186           CD636501.1         1-116               c
            1187-2486           AK127544.1         827-2126
            2487-2503           BC025357.1         2085-2101
FEATURES             Location/Qualifiers
     source          1..2503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..2503
                     /gene="B3GNT6"
                     /gene_synonym="3-Gn-T6; B3Gn-T6; beta-1; beta3Gn-T6;
                     BGnT-6"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 6"
                     /db_xref="GeneID:192134"
                     /db_xref="HGNC:HGNC:24141"
                     /db_xref="MIM:615315"
     exon            1..81
                     /gene="B3GNT6"
                     /gene_synonym="3-Gn-T6; B3Gn-T6; beta-1; beta3Gn-T6;
                     BGnT-6"
                     /inference="alignment:Splign:2.1.0"
     exon            82..2503
                     /gene="B3GNT6"
                     /gene_synonym="3-Gn-T6; B3Gn-T6; beta-1; beta3Gn-T6;
                     BGnT-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1236
                     /gene="B3GNT6"
                     /gene_synonym="3-Gn-T6; B3Gn-T6; beta-1; beta3Gn-T6;
                     BGnT-6"
                     /EC_number="2.4.1.147"
                     /note="beta-1,3-N-acetylglucosaminyltransferase protein;
                     core 3 synthase; beta-1,3-N-acetylglucosaminyltransferase
                     6"
                     /codon_start=1
                     /product="acetylgalactosaminyl-O-glycosyl-glycoprotein
                     beta-1,3-N-acetylglucosaminyltransferase"
                     /protein_id="NP_619651.3"
                     /db_xref="CCDS:CCDS53681.1"
                     /db_xref="GeneID:192134"
                     /db_xref="HGNC:HGNC:24141"
                     /db_xref="MIM:615315"
                     /translation="MAFPCRRSLTAKTLACLLVGVSFLALQQWFLQAPRSPREERSPQ
                     EETPEGPTDAPAADEPPSELVPGPPCVANASANATADFEQLPARIQDFLRYRHCRHFP
                     LLWDAPAKCAGGRGVFLLLAVKSAPEHYERRELIRRTWGQERSYGGRPVRRLFLLGTP
                     GPEDEARAERLAELVALEAREHGDVLQWAFADTFLNLTLKHLHLLDWLAARCPHARFL
                     LSGDDDVFVHTANVVRFLQAQPPGRHLFSGQLMEGSVPIRDSWSKYFVPPQLFPGSAY
                     PVYCSGGGFLLSGPTARALRAAARHTPLFPIDDAYMGMCLERAGLAPSGHEGIRPFGV
                     QLPGAQQSSFDPCMYRELLLVHRFAPYEMLLMWKALHSPALSCDRGHRVS"
ORIGIN      
        1 agtgtgtgaa gtaaagggat taaaggctag tctcaggctg gggatggctc ctgtctattt
       61 cttctctctc agagactgca gatggctttt ccctgccgca ggtccctgac tgccaagact
      121 ctggcctgcc tcctggtggg cgtgagtttc ttagcactgc agcagtggtt cctccaggcg
      181 ccaaggtccc cgcgggagga gaggtccccg caggaggaga cgccagaggg tcccaccgac
      241 gctcccgcgg ctgacgagcc gccctcggag ctcgtccccg ggcccccgtg cgtggcgaac
      301 gcctcggcga acgccacggc cgacttcgag cagctgcccg cgcgcatcca ggacttcctg
      361 cggtaccgcc actgccgcca cttcccgctg ctttgggacg caccggccaa gtgcgccggc
      421 ggccgaggcg tgttcctgct cctggcggtg aagtcggcgc ctgagcacta cgagcgacgc
      481 gagctcatcc ggcgcacgtg ggggcaagag cgcagctacg gcgggcggcc agtgcgccgc
      541 ctctttctat tgggcacccc gggccccgag gacgaggcgc gcgcggagcg gctggcggag
      601 ctggtggcgc tggaggcgcg cgagcacggc gacgtgctgc agtgggcctt cgcggacacc
      661 ttcctcaacc tcacgctcaa gcacctgcac ttgctcgact ggctggctgc acgctgcccg
      721 cacgcgcgct ttctgctcag cggcgacgac gacgtgttcg tgcacaccgc caacgtagtc
      781 cgcttcctgc aggcgcagcc acccggccgc cacctgttct ccggccagct catggagggc
      841 tccgtgccca tccgcgacag ctggagcaag tacttcgtgc cgccgcagct cttccccggg
      901 tccgcttacc cggtgtactg cagcggcggc ggcttcctcc tgtccggccc cacggcccgg
      961 gccctgcgcg cggccgcccg ccacaccccg ctcttcccca tcgacgacgc ctacatgggc
     1021 atgtgtctgg agcgcgccgg cctggcgccc agcggccacg agggcatccg acccttcggc
     1081 gtgcagctgc ctggcgcaca gcagtcctcc ttcgacccct gcatgtaccg cgagttgctg
     1141 ctagtgcacc gcttcgcgcc ctacgagatg ctgctcatgt ggaaggcgct gcacagcccc
     1201 gcgctcagct gtgaccgggg acaccgggtc tcctgaggcc agttgggcgg cttcagcccc
     1261 gggcctccaa ccatgtccat gctgagaagg cagctttccc gctctgggta ccttacgtcc
     1321 tgcccagctc tgtgcacctg aaccccagct gcgcactgaa atcagctggg gtggggggtg
     1381 tggaaaatgc ctacatcctg gctccatctc ccgaagtttc gatttgatta gtctggggtg
     1441 gacccagaca tgttaagtat tttttaagtt cctccagtga tgcgaatgtg cagctaggcc
     1501 tgaggaccac tcggctagac tatctcttca tcctcgcaaa gccagctcca ccgccctctc
     1561 tgcaagaatt ccgggcccct cgctcccaca ctcgggtcct cttgagcagt ggagcaaggg
     1621 agacctggga gcgtgggagc caggatcagc gccccctgcc atgtgcctac aaatgtcagt
     1681 tgtgatttcc actgtttaca agtgagtgga gctggagctg ggctgacagt atcaggtgga
     1741 tcccgcttcc ccctccccca agaagtcagc caacacgcag ctgaggcgca tgtggtggcc
     1801 ttcttcccac cactacccca gtacaccgtg aggtagaaat cttcaccgtg caaagtggaa
     1861 accagaggcc cggtcagaca gtgactaatc cagggccgtg gcattcccag acagcacacc
     1921 actgtggtcc cctccacact caccccaacc aaagctaatg gcctagttgg gtcctgcccg
     1981 ccaataatca cccccacggg tcagagacag gctccttgcc ggggtctggg cctcaggctc
     2041 agtgggcctt ggacaaccca gcagggagtt ccggggagtc cgaagtggag aaaggctggt
     2101 gggaacatgg aggccagtgt tggggagcct gtggaggcag gtgtgtagaa ttgtgttcgg
     2161 gaggtggggg atctgagacc gaagtggaca gtggttaaga ttgtggggcc gggcgaggtg
     2221 gctcacgcct gtaatcccag cactttggga ggctgaggag gtcggatcat gaggtcaaga
     2281 gttcgagacc agcctggcca atatggtgaa accccgtctc tattgggagt acaaaaatta
     2341 gccggccata gtggctcgtg cctgtaatct cagctatttg ggaggctgag gcaggagaat
     2401 cacttgaacc tgggaggcgg aggttgcagt gagccgagat cgtgccactg cactccagcc
     2461 tgggcgacag agcaagactg catctcaaaa aaaaaaaaaa aaa
//
