LOCUS       NM_014256               2692 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3), mRNA.
ACCESSION   NM_014256
VERSION     NM_014256.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2692)
  AUTHORS   Lu,J., Lei,T., Yu,H., Su,X., Zhang,L. and Zhang,Y.
  TITLE     The role of B3GNT3 as an oncogene in the growth, invasion and
            migration of esophageal cancer cells
  JOURNAL   Acta Cir Bras 38, e380923 (2023)
   PUBMED   36995820
  REMARK    GeneRIF: The role of B3GNT3 as an oncogene in the growth, invasion
            and migration of esophageal cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2692)
  AUTHORS   Xu,J., Guo,Z., Yuan,S., Li,H. and Luo,S.
  TITLE     Upregulation of B3GNT3 is associated with immune infiltration and
            activation of NF-kappaB pathway in gynecologic cancers
  JOURNAL   J Reprod Immunol 152, 103658 (2022)
   PUBMED   35777165
  REMARK    GeneRIF: Upregulation of B3GNT3 is associated with immune
            infiltration and activation of NF-kappaB pathway in gynecologic
            cancers.
REFERENCE   3  (bases 1 to 2692)
  AUTHORS   Zhou,H., Zhao,J., Yang,X., Liu,J. and Huang,W.
  TITLE     Study on the Expression of beta-1,3-N-acetylglucosaminyltransferase
            3 in Gastric Cancer and the Mechanism Promoting Gastric Cancer
            Progression Based on the Extraction Method of Nanomagnetic Beads
  JOURNAL   J Biomed Nanotechnol 18 (3), 677-692 (2022)
   PUBMED   35715910
  REMARK    GeneRIF: Study on the Expression of
            beta-1,3-N-acetylglucosaminyltransferase 3 in Gastric Cancer and
            the Mechanism Promoting Gastric Cancer Progression Based on the
            Extraction Method of Nanomagnetic Beads.
REFERENCE   4  (bases 1 to 2692)
  AUTHORS   Wang,J.S., Ruan,F., Guo,L.Z., Wang,F.G., Wang,F.L. and An,H.M.
  TITLE     B3GNT3 acts as a carcinogenic factor in endometrial cancer via
            facilitating cell growth, invasion and migration through regulating
            RhoA/RAC1 pathway-associated markers
  JOURNAL   Genes Genomics 43 (5), 447-457 (2021)
   PUBMED   33683574
  REMARK    GeneRIF: B3GNT3 acts as a carcinogenic factor in endometrial cancer
            via facilitating cell growth, invasion and migration through
            regulating RhoA/RAC1 pathway-associated markers.
REFERENCE   5  (bases 1 to 2692)
  AUTHORS   Zhuang,H., Zhou,Z., Zhang,Z., Chen,X., Ma,Z., Huang,S., Gong,Y.,
            Zhang,C. and Hou,B.
  TITLE     B3GNT3 overexpression promotes tumor progression and inhibits
            infiltration of CD8+ T cells in pancreatic cancer
  JOURNAL   Aging (Albany NY) 13 (2), 2310-2329 (2020)
   PUBMED   33316775
  REMARK    GeneRIF: B3GNT3 overexpression promotes tumor progression and
            inhibits infiltration of CD8(+) T cells in pancreatic cancer.
REFERENCE   6  (bases 1 to 2692)
  AUTHORS   Cerhan,J.R., Ansell,S.M., Fredericksen,Z.S., Kay,N.E., Liebow,M.,
            Call,T.G., Dogan,A., Cunningham,J.M., Wang,A.H., Liu-Mares,W.,
            Macon,W.R., Jelinek,D., Witzig,T.E., Habermann,T.M. and Slager,S.L.
  TITLE     Genetic variation in 1253 immune and inflammation genes and risk of
            non-Hodgkin lymphoma
  JOURNAL   Blood 110 (13), 4455-4463 (2007)
   PUBMED   17827388
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2692)
  AUTHORS   Yeh,J.C., Hiraoka,N., Petryniak,B., Nakayama,J., Ellies,L.G.,
            Rabuka,D., Hindsgaul,O., Marth,J.D., Lowe,J.B. and Fukuda,M.
  TITLE     Novel sulfated lymphocyte homing receptors and their control by a
            Core1 extension beta 1,3-N-acetylglucosaminyltransferase
  JOURNAL   Cell 105 (7), 957-969 (2001)
   PUBMED   11439191
REFERENCE   8  (bases 1 to 2692)
  AUTHORS   Shiraishi,N., Natsume,A., Togayachi,A., Endo,T., Akashima,T.,
            Yamada,Y., Imai,N., Nakagawa,S., Koizumi,S., Sekine,S.,
            Narimatsu,H. and Sasaki,K.
  TITLE     Identification and characterization of three novel beta
            1,3-N-acetylglucosaminyltransferases structurally related to the
            beta 1,3-galactosyltransferase family
  JOURNAL   J Biol Chem 276 (5), 3498-3507 (2001)
   PUBMED   11042166
REFERENCE   9  (bases 1 to 2692)
  AUTHORS   Amado,M., Almeida,R., Schwientek,T. and Clausen,H.
  TITLE     Identification and characterization of large galactosyltransferase
            gene families: galactosyltransferases for all functions
  JOURNAL   Biochim Biophys Acta 1473 (1), 35-53 (1999)
   PUBMED   10580128
  REMARK    Review article
REFERENCE   10 (bases 1 to 2692)
  AUTHORS   Yokoyama-Kobayashi,M., Yamaguchi,T., Sekine,S. and Kato,S.
  TITLE     Selection of cDNAs encoding putative type II membrane proteins on
            the cell surface from a human full-length cDNA bank
  JOURNAL   Gene 228 (1-2), 161-167 (1999)
   PUBMED   10072769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA385410.1, AB015630.1,
            AB049585.1, DB104034.1 and AW848963.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_014256.3.
            
            Summary: This gene encodes a member of the
            beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a
            type II transmembrane protein and contains a signal anchor that is
            not cleaved. It prefers the substrates of lacto-N-tetraose and
            lacto-N-neotetraose, and is involved in the biosynthesis of
            poly-N-acetyllactosamine chains and the biosynthesis of the
            backbone structure of dimeric sialyl Lewis a. It plays dominant
            roles in L-selectin ligand biosynthesis, lymphocyte homing and
            lymphocyte trafficking. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB049585.1, AB015630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318683.7/ ENSP00000321874.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA385410.1         29-30
            3-1101              AB015630.1         1-1099
            1102-2197           AB049585.1         1085-2180
            2198-2592           DB104034.1         153-547
            2593-2692           AW848963.1         285-384
FEATURES             Location/Qualifiers
     source          1..2692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2692
                     /gene="B3GNT3"
                     /gene_synonym="B3GAL-T8; B3GN-T3; B3GNT-3; beta3Gn-T3;
                     HP10328; TMEM3"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 3"
                     /db_xref="GeneID:10331"
                     /db_xref="HGNC:HGNC:13528"
                     /db_xref="MIM:605863"
     exon            1..69
                     /gene="B3GNT3"
                     /gene_synonym="B3GAL-T8; B3GN-T3; B3GNT-3; beta3Gn-T3;
                     HP10328; TMEM3"
                     /inference="alignment:Splign:2.1.0"
     exon            70..686
                     /gene="B3GNT3"
                     /gene_synonym="B3GAL-T8; B3GN-T3; B3GNT-3; beta3Gn-T3;
                     HP10328; TMEM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1238
                     /gene="B3GNT3"
                     /gene_synonym="B3GAL-T8; B3GN-T3; B3GNT-3; beta3Gn-T3;
                     HP10328; TMEM3"
                     /EC_number="2.4.1.149"
                     /EC_number="2.4.1.146"
                     /note="beta-1,3-N-acetylglucosaminyltransferase bGnT-3;
                     transmembrane protein 3; putative type II membrane
                     protein; beta-1,3-galactosyl-O-glycosyl-glycoprotein
                     beta-1,3-N-acetylglucosaminyltransferase; beta3GalT8;
                     beta-3-Gx-T8; beta-1,3-Gn-T3; beta-1,3-GalTase 8;
                     core1-beta3GlcNAcT; UDP-Gal:beta-GlcNAc
                     beta-1,3-galactosyltransferase 8; core 1 extending
                     beta-1,3-N-acetylglucosaminyltransferase;
                     UDP-galactose:beta-N-acetylglucosamine
                     beta-1,3-galactosyltransferase 8"
                     /codon_start=1
                     /product="N-acetyllactosaminide
                     beta-1,3-N-acetylglucosaminyltransferase 3"
                     /protein_id="NP_055071.2"
                     /db_xref="CCDS:CCDS12364.1"
                     /db_xref="GeneID:10331"
                     /db_xref="HGNC:HGNC:13528"
                     /db_xref="MIM:605863"
                     /translation="MKYLRHRRPNATLILAIGAFTLLLFSLLVSPPTCKVQEQPPAIP
                     EALAWPTPPTRPAPAPCHANTSMVTHPDFATQPQHVQNFLLYRHCRHFPLLQDVPPSK
                     CAQPVFLLLVIKSSPSNYVRRELLRRTWGRERKVRGLQLRLLFLVGTASNPHEARKVN
                     RLLELEAQTHGDILQWDFHDSFFNLTLKQVLFLQWQETRCANASFVLNGDDDVFAHTD
                     NMVFYLQDHDPGRHLFVGQLIQNVGPIRAFWSKYYVPEVVTQNERYPPYCGGGGFLLS
                     RFTAAALRRAAHVLDIFPIDDVFLGMCLELEGLKPASHSGIRTSGVRAPSQRLSSFDP
                     CFYRDLLLVHRFLPYEMLLMWDALNQPNLTCGNQTQIY"
     exon            687..2692
                     /gene="B3GNT3"
                     /gene_synonym="B3GAL-T8; B3GN-T3; B3GNT-3; beta3Gn-T3;
                     HP10328; TMEM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2175..2180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GNT3"
                     /gene_synonym="B3GAL-T8; B3GN-T3; B3GNT-3; beta3Gn-T3;
                     HP10328; TMEM3"
                     /note="hexamer: TATAAA"
     polyA_site      2198
                     /gene="B3GNT3"
                     /gene_synonym="B3GAL-T8; B3GN-T3; B3GNT-3; beta3Gn-T3;
                     HP10328; TMEM3"
                     /note="major polyA site"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GNT3"
                     /gene_synonym="B3GAL-T8; B3GN-T3; B3GNT-3; beta3Gn-T3;
                     HP10328; TMEM3"
                     /note="hexamer: AATAAA"
     polyA_site      2421
                     /gene="B3GNT3"
                     /gene_synonym="B3GAL-T8; B3GN-T3; B3GNT-3; beta3Gn-T3;
                     HP10328; TMEM3"
ORIGIN      
        1 aaactctttc ttcggctcgc gagctgagag gagcaggtag aggggcagag gcgggactgt
       61 cgtctggggg agccgcccag gaggctcctc aggccgaccc cagaccctgg ctggccagga
      121 tgaagtatct ccggcaccgg cggcccaatg ccaccctcat tctggccatc ggcgctttca
      181 ccctcctcct cttcagtctg ctagtgtcac cacccacctg caaggtccag gagcagccac
      241 cggcgatccc cgaggccctg gcctggccca ctccacccac ccgcccagcc ccggccccgt
      301 gccatgccaa cacctctatg gtcacccacc cggacttcgc cacgcagccg cagcacgttc
      361 agaacttcct cctgtacaga cactgccgcc actttcccct gctgcaggac gtgcccccct
      421 ctaagtgcgc gcagccggtc ttcctgctgc tggtgatcaa gtcctcccct agcaactatg
      481 tgcgccgcga gctgctgcgg cgcacgtggg gccgcgagcg caaggtacgg ggtttgcagc
      541 tgcgcctcct cttcctggtg ggcacagcct ccaacccgca cgaggcccgc aaggtcaacc
      601 ggctgctgga gctggaggca cagactcacg gagacatcct gcagtgggac ttccacgact
      661 ccttcttcaa cctcacgctc aagcaggtcc tgttcttaca gtggcaggag acaaggtgcg
      721 ccaacgccag cttcgtgctc aacggggatg atgacgtctt tgcacacaca gacaacatgg
      781 tcttctacct gcaggaccat gaccctggcc gccacctctt cgtggggcaa ctgatccaaa
      841 acgtgggccc catccgggct ttttggagca agtactatgt gccagaggtg gtgactcaga
      901 atgagcggta cccaccctat tgtgggggtg gtggcttctt gctgtcccgc ttcacggccg
      961 ctgccctgcg ccgtgctgcc catgtcttgg acatcttccc cattgatgat gtcttcctgg
     1021 gtatgtgtct ggagcttgag ggactgaagc ctgcctccca cagcggcatc cgcacgtctg
     1081 gcgtgcgggc tccatcgcaa cgcctgtcct cctttgaccc ctgcttctac cgagacctgc
     1141 tgctggtgca ccgcttccta ccttatgaga tgctgctcat gtgggatgcg ctgaaccagc
     1201 ccaacctcac ctgcggcaat cagacacaga tctactgagt cagcatcagg gtccccagcc
     1261 tctgggctcc tgtttccata ggaaggggcg acaccttcct cccaggaagc tgagaccttt
     1321 gtggtctgag cataagggag tgccagggaa ggtttgaggt ttgatgagtg aatattctgg
     1381 ctggcgaact cctacacatc cttcaaaacc cacctggtac tgttccagca tcttccctgg
     1441 atggctggag gaactccaga aaatatccat cttctttttg tggctgctaa tggcagaagt
     1501 gcctgtgcta gagttccaac tgtggatgca tccgtcccgt ttgagtcaaa gtcttacttc
     1561 cctgctctca cctactcaca gacgggatgc taagcagtgc acctgcagtg gtttaatggc
     1621 agataagctc cgtctgcagt tccaggccag ccagaaactc ctgtgtccac atagagctga
     1681 cgtgagaaat atctttcagc ccaggagaga ggggtcctga tcttaaccct ttcctgggtc
     1741 tcagacaact cagaaggttg gggggatacc agagaggtgg tggaatagga ccgccccctc
     1801 cttacttgtg ggatcaaatg ctgtaatggt ggaggtgtgg gcagaggagg gaggcaagtg
     1861 tcctttgaaa gttgtgagag ctcagagttt ctggggtcct cattaggagc ccccatccct
     1921 gtgttcccca agaattcaga gaacagcact ggggctggaa tgatctttaa tgggcccaag
     1981 gccaacaggc atatgcctca ctactgcctg gagaagggag agattcaggt cctccagcag
     2041 cctccctcac ccagtatgtt ttacagatta cggggggacc gggtgagcca gtgaccccct
     2101 gtagccccca gcttcaggcc tcagtgtctg ccagtcaagc ttcacaggca ttgtgatggg
     2161 gcagccttgg ggaatataaa attttgtgaa gacttggaga tctttttttt tttttaagca
     2221 aatttacaag tttcaacaga caagtccaca ttcatcccta aaagtctcat tttccagtag
     2281 aaaatataca ctggtaaaaa cggggcatgg ggccgtggct cagggctgta attctagcac
     2341 attgggagac caaagtggga ggatcacttg agcccaggag ttctggatcc tgtctctgca
     2401 caaaataaaa aattactcag gcgtggtggt gctcacatgc ctgtagtccc agctatactt
     2461 gggaggctga ggcgagagga tcgcttgagc ccaggagttg gaggctgcag tgaaccatga
     2521 ttgcgccact gtactccact gggcggcaat aagaagacaa aaacataaaa caggacatgt
     2581 gtgaggcaaa agctgcagga atttctatca ggcagatctg acctcatccc acccaccccc
     2641 tgctcagata cccttcatag ctccttattg ctttcagctc ataaccccac at
//
