LOCUS       NM_006577               2761 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), transcript
            variant 1, mRNA.
ACCESSION   NM_006577
VERSION     NM_006577.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2761)
  AUTHORS   Wang,C.M., Jan Wu,Y.J., Lin,J.C., Huang,L.Y., Wu,J. and Chen,J.Y.
  TITLE     Genetic effects of B3GNT2 on ankylosing spondylitis susceptibility
            and clinical manifestations in Taiwanese
  JOURNAL   J Formos Med Assoc 121 (7), 1283-1294 (2022)
   PUBMED   34645591
  REMARK    GeneRIF: Genetic effects of B3GNT2 on ankylosing spondylitis
            susceptibility and clinical manifestations in Taiwanese.
REFERENCE   2  (bases 1 to 2761)
  AUTHORS   Luo,Z., Hu,Q., Tang,Y., Leng,Y., Tian,T., Tian,S., Huang,C.,
            Liu,A., Deng,X. and Shen,L.
  TITLE     Construction and investigation of beta3GNT2-associated regulatory
            network in esophageal carcinoma
  JOURNAL   Cell Mol Biol Lett 27 (1), 8 (2022)
   PUBMED   35073841
  REMARK    GeneRIF: Construction and investigation of beta3GNT2-associated
            regulatory network in esophageal carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2761)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2761)
  AUTHORS   Kadirvelraj,R., Yang,J.Y., Kim,H.W., Sanders,J.H., Moremen,K.W. and
            Wood,Z.A.
  TITLE     Comparison of human poly-N-acetyl-lactosamine synthase structure
            with GT-A fold glycosyltransferases supports a modular assembly of
            catalytic subsites
  JOURNAL   J Biol Chem 296, 100110 (2021)
   PUBMED   33229435
  REMARK    GeneRIF: Comparison of human poly-N-acetyl-lactosamine synthase
            structure with GT-A fold glycosyltransferases supports a modular
            assembly of catalytic subsites.
REFERENCE   5  (bases 1 to 2761)
  AUTHORS   Hao,Y., Crequer-Grandhomme,A., Javier,N., Singh,A., Chen,H.,
            Manzanillo,P., Lo,M.C. and Huang,X.
  TITLE     Structures and mechanism of human glycosyltransferase
            beta1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), an important
            player in immune homeostasis
  JOURNAL   J Biol Chem 296, 100042 (2021)
   PUBMED   33158990
  REMARK    GeneRIF: Structures and mechanism of human glycosyltransferase
            beta1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), an important
            player in immune homeostasis.
REFERENCE   6  (bases 1 to 2761)
  AUTHORS   Isshiki,S., Kudo,T., Nishihara,S., Ikehara,Y., Togayachi,A.,
            Furuya,A., Shitara,K., Kubota,T., Watanabe,M., Kitajima,M. and
            Narimatsu,H.
  TITLE     Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally
            regulated by homeoproteins
  JOURNAL   J Biol Chem 278 (38), 36611-36620 (2003)
   PUBMED   12855703
  REMARK    GeneRIF: beta3Gal-T5, controlled by the intestinal homeoproteins,
            may play an important role in the specific function of intestinal
            cells by modifying the carbohydrate structure of glycoproteins
REFERENCE   7  (bases 1 to 2761)
  AUTHORS   Ju,T. and Cummings,R.D.
  TITLE     A unique molecular chaperone Cosmc required for activity of the
            mammalian core 1 beta 3-galactosyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16613-16618 (2002)
   PUBMED   12464682
REFERENCE   8  (bases 1 to 2761)
  AUTHORS   Shiraishi,N., Natsume,A., Togayachi,A., Endo,T., Akashima,T.,
            Yamada,Y., Imai,N., Nakagawa,S., Koizumi,S., Sekine,S.,
            Narimatsu,H. and Sasaki,K.
  TITLE     Identification and characterization of three novel beta
            1,3-N-acetylglucosaminyltransferases structurally related to the
            beta 1,3-galactosyltransferase family
  JOURNAL   J Biol Chem 276 (5), 3498-3507 (2001)
   PUBMED   11042166
REFERENCE   9  (bases 1 to 2761)
  AUTHORS   Amado,M., Almeida,R., Schwientek,T. and Clausen,H.
  TITLE     Identification and characterization of large galactosyltransferase
            gene families: galactosyltransferases for all functions
  JOURNAL   Biochim Biophys Acta 1473 (1), 35-53 (1999)
   PUBMED   10580128
  REMARK    Review article
REFERENCE   10 (bases 1 to 2761)
  AUTHORS   Zhou,D., Dinter,A., Gutierrez Gallego,R., Kamerling,J.P.,
            Vliegenthart,J.F., Berger,E.G. and Hennet,T.
  TITLE     A beta-1,3-N-acetylglucosaminyltransferase with
            poly-N-acetyllactosamine synthase activity is structurally related
            to beta-1,3-galactosyltransferases
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 406-411 (1999)
   PUBMED   9892646
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018462.4, BC047933.1,
            BC030579.2 and AB049584.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006577.5.
            
            Summary: This gene encodes a member of the
            beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a
            type II transmembrane protein. It prefers the substrate of
            lacto-N-neotetraose, and is involved in the biosynthesis of
            poly-N-acetyllactosamine chains. Two transcript variants encoding
            the same protein have been found for this gene. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 3 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047933.1, SRR1660809.233184.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301998.5/ ENSP00000305595.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC018462.4         24294-24305         c
            13-1511             BC047933.1         1-1499
            1512-1525           BC030579.2         1369-1382
            1526-1635           BC047933.1         1514-1623
            1636-1809           AB049584.1         1619-1792
            1810-2761           BC047933.1         1797-2748
FEATURES             Location/Qualifiers
     source          1..2761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..2761
                     /gene="B3GNT2"
                     /gene_synonym="3-Gn-T1; 3-Gn-T2; B3GN-T2; B3GNT; B3GNT-2;
                     B3GNT1; beta-1; beta3Gn-T1; beta3Gn-T2; BETA3GNT; BGnT-2;
                     BGNT2"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 2"
                     /db_xref="GeneID:10678"
                     /db_xref="HGNC:HGNC:15629"
                     /db_xref="MIM:605581"
     exon            1..241
                     /gene="B3GNT2"
                     /gene_synonym="3-Gn-T1; 3-Gn-T2; B3GN-T2; B3GNT; B3GNT-2;
                     B3GNT1; beta-1; beta3Gn-T1; beta3Gn-T2; BETA3GNT; BGnT-2;
                     BGNT2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..2761
                     /gene="B3GNT2"
                     /gene_synonym="3-Gn-T1; 3-Gn-T2; B3GN-T2; B3GNT; B3GNT-2;
                     B3GNT1; beta-1; beta3Gn-T1; beta3Gn-T2; BETA3GNT; BGnT-2;
                     BGNT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1444
                     /gene="B3GNT2"
                     /gene_synonym="3-Gn-T1; 3-Gn-T2; B3GN-T2; B3GNT; B3GNT-2;
                     B3GNT1; beta-1; beta3Gn-T1; beta3Gn-T2; BETA3GNT; BGnT-2;
                     BGNT2"
                     /EC_number="2.4.1.149"
                     /note="beta-1,3-N-acetylglucosaminyltransferase bGnT-2;
                     UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 1;
                     beta-1,3-N-acetylglucosaminyltransferase bGnT-1"
                     /codon_start=1
                     /product="N-acetyllactosaminide
                     beta-1,3-N-acetylglucosaminyltransferase 2"
                     /protein_id="NP_006568.2"
                     /db_xref="CCDS:CCDS1870.1"
                     /db_xref="GeneID:10678"
                     /db_xref="HGNC:HGNC:15629"
                     /db_xref="MIM:605581"
                     /translation="MSVGRRRIKLLGILMMANVFIYFIMEVSKSSSQEKNGKGEVIIP
                     KEKFWKISTPPEAYWNREQEKLNRQYNPILSMLTNQTGEAGRLSNISHLNYCEPDLRV
                     TSVVTGFNNLPDRFKDFLLYLRCRNYSLLIDQPDKCAKKPFLLLAIKSLTPHFARRQA
                     IRESWGQESNAGNQTVVRVFLLGQTPPEDNHPDLSDMLKFESEKHQDILMWNYRDTFF
                     NLSLKEVLFLRWVSTSCPDTEFVFKGDDDVFVNTHHILNYLNSLSKTKAKDLFIGDVI
                     HNAGPHRDKKLKYYIPEVVYSGLYPPYAGGGGFLYSGHLALRLYHITDQVHLYPIDDV
                     YTGMCLQKLGLVPEKHKGFRTFDIEEKNKNNICSYVDLMLVHSRKPQEMIDIWSQLQS
                     AHLKC"
     regulatory      2740..2745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GNT2"
                     /gene_synonym="3-Gn-T1; 3-Gn-T2; B3GN-T2; B3GNT; B3GNT-2;
                     B3GNT1; beta-1; beta3Gn-T1; beta3Gn-T2; BETA3GNT; BGnT-2;
                     BGNT2"
                     /note="hexamer: AATAAA"
     polyA_site      2761
                     /gene="B3GNT2"
                     /gene_synonym="3-Gn-T1; 3-Gn-T2; B3GN-T2; B3GNT; B3GNT-2;
                     B3GNT1; beta-1; beta3Gn-T1; beta3Gn-T2; BETA3GNT; BGnT-2;
                     BGNT2"
                     /note="major polyA site"
ORIGIN      
        1 agcctggagt gaggcgcagc ggcagcggca gcagcggcaa caagtgccgg aggctagcag
       61 agccaagccg gagcagtccc tgccgccgac accgccgggc cgcccgtccg gggcgccgcg
      121 catggagcgt gagctgcggc ggtcgccggg ctgagccgcg cggagcggcc gggacgtgga
      181 tgtggccgcg atctcccgcc cttgcccccg ccccgccgag ctggagctgc tcccggacaa
      241 gatatgagaa atgagtgttg gacgtcgaag aataaagttg ttgggtatcc tgatgatggc
      301 aaatgtcttc atttatttta ttatggaagt ctccaaaagc agtagccaag aaaaaaatgg
      361 aaaaggggaa gtaataatac ccaaagagaa gttctggaag atatctaccc ctcccgaggc
      421 atactggaac cgagagcaag agaagctgaa ccggcagtac aaccccatcc tgagcatgct
      481 gaccaaccag acgggggagg cgggcaggct ctccaatata agccatctga actactgcga
      541 acctgacctg agggtcacgt cggtggttac gggttttaac aacttgccgg acagatttaa
      601 agactttctg ctgtatttga gatgccgcaa ttattcactg cttatagatc agccggataa
      661 gtgtgcaaag aaacctttct tgttgctggc gattaagtcc ctcactccac attttgccag
      721 aaggcaagca atccgggaat cctggggcca agaaagcaac gcagggaacc aaacggtggt
      781 gcgagtcttc ctgctgggcc agacaccccc agaggacaac caccccgacc tttcagatat
      841 gctgaaattt gagagtgaga agcaccaaga cattcttatg tggaactaca gagacacttt
      901 cttcaacttg tctctgaagg aagtgctgtt tctcaggtgg gtaagtactt cctgcccaga
      961 cactgagttt gttttcaagg gcgatgacga tgtttttgtg aacacccatc acatcctgaa
     1021 ttacttgaat agtttatcca agaccaaagc caaagatctc ttcataggtg atgtgatcca
     1081 caatgctgga cctcatcggg ataagaagct gaagtactac atcccagaag ttgtttactc
     1141 tggcctctac ccaccctatg cagggggagg ggggttcctc tactccggcc acctggccct
     1201 gaggctgtac catatcactg accaggtcca tctctacccc attgatgacg tttatactgg
     1261 aatgtgcctt cagaaactcg gcctcgttcc agagaaacac aaaggcttca ggacatttga
     1321 tatcgaggag aaaaacaaaa ataacatctg ctcctatgta gatctgatgt tagtacatag
     1381 tagaaaacct caagagatga ttgatatttg gtctcagttg cagagtgctc atttaaaatg
     1441 ctaaaataga tacaaactca attttgcata gaaaggtgta ttttgaatag ttcccatgtt
     1501 gtgttctcac attagagtaa tttctatatt aaaccatgaa aattgccttt atgagtgata
     1561 cccatttgag ggcctctaaa cccttcaatt tggtactcac gtgaagaggg aaagcggaag
     1621 atggtaattt ttttttatgg atgatatggc aggatgattg gttctgatct taccggctag
     1681 tggtcatttt taaaaaactt gtaccctctt atctgaaatc ctgtttctgg aatttggcca
     1741 ttttaagtga ttttgtttgc cctcttctat aatattccta cttcccataa taatgactga
     1801 tttatttgta attcaggtat ttataaacct attggctaca aagactttgt taaacattat
     1861 ccagtggttt tcgtgaaatg gaattatgtt tatttttatg ggatttgggt aaattttaaa
     1921 ttgtctagaa aactgaaatt tcagttgtca gttgtggaat tcagtttttc aattgtggaa
     1981 atttcctgcc accccaacag tatttttgtg tgttaattaa ttttgcaaaa tgagaatcat
     2041 ggtgtgacac tcatctaatt tatcttgttg tgatgttatg gtcataataa ggagaaagag
     2101 ggtttaattt ttcttgtatt tggtttcctg gtggtatcat agtgtaattt tagtatttga
     2161 aaatcagtgt gattccttaa tggccaactg aagattgaat tgccgctaac aaccatatcg
     2221 tgttagtgaa ttttcaatat ggaccaggaa ggcatatgta ttttgaactt gagtgaaaag
     2281 gttgaagtta cagacttttg catagatggt ttgtcaattt aaaattccag aatttattat
     2341 tgccatattt tcacatgctg cttatacaag attattattg agtagtaact gcttccctgt
     2401 ctatgtagaa gtgcctgtgt ttttatttat tgttcagatc aaagaccaaa acattttctt
     2461 aaatatattt tatgtaatat tttatttgta tacagtgttg ttgatgaaat atttaactag
     2521 agcatgatat tttaaatgtt aaggtgtaac atatgttaaa taaaactgtt atttttgaat
     2581 tttaaaattt gttttttggg ggtatgaact actagagttt aaaattctgc caaactatta
     2641 cttatatgta ctattgtgta acatactttc ttgaaatatt tttgtttata gaattgaagg
     2701 ttcttatcag atgggatact ggggactata aacaatggaa ataaagccac tgtattttta
     2761 a
//
