LOCUS       NM_194318               4215 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens beta 3-glucosyltransferase (B3GLCT), mRNA.
ACCESSION   NM_194318 XM_085042
VERSION     NM_194318.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4215)
  AUTHORS   Lauwen,S., Baerenfaenger,M., Ruigrok,S., de Jong,E.K.,
            Wessels,H.J.C.T., den Hollander,A.I. and Lefeber,D.J.
  TITLE     Loss of the AMD-associated B3GLCT gene affects glycosylation of
            TSP1 without impairing secretion in retinal pigment epithelial
            cells
  JOURNAL   Exp Eye Res 213, 108798 (2021)
   PUBMED   34695439
  REMARK    GeneRIF: Loss of the AMD-associated B3GLCT gene affects
            glycosylation of TSP1 without impairing secretion in retinal
            pigment epithelial cells.
REFERENCE   2  (bases 1 to 4215)
  AUTHORS   Zhang,A., Venkat,A., Taujale,R., Mull,J.L., Ito,A., Kannan,N. and
            Haltiwanger,R.S.
  TITLE     Peters plus syndrome mutations affect the function and stability of
            human beta1,3-glucosyltransferase
  JOURNAL   J Biol Chem 297 (1), 100843 (2021)
   PUBMED   34058199
  REMARK    GeneRIF: Peters plus syndrome mutations affect the function and
            stability of human beta1,3-glucosyltransferase.
REFERENCE   3  (bases 1 to 4215)
  AUTHORS   Wang,Y.E., Ramirez,D.A., Chang,T.C. and Berrocal,A.
  TITLE     Peters plus syndrome and Chorioretinal findings associated with
            B3GLCT gene mutation - a case report
  JOURNAL   BMC Ophthalmol 20 (1), 118 (2020)
   PUBMED   32204707
  REMARK    GeneRIF: Peters plus syndrome and Chorioretinal findings associated
            with B3GLCT gene mutation - a case report.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4215)
  AUTHORS   Jaeken,J., Lefeber,D.J. and Matthijs,G.
  TITLE     Clinical utility gene card for: Peters plus syndrome
  JOURNAL   Eur J Hum Genet 24 (8) (2016)
   PUBMED   27049305
  REMARK    GeneRIF: Studies indicate that Peters Plus syndrome is caused by
            mutations in beta 3-glucosyltransferase (B3GALTL).
REFERENCE   5  (bases 1 to 4215)
  AUTHORS   Vasudevan,D., Takeuchi,H., Johar,S.S., Majerus,E. and
            Haltiwanger,R.S.
  TITLE     Peters plus syndrome mutations disrupt a noncanonical ER
            quality-control mechanism
  JOURNAL   Curr Biol 25 (3), 286-295 (2015)
   PUBMED   25544610
  REMARK    GeneRIF: POFUT2 and B3GLCT mediate a noncanonical endoplasmic
            reticulum quality-control mechanism that recognizes folded
            thrombospondin type 1 repeats and stabilizes them by glycosylation.
REFERENCE   6  (bases 1 to 4215)
  AUTHORS   Sato,T., Sato,M., Kiyohara,K., Sogabe,M., Shikanai,T., Kikuchi,N.,
            Togayachi,A., Ishida,H., Ito,H., Kameyama,A., Gotoh,M. and
            Narimatsu,H.
  TITLE     Molecular cloning and characterization of a novel human
            beta1,3-glucosyltransferase, which is localized at the endoplasmic
            reticulum and glucosylates O-linked fucosylglycan on thrombospondin
            type 1 repeat domain
  JOURNAL   Glycobiology 16 (12), 1194-1206 (2006)
   PUBMED   16899492
  REMARK    GeneRIF: We report here the molecular cloning and characterization
            of a novel beta1,3-glucosyltransferase (beta3Glc-T) that
            synthesizes a Glcbeta1,3Fucalpha- structure on the TSR domain.
REFERENCE   7  (bases 1 to 4215)
  AUTHORS   Lesnik Oberstein,S.A., Kriek,M., White,S.J., Kalf,M.E., Szuhai,K.,
            den Dunnen,J.T., Breuning,M.H. and Hennekam,R.C.
  TITLE     Peters Plus syndrome is caused by mutations in B3GALTL, a putative
            glycosyltransferase
  JOURNAL   Am J Hum Genet 79 (3), 562-566 (2006)
   PUBMED   16909395
  REMARK    GeneRIF: Biallelic truncating mutations in the beta
            1,3-galactosyltransferase-like gene (B3GALTL) in all 20 tested
            patients, showed that Peters Plus is a monogenic, primarily
            single-mutation syndrome.
            Erratum:[Am J Hum Genet. 2006 Nov;79(5):985]
REFERENCE   8  (bases 1 to 4215)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   9  (bases 1 to 4215)
  AUTHORS   Heinonen,T.Y., Pasternack,L., Lindfors,K., Breton,C.,
            Gastinel,L.N., Maki,M. and Kainulainen,H.
  TITLE     A novel human glycosyltransferase: primary structure and
            characterization of the gene and transcripts
  JOURNAL   Biochem Biophys Res Commun 309 (1), 166-174 (2003)
   PUBMED   12943678
  REMARK    GeneRIF: B3GTL is transcribed in a wide range of tissues and has
            conserved domains and motifs
REFERENCE   10 (bases 1 to 4215)
  AUTHORS   Lesnik Oberstein,S.A.J., Ruivenkamp,C.A.L. and Hennekam,R.C.
  TITLE     Peters Plus Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301637
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN999521.1, AB101481.1,
            DA290408.1, AY190526.1, AV728071.1 and AA769548.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_194318.3.
            
            Summary: The protein encoded by this gene is a
            beta-1,3-glucosyltransferase that transfers glucose to O-linked
            fucosylglycans on thrombospondin type-1 repeats (TSRs) of several
            proteins. The encoded protein is a type II membrane protein.
            Defects in this gene are a cause of Peters-plus syndrome
            (PPS).[provided by RefSeq, Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.24667.1,
                                           SRR1803612.199776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343307.5/ ENSP00000343002.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               DN999521.1         41-310
            271-457             AB101481.1         161-347
            458-467             DN999521.1         499-508
            468-1217            AB101481.1         358-1107
            1218-1279           DA290408.1         515-576
            1280-1607           AB101481.1         1170-1497
            1608-2495           AY190526.1         1498-2385
            2496-3459           AY190526.1         2387-3350
            3460-4071           AV728071.1         87-698
            4072-4215           AA769548.1         7-150               c
FEATURES             Location/Qualifiers
     source          1..4215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     gene            1..4215
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /note="beta 3-glucosyltransferase"
                     /db_xref="GeneID:145173"
                     /db_xref="HGNC:HGNC:20207"
                     /db_xref="MIM:610308"
     exon            1..180
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1607
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /EC_number="2.4.1.122"
                     /note="beta 3-glycosyltransferase-like;
                     beta-1,3-glucosyltransferase; UDP-GAL:beta-GlcNAc
                     beta-1,3-galactosyltransferase-like; beta
                     1,3-galactosyltransferase-like"
                     /codon_start=1
                     /product="beta-1,3-glucosyltransferase precursor"
                     /protein_id="NP_919299.3"
                     /db_xref="CCDS:CCDS9341.1"
                     /db_xref="GeneID:145173"
                     /db_xref="HGNC:HGNC:20207"
                     /db_xref="MIM:610308"
                     /translation="MRPPACWWLLAPPALLALLTCSLAFGLASEDTKKEVKQSQDLEK
                     SGISRKNDIDLKGIVFVIQSQSNSFHAKRAEQLKKSILKQAADLTQELPSVLLLHQLA
                     KQEGAWTILPLLPHFSVTYSRNSSWIFFCEEETRIQIPKLLETLRRYDPSKEWFLGKA
                     LHDEEATIIHHYAFSENPTVFKYPDFAAGWALSIPLVNKLTKRLKSESLKSDFTIDLK
                     HEIALYIWDKGGGPPLTPVPEFCTNDVDFYCATTFHSFLPLCRKPVKKKDIFVAVKTC
                     KKFHGDRIPIVKQTWESQASLIEYYSDYTENSIPTVDLGIPNTDRGHCGKTFAILERF
                     LNRSQDKTAWLVIVDDDTLISISRLQHLLSCYDSGEPVFLGERYGYGLGTGGYSYITG
                     GGGMVFSREAVRRLLASKCRCYSNDAPDDMVLGMCFSGLGIPVTHSPLFHQARPVDYP
                     KDYLSHQVPISFHKHWNIDPVKVYFTWLAPSDEDKARQETQKGFREEL"
     exon            181..230
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            231..270
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            271..380
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            381..457
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            458..569
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            570..706
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            707..770
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            771..890
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            891..960
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1074
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1174
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1294
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1439
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..4215
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2784..2789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /note="hexamer: AATAAA"
     polyA_site      2805
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /note="major polyA site"
     regulatory      3442..3447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /note="hexamer: AGTAAA"
     polyA_site      3461
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /note="major polyA site"
     regulatory      4189..4194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /note="hexamer: AATAAA"
     polyA_site      4215
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /note="major polyA site"
ORIGIN      
        1 agagaagggt cagccgcggc ggcagggcgg cggcggcagc ggcgcagctc cgctccccgc
       61 gcgtctccct tccccgcgcc caggtagggc gctcagcctc cgccgccagg atgcggccgc
      121 ccgcctgctg gtggctgctc gcgccgccgg cgctgctcgc gctcctcacc tgctccctgg
      181 cttttggttt ggcttctgaa gatacaaaga aagaggtcaa gcagtctcag gatttggaga
      241 aaagtggtat atcaaggaaa aatgacatag acttaaaagg aattgtattc gtcatccaga
      301 gtcaaagtaa ttcttttcat gcaaagagag cagagcagtt aaaaaaaagc atcttaaagc
      361 aggctgcaga tcttacacag gagctcccca gtgtcctcct ccttcatcag ctggctaaac
      421 aagaaggtgc atggaccata cttccgttgt taccgcattt ttctgtaaca tatagcagaa
      481 attcatcttg gattttcttc tgtgaagaag agacaagaat acagattcca aaactcttgg
      541 aaaccctcag aagatatgac ccctctaagg aatggttttt gggaaaagca ttacatgatg
      601 aagaagctac aataattcac cattatgcct tttccgagaa tcctacagtt tttaagtatc
      661 cagactttgc tgcaggctgg gccttaagta ttccacttgt aaacaagctt accaagagac
      721 taaagagtga atccttgaaa tccgacttta caatagattt aaaacatgag attgccctct
      781 acatctggga caaaggcgga ggacctcccc tgaccccagt gcctgagttt tgtaccaatg
      841 acgtggactt ctactgtgct accacattcc attcttttct accgctttgt agaaagccag
      901 tgaagaagaa ggatattttt gttgcagtaa aaacatgcaa gaaatttcat ggtgacagaa
      961 tacctattgt taagcagact tgggagagcc aggcaagtct cattgaatac tatagtgact
     1021 atactgaaaa ttccattcct actgtggatt tgggaattcc taatacagat agaggtcatt
     1081 gtggaaagac atttgccatt ttggaaagat ttctgaatcg tagccaggac aaaacagcat
     1141 ggttagtcat tgtggatgat gatacattaa taagtatctc caggctccag cacttgctta
     1201 gctgttatga ctccggcgag cctgtgtttc tgggagagcg ctacggctac ggcctgggca
     1261 ctggtggcta cagctacatc acgggaggag gaggaatggt cttcagcaga gaagccgtca
     1321 ggagacttct cgccagtaaa tgtcgatgct acagcaatga tgctcccgat gatatggtcc
     1381 tgggaatgtg ctttagtggc ttgggaatcc ctgtgacaca cagccctctc ttccatcagg
     1441 ctcggccggt ggattaccct aaggactacc tttctcatca agttcccata tcgttccaca
     1501 aacactggaa catcgatcca gtgaaggtgt atttcacatg gttggcaccc agtgacgaag
     1561 acaaagccag gcaggagaca cagaaaggtt ttcgagagga gttataaatc agggtgacct
     1621 gtgcgcctag cctgcgcagg gaatgaactg gagactgtgg cctcatccca ctgtgctgtg
     1681 ctcacaacac ttgtgtctgc cacatggcat tgggtgcttc ctgactttag ggggagattt
     1741 tatgtatggt attttttgac agaggaagaa aaggggtcac aggagaaaca tttttttttc
     1801 tgggaaaaat cacttgcttt tgacttatgc agttgtttta acacttagtg atgactgtgt
     1861 attctccaag ctgtgataca gcagtttttt tttattgtca cagggaaata aatggtacca
     1921 gaagtccctt tcctgttctg tctcttcatt gtaatggaag tttcagttgg gcatgagcct
     1981 ggagagatgt gactgtctac agttctattt gtatatataa aaagaagact gaaagtcttt
     2041 tgacatggat attgtgaatg gtatgaactt ttaaaccata ttattgatga tgaaaattat
     2101 ttcctgggaa ctcagtagga ataataccgt attaaggaat aatactgtac ataaaacatc
     2161 atgaaaccct agatatgaaa tcccctgaag tctgtaatca tggtggttat gttttgtcta
     2221 ttcttttgct gtttgtgcct cataaaaaga gaatgaggtc ttctgctaga gcttcgtatt
     2281 gctttggaag ttcatctgtg ttttatttct ccctgaagcc ctatctttat ggcttacttg
     2341 taacatgaaa gtagtagatg ctgccagaaa atagtgtcct caatatttta aaacaatgtt
     2401 gacatgtttt gttcaagtca gcaagctcta tgtgagtctc aggaagtgaa ttaaatttgg
     2461 accttatgtt ttactcttgt tttttttttt tttttaaatg ttacttaatg actctctcct
     2521 gactcaggag agaaacccct tgtggaagga cagcatggtg atcaggcaat ttctctgggt
     2581 tcccaaagaa tgacatttga acacagtatt ttgaaacagc tctagttttc aaattatatc
     2641 tttaatatat agtaatgtaa catattcagt attaatgtat aaaaagcact ctaattatat
     2701 aattcagttt ttgtaaaggt atttgcataa aatttaatat gtcttaaact aattttggta
     2761 aattacttct tttttttctt tttaataaaa actgttactc attaactttg cttataatgc
     2821 tttttatagc ccagcacaga atttaaagcc ataccaccaa aagtacctgt gtgtgttaat
     2881 atgtttttct tgtagcatag attgactatt tgcaatagta ttagtattta ccatttttcc
     2941 aaattagcaa ctaccagacc tcacgtgttg cagtgataac acaatgcatt ggattcagtt
     3001 ttgtgaaaat ggattctgtg gccatccaag ggatgtatca gggatgatca gctgatgaga
     3061 ggctccagaa ggatttctag atcgcttcaa gcctatactg atggccttag ctttgttcag
     3121 tcattgtaac tgggattgtt gtcattgcta ccgtggtagt caccttcatg tcatctataa
     3181 tagtactcct ggagagccct ggctgcctac accagtggaa aagagtctcc agttctgctc
     3241 tggcctacta actgttacca ctgagagaac aacatgttca tttgacatga ttgaagctgg
     3301 catccgtata tgaagatcct tgtcaagctt tcttctgtgg tctgattagt gccttctact
     3361 gataccgggg cacctcctct ggtactttta agtgttttgt taattatatt tactttttgg
     3421 aatggtgtaa gcctaaccac aagtaaaaga tctttgccta agtttttgat ttctcaaata
     3481 ttgtgttcat tagtctagac tgggaatggg gaggggaaat ggggaaaatg aatgaatgaa
     3541 atcagaaaaa agtcagcggc tcagtaaata cagtttaaag agagaataat tacttcagag
     3601 ctaccctttt aagagaaaac catcagaaat tgataatgtt tatataaagt ttataaagcc
     3661 attgtgtttt gttatataac aaatcagaga tgttatttta gaatcgattc ccatctaaag
     3721 aactcaattt tgagtctgac atttccagga ccagatattg tcttactcac atttcctttg
     3781 ctttgaaata gggctttcct tccaaatggc tatttttagg ctagggatgt taacatcagg
     3841 gatttgtgtg tggaataact ggaatgtcat ttttgctttt aagccatttc tgatgatata
     3901 gccaaagcag gttgtctgac tatgtaggat ttttacatct tgaaactaaa tcagaaatcc
     3961 agacatgaaa ataacctttc tagaatgcct aggagcagaa aacaataata gcatgctaaa
     4021 tcacaaatga tgctatgtat gggtatgtaa atatcagtgc tgtctgcatt tctgggttta
     4081 ttgaagacct cttgttgtat atatcctcaa aaattaatgt aattgacatc ttcaagaatg
     4141 tttctattgt cttccattca taatcagaga tgtaatttgt atggactaaa taaaaacttt
     4201 attatgtaat gaaaa
//
