LOCUS       NM_080742               6587 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens beta-1,3-glucuronyltransferase 2 (B3GAT2), mRNA.
ACCESSION   NM_080742
VERSION     NM_080742.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6587)
  AUTHORS   Ruhle,F., Witten,A., Barysenka,A., Huge,A., Arning,A., Heller,C.,
            Krumpel,A., Mesters,R., Franke,A., Lieb,W., Riemenschneider,M.,
            Hiersche,M., Limperger,V., Nowak-Gottl,U. and Stoll,M.
  TITLE     Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to
            pediatric venous thromboembolism
  JOURNAL   Blood 129 (6), 783-790 (2017)
   PUBMED   28011674
  REMARK    GeneRIF: The study identified a region on chromosome 6 comprising
            the genes SMAP1, B3GAT2, and RIMS1 as novel susceptibility locus
            for pediatric venous thromboembolism.
REFERENCE   2  (bases 1 to 6587)
  AUTHORS   Yu,M., O'Leary,R.M., Kaz,A.M., Morris,S.M., Carter,K.T., Chak,A.,
            Chandar,A., Willis,J.E., Moinova,H.R., Markowitz,S.D.,
            Brenner,D.E., Anandabapasathy,S., Westerhoff,M., Wong,C.J.,
            Shaheen,N.J., Chen,Y., Barnholtz-Sloan,J.S. and Grady,W.M.
  TITLE     Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for
            Barrett's Esophagus
  JOURNAL   Cancer Epidemiol Biomarkers Prev 24 (12), 1890-1897 (2015)
   PUBMED   26545406
  REMARK    GeneRIF: B3GAT2 and ZNF793 are hypermethylated in BE, and the
            methylation status of these genes can be used to detect BE in
            tissue samples.
REFERENCE   3  (bases 1 to 6587)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 6587)
  AUTHORS   Bhatnagar,P., Purvis,S., Barron-Casella,E., DeBaun,M.R.,
            Casella,J.F., Arking,D.E. and Keefer,J.R.
  TITLE     Genome-wide association study identifies genetic variants
            influencing F-cell levels in sickle-cell patients
  JOURNAL   J Hum Genet 56 (4), 316-323 (2011)
   PUBMED   21326311
REFERENCE   5  (bases 1 to 6587)
  AUTHORS   Kahler,A.K., Djurovic,S., Rimol,L.M., Brown,A.A., Athanasiu,L.,
            Jonsson,E.G., Hansen,T., Gustafsson,O., Hall,H., Giegling,I.,
            Muglia,P., Cichon,S., Rietschel,M., Pietilainen,O.P., Peltonen,L.,
            Bramon,E., Collier,D., St Clair,D., Sigurdsson,E., Petursson,H.,
            Rujescu,D., Melle,I., Werge,T., Steen,V.M., Dale,A.M.,
            Matthews,R.T., Agartz,I. and Andreassen,O.A.
  TITLE     Candidate gene analysis of the human natural killer-1 carbohydrate
            pathway and perineuronal nets in schizophrenia: B3GAT2 is
            associated with disease risk and cortical surface area
  JOURNAL   Biol Psychiatry 69 (1), 90-96 (2011)
   PUBMED   20950796
  REMARK    GeneRIF: results suggest that effects on biosynthesis of the
            neuronal epitope HNK-1, through common B3GAT2 variation, could
            increase the risk of SCZ, possibly by decreasing cortical area.
            GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   6  (bases 1 to 6587)
  AUTHORS   Shiba,T., Kakuda,S., Ishiguro,M., Morita,I., Oka,S., Kawasaki,T.,
            Wakatsuki,S. and Kato,R.
  TITLE     Crystal structure of GlcAT-S, a human glucuronyltransferase,
            involved in the biosynthesis of the HNK-1 carbohydrate epitope
  JOURNAL   Proteins 65 (2), 499-508 (2006)
   PUBMED   16897771
  REMARK    GeneRIF: Residues interacting with UDP molecule, which is a part of
            the donor substrate, are highly conserved between GlcAT-P and
            GlcAT-S
REFERENCE   7  (bases 1 to 6587)
  AUTHORS   Kakuda,S., Sato,Y., Tonoyama,Y., Oka,S. and Kawasaki,T.
  TITLE     Different acceptor specificities of two glucuronyltransferases
            involved in the biosynthesis of HNK-1 carbohydrate
  JOURNAL   Glycobiology 15 (2), 203-210 (2005)
   PUBMED   15470230
REFERENCE   8  (bases 1 to 6587)
  AUTHORS   Kakuda,S., Oka,S. and Kawasaki,T.
  TITLE     Purification and characterization of two recombinant human
            glucuronyltransferases involved in the biosynthesis of HNK-1
            carbohydrate in Escherichia coli
  JOURNAL   Protein Expr Purif 35 (1), 111-119 (2004)
   PUBMED   15039073
REFERENCE   9  (bases 1 to 6587)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 6587)
  AUTHORS   Marcos,I., Galan,J.J., Borrego,S. and Antinolo,G.
  TITLE     Cloning, characterization, and chromosome mapping of the human
            GlcAT-S gene
  JOURNAL   J Hum Genet 47 (12), 677-680 (2002)
   PUBMED   12522689
  REMARK    GeneRIF: human GlcAT-S gene-located on human chromosome 6 encodes a
            protein involved in biosynthesis of HNK-1 carbohydrate epitope on
            glycoproteins.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA782678.1, AB075843.1 and
            AL121961.8.
            
            On May 17, 2019 this sequence version replaced NM_080742.2.
            
            Summary: The product of this gene is a transmembrane protein
            belonging to the glucuronyltransferase family, and catalyzes the
            transfer of a beta-1,3 linked glucuronic acid to a terminal
            galactose in different glycoproteins or glycolipids containing a
            Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded
            protein is involved in the synthesis of the human natural killer-1
            (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated
            in cellular migration and adhesion in the nervous system. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB075843.1, SRR1803615.173590.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230053.11/ ENSP00000230053.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DA782678.1         26-47
            23-1900             AB075843.1         1-1878
            1901-6587           AL121961.8         23004-27690         c
FEATURES             Location/Qualifiers
     source          1..6587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q13"
     gene            1..6587
                     /gene="B3GAT2"
                     /gene_synonym="GLCATS"
                     /note="beta-1,3-glucuronyltransferase 2"
                     /db_xref="GeneID:135152"
                     /db_xref="HGNC:HGNC:922"
                     /db_xref="MIM:607497"
     exon            1..1222
                     /gene="B3GAT2"
                     /gene_synonym="GLCATS"
                     /inference="alignment:Splign:2.1.0"
     CDS             632..1603
                     /gene="B3GAT2"
                     /gene_synonym="GLCATS"
                     /EC_number="2.4.1.135"
                     /note="uridine diphosphate glucuronic acid:acceptor
                     glucuronosyltransferase;
                     galactosylgalactosylxylosylprotein
                     3-beta-glucuronosyltransferase 2;
                     UDP-glucuronyltransferase S; glcAT-D;
                     glucuronosyltransferase S; UDP-glucuronosyltransferase S"
                     /codon_start=1
                     /product="galactosylgalactosylxylosylprotein
                     3-beta-glucuronosyltransferase 2 precursor"
                     /protein_id="NP_542780.1"
                     /db_xref="CCDS:CCDS4974.1"
                     /db_xref="GeneID:135152"
                     /db_xref="HGNC:HGNC:922"
                     /db_xref="MIM:607497"
                     /translation="MKSALFTRFFILLPWILIVIIMLDVDTRRPVPPLTPRPYFSPYA
                     VGRGGARLPLRRGGPAHGTQKRNQSRPQPQPEPQLPTIYAITPTYSRPVQKAELTRLA
                     NTFRQVAQLHWILVEDAAARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQR
                     NAGLAWLRQRHQHQRAQPGVLFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYE
                     RPLVENGKVVGWYTGWRADRPFAIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDF
                     LKQITTVEELEPKANNCTKVLVWHTRTEKVNLANEPKYHLDTVKIEV"
     exon            1223..1367
                     /gene="B3GAT2"
                     /gene_synonym="GLCATS"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1516
                     /gene="B3GAT2"
                     /gene_synonym="GLCATS"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..6587
                     /gene="B3GAT2"
                     /gene_synonym="GLCATS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6033..6038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GAT2"
                     /gene_synonym="GLCATS"
                     /note="hexamer: AATAAA"
     polyA_site      6053
                     /gene="B3GAT2"
                     /gene_synonym="GLCATS"
                     /note="major polyA site"
     regulatory      6480..6485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GAT2"
                     /gene_synonym="GLCATS"
                     /note="hexamer: AATAAA"
     polyA_site      6501
                     /gene="B3GAT2"
                     /gene_synonym="GLCATS"
ORIGIN      
        1 gctgctggat ccggagaggt tctgagaaga caagagcaag ggactgagag caggcttccg
       61 ctgcggcgcg cgaacacagc cgggacacaa cccccagcgt ctccacccgc tcctcgccac
      121 cccggcggga atgtgaggaa ggaaagcccc cagcgccgcc gcccgccctc gaaggcgtcc
      181 cagagagcgt cctgggggcc cgcggctgga gcccttgtgc ccgcagcacc gccggactgg
      241 agcggcgagg cgcaccgggt gccgcttctc ggcttccact cttcagaaag agcgcggtgg
      301 ggatcagcgc ctttcccgca ctcggcacaa ctccgggacc ggcggcgcgc ggctggaccg
      361 agtcccgctt cccgccagct cacctggagt cgggggcagc ccctgcccgc ccgcctgcac
      421 cccttgtcgc tctagcttgc gcgaacctgc cgctcctcca cgcccaggta gtgagccccg
      481 cggctccagg tctctgcagc gccctcggcc ccatggacag cgcacccatc accactccct
      541 aagtgctggc gccgccgctg tccaagctgc gcactggggt ccctcggctc gcccctctct
      601 ggggtgtccg agaggccagg gagcgtgcac catgaagtcc gcgcttttca cccgcttctt
      661 tatcctcctg ccctggatcc taattgtcat catcatgctc gacgtggaca cgcgcaggcc
      721 agtgcccccg ctcaccccgc gcccctactt ctctccctac gcggtgggcc gcgggggcgc
      781 ccgactcccg ctccgcaggg gcggcccggc tcacgggacc caaaagcgca accagtctcg
      841 gccgcagcca cagccggagc cgcagctgcc caccatctat gccatcacgc ccacctacag
      901 ccgcccggtg cagaaagcgg agctgacccg cctggccaac acgttccgcc aggtggcgca
      961 gctgcactgg atcctggtgg aggacgcggc ggcgcgcagc gagctggtga gccgcttcct
     1021 ggcgcgggcc gggctgccca gcactcacct gcacgtgccc acgccgcggc gctacaagcg
     1081 gcccgggctg ccgcgcgcca ctgagcagcg caacgcgggc ctcgcctggc tgcgccagag
     1141 gcaccagcac cagcgcgcgc agcccggcgt gctcttcttc gctgacgacg acaacaccta
     1201 tagtctggag ctcttccagg agatgcgaac cacccgcaag gtctccgtct ggcctgtggg
     1261 cctggttggt gggcggcgct acgaacgtcc gctggtggaa aacggcaaag ttgttggctg
     1321 gtacaccggc tggagagcag acaggccttt tgccatcgac atggcaggat ttgctgtaag
     1381 tcttcaagtc attttgtcca atccaaaagc tgtatttaag cgtcgtggat cccagccagg
     1441 gatgcaagaa tctgactttc tcaaacagat aacaacagtc gaagaactgg aaccgaaagc
     1501 aaataactgc actaaggttc tcgtgtggca cactcggaca gagaaggtta atctagccaa
     1561 cgagccaaag taccacctgg acacagtgaa aattgaggta taaattgaag cagcaactgg
     1621 tgcagtttgt ccagccagtg gatccatatg gaagaggatg tttggagttt aggctacaga
     1681 gcattcaggt attgtttgtt ttacttcagt acagcagcct ttcttgtcat ctgatggaca
     1741 tctgtttaaa tggagcttgt cagttaacat aagctaattg gatggttggt acaaaatgta
     1801 tgttttgtct tcatttgttc tgcatgtttt ctctacaaca actaaattgg aagatttttt
     1861 tgtacagtgc cgatactgca agataccact cttgagtata tattttttct ttttctccaa
     1921 tttgccctta taattggtag acttgaacag gttggtagac ttgaacaggt ttttaaaaca
     1981 gacaagtatt ttgtcagcta aacgttcctg atgattcctg actttgcaat actaagtaat
     2041 ttttggaagg ttagtggcag tatacatcat aggaaataaa aacccacaaa tgaaaaggtc
     2101 tatggagtca tgtttaatgt agggaaataa cattttgtca atactaggca ccataaaatg
     2161 taaacacaat tactgtcata aacctagata taccttcaag gattgaagat tgaaagtggc
     2221 tttgttttag ttagttaccc tgtttgcata tagtgcagaa aaaggtcttc atgttagcac
     2281 tatgtacatt aagaagagat ccaaattaca agagaggcag ataaaatttg aattctttaa
     2341 gcattcatta aacgaagttt tggagtaaca tccacgttta tcttcctttc actaatcacg
     2401 ttccctgtta agcacatcat aacaacagca cagtgaagtg aatgatgaaa taagagcatt
     2461 ttgatacact agaaaacagt gctcagtgag acatttacat tctatttata tgattaaaca
     2521 tttgatcata cagtaccttc ctacaggatt actggctaat tttggggtgg ggtttatact
     2581 attagaggta ttactaacat gataactact tcccttatat gcaaacatta gagctataat
     2641 tttattgaga ggaaaactga ttttgcaagt tgagcagctt ctcaaataat gcagtacatg
     2701 aaatcatggg aaatatgagc aaagctgccc ttgacataaa atgatttatc aacctgcttt
     2761 tcaccacatc aaattgaatc agtacagacc aacacggtca atcagatcat tcttaatatg
     2821 aacaaatggg taaaaagaaa aaaaatatgc atatgaataa acaggggaac tagatgcgtt
     2881 tcagcaagga atgtcaggtg gtagttctgg atgaaacttg tattgcagtt ttcatttcca
     2941 cagttgtgtg ctgagagtct gacctgatga gcttccagac catcctgctg ttgtgctgga
     3001 gggctggcca aaacctgcag taggggttgc actactgata ctcatgccag ccatctgctg
     3061 attcatctgt gaaacatata aaaggcttag ttcaagaggc ttacttcact tttaattctt
     3121 gtttctttag ccacacagtt ggtcattttt tcattaatgt gacaactagt ccaagcactg
     3181 gaataaaaac agagtaccat acaaatattt cttaaagcaa atagctactt tgttcccttc
     3241 tttatctact ttctagatac agtttcccca aagattaacc acaacttact taaaaaaaaa
     3301 taccaaagca atcttgggat tttaatgagt ccgctactct aactaacttt cacctacact
     3361 aggatattgt gctttaacta ctaaggagta agaaaatttt aggaagtaaa atagtctaaa
     3421 attatcctat aaactttgta tgatagatat tattctctat taaaatctta tatacttcct
     3481 aaatattttt aaagtggtca taaagcattt atttctctcg ctgatctaac aacataaaca
     3541 tctaaaattt attttcattg tatgcaataa agcataagat tacatgtatt tttcttcaag
     3601 actggagtca aatatatata tatataagca tcttaaccct gtgattctct tacttccaaa
     3661 attggtgata agagaaggaa aggcaagatt taccatatag tgagtgggtt taaaacttac
     3721 actcagagtt agactgtgtt cttaatttaa tacatttgac ttgacttatt tacagtttca
     3781 aagacactaa cataaactac atcactaatc aggcataagt gtctgaagaa gcagatcacg
     3841 tcttcatacc tactaaagga cattttaacc accttgtcat tggccagtag attgcactga
     3901 tggagtgctg gagaacagca tcacccttct gcattatctg gaagtaagag ccagtattaa
     3961 ctccttcctg gttcatctag caccttaacc tgagctgggt gtgcttcagc atgttgacca
     4021 tgtgactgac acttagcaca tacaattttt tagattccca gcgggtagag accaatgttt
     4081 tacctatatt cttgtaaatg gtggtagcaa aattaactgt gatatatagt gattgtgcta
     4141 atgttagaaa tcactctaga ctattccctg aatgctctaa aggtaaaaca agtgaccaaa
     4201 cagaaaccaa gattgccaaa atgctggagg aacatcaatg ggaagtgtaa aaggaagaag
     4261 agtgggagca tgaacctctc taagagcctt tgtctgtgca gctagagaaa agtcagaaca
     4321 cagcacctga aatagaaatg ttctatctca gctctaactt aggtagaaat aggattttat
     4381 aatatgaggg gatgtctggt tcacacctta tgggaattga atctttttgt actcttttta
     4441 aacataaaag tcattatagg gtatgtaaaa agaaaataca actttacaaa ggtttctcaa
     4501 caaaaagaat ttttacagag ccatggggca gtaatcatcc gacctgaaaa atagccttag
     4561 atccctcata aaatagtgct ttgagaatat gaggctagat ttttattttc taataaaaga
     4621 tcctaaaatt attagtgaag ctaagttgtc taagtggact gtaaaaatgt cccaccagca
     4681 agctggataa agcttagtgc taatctcaga ggtgacagag agggagtctc atgatgcctg
     4741 agataatttc tggccattag tggtgttcac gttacagtta cattacaatt tgaaatgaaa
     4801 gatgtttaac ctttttttta cagaatactc taaaatagcg ataataacac atcatttgtc
     4861 tatctgatac aacttcataa tatttataga tacttttgac cctataacat attatcccta
     4921 ttgaattctt tctgccagat cactagactt aaaaaaaaaa aaaaaaaaaa aaaaaaaaga
     4981 tttagaaaat aaatctggtt tgatttggga gaagctagaa agtaaatgac ccctacctgt
     5041 gagaggctcc actggggctg ctgagcttgc ggcaggccaa acttactctg gggtgcaccc
     5101 atttgtccca ccattcctcc ttgggggcca acaacgttct gaggaagtgg catcacacca
     5161 gtttgtgcat ttcccataaa cccattgggc atgggcatgc ccaccatcat gcttggactc
     5221 tgtcccatca catttcctat aaggccagga gctgcaggca caggcacgcc catcgatgga
     5281 aagccctgaa atgcagctgg tgcttgtgag gtaaatggta tatttgtggg tcccataaat
     5341 acacctgcac cacaaaaaga aaatgaatga agacagagct atcacgtgta gttgcactca
     5401 tctctataat cacagaaaaa ttgcctttct gaactactca cagcaaacat tttaattcca
     5461 gtttggctgc tcctactact cagaccaacc cacacctaaa ccctgagagc tggttgtttc
     5521 taggatgcag acaaatcagt tattaacctg agtaaattta attaagaaat gtaaatcata
     5581 tgcaacagcc acacaaaata tcttccactg tgaagaccaa actatgtagc atgacatcat
     5641 acactgtttt attgctgatt tgtaccactg gtcccccagt acgaaacagg gaagtgagag
     5701 ctgactatat ctcgcttcaa taggtgtagt gggctgccca acaattttag ctcacatgtg
     5761 aaatgcagct cattatttta aaggaaatgg tgtgaaagat taaaactctg taaacaataa
     5821 ggcttatgct aatattttgt tatgattaca aaaaaattca tagatttttt ttaatccatg
     5881 tggtaactca agactgttta cctgcagaga aaatacactg tacgcagtca taaacttcat
     5941 gcaaatcgtt tcaataattc atcaaagata atccatgttc tataagcttg tgaaacaaca
     6001 tttagtgatc tatgaacagc ttgttaattc caaataaagt tctgtgaatc ctgtacatgc
     6061 ctcttaattt tttaattcta atgctcattc atttcggctt catagttgta taaactgcaa
     6121 caacaaaagc actcactaca tggaacaata aaagatatat aattgatctt attatataat
     6181 tacaaaggat gtacttctag taatgtcact gaaagcagat atcaaaattc attaccagga
     6241 gtactttgct gttgaatggt tcctgtgcca tacagagata agatggagtc tttggaaagt
     6301 tgtttctttg ccacttcttc tgattttgta gtttgctcag tgaataaatc tagatcccca
     6361 gatgttactg tagacagggt tgcagctgct ggtgcagagg gtgtcccctg agacaaacac
     6421 caaaataagc tatcaaattc tgcatagtaa agcgcagctt atccattact taaaatccaa
     6481 ataaagttat aaaattagat aggaatcaaa caattgtaga aggtaaaatg gtgccattca
     6541 agaggatcac ttacaagccc aagcccatat aaaaacatct acaatca
//
