LOCUS       NM_001356336           13097 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens beta-1,3-galactosyltransferase 5 (B3GALT5), transcript
            variant 7, mRNA.
ACCESSION   NM_001356336 XM_017028235
VERSION     NM_001356336.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13097)
  AUTHORS   Feng,W., Tang,Y., Jing,R., Ju,S. and Zong,W.
  TITLE     Highly expressed B3GALT5-AS1 contributes to gastric cancer
            progression by recruiting WDR5 to mediate B3GALT5 and regulating
            beta-catenin/ZEB1 axis
  JOURNAL   J Cell Mol Med 28 (17), e70061 (2024)
   PUBMED   39224045
  REMARK    GeneRIF: Highly expressed B3GALT5-AS1 contributes to gastric cancer
            progression by recruiting WDR5 to mediate B3GALT5 and regulating
            beta-catenin/ZEB1 axis.
REFERENCE   2  (bases 1 to 13097)
  AUTHORS   Tsuchida,A., Hachisu,K., Mizuno,M., Takada,Y. and Ideo,H.
  TITLE     High expression of B3GALT5 suppresses the galectin-4-mediated
            peritoneal dissemination of poorly differentiated gastric cancer
            cells
  JOURNAL   Glycobiology 34 (10) (2024)
   PUBMED   39163480
  REMARK    GeneRIF: High expression of B3GALT5 suppresses the
            galectin-4-mediated peritoneal dissemination of poorly
            differentiated gastric cancer cells.
REFERENCE   3  (bases 1 to 13097)
  AUTHORS   Zhang,X., Liu,H., Wang,H., Zhao,R., Lu,Q., Liu,Y., Han,Y., LuluRen,
            Pan,H. and Han,W.
  TITLE     B3galt5 deficiency attenuates hepatocellular carcinoma by
            suppressing mTOR/p70s6k-mediated glycolysis
  JOURNAL   Cell Mol Life Sci 80 (1), 8 (2022)
   PUBMED   36495345
  REMARK    GeneRIF: B3galt5 deficiency attenuates hepatocellular carcinoma by
            suppressing mTOR/p70s6k-mediated glycolysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13097)
  AUTHORS   Mare,L. and Trinchera,M.
  TITLE     Comparative analysis of retroviral and native promoters driving
            expression of beta1,3-galactosyltransferase beta3Gal-T5 in human
            and mouse tissues
  JOURNAL   J Biol Chem 282 (1), 49-57 (2007)
   PUBMED   17107959
REFERENCE   5  (bases 1 to 13097)
  AUTHORS   Dunn,C.A., Medstrand,P. and Mager,D.L.
  TITLE     An endogenous retroviral long terminal repeat is the dominant
            promoter for human beta1,3-galactosyltransferase 5 in the colon
  JOURNAL   Proc Natl Acad Sci U S A 100 (22), 12841-12846 (2003)
   PUBMED   14534330
REFERENCE   6  (bases 1 to 13097)
  AUTHORS   Isshiki,S., Kudo,T., Nishihara,S., Ikehara,Y., Togayachi,A.,
            Furuya,A., Shitara,K., Kubota,T., Watanabe,M., Kitajima,M. and
            Narimatsu,H.
  TITLE     Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally
            regulated by homeoproteins
  JOURNAL   J Biol Chem 278 (38), 36611-36620 (2003)
   PUBMED   12855703
REFERENCE   7  (bases 1 to 13097)
  AUTHORS   Salvini,R., Bardoni,A., Valli,M. and Trinchera,M.
  TITLE     beta 1,3-Galactosyltransferase beta 3Gal-T5 acts on the GlcNAcbeta
            1-->3Galbeta 1-->4GlcNAcbeta 1-->R sugar chains of carcinoembryonic
            antigen and other N-linked glycoproteins and is down-regulated in
            colon adenocarcinomas
  JOURNAL   J Biol Chem 276 (5), 3564-3573 (2001)
   PUBMED   11058588
REFERENCE   8  (bases 1 to 13097)
  AUTHORS   Amado,M., Almeida,R., Schwientek,T. and Clausen,H.
  TITLE     Identification and characterization of large galactosyltransferase
            gene families: galactosyltransferases for all functions
  JOURNAL   Biochim Biophys Acta 1473 (1), 35-53 (1999)
   PUBMED   10580128
  REMARK    Review article
REFERENCE   9  (bases 1 to 13097)
  AUTHORS   Zhou,D., Berger,E.G. and Hennet,T.
  TITLE     Molecular cloning of a human UDP-galactose:GlcNAcbeta1,3GalNAc
            beta1, 3 galactosyltransferase gene encoding an O-linked
            core3-elongation enzyme
  JOURNAL   Eur J Biochem 263 (2), 571-576 (1999)
   PUBMED   10406968
REFERENCE   10 (bases 1 to 13097)
  AUTHORS   Isshiki,S., Togayachi,A., Kudo,T., Nishihara,S., Watanabe,M.,
            Kubota,T., Kitajima,M., Shiraishi,N., Sasaki,K., Andoh,T. and
            Narimatsu,H.
  TITLE     Cloning, expression, and characterization of a novel
            UDP-galactose:beta-N-acetylglucosamine
            beta1,3-galactosyltransferase (beta3Gal-T5) responsible for
            synthesis of type 1 chain in colorectal and pancreatic epithelia
            and tumor cells derived therefrom
  JOURNAL   J Biol Chem 274 (18), 12499-12507 (1999)
   PUBMED   10212226
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292951.1, DQ645732.1,
            AB020337.1, AW136254.1, AF064860.2 and KF457302.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001356336.1.
            
            Summary: This gene encodes a member of a family of membrane-bound
            glycoproteins. The encoded protein may synthesize type 1 Lewis
            antigens, which are elevated in gastrointestinal and pancreatic
            cancers. Alternatively spliced transcript variants using multiple
            alternate promoters have been observed for this gene. [provided by
            RefSeq, Sep 2017].
            
            Transcript Variant: This variant (7) represents use of the
            alternate A promoter and contains an alternate 5' UTR compared to
            variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000684187.2/ ENSP00000506797.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AK292951.1         1-128
            129-519             DQ645732.1         24-414
            520-2848            AB020337.1         434-2762
            2849-2849           AW136254.1         17-17               c
            2850-6523           AF064860.2         92378-96051
            6524-6828           KF457302.1         1-305
            6829-13097          AF064860.2         96357-102625
FEATURES             Location/Qualifiers
     source          1..13097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.2"
     gene            1..13097
                     /gene="B3GALT5"
                     /gene_synonym="3-GalTase 5; B3GalT-V; B3GalTx; B3T5;
                     beta-1; beta-3-Gx-T5; beta3Gal-T5; GLCT5"
                     /note="beta-1,3-galactosyltransferase 5"
                     /db_xref="GeneID:10317"
                     /db_xref="HGNC:HGNC:920"
                     /db_xref="MIM:604066"
     exon            1..128
                     /gene="B3GALT5"
                     /gene_synonym="3-GalTase 5; B3GalT-V; B3GalTx; B3T5;
                     beta-1; beta-3-Gx-T5; beta3Gal-T5; GLCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            129..359
                     /gene="B3GALT5"
                     /gene_synonym="3-GalTase 5; B3GalT-V; B3GalTx; B3T5;
                     beta-1; beta-3-Gx-T5; beta3Gal-T5; GLCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            360..519
                     /gene="B3GALT5"
                     /gene_synonym="3-GalTase 5; B3GalT-V; B3GalTx; B3T5;
                     beta-1; beta-3-Gx-T5; beta3Gal-T5; GLCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            520..13097
                     /gene="B3GALT5"
                     /gene_synonym="3-GalTase 5; B3GalT-V; B3GalTx; B3T5;
                     beta-1; beta-3-Gx-T5; beta3Gal-T5; GLCT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..1452
                     /gene="B3GALT5"
                     /gene_synonym="3-GalTase 5; B3GalT-V; B3GalTx; B3T5;
                     beta-1; beta-3-Gx-T5; beta3Gal-T5; GLCT5"
                     /note="isoform a is encoded by transcript variant 7;
                     homolog of C. elegans Bt toxin resistance gene bre-5;
                     UDP-galactose:beta-N-acetylglucosamine
                     beta-1,3-galactosyltransferase 5; UDP-Gal:betaGlcNAc beta
                     1,3-galactosyltransferase, polypeptide 5"
                     /codon_start=1
                     /product="beta-1,3-galactosyltransferase 5 isoform a"
                     /protein_id="NP_001343265.1"
                     /db_xref="CCDS:CCDS13667.1"
                     /db_xref="GeneID:10317"
                     /db_xref="HGNC:HGNC:920"
                     /db_xref="MIM:604066"
                     /translation="MAFPKMRLMYICLLVLGALCLYFSMYSLNPFKEQSFVYKKDGNF
                     LKLPDTDCRQTPPFLVLLVTSSHKQLAERMAIRQTWGKERMVKGKQLKTFFLLGTTSS
                     AAETKEVDQESQRHGDIIQKDFLDVYYNLTLKTMMGIEWVHRFCPQAAFVMKTDSDMF
                     INVDYLTELLLKKNRTTRFFTGFLKLNEFPIRQPFSKWFVSKSEYPWDRYPPFCSGTG
                     YVFSGDVASQVYNVSKSVPYIKLEDVFVGLCLERLNIRLEELHSQPTFFPGGLRFSVC
                     LFRRIVACHFIKPRTLLDYWQALENSRGEDCPPV"
     regulatory      13079..13084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GALT5"
                     /gene_synonym="3-GalTase 5; B3GalT-V; B3GalTx; B3T5;
                     beta-1; beta-3-Gx-T5; beta3Gal-T5; GLCT5"
                     /note="hexamer: AATAAA"
     polyA_site      13097
                     /gene="B3GALT5"
                     /gene_synonym="3-GalTase 5; B3GalT-V; B3GalTx; B3T5;
                     beta-1; beta-3-Gx-T5; beta3Gal-T5; GLCT5"
                     /note="major polyA site"
ORIGIN      
        1 atcctcggcc tggacccagc gcctccgggg accggccgcg cgccccctgc gtccgcgggc
       61 cgggatgcgg ctctgagcca gcggcggctt ccagcccgac tgggcctgcc ggggctgccc
      121 cgcgcacgtt tcatctggaa gagaggccat tgaaaccaag catttgtgtt caagtaagaa
      181 aatgtatcca agtcacaaag aaacataatt tggcttttgg agacatgagc agcttcattt
      241 ctcatttgtt cattcgaaag tctccactgg gcttctgagt gccacatcct gtccagaatg
      301 atgaaagata cagaaaatgg tgcctgctga ccttctggag ttattggcta gtaagaaagt
      361 gattcctgtc agaatcacca tttttggtaa acaaaccaag cccagaacct gataattatg
      421 gagcattcta cactgacagt tctttgagac aaatttcctc ttggcattta cactgtggct
      481 ttagctttca aaccagaggt tcctcttacc cagcaaaaaa tggctttccc gaagatgaga
      541 ttgatgtata tttgccttct ggttctgggg gctctttgtt tgtattttag catgtacagt
      601 ctaaatcctt tcaaagaaca gtcctttgtt tacaagaaag acgggaactt ccttaagctc
      661 ccagatacag actgcaggca gacacctccc ttcctcgtcc tgctggtgac ctcatcccac
      721 aaacagttgg ctgagcgcat ggccatccgg cagacgtggg ggaaagagag gatggtgaag
      781 ggaaagcagc tgaagacatt cttcctcctg gggaccacca gcagtgcagc ggaaacgaaa
      841 gaggtggacc aggagagcca gcgacacggg gacattatcc agaaggattt cctagacgtc
      901 tattacaatc tgaccctgaa gaccatgatg ggcatagaat gggtccatcg cttttgtcct
      961 caggcggcgt ttgtgatgaa aacagactca gacatgttca tcaatgttga ctatctgact
     1021 gaactgcttc tgaagaaaaa cagaacaacc aggtttttca ctggcttctt gaaactcaat
     1081 gagtttccca tcaggcagcc attcagcaag tggtttgtca gtaaatctga atatccgtgg
     1141 gacaggtacc caccattctg ctccggcacc ggctacgtgt tttctggcga cgtggcgagt
     1201 caggtgtaca atgtctccaa gagcgtccca tacattaaac tggaagacgt gtttgtgggg
     1261 ctctgcctcg aaaggctgaa catcagattg gaggagctcc actcccagcc gacctttttt
     1321 ccagggggct tacgcttctc cgtatgcctc ttcaggagga tcgtggcctg ccacttcatc
     1381 aagcctcgga ctctcttgga ctactggcag gctctagaga attcccgggg ggaagattgt
     1441 ccgcctgtct gaggggagcc cagaggcaca tccggacaag tttcagataa cccgtgggga
     1501 tagtttttgc tagattttgg aagagggggc gggacagagg atgctgttct tcagtgctga
     1561 aatccacgcc agaatgtcgg tgttcatgaa gtcactgatt agttcccact tggtgcccca
     1621 ggcaataata ggcccgtctc ttgggcacgc acactcttca tactaagtgt ttgacataca
     1681 cctggatttt tgcatttcag gggtcagtat cctatgacat gatgggtgtt accatcctaa
     1741 ttttacaggc aaggacacag cagctgcgag aggtacagaa acttgtccca aggctcacag
     1801 ccagtaggca taggagcggg aatgaaaatc gagcactgtc agaatctggt gggcagcccc
     1861 tgacttgaac cactcccacg tgctgcctcc cttaggaggg gacactgatg atgaggtctc
     1921 ggagccggca tccttccatc cctgtcgagt cccctccacc tcagctccca gtccttgtgc
     1981 tttttggagc taagcctggg atgaccaaat tcaccccagc tccttcattc acagggctgg
     2041 atgtagctgg gattgagtcc atgttatcgg ctcggtactc aacacaaccc aagtttcatc
     2101 cgaggaaatg tccccgcagt ggatgcagct cacatgctga ggaacaccca gctctggaca
     2161 gagttcttat aaatgtataa attaggctca gaaaccactg cattctgacc tgctgtacag
     2221 actgcccaca ctgctgacct gcctagcgag caggacatcc cttctgagcc atctgctgct
     2281 ctctcatttc atcaccccaa ctgtcccttg tttttgatca atggggacca gccactgccc
     2341 caggagcact ttagggctct cagttcaaac tgaaggacag ttgaactcag atggggttca
     2401 tgtgggattc tgggagcttt ctgggaattc agttggagtc aagtcaggat gctctcaagg
     2461 acccctcggg ctcagagccc taaagtgggc cctggtgaag cagggtggtc ctgcgtccac
     2521 ttcccaagcc tgagccaagc tcatcttcat tgaatgtctc atttggccga ggaacaactg
     2581 aactttgtgg tttgctgttt agccttcagt ttgctccgct gcctcctacc cagaggtttg
     2641 tgcgagcctg tgttgcaggg ttgtataaaa ccaaggtact tcgttagttt tgcccattca
     2701 gccatggtca cgtgacatgc aaagtaatct tgctcctaat tatagaaatg atttttcttt
     2761 taatttttta ctttaccaga ctttactttg tactcagaga agaggcctca catggctgtg
     2821 tcacatataa atgttggact aaactcttac ttgaactcag gaaaagttac ttgctgcaaa
     2881 atggttttga ccatgttcaa ttgcaaaagt acgtctgata tcctattttg cataccattt
     2941 cttgtgtttg gattaagctg cttctttgta gatgtgtttc ctcatcctgg ctgctctgaa
     3001 cgcactgggt catgttcaga aaagcctcct tctcaggtgg aaaaaatcag ggactgagct
     3061 tgtcttttga agcccaaatt taagagccac gcctctcggt tccataggat gggccgcctc
     3121 tcattctgaa gatgactgtg ctttgaggga gaagtcgtct gtttggcagt aggcctgcgt
     3181 ctgtgtttcg tggtctacct tgtcaggtgt gtgtctgtgt ggccactggt ctcagtcggc
     3241 gaggccggtc cagctgctgc ctctgtgtga ctggctttgg gtctggcctt cacagcatca
     3301 gctcacagcc cacagctcca gggacaaatg aggacaggcg tgggctctcc ctactgcttc
     3361 tgtgtgttct taaaggattt tctttgagac ccattgtttc ccctcccctc ccctcccctc
     3421 ccatcccctt ccctcttctt ttcttttctt tttttctgac agggtctcac cctgtcaccc
     3481 aagctggagc gtagtggcct gatctcgctg cagccttgaa ctcaacgagc ctcaaacgag
     3541 cctcctgcct cagccagtgg gtagttggga ttacaggtgt gtatttcttt atacaatgaa
     3601 taattctttt tcttgaggaa aaaacattat ttcatgaatc tagaacttga aggaacctta
     3661 gagctcattc aatcctgcct cctcttttat gtgggatgca aacgaggctc agagagacgt
     3721 aacaacttgc ccaggacctt cccagcttgt ttgttgcaga aggagggttc cagctcagcg
     3781 tgggtttcct ggtgctgtct tgtctggatg tgagagtgag aaacaatgtg aaagcatgag
     3841 tgaggaggcc aagcagtgct tccccaggaa cacccagcgc tagctccaga gtgggaatgg
     3901 agaggtccag gttggccggg ccggggcttc accgcaggca cccagagagg aaggattccg
     3961 atgggcaggt gctgagctag gggctgtgta ggtattgcct catctacatg ctctcaatga
     4021 gttttccggg ggcagagacc tgcagttgct caggtttaca gattaggaaa ctgaggcaga
     4081 gagagagagg gtgaacaact cattcaaggt tacataggtg aaaagtggtg gaaacggggt
     4141 gaccctaagc tgccctgtgg cctccccagc cacctgctga cggagctgtg ggagcacatt
     4201 gcattggctg ctcccactgc ctctctgggg tgcctcctca gactccccca accatacacg
     4261 cctacaccca gcccccaaac ctccgtactc tgccttctac tgtgactgtg gcagaagcca
     4321 cttggccccc gtggtgccag aacccctggt attggactga ctccagctct tcttccacag
     4381 ctcctgatgt ggcctcactc tcgtcctacc acctgctgtc ccctctgctg gatcacccca
     4441 ttagcacaca gacacgctgc cattttccac ctgaccagaa atggccacca ccttccccga
     4501 ccccttccct gacccccttc cccgtcccgc tgccccatcc tgttgcgttt ctggtggaac
     4561 cccgcacgag agttttactt gtctgttgcc tcgtcctaat ccttcccttc tttcccaaat
     4621 gccgtctcat cagacttctg cacccccact ccacccacat ggcccttctc agggcaccca
     4681 ccaccccctg tggctgggtc ctgtgggcag ttcttgttct cctcctgctt gacgtggcga
     4741 gtcctcatca ccagcttcca ggacaccggg tgctcttggt ctccctcctc cttgctgctc
     4801 gccttttcca tctcccctgc ttgctccttc tctttgctct gacagtgtcg tgctggagga
     4861 tcctgggctc tgcgtggggc cccctttctt ccctggttat acccagtcct ccgaggggcc
     4921 caccttgtct catggcttta aatatgttga tgatgtttcc atttatctcc agcctagaac
     4981 tctttcttgc tcttcaatcc actgcctacc tgatttccca tagtgaacaa tccaacactg
     5041 accttctggt taactgcccc acatccagcc catctgcagc cattcccgtc tcaggtaatg
     5101 gccactccat cttcctgcag ctcaagtggg aagccctgga gccattccga ctcctctccc
     5161 atctggtgca tcaggaaaga ctgtgggaac taccttcaaa ttctctccag gagccaacca
     5221 cctcctgccc ctccactgcg accacccttg ttcaagcctg cattgcctct cacctgcatt
     5281 cgtgcagcta cctccagacc ctccctcagc ttccattatt gcatcctttg gtctcttccc
     5341 agcagcatcc agagtgatcc tttgaaaatc tcatttctct gctcaaaacc ctcctgaggt
     5401 ttcccatcac caaggatatt aaggataaaa accacatcct tcataccatt gtctacctgt
     5461 gattccctaa tcgtgtccct ttgctcactc cctctggcct cttgctgttc cctgaacagc
     5521 agtctgttcc agccacagca gcccctttgc cctatgtgcc catccccgtc agccttggca
     5581 ctggctgtcc tctctgctgg gagtgccctt tcttcagatg ctctcatgct tcgcttcttt
     5641 gccttgttga catttggtca atgtcacctt ctcagtgagg cctaccctga cctccctgta
     5701 ggaaaatgca actcacctca ctcccatgcc ccgtacctta tattgttttc cttgcactta
     5761 ccaatttcta acaaagcatg taatatctgt ttattataac atatctatat tttatggttt
     5821 atgtttcacg caacttgaat gtaacctttg tgtgggccgt gggtctttct ctgtttcctt
     5881 cactgacgca ccttggattc ttagcatggt cccagcacat agtagatgct caataaacat
     5941 ttgttgagtg gaactgaatg tattggtatg gtaggtgggt tttagaaggg aatgggtgaa
     6001 ccaggactga aaaaaaagaa atatttttca aagtaagcca acactgtggt ttcacttgag
     6061 tcagtaagta ggaaatgggt gcgactctgt gacctgaaaa cctagaaatg ctccacagcc
     6121 atgctcttca ccccttttct tccaaaacgg aaaacctcac acaatgcagg gtggacagaa
     6181 tcacacggtg cagtctgtgc gcctgtcctc cagcccgaca cctggccagt cctgtctcat
     6241 ctacactgtc atgcaaactc ttgtttttgt ttgtttgttt ttgagacaga gtctcactct
     6301 gtcacctagg ctgaagtgca gtggtgcagt cttggatcac tgcaacctcc acctcctggg
     6361 ttcttgtgcc tcagcctccc gagtagctag gattataggc atgcaccacc aaccagctaa
     6421 tttttgtatt gttagtagag acggggtttc accatgttgg ccaggctggt cttgagctcc
     6481 tgacctcagg taatctacgt gcctcagcct cccagagtgc tgggattata ggtgtgagcc
     6541 accacaccca gccatgtttc aagaatttgt gcttcagctc agcacttagt ggcagtggga
     6601 agaccagacc tcctgaccct tcagcctgct ggcatccacc atgccttaaa aaacaaaaca
     6661 aaaccctaaa tgtatttaat tcctgctcct cttcaaacac accattgtaa ccacataata
     6721 cactgtgtga aaagagagga aagaaaaatc caagtcaaca ataacttgcc aggccttctt
     6781 tccttgagcc ccatatccca cgcccgctgt gctaacctct ggcttgccgc ccacacctgt
     6841 ctggattcat cccgactcga gccacctcct cctaactggt cccacgggcc tgtccctgcc
     6901 actttccaat ctgtcctcca cttgacattt ggagtaattt tttaaaacag caaatctgat
     6961 taggaaactc agaggcccag ggaagccagt gacttgccct ctggcaccct gtcctgaggg
     7021 tagagcttcc tggcacaggg tcagtgagcc ccgaggccac ctccctggag gctgcaggag
     7081 ggtgagcgtg gtcaagagca gcaattttca ttgtttcatg tgtcattgcc tatttaacga
     7141 gcttcgcagt gccctcaatt tgctaagtta actttggcca cgccgtccgt gagaggtcag
     7201 actggtgatt tccaactccc gccgggcacc gggtgctgca ccggttatcc caacaggctg
     7261 gcacagaggg ctgaaatgga cttggaaagc caaataatta attttcatgc gagtttttga
     7321 tccccttgag tgtggttatt tttgtgcaaa aaattatccc gatgtttact ttggtttcat
     7381 aagtaattta ttaaaattcc ttcctaagct ttaaatttca gctaacaaat atgagcatgg
     7441 cctctgggaa tggtaagaac aaggaagcat tgtgtgtgtg tgtgcacacc ccaaggttgt
     7501 gcagctagaa gtgcagaatg tggattccgt ccgctcttta gggcacagct agccctgtgc
     7561 acctgtagaa actgtactga cgtacagcct tgcagagcct ccagcttcca tggtggcagg
     7621 agccatggaa aatagagacc cacccggtaa ggaggtaact gggacaccag gttactgtct
     7681 acctggtggg gaagctgggg aaaagggccc atgggaggat actaactggg gaagaggaga
     7741 ccttgcttcc agggctgggc gacccactta cggaggcccc attccattta catctccgct
     7801 caagcctccg cctccgggtt ccagccctgg ctctgcaatt tgctagctgt ggccccaggt
     7861 ggtcattctc tctgcacctc agtctctgca tctctataaa atgggatgat aatagtgttc
     7921 acctcagaag gttgtcagag gtgtggaaat taagataatt cacattgagt tcttggcacg
     7981 gctgtgccta gcactgggtg caggctgaat gcatgggctg ctatcgcgat gttgtatcta
     8041 atggcctgca gtggttgctt agcagcaatg ggtttgcttg gttatttcct gatttggggt
     8101 aaatagatcc agagaccaag gctccatgtt atccccagca ccgggctgac cccaagtacc
     8161 agagaggtct ccatggcccc aggctgcaga ggacccaggt tacaacttgc tcaagtagac
     8221 ccaggatcta ggcttatcct agtagatctt ggtaccaggc cagcctctgt gacctgagac
     8281 tccaagacca ccattgcaga cccaggctct aagctagcct ctgcaaactc aggatatata
     8341 ttccaaatat ccctgatttg gggggcaagg tctgtgtgtg atttgcagag taacgatatg
     8401 aagaaggagg tcttgttaag atggcgtggt gtggagtgcc caggtgtgaa atggttgtct
     8461 caatggaagt tgtagcctcc tcctcccatg acatcatcct cacacgtgct cagtgttagg
     8521 cattttttcc ccctcctgct ctgaatcaat gcgagtgaga tatgcatgcg ggagggacaa
     8581 gcttgcatgg cacccagctg tggtacattt agaactcggc ctcagccctc cagtgtgacc
     8641 ttgggcatac ccttcacccc cgggctctgt tcgctggggc agggtctgcg ctctggagtc
     8701 aggctgcctg ggtttgaatt ttaccttcct cgccaagtcc cttgagtggc aagttactta
     8761 tcttctcatt gtctccgttt tgttatctga agaatgggac catagtagtt cccgcctcat
     8821 gggatgatca tgtgggttaa atgagaggat gagtataaac tgctcaacat cccatggtag
     8881 gtgctcagta aatgcaggtg cttatgatta tagtcagtgt ttgggctgtg aattttggtg
     8941 gattctatgg tggtgtatac agcactatct atcagtgtac ctgtcagtgt ctggtgatct
     9001 ctgtgcaaat caaaaactct tcagattgag tctgtagggc tttgtttcag ctcttgttct
     9061 ttttcttcat ttgaatcttt cctggaactc ttggagaagt tcttctgttc gtgacattct
     9121 tcacaatcag agcactgtgt tcttgaccct cttaattcag aatatgtgaa aatctgaatg
     9181 aggtaaaaga agttggagct ggaagatgcc ttagaaatta tctacagtat tttttttttt
     9241 aagataaaac cttttacagt taggaaagcc aaagctcaga aaaatggagt gactttgcca
     9301 ggtccttcag cgagtggcac atccaggatt aaaagctggc atcagaaatc ccatgtcaga
     9361 cattcattcg tttatttatt catctgttga gtgctcagtg ctttgaccgg gcatcctgaa
     9421 tgagggtcaa gctgaggttc gaggccgtgg gttttgcata cagagctttc actgggtaaa
     9481 tacacaatgc tgagaagatt atcaggggca cctgatccct tgacagctga ataaagaagc
     9541 gttccagtgc cttctctgtg ggcatcgtaa gccatgtcca tccatacctg ctgtttcact
     9601 gaaaccccac agcagcctct ggagggcacc attcttataa ttatgcccct ggatttaaga
     9661 ggaggaaact gaggggcagg tgactcagtg acttccccgg gggctcagac gtggtggaga
     9721 cacaggccct cggcctccaa atgctgcctc ccgcgagcag ccttgctttt ctccacttgg
     9781 cacagtggtg agtcctccga tgtatctgct ttcataggaa gcttgggacc agccctgccc
     9841 aaggagtgtg ccacctgacc ccttttcctg tcttctgtca cttttttttt tccaagtgtt
     9901 gatatgagtt tcagtctgcc ccttcctggg cctgtttgac ctcctgggat tcggcactta
     9961 gttatctgtg tcattcccaa ggacctcccg tttagctgga tcccctgacc tgtcctgccc
    10021 tggccagccc tctcttgagg ttactcaagt gtccaatggc agcccaaaca aatgtctggc
    10081 ttcagaaaat aaactcttca gtccagccca ctttccctgt ctccctatct aatgcccttg
    10141 caaaacaagc ccgggggcgc cacactcaga ctgtgtgtgt gtgtgtgtgt gtgtgtatct
    10201 atgagagaga gagagacaga cagacagatc tgaggctcta attagagata ccatgctcag
    10261 tggaagctgg ttctgaacaa tgttaactgc cccacccgtg tccatgaagg gcagtggaag
    10321 agcaaggggc ggtttaatta cctgggatgt aaaacagcag gcacccccac tgccctcctc
    10381 agctgttggg gtggcagggt ggagttgagg gcctcactcg ttttcacctt tgcacaatca
    10441 gtcacacatt tgttatatga cagctatgtg ccacacaccc atgttcagta aggtggaagc
    10501 cagctgcagg cgtggtccac agttccagac atctctgaag gatgtgacac caactttcag
    10561 gcagaacatt tagaaagagt gaaataaagt gaaacagatc aaccagccta ttgagtatct
    10621 acgtgttttt tttacaggca agaactgagg aggcaatact atttagaatc cttgataaac
    10681 agttccaaaa gaaaaaaaaa aacaggcttt ggtgactctc atgggccctc cgtgccaaga
    10741 gtctatggct ctgtgatata ttaaatcagg cttgttaatt atttaatcta acagctgcca
    10801 tgcaccctca ttttaaaaac agatgaggca atgtttacat tttctccatg tcctccattt
    10861 ggaagtgtct tagtttgttt tgtgttgctg taacagaata ccacagactg ggcgatttat
    10921 agacaataga aattaatctg gctcatggtt ctagaggcta ggaagtccaa gagcttggca
    10981 ctggcctctg gtgagggcct tcatgctgtg tcattgtggg caaaagagca aaacttgctt
    11041 tgataaaatc actcttggca ataactgacc ctcctcttat aataacatta attcattcat
    11101 gacagcagaa ccctcctgac ccagtcacct cttaaaaggt cccacctctc aacgctgttg
    11161 cactggggat taagtttcct tacacatgca ctttggggga cacattcaaa ctgtagcagg
    11221 aattatttgc tttctcataa cattttttta attaattaat tttcagcgtt tgttatatca
    11281 gaatggacat tatagcaatt tccatggctg tgtcgctcct ggcagatttt aaagttcttc
    11341 cagcctgatt cctctctctg tttgggtctc tggcatggtg cctgctggag agtagatact
    11401 tgataattat ctattgggtt ctcaggggat ctctcaaagg tggtattcag gcacccacaa
    11461 ggcaactccc atcacaagaa agaatggtgg cctgggagtg agctgtaagg ttccttcaaa
    11521 catcagttcc tgaagcctct tttattcatt attgttggga cttgttttta tttctgtttc
    11581 gttctacgtg accccaaaat ctgtatgtga acactaggaa ctttatcatg ggctgaggtg
    11641 tatttgaagt aaactcttaa ctatgtctct gggatatgaa aggtgcttac attctctgtt
    11701 gggaatgtag agagaaggat ttgcagtgtg tggcccctgg gaatgtagag gcatgaattt
    11761 ctgtctgttt tcctgctgtt gaaatctgag tgctaggaac ggacctcttg ctctcagatt
    11821 ggccttgaag ctgaagggaa cctgtccacc ctctgcacag ggcaagagcc acgccaacag
    11881 gaggaagttg gagtgcatcc tggcacctgc caatcggaag actgacaaac aaaaaattag
    11941 tttttaatta atttaaaaaa tgatcttcct acttatcaga cacaatcact tttaaatatg
    12001 agcagaaaaa cgaactccat agccaaatgc aacattttgt gtcatactgc tttacatcat
    12061 ctattctacc tccattcact ggtcaaagaa gcgcagagtt aagttggcca gtgtggcgtg
    12121 gacacagcca ggcgcagacc ctcctgccag cgaagccagc gtgaggtctg ttggctcagg
    12181 ggtccagtcc ctgggtcccc gaagaggtaa gccaaagaca tagtgatact tggttcaatt
    12241 cggctccaga gagtatcaga tgggaaatag atgacttgtt ttacctggtc aaataagaca
    12301 tcactaaaat ctaccatgac tggaaattac ttaatgcaac cagaggagac ttcgcagtca
    12361 aattttgctt ttcctaaaag acacgaaatt aaatttacat gtcactgaat gctatttgaa
    12421 actgtcattt ccttgtatat tagggggatc tgctagactc ttatgtcatt gtattttgga
    12481 aatgggtata tgtccttatt attggttaat aatcatattt atttttaatg aaaattaaat
    12541 tatgaaaata atgcacttaa ctaggtgagt tttaggttgt cgattgatgt gataattcac
    12601 tcttcccgaa aaattggcaa ggtaatggtc tgaatcggac aatccttttg tttttacatt
    12661 gatgttttct atatttattt tgtacctgga aaaatatttt tacaatttat tttgatttta
    12721 tatgtgtaga aaaatgtact gaacaatgtt gacatgctta tttttgtaag agatgggtac
    12781 ttcttgttcc ccttggattt cggaagcaaa gcaatgggac cctacgcttc agagtcttaa
    12841 tggggtgggg cagtgtccat tgaggtgtcc tgtcgggaat gacaagtcca gggcagatta
    12901 tgaggcaggc atcctttgga gttcttctct caggtatatt ttaactaaaa gctatcattt
    12961 aagttgaaga aatcaagtct tgtgaattga tacgattgta cttctagagt ctttgatgat
    13021 aagttgtctt tgcggtacag attggctcct cgatctttca aagtgtcatt taaatggaaa
    13081 taaatgtctg aaacaga
//
