LOCUS       NM_003783               3548 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens beta-1,3-galactosyltransferase 2 (B3GALT2), mRNA.
ACCESSION   NM_003783
VERSION     NM_003783.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3548)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3548)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 3548)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
REFERENCE   4  (bases 1 to 3548)
  AUTHORS   Amado,M., Almeida,R., Schwientek,T. and Clausen,H.
  TITLE     Identification and characterization of large galactosyltransferase
            gene families: galactosyltransferases for all functions
  JOURNAL   Biochim Biophys Acta 1473 (1), 35-53 (1999)
   PUBMED   10580128
  REMARK    Review article
REFERENCE   5  (bases 1 to 3548)
  AUTHORS   Amado,M., Almeida,R., Carneiro,F., Levery,S.B., Holmes,E.H.,
            Nomoto,M., Hollingsworth,M.A., Hassan,H., Schwientek,T.,
            Nielsen,P.A., Bennett,E.P. and Clausen,H.
  TITLE     A family of human beta3-galactosyltransferases. Characterization of
            four members of a
            UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine
            beta-1,3-galactosyltransferase family
  JOURNAL   J Biol Chem 273 (21), 12770-12778 (1998)
   PUBMED   9582303
REFERENCE   6  (bases 1 to 3548)
  AUTHORS   Kolbinger,F., Streiff,M.B. and Katopodis,A.G.
  TITLE     Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose
            3beta-galactosyltransferase catalyzing the formation of type 1
            chains
  JOURNAL   J Biol Chem 273 (1), 433-440 (1998)
   PUBMED   9417100
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA116294.1, AK314116.1 and
            AL390863.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 3, 2008 this sequence version replaced NM_003783.2.
            
            Summary: This gene is a member of the
            beta-1,3-galactosyltransferase (beta3GalT) gene family. This family
            encodes type II membrane-bound glycoproteins with diverse enzymatic
            functions using different donor substrates (UDP-galactose and
            UDP-N-acetylglucosamine) and different acceptor sugars
            (N-acetylglucosamine, galactose, N-acetylgalactosamine). The
            beta3GalT genes are distantly related to the Drosophila Brainiac
            gene and have the protein coding sequence contained in a single
            exon. The beta3GalT proteins also contain conserved sequences not
            found in the beta4GalT or alpha3GalT proteins. The carbohydrate
            chains synthesized by these enzymes are designated as type 1,
            whereas beta4GalT enzymes synthesize type 2 carbohydrate chains.
            The ratio of type 1:type 2 chains changes during embryogenesis. By
            sequence similarity, the beta3GalT genes fall into at least two
            groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3,
            beta3GalT5). This gene encodes a protein that functions in N-linked
            glycoprotein glycosylation and shows strict donor substrate
            specificity for UDP-galactose. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.190253.1,
                                           SRR1660805.230968.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367434.5/ ENSP00000356404.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               DA116294.1         1-282
            283-1869            AK314116.1         1-1587
            1870-3548           AL390863.9         59112-60790         c
FEATURES             Location/Qualifiers
     source          1..3548
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.2"
     gene            1..3548
                     /gene="B3GALT2"
                     /gene_synonym="beta3Gal-T2; BETA3GALT2; GLCT2"
                     /note="beta-1,3-galactosyltransferase 2"
                     /db_xref="GeneID:8707"
                     /db_xref="HGNC:HGNC:917"
                     /db_xref="MIM:603018"
     exon            1..595
                     /gene="B3GALT2"
                     /gene_synonym="beta3Gal-T2; BETA3GALT2; GLCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..3548
                     /gene="B3GALT2"
                     /gene_synonym="beta3Gal-T2; BETA3GALT2; GLCT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             716..1984
                     /gene="B3GALT2"
                     /gene_synonym="beta3Gal-T2; BETA3GALT2; GLCT2"
                     /EC_number="2.4.1.86"
                     /note="beta-3-galt2; beta-1,3-GalTase 2;
                     UDP-galactose:2-acetamido-2-deoxy-D-glucose
                     3beta-galactosyltransferase 2; UDP-Gal:betaGlcNAc beta
                     1,3-galactosyltransferase, polypeptide 2"
                     /codon_start=1
                     /product="beta-1,3-galactosyltransferase 2"
                     /protein_id="NP_003774.1"
                     /db_xref="CCDS:CCDS1383.1"
                     /db_xref="GeneID:8707"
                     /db_xref="HGNC:HGNC:917"
                     /db_xref="MIM:603018"
                     /translation="MLQWRRRHCCFAKMTWNAKRSLFRTHLIGVLSLVFLFAMFLFFN
                     HHDWLPGRAGFKENPVTYTFRGFRSTKSETNHSSLRNIWKETVPQTLRPQTATNSNNT
                     DLSPQGVTGLENTLSANGSIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAE
                     PGQIEARRAIRQTWGNESLAPGIQITRIFLLGLSIKLNGYLQRAILEESRQYHDIIQQ
                     EYLDTYYNLTIKTLMGMNWVATYCPHIPYVMKTDSDMFVNTEYLINKLLKPDLPPRHN
                     YFTGYLMRGYAPNRNKDSKWYMPPDLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGI
                     RRLHLEDVYVGICLAKLRIDPVPPPNEFVFNHWRVSYSSCKYSHLITSHQFQPSELIK
                     YWNHLQQNKHNACANAAKEKAGRYRHRKLH"
     regulatory      2690..2695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GALT2"
                     /gene_synonym="beta3Gal-T2; BETA3GALT2; GLCT2"
                     /note="hexamer: ATTAAA"
     polyA_site      2709
                     /gene="B3GALT2"
                     /gene_synonym="beta3Gal-T2; BETA3GALT2; GLCT2"
                     /note="major polyA site"
     regulatory      3210..3215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="B3GALT2"
                     /gene_synonym="beta3Gal-T2; BETA3GALT2; GLCT2"
                     /note="hexamer: AATAAA"
     polyA_site      3233
                     /gene="B3GALT2"
                     /gene_synonym="beta3Gal-T2; BETA3GALT2; GLCT2"
                     /note="major polyA site"
ORIGIN      
        1 acatttaaac tgctgcctgc ctgtgcagca gctgaggaac cgtggatttc atattataga
       61 ctaaaacccc attaaaactg ctcaaaatcc ttcctgcagc tgccaggcaa caacgaaaga
      121 agagaggtaa atcctattct tttccaatac aactgaagca ctacatttta gctctggctg
      181 ctttacattg cagctcagtg ttattagtag aaatatggat actgagacga gaacacagca
      241 ctgcattgtc cagccaggaa aatagcagat gtaaaaagct tcaatgcatc aactgtcggg
      301 aagagtcaac agtgctacaa gcagaacggg caactacagc tcttttgttt aacgaaagag
      361 agaaaatgaa agaaagggaa aatttcagaa gactaggacc catatgaaca aggagggtaa
      421 ctcgaagaca agcagacaga tggacacttt ggatactgtg aaaagcaatc gcaggaggca
      481 gactgttggg ggatgtgcgc atgttcgata gcatcttttt tgctgaagtg atggcgtgcc
      541 aaaagtattt tcagtgggca taatcctctt cacataaatg gcctgaccaa ggaagaatga
      601 ctacaagaga gacaatgtga ctgaattaga aaatgattgc caaagaatag tattaaggag
      661 aagaaaacat ttttggtcac caatctctca tataccacta ctggatattt acaacatgct
      721 tcagtggagg agaagacact gctgctttgc aaagatgacc tggaatgcca aaaggtctct
      781 gttccgcact catcttattg gagtactttc tctagtgttt ctttttgcta tgtttttgtt
      841 tttcaatcat catgactggc tgccaggcag agctggattc aaagaaaacc ctgtgacata
      901 cactttccga ggatttcggt caacaaaaag tgagacaaac cacagctccc ttcggaacat
      961 ttggaaagaa acagtccctc aaaccctgag gcctcaaaca gcaactaact ctaataacac
     1021 agacctgtca ccacaaggag ttacaggcct ggagaataca cttagtgcca atggaagtat
     1081 ttacaatgaa aaaggtactg gacatccaaa ttcttaccat ttcaaatata ttattaatga
     1141 gcctgaaaaa tgccaagaga aaagtccttt tttaatacta ctaatagctg cagagcctgg
     1201 acaaatagaa gctagaagag ctattcggca aacttggggc aatgaaagtc tagcacctgg
     1261 tattcaaatc acaagaatat ttttgttggg cttaagtatt aagctaaatg gctaccttca
     1321 acgtgcaata ctggaagaaa gcagacaata tcatgatata attcaacagg aatacttaga
     1381 tacgtactat aatttgacca ttaaaacact aatgggcatg aactgggttg caacatactg
     1441 tccacatatt ccatatgtta tgaaaactga cagtgacatg tttgtcaaca ctgaatattt
     1501 aatcaataag ttactgaagc cagatctgcc tcccagacat aactatttca ctggttacct
     1561 aatgcgagga tatgcaccca atcgaaacaa agatagcaag tggtacatgc caccagacct
     1621 ctacccaagt gagcgttatc ctgtcttctg ttctggaact ggttatgttt tttctggaga
     1681 tctggcagaa aagattttta aagtttcttt aggtatccgc cgtttgcact tggaagatgt
     1741 atatgtaggg atctgtcttg ccaagttgag aattgatcct gtaccccctc ccaatgagtt
     1801 tgtgttcaat cactggcgag tctcttattc gagctgtaaa tacagccacc taattacctc
     1861 tcatcagttc cagcctagtg aactgataaa atactggaac catttacaac aaaataagca
     1921 caatgcctgt gccaacgcag caaaagaaaa ggcaggcagg tatcgccacc gtaaactaca
     1981 ttagaaaaga caattttttt tcaaatgtgc aatttgtaaa tattgctaaa agcatgtata
     2041 gttagaactg attacatccg taggacaagt tttagttaaa actcatcaca taaagaaatt
     2101 caagaagtat ttttttaatt tctgaagaag ttaattctta aaactataac attatataac
     2161 aaaaaaggtt tcccaaaaca atctatttaa aaaactgtat aaggagattc tgtgtattaa
     2221 catgcaataa caagcatgca taaatcaatg gttcaagtct tctgttaggg gccaataaaa
     2281 tgtatctgca tatgttttcc acataaattt taattcaaga aatgacagtc aaaagatcct
     2341 tcattttaga ttaagctttt cattttaata tataatttaa tgtaaataaa acatcactat
     2401 caattttaag gaaacttttt aattgtgcaa aggataaatt ttttgaccta ttttagggtt
     2461 ctaaatgcaa taagatttag ttgagttatt ccacaaacac attataaagt tcagatgttt
     2521 catcaatgca gttctcacga aagtatttac tttttaaaaa taactgagat attattttaa
     2581 atttctttta ttaatacttt cttttattaa tatatggggg aaaattattt tgacatgacg
     2641 tggtaaaatg tgaaaaacta atgtgtctca ggctcaagtt tttatagtta ttaaatgttt
     2701 caaaatagac aagttttgtt tcctcattga tgttaagaac caaactccta tttcaatgag
     2761 ttattggatt agaccaatta ctgcactctt aaacagcacc accatttaat ttcatgtata
     2821 tctaacttcg aatatatctg taaagataat cgaagcaaaa gtaatcactt aaaggcacaa
     2881 ataggatgta ctgttgaaaa agataaagag tgcaggtgca gtttcattca acacattttt
     2941 aagatgcatg tctgccaaaa tgcaacatac gggaagttta tttcctgaca gcaggtgtac
     3001 acatgccaac acttaatcat tttatggcac ctatttcttt cttggagtgc caagtttgca
     3061 aacctgcagt ttttaatttg gtagatgaca aatattctga atcaccaatt aaaaaccttt
     3121 ttgggaggga tggggaaaac tacaaacgtt tgacaaacac aattctagga tgaacaatgt
     3181 atacaatgca cttttatgaa gtttttaaaa ataaaggaaa acaaaaaact ttactgagtg
     3241 ttataagtat tttcacaata attttgtttg actccatcat gaattttaaa atcaagaaat
     3301 accaacctac taactaaaat agtgttttta ttccatacaa gtatgtaaat ctgtcaatct
     3361 taatttagtc agaatgtttc ttaattctaa taacaatcat ttttacctct tattctatta
     3421 ttaagggata aatcaccaga agagaattgt aacatttgtg aaacttgaaa acactaaaac
     3481 tgtttaagtg cttatctcca tttcaaatca gtagcctaag tgttctactc taaatcaagt
     3541 gattctga
//
