LOCUS       NM_052998               5240 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens antizyme inhibitor 2 (AZIN2), transcript variant 1,
            mRNA.
ACCESSION   NM_052998
VERSION     NM_052998.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5240)
  AUTHORS   Park,M.Y., Kim,S., Kwon,N.H., Moon,G., Cha,J. and Kwon,I.
  TITLE     Enhanced anti-tumor activity of arginine decarboxylase through the
            incorporation of aromatic amino acids at the multimer-forming
            interface
  JOURNAL   Biotechnol J 19 (1), e2300453 (2024)
   PUBMED   37899497
  REMARK    GeneRIF: Enhanced anti-tumor activity of arginine decarboxylase
            through the incorporation of aromatic amino acids at the
            multimer-forming interface.
REFERENCE   2  (bases 1 to 5240)
  AUTHORS   Hametoja,H., Andersson,L.C., Makitie,A., Back,L., Hagstrom,J. and
            Haglund,C.
  TITLE     Antizyme inhibitor 2 (AZIN2) associates with better prognosis of
            head and neck minor salivary gland adenoid cystic carcinoma
  JOURNAL   APMIS 129 (8), 503-511 (2021)
   PUBMED   34046926
  REMARK    GeneRIF: Antizyme inhibitor 2 (AZIN2) associates with better
            prognosis of head and neck minor salivary gland adenoid cystic
            carcinoma.
REFERENCE   3  (bases 1 to 5240)
  AUTHORS   Sandusky-Beltran,L.A., Kovalenko,A., Placides,D.S., Ratnasamy,K.,
            Ma,C., Hunt,J.B. Jr., Liang,H., Calahatian,J.I.T., Michalski,C.,
            Fahnestock,M., Blair,L.J., Darling,A.L., Baker,J.D., Fontaine,S.N.,
            Dickey,C.A., Gamsby,J.J., Nash,K.R., Abner,E., Selenica,M.B. and
            Lee,D.C.
  TITLE     Aberrant AZIN2 and polyamine metabolism precipitates tau
            neuropathology
  JOURNAL   J Clin Invest 131 (4) (2021)
   PUBMED   33586680
  REMARK    GeneRIF: Aberrant AZIN2 and polyamine metabolism precipitates tau
            neuropathology.
REFERENCE   4  (bases 1 to 5240)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5240)
  AUTHORS   Lopez-Contreras,A.J., Ramos-Molina,B., Cremades,A. and Penafiel,R.
  TITLE     Antizyme inhibitor 2: molecular, cellular and physiological aspects
  JOURNAL   Amino Acids 38 (2), 603-611 (2010)
   PUBMED   19956990
  REMARK    GeneRIF: AZIN2 expression appears to be restricted to brain and
            testis and it is a labile protein degraded by a ubiquitin-dependent
            mechanism.
            Review article
REFERENCE   6  (bases 1 to 5240)
  AUTHORS   Kanerva,K., Lappalainen,J., Makitie,L.T., Virolainen,S.,
            Kovanen,P.T. and Andersson,L.C.
  TITLE     Expression of antizyme inhibitor 2 in mast cells and role of
            polyamines as selective regulators of serotonin secretion
  JOURNAL   PLoS One 4 (8), e6858 (2009)
   PUBMED   19718454
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5240)
  AUTHORS   Kanerva,K., Makitie,L.T., Pelander,A., Heiskala,M. and
            Andersson,L.C.
  TITLE     Human ornithine decarboxylase paralogue (ODCp) is an antizyme
            inhibitor but not an arginine decarboxylase
  JOURNAL   Biochem J 409 (1), 187-192 (2008)
   PUBMED   17900240
REFERENCE   8  (bases 1 to 5240)
  AUTHORS   Coleman,C.S., Hu,G. and Pegg,A.E.
  TITLE     Putrescine biosynthesis in mammalian tissues
  JOURNAL   Biochem J 379 (Pt 3), 849-855 (2004)
   PUBMED   14763899
REFERENCE   9  (bases 1 to 5240)
  AUTHORS   Zhu,M.Y., Iyo,A., Piletz,J.E. and Regunathan,S.
  TITLE     Expression of human arginine decarboxylase, the biosynthetic enzyme
            for agmatine
  JOURNAL   Biochim Biophys Acta 1670 (2), 156-164 (2004)
   PUBMED   14738999
REFERENCE   10 (bases 1 to 5240)
  AUTHORS   Pitkanen,L.T., Heiskala,M. and Andersson,L.C.
  TITLE     Expression of a novel human ornithine decarboxylase-like protein in
            the central nervous system and testes
  JOURNAL   Biochem Biophys Res Commun 287 (5), 1051-1057 (2001)
   PUBMED   11587527
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC028128.1, AW450278.1 and
            AL020995.14.
            
            On Nov 22, 2018 this sequence version replaced NM_052998.3.
            
            Summary: The protein encoded by this gene belongs to the antizyme
            inhibitor family, which plays a role in cell growth and
            proliferation by maintaining polyamine homeostasis within the cell.
            Antizyme inhibitors are homologs of ornithine decarboxylase (ODC,
            the key enzyme in polyamine biosynthesis) that have lost the
            ability to decarboxylase ornithine; however, retain the ability to
            bind to antizymes. Antizymes negatively regulate intracellular
            polyamine levels by binding to ODC and targeting it for
            degradation, as well as by inhibiting polyamine uptake. Antizyme
            inhibitors function as positive regulators of polyamine levels by
            sequestering antizymes and neutralizing their effect. This gene
            encodes antizyme inhibitor 2, the second member of this gene
            family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts
            with all 3 antizymes and stimulates ODC activity and polyamine
            uptake. However, unlike antizyme inhibitor 1, which is ubiquitously
            expressed and localized in the nucleus and cytoplasm, antizyme
            inhibitor 2 is predominantly expressed in the brain and testis and
            localized in the endoplasmic reticulum-golgi intermediate
            compartment. Recent studies indicate that antizyme inhibitor 2 is
            also expressed in specific cell types in ovaries, adrenal glands
            and pancreas, and in mast cells. The exact function of this gene is
            not known, however, available data suggest its role in cell growth,
            spermiogenesis, vesicular trafficking and secretion. Accumulation
            of antizyme inhibitor 2 has also been observed in brains of
            patients with Alzheimer's disease. There has been confusion in
            literature and databases over the nomenclature of this gene,
            stemming from an earlier report that a human cDNA clone (identical
            to ODCp/AZIN2) had arginine decarboxylase (ADC) activity
            (PMID:14738999). Subsequent studies in human and mouse showed that
            antizyme inhibitor 2 was devoid of arginine decarboxylase activity
            (PMID:19956990). Alternatively spliced transcript variants have
            been described for this gene. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (1). Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028128.1, ERR3218372.193142.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294517.11/ ENSP00000294517.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2142              BC028128.1         41-2182
            2143-2279           AW450278.1         17-153              c
            2280-5240           AL020995.14        130052-133012
FEATURES             Location/Qualifiers
     source          1..5240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..5240
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /note="antizyme inhibitor 2"
                     /db_xref="GeneID:113451"
                     /db_xref="HGNC:HGNC:29957"
                     /db_xref="MIM:608353"
     exon            1..142
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     exon            143..263
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     exon            264..475
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     exon            476..652
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     CDS             548..1930
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ornithine decarboxylase like; ornithine
                     decarboxylase-paralog; ODC antizyme inhibitor-2; arginine
                     decarboxylase; ODC-paralogue; ornithine decarboxylase-like
                     protein; ODC-like protein"
                     /codon_start=1
                     /product="antizyme inhibitor 2 isoform 1"
                     /protein_id="NP_443724.1"
                     /db_xref="CCDS:CCDS375.1"
                     /db_xref="GeneID:113451"
                     /db_xref="HGNC:HGNC:29957"
                     /db_xref="MIM:608353"
                     /translation="MAGYLSESDFVMVEEGFSTRDLLKELTLGASQATTDEVAAFFVA
                     DLGAIVRKHFCFLKCLPRVRPFYAVKCNSSPGVLKVLAQLGLGFSCANKAEMELVQHI
                     GIPASKIICANPCKQIAQIKYAAKHGIQLLSFDNEMELAKVVKSHPSAKMVLCIATDD
                     SHSLSCLSLKFGVSLKSCRHLLENAKKHHVEVVGVSFHIGSGCPDPQAYAQSIADARL
                     VFEMGTELGHKMHVLDLGGGFPGTEGAKVRFEEIASVINSALDLYFPEGCGVDIFAEL
                     GRYYVTSAFTVAVSIIAKKEVLLDQPGREEENGSTSKTIVYHLDEGVYGIFNSVLFDN
                     ICPTPILQKKPSTEQPLYSSSLWGPAVDGCDCVAEGLWLPQLHVGDWLVFDNMGAYTV
                     GMGSPFWGTQACHITYAMSRVAWEALRRQLMAAEQEDDVEGVCKPLSCGWEITDTLCV
                     GPVFTPASIM"
     exon            653..826
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     exon            827..999
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1134
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1300
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1463
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1576
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1791
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..5240
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2123..2128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /note="hexamer: CATAAA"
     polyA_site      2142
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
     regulatory      2251..2256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /note="hexamer: AATAAA"
     polyA_site      2279
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /note="major polyA site"
     regulatory      5218..5223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
                     /note="hexamer: AATAAA"
     polyA_site      5240
                     /gene="AZIN2"
                     /gene_synonym="ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp"
ORIGIN      
        1 gcgtgggggt ctgtggctgc tgggctggcg gggcgcaggc cgcgggaccc gagcccgggg
       61 aagcgagaga gcggaggcgc cgaggatccg attcactccc tggggagacc tatgggccga
      121 agccgtgtaa atgcgtttta agcagaggcc tcggctccgc aactgccact cctcctcggg
      181 gtgttgcaca agtttcgagg tcaccggcga ccccccctag cagcgcgcct ggctctggcc
      241 cccgcgaagg aggacggagt ttggagcttg cggcccccac ccaccgcgtg gcgtccccag
      301 gcacgcctag aattctagca cctcaggatc agtccagccc ccatttacaa ttggggaaac
      361 tgcggctccg aaagggtcag agggtacccg aggtcaagca gtagagagcg gactcgaact
      421 taagctcttg ctcttaggct gagacgcctt gatgtggcca ccggctaccc tctagtgtgt
      481 tgcatacttt ctaaggcggc ggctgcagca gcggctccat ccagcccgtc agctcctcct
      541 gcaaggcatg gctggctacc tgagtgaatc ggactttgtg atggtggagg agggcttcag
      601 tacccgagac ctgctgaagg aactcactct gggggcctca caggccacca cggacgaggt
      661 agctgccttc ttcgtggctg acctgggtgc catagtgagg aagcactttt gctttctgaa
      721 gtgcctgcca cgagtccggc ccttttatgc tgtcaagtgc aacagcagcc caggtgtgct
      781 gaaggttctg gcccagctgg ggctgggctt tagctgtgcc aacaaggcag agatggagtt
      841 ggtccagcat attggaatcc ctgccagtaa gatcatctgc gccaacccct gtaagcaaat
      901 tgcacagatc aaatatgctg ccaagcatgg gatccagctg ctgagctttg acaatgagat
      961 ggagctggca aaggtggtaa agagccaccc cagtgccaag atggttctgt gcattgctac
     1021 cgatgactcc cactccctga gctgcctgag cctaaagttt ggagtgtcac tgaaatcctg
     1081 cagacacctg cttgaaaatg cgaagaagca ccatgtggag gtggtgggtg tgagttttca
     1141 cattggcagt ggctgtcctg accctcaggc ctatgctcag tccatcgcag acgcccggct
     1201 cgtgtttgaa atgggcaccg agctgggtca caagatgcac gttctggacc ttggtggtgg
     1261 cttccctggc acagaagggg ccaaagtgag atttgaagag attgcttccg tgatcaactc
     1321 agccttggac ctgtacttcc cagagggctg tggcgtggac atctttgctg agctggggcg
     1381 ctactacgtg acctcggcct tcactgtggc agtcagcatc attgccaaga aggaggttct
     1441 gctagaccag cctggcaggg aggaggaaaa tggttccacc tccaagacca tcgtgtacca
     1501 ccttgatgag ggcgtgtatg ggatcttcaa ctcagtcctg tttgacaaca tctgccctac
     1561 ccccatcctg cagaagaaac catccacgga gcagcccctg tacagcagca gcctgtgggg
     1621 cccggcggtt gatggctgtg attgcgtggc tgagggcctg tggctgccgc aactacacgt
     1681 aggggactgg ctggtctttg acaacatggg cgcctacact gtgggcatgg gttccccctt
     1741 ttgggggacc caggcctgcc acatcaccta tgccatgtcc cgggtggcct gggaagcgct
     1801 gcgaaggcag ctgatggctg cagaacagga ggatgacgtg gagggtgtgt gcaagcctct
     1861 gtcctgcggc tgggagatca cagacaccct gtgcgtgggc cctgtcttca ccccagcgag
     1921 catcatgtga gtgggcctcg ttccccccgg agaatcccag cggggcctca gagatgcatc
     1981 tgggagaggt ggggaagatg gcaggcaagg gtacccttgg ccaggactct ggtgcccacc
     2041 ctgccacccc cgcgctccac ctgcagtgtt tctgccctgt aaataggacc agtcttacac
     2101 tcgctgtagt tcaagtatgc aacataaatc ctgttccttc cagctgtgtc tgcctcctct
     2161 gcagtgcaag gggcctggtc agccaggtgt gggggtgttc ttggggtctc ctttggtctc
     2221 cttcccacct ttgtaaatat aatgcaaata aataaatatt taggttttta aaaactgcag
     2281 cggaatctgg cagtttgatt cacaaagcag cctgggctag gcctggggca ggatttcccc
     2341 atcactcact gatgagccca caccctctgc tttagtcctg agccctggct gcagcgtgtg
     2401 cctcccccac tagtactcac cttatctgac tcatctctct cctcctcatg ggcctccagg
     2461 cctggtgcca taaggaaggg gctgctgtca gggactgaga tgggcagtta cgtagctcat
     2521 aactggtgaa tggcctttgg gtcagcccaa cacccagctt aaggcctggc ccagagtagg
     2581 ggcaatggag tatttaacac agctgtggaa attcatactg aagatacaga gccaagaaat
     2641 gggtgtgtgg gaggttttga gtggaccctg cacccttgct ctccctgcag gttggcaagg
     2701 cagtcagagt aaagcagaca cctggtggtc gcttttgctt ctttgggcag tgcctgttag
     2761 aacagggctg gccacggagt attgctgtgt ccagtgccga cagccctggc atcccctgag
     2821 actggcagtg cttatcagga caaaggctcc ttcacactgc cgggttccca aattatgccc
     2881 cggggtgtgt gagctgttga gcaaaggagt tcagatttta gagtccccct cagtggctgc
     2941 aggggactct aaatattttt ctgctgcaat taaaagattt gagatgtaat tcatatgcaa
     3001 tcatcaaatt caccctttta aatgcagaag cctgggtgca gtggctcaca cctgtaatcc
     3061 cagcactttg ggaggctgag gcaggtgatc acctgaggtc aggagttcga gaccagcctg
     3121 gccaacatgg caaaaccccg tctctactaa aaatacaaaa attagccagg tgtggtggta
     3181 tgtgcctgta attccagcta ctcaggaggc tgaggcagga gaatcacttg aacagggagg
     3241 tggaggtcgc agtgagccga ggttgcagtg agccgagatt gcaccactgc actccagcct
     3301 gggcgactga gcgagaccct gcctcaaata aagaaataaa taaataaagt ggagaagtta
     3361 gtggtttctg gtgtattcag agttgtgtaa ccatcaccct agaaagaaat cccataccca
     3421 ttagcagtca ctctccattt ttcccattcc ccagtccctg atgacacaaa tctaccttcc
     3481 atctctatgg atttgcttat tctggacatt gtattgtgat ggattttcta tcttcacttg
     3541 agcttctctc taggtaagcc tgaccatcct gcttcagtat ctcagccagt cctggtggga
     3601 actgtacgtg gctttgaggt catctcatga ggcaatgtgg catgggtttg gagtgaacga
     3661 ggtgctttct caaagccagg ggtgtctccc ttttccaggt gggatctagt tttcggtatc
     3721 ttgacaataa ataggctgaa agcttgggac atcaaaagac tcagggcaat cagaaagggt
     3781 tactctacta ccccgtgatc catcaaagcc acgatttaca ggtattacca tgccagtaat
     3841 tgtctatcag actctgagac ttcttccatc tcagatctcc aagcactcat acttcttttg
     3901 cggagaggga cataggtttt ctgctggaac caggcatctg ctgtgaaaag cgcaggaatc
     3961 ctgggaagat ctcatggctg gctacagtga gacccaggtg tagctgattc cctcttctga
     4021 gcaagtccac tgagggggca ttctgtggct tttgaaatga cagtggctgt catggagttt
     4081 ggatggattt ctcactggag cctttctagt gtttcatgtt ccatttgcag caaggatgtg
     4141 aaatttactt ttccaagaaa gatacacgca gaacttgatg tggcttactt gaggataata
     4201 gttaatagtc attttttccc agttatttgt ttttgtttct tatttcaatc tttttctaaa
     4261 gagaagaaaa aagcctgaaa tgtggagaat ggtaaggggc ttcaggcttg tgcaggcgaa
     4321 tctaagcagg ggtctcctgg acccctggct gcatgggcac tgcctcctcc aagctccctg
     4381 ctgagcgacc cactggcagt ggctcctcat gcctcctggc tgccttggaa gtcagatgtt
     4441 cctgttggcc tatcacagac ccatccttcc ctggggcatc acctgaggaa catcctcttc
     4501 ccaatgcctc cctacaaccc acctgtgcct cctgaagccc ctcctgcgcg cacactcact
     4561 ctctctcatt ctctccttca aggagttaac agatctgagc ttccatcttc tcatactcag
     4621 gactggcccc ttcttcccct ttcccctcca cagtccatcc tccactcagc agccagatgc
     4681 cgtacctcct gggattccgt ttcaccaaga atgaaattta aagtccttgg ccagctggct
     4741 ctctgactcc cacacttccc tctcacgcac tgggtcctgg ccacactggc ctcccctctg
     4801 ttcttcaaac actccactgc tgggcatgca tttactgtcc cctctctaga atgatcttcc
     4861 tgggttatct gtgggcctca ctcacttcat tcaggttctg tgcaaatgtt ttctttaggt
     4921 gaagccttct ggatcaccct ttagaaaata gcatgtccta gtctctctct tttctcttaa
     4981 ctagttttct ttttcttcat agtacctacc accactcaac atactctata acataactcc
     5041 ataatgtgtt ccataacaca agggcaactg tcagcccttc tagaatgtga gctctaggct
     5101 cttggaataa acctgattta ttttttcact gctgtgtcct tattacctag aacggagtag
     5161 gtgttcaaaa agtatatgct ggatgggcaa atgaataaac atgtctgaat ctgtctgaat
     5221 aaacatgctc ttaacctgtc
//
