LOCUS       NM_001185               1181 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens alpha-2-glycoprotein 1, zinc-binding (AZGP1), mRNA.
ACCESSION   NM_001185
VERSION     NM_001185.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1181)
  AUTHORS   Shen,W., Wei,W., Wang,S., Yang,X., Wang,R. and Tian,H.
  TITLE     RNA-binding protein AZGP1 inhibits epithelial cell proliferation by
            regulating the genes of alternative splicing in COPD
  JOURNAL   Gene 927, 148736 (2024)
   PUBMED   38950687
  REMARK    GeneRIF: RNA-binding protein AZGP1 inhibits epithelial cell
            proliferation by regulating the genes of alternative splicing in
            COPD.
REFERENCE   2  (bases 1 to 1181)
  AUTHORS   Kim,S.H., Oh,J.M., Roh,H., Lee,K.W., Lee,J.H. and Lee,W.J.
  TITLE     Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III
            Collagen Expression via Suppression of TGF-beta and p-Smad 2/3
            Pathway in Keloid Fibroblasts and Rat Incisional Model
  JOURNAL   Tissue Eng Regen Med 21 (7), 1079-1092 (2024)
   PUBMED   39105875
  REMARK    GeneRIF: Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and
            III Collagen Expression via Suppression of TGF-beta and p-Smad 2/3
            Pathway in Keloid Fibroblasts and Rat Incisional Model.
REFERENCE   3  (bases 1 to 1181)
  AUTHORS   Yang,S., Yin,Y., Sun,Y., Ai,D., Xia,X., Xu,X. and Song,J.
  TITLE     AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis in
            Periodontitis
  JOURNAL   J Dent Res 103 (6), 631-641 (2024)
   PUBMED   38491721
  REMARK    GeneRIF: AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis
            in Periodontitis.
REFERENCE   4  (bases 1 to 1181)
  AUTHORS   Wen,R.M., Qiu,Z., Marti,G.E.W., Peterson,E.E., Marques,F.J.G.,
            Bermudez,A., Wei,Y., Nolley,R., Lam,N., Polasko,A.L., Chiu,C.L.,
            Zhang,D., Cho,S., Karageorgos,G.M., McDonough,E., Chadwick,C.,
            Ginty,F., Jung,K.J., Machiraju,R., Mallick,P., Crowley,L.,
            Pollack,J.R., Zhao,H., Pitteri,S.J. and Brooks,J.D.
  TITLE     AZGP1 deficiency promotes angiogenesis in prostate cancer
  JOURNAL   J Transl Med 22 (1), 383 (2024)
   PUBMED   38659028
  REMARK    GeneRIF: AZGP1 deficiency promotes angiogenesis in prostate cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1181)
  AUTHORS   Kurtulus,E.M., Karis,D., Ercan,A.M. and Konukoglu,D.
  TITLE     Zinc Alpha-2 Glycoprotein, Acylated Ghrelin, and Zinc Levels in
            Prediabetics
  JOURNAL   In Vivo 38 (2), 975-981 (2024)
   PUBMED   38418147
  REMARK    GeneRIF: Zinc Alpha-2 Glycoprotein, Acylated Ghrelin, and Zinc
            Levels in Prediabetics.
REFERENCE   6  (bases 1 to 1181)
  AUTHORS   Freije,J.P., Fueyo,A., Uria,J.A., Velasco,G., Sanchez,L.M.,
            Lopez-Boado,Y.S. and Lopez-Otin,C.
  TITLE     Human Zn-alpha 2-glycoprotein: complete genomic sequence,
            identification of a related pseudogene and relationship to class I
            major histocompatibility complex genes
  JOURNAL   Genomics 18 (3), 575-587 (1993)
   PUBMED   8307568
REFERENCE   7  (bases 1 to 1181)
  AUTHORS   Freije,J.P., Fueyo,A., Uria,J. and Lopez-Otin,C.
  TITLE     Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis
            in benign and malignant breast tissues
  JOURNAL   FEBS Lett 290 (1-2), 247-249 (1991)
   PUBMED   1915885
REFERENCE   8  (bases 1 to 1181)
  AUTHORS   Tada,T., Ohkubo,I., Niwa,M., Sasaki,M., Tateyama,H. and Eimoto,T.
  TITLE     Immunohistochemical localization of Zn-alpha 2-glycoprotein in
            normal human tissues
  JOURNAL   J Histochem Cytochem 39 (9), 1221-1226 (1991)
   PUBMED   1918940
REFERENCE   9  (bases 1 to 1181)
  AUTHORS   Ueyama,H., Niwa,M., Tada,T., Sasaki,M. and Ohkubo,I.
  TITLE     Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein
            cDNA and chromosomal assignment of its gene
  JOURNAL   Biochem Biophys Res Commun 177 (2), 696-703 (1991)
   PUBMED   2049092
REFERENCE   10 (bases 1 to 1181)
  AUTHORS   Araki,T., Gejyo,F., Takagaki,K., Haupt,H., Schwick,H.G., Burgi,W.,
            Marti,T., Schaller,J., Rickli,E., Brossmer,R. et al.
  TITLE     Complete amino acid sequence of human plasma Zn-alpha
            2-glycoprotein and its homology to histocompatibility antigens
  JOURNAL   Proc Natl Acad Sci U S A 85 (3), 679-683 (1988)
   PUBMED   3422450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005306.1 and BC033830.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001185.3.
            
            CCDS Note: This CCDS representation uses the 5'-most in-frame start
            codon, which is conserved in higher primates, dog and horse. An
            alternative downstream start codon also exists, and would result in
            a protein that is 3 aa shorter at the N-terminus. Both the longer
            and shorter N-termini have predicted signal peptides according to
            SignalP 3.0. There is no experimental evidence showing which start
            codon is preferentially used in vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005306.1, BC033830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292401.9/ ENSP00000292401.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               BC005306.1         1-107
            108-322             BC033830.1         136-350
            323-1181            BC005306.1         323-1181
FEATURES             Location/Qualifiers
     source          1..1181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1181
                     /gene="AZGP1"
                     /gene_synonym="ZA2G; ZAG"
                     /note="alpha-2-glycoprotein 1, zinc-binding"
                     /db_xref="GeneID:563"
                     /db_xref="HGNC:HGNC:910"
                     /db_xref="MIM:194460"
     exon            1..87
                     /gene="AZGP1"
                     /gene_synonym="ZA2G; ZAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..908
                     /gene="AZGP1"
                     /gene_synonym="ZA2G; ZAG"
                     /note="Alpha-2-glycoprotein, zinc;
                     zinc-alpha-2-glycoprotein; Zn-alpha2-glycoprotein;
                     zn-alpha-2-GP; zn-alpha-2-glycoprotein; testicular tissue
                     protein Li 227"
                     /codon_start=1
                     /product="zinc-alpha-2-glycoprotein precursor"
                     /protein_id="NP_001176.1"
                     /db_xref="CCDS:CCDS5680.1"
                     /db_xref="GeneID:563"
                     /db_xref="HGNC:HGNC:910"
                     /db_xref="MIM:194460"
                     /translation="MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDV
                     PAFQALGSLNDLQFFRYNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLK
                     DIVEYYNDSNGSHVLQGRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPA
                     AQITKQKWEAEPVYVQRAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPG
                     EKKKLKCLAYDFYPGKIDVHWTRAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQDTA
                     PYSCHVQHSSLAQPLVVPWEAS"
     exon            88..348
                     /gene="AZGP1"
                     /gene_synonym="ZA2G; ZAG"
                     /inference="alignment:Splign:2.1.0"
     exon            349..624
                     /gene="AZGP1"
                     /gene_synonym="ZA2G; ZAG"
                     /inference="alignment:Splign:2.1.0"
     exon            625..1181
                     /gene="AZGP1"
                     /gene_synonym="ZA2G; ZAG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1153..1158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AZGP1"
                     /gene_synonym="ZA2G; ZAG"
                     /note="hexamer: AATAAA"
     polyA_site      1181
                     /gene="AZGP1"
                     /gene_synonym="ZA2G; ZAG"
                     /note="major polyA site"
ORIGIN      
        1 aagcagacac aatggtaaga atggtgcctg tcctgctgtc tctgctgctg cttctgggtc
       61 ctgctgtccc ccaggagaac caagatggtc gttactctct gacctatatc tacactgggc
      121 tgtccaagca tgttgaagac gtccccgcgt ttcaggccct tggctcactc aatgacctcc
      181 agttctttag atacaacagt aaagacagga agtctcagcc catgggactc tggagacagg
      241 tggaaggaat ggaggattgg aagcaggaca gccaacttca gaaggccagg gaggacatct
      301 ttatggagac cctgaaagac atcgtggagt attacaacga cagtaacggg tctcacgtat
      361 tgcagggaag gtttggttgt gagatcgaga ataacagaag cagcggagca ttctggaaat
      421 attactatga tggaaaggac tacattgaat tcaacaaaga aatcccagcc tgggtcccct
      481 tcgacccagc agcccagata accaagcaga agtgggaggc agaaccagtc tacgtgcagc
      541 gggccaaggc ttacctggag gaggagtgcc ctgcgactct gcggaaatac ctgaaataca
      601 gcaaaaatat cctggaccgg caagatcctc cctctgtggt ggtcaccagc caccaggccc
      661 caggagaaaa gaagaaactg aagtgcctgg cctacgactt ctacccaggg aaaattgatg
      721 tgcactggac tcgggccggc gaggtgcagg agcctgagtt acggggagat gttcttcaca
      781 atggaaatgg cacttaccag tcctgggtgg tggtggcagt gcccccgcag gacacagccc
      841 cctactcctg ccacgtgcag cacagcagcc tggcccagcc cctcgtggtg ccctgggagg
      901 ccagctagga agcaagggtt ggaggcaatg tgggatctca gacccagtag ctgcccttcc
      961 tgcctgatgt gggagctgaa ccacagaaat cacagtcaat ggatccacaa ggcctgagga
     1021 gcagtgtggg gggacagaca ggaggtggat ttggagaccg aagactggga tgcctgtctt
     1081 gagtagactt ggacccaaaa aatcatctca ccttgagccc acccccaccc cattgtctaa
     1141 tctgtagaag ctaataaata atcatccctc cttgcctagc a
//
