LOCUS       NM_021913               4717 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens AXL receptor tyrosine kinase (AXL), transcript variant
            1, mRNA.
ACCESSION   NM_021913
VERSION     NM_021913.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4717)
  AUTHORS   Sinha,S., Guo,R., Del Busso,M.D., Han,W., Boysen,J., Wellik,L.E.,
            Ghosh,A.K. and Kay,N.E.
  TITLE     Aberrant activation of AXL may drive progression of squamous cell
            carcinoma in CLL patients: a mechanistic study with clinical
            implications
  JOURNAL   Br J Cancer 131 (3), 589-600 (2024)
   PUBMED   38886556
  REMARK    GeneRIF: Aberrant activation of AXL may drive progression of
            squamous cell carcinoma in CLL patients: a mechanistic study with
            clinical implications.
REFERENCE   2  (bases 1 to 4717)
  AUTHORS   Baskol,G., Yetkin,M.O., Sevim,D.G., Guclu,K., Arda,H.,
            Saracoglu,H., Gahramanov,K. and Evereklioglu,C.
  TITLE     Serum GAS6, sAXL, IL-10, NO, and BCL-2 levels are decreased in
            patients with Behcet's disease
  JOURNAL   Indian J Ophthalmol 72 (Suppl 3), S468-S472 (2024)
   PUBMED   38648454
  REMARK    GeneRIF: Serum GAS6, sAXL, IL-10, NO, and BCL-2 levels are
            decreased in patients with Behcet's disease.
REFERENCE   3  (bases 1 to 4717)
  AUTHORS   Nerviani,A., Boutet,M.A., Ghirardi,G.M., Goldmann,K., Sciacca,E.,
            Rivellese,F., Pontarini,E., Prediletto,E., Abatecola,F.,
            Caliste,M., Pagani,S., Mauro,D., Bellan,M., Cubuk,C., Lau,R.,
            Church,S.E., Hudson,B.M., Humby,F., Bombardieri,M., Lewis,M.J. and
            Pitzalis,C.
  TITLE     Axl and MerTK regulate synovial inflammation and are modulated by
            IL-6 inhibition in rheumatoid arthritis
  JOURNAL   Nat Commun 15 (1), 2398 (2024)
   PUBMED   38493215
  REMARK    GeneRIF: Axl and MerTK regulate synovial inflammation and are
            modulated by IL-6 inhibition in rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4717)
  AUTHORS   Repici,A., Ardizzone,A., De Luca,F., Colarossi,L.,
            Prestifilippo,A., Pizzino,G., Paterniti,I., Esposito,E. and
            Capra,A.P.
  TITLE     Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to
            the Pathogenetic Mechanisms of Glioblastoma
  JOURNAL   Cells 13 (4), 361 (2024)
   PUBMED   38391974
  REMARK    GeneRIF: Signaling Pathways of AXL Receptor Tyrosine Kinase
            Contribute to the Pathogenetic Mechanisms of Glioblastoma.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4717)
  AUTHORS   Chen,M., Yin,B., Liu,Y., Li,M., Shen,S., Wu,J., Li,W. and Fan,J.
  TITLE     ARRDC3 regulates the targeted therapy sensitivity of clear cell
            renal cell carcinoma by promoting AXL degradation
  JOURNAL   Cell Cycle 23 (1), 56-69 (2024)
   PUBMED   38389126
  REMARK    GeneRIF: ARRDC3 regulates the targeted therapy sensitivity of clear
            cell renal cell carcinoma by promoting AXL degradation.
REFERENCE   6  (bases 1 to 4717)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
REFERENCE   7  (bases 1 to 4717)
  AUTHORS   Bergsagel,P.L., Victor-Kobrin,C., Timblin,C.R., Trepel,J. and
            Kuehl,W.M.
  TITLE     A murine cDNA encodes a pan-epithelial glycoprotein that is also
            expressed on plasma cells
  JOURNAL   J Immunol 148 (2), 590-596 (1992)
   PUBMED   1729376
REFERENCE   8  (bases 1 to 4717)
  AUTHORS   Janssen,J.W., Schulz,A.S., Steenvoorden,A.C., Schmidberger,M.,
            Strehl,S., Ambros,P.F. and Bartram,C.R.
  TITLE     A novel putative tyrosine kinase receptor with oncogenic potential
  JOURNAL   Oncogene 6 (11), 2113-2120 (1991)
   PUBMED   1834974
REFERENCE   9  (bases 1 to 4717)
  AUTHORS   O'Bryan,J.P., Frye,R.A., Cogswell,P.C., Neubauer,A., Kitch,B.,
            Prokop,C., Espinosa,R. 3rd, Le Beau,M.M., Earp,H.S. and Liu,E.T.
  TITLE     axl, a transforming gene isolated from primary human myeloid
            leukemia cells, encodes a novel receptor tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (10), 5016-5031 (1991)
   PUBMED   1656220
REFERENCE   10 (bases 1 to 4717)
  AUTHORS   Partanen,J., Makela,T.P., Alitalo,R., Lehvaslaiho,H. and Alitalo,K.
  TITLE     Putative tyrosine kinases expressed in K-562 human leukemia cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (22), 8913-8917 (1990)
   PUBMED   2247464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL556721.3, HY045208.1,
            BC032229.1, AK309139.1, X66029.1, CA437238.1, AI309979.1 and
            AI300772.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021913.4.
            
            Summary: The protein encoded by this gene is a member of the
            Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded
            protein possesses an extracellular domain which is composed of two
            immunoglobulin-like motifs at the N-terminal, followed by two
            fibronectin type-III motifs. It transduces signals from the
            extracellular matrix into the cytoplasm by binding to the vitamin
            K-dependent protein growth arrest-specific 6 (Gas6). This gene may
            be involved in several cellular functions including growth,
            migration, aggregation and anti-inflammation in multiple cell
            types. The encoded protein acts as a host cell receptor for
            multiple viruses, including Marburg, Ebola and Lassa viruses and is
            a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq,
            Sep 2021].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.147591.1, BC032229.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000301178.9/ ENSP00000301178.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL556721.3         21-22
            3-144               HY045208.1         2-143
            145-1715            BC032229.1         140-1710
            1716-3245           AK309139.1         1118-2647
            3246-3280           X66029.1           202-236
            3281-3306           CA437238.1         19-44
            3307-3724           AI309979.1         31-448
            3725-4299           X66029.1           684-1258
            4300-4717           AI300772.1         10-427              c
FEATURES             Location/Qualifiers
     source          1..4717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..4717
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /note="AXL receptor tyrosine kinase"
                     /db_xref="GeneID:558"
                     /db_xref="HGNC:HGNC:905"
                     /db_xref="MIM:109135"
     exon            1..255
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..2855
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; AXL transforming sequence/gene;
                     tyrosine-protein kinase receptor UFO; AXL oncogene"
                     /codon_start=1
                     /product="tyrosine-protein kinase receptor UFO isoform 1
                     precursor"
                     /protein_id="NP_068713.2"
                     /db_xref="CCDS:CCDS12575.1"
                     /db_xref="GeneID:558"
                     /db_xref="HGNC:HGNC:905"
                     /db_xref="MIM:109135"
                     /translation="MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNI
                     TGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQL
                     RITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSC
                     QAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRT
                     ATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEP
                     DPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPL
                     GPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLE
                     LQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPW
                     WYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRT
                     TEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAV
                     KTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMK
                     HGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNE
                     NMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMW
                     EIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTE
                     LREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLT
                     AAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA"
     exon            256..478
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            479..579
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            580..756
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            757..837
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            838..953
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1164
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1304
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1455
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1482
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1615
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1707
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1803
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1881
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1974
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2096
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2206
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2366
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2503
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..4717
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4695..4700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /note="hexamer: CATAAA"
     polyA_site      4717
                     /gene="AXL"
                     /gene_synonym="ARK; AXL3; JTK11; Tyro7; UFO"
                     /note="major polyA site"
ORIGIN      
        1 gagaaggcgg ctgctgggca gagccggtgg caagggcctc ccctgccgct gtgccaggca
       61 ggcagtgcca aatccgggga gcctggagct ggggggaggg ccggggacag cccggccctg
      121 ccccctcccc cgctgggagc ccaacaactt ctgaggaaag tttggcaccc atggcgtggc
      181 ggtgccccag gatgggcagg gtcccgctgg cctggtgctt ggcgctgtgc ggctgggcgt
      241 gcatggcccc caggggcacg caggctgaag aaagtccctt cgtgggcaac ccagggaata
      301 tcacaggtgc ccggggactc acgggcaccc ttcggtgtca gctccaggtt cagggagagc
      361 cccccgaggt acattggctt cgggatggac agatcctgga gctcgcggac agcacccaga
      421 cccaggtgcc cctgggtgag gatgaacagg atgactggat agtggtcagc cagctcagaa
      481 tcacctccct gcagctttcc gacacgggac agtaccagtg tttggtgttt ctgggacatc
      541 agaccttcgt gtcccagcct ggctatgttg ggctggaggg cttgccttac ttcctggagg
      601 agcccgaaga caggactgtg gccgccaaca cccccttcaa cctgagctgc caagctcagg
      661 gacccccaga gcccgtggac ctactctggc tccaggatgc tgtccccctg gccacggctc
      721 caggtcacgg cccccagcgc agcctgcatg ttccagggct gaacaagaca tcctctttct
      781 cctgcgaagc ccataacgcc aagggggtca ccacatcccg cacagccacc atcacagtgc
      841 tcccccagca gccccgtaac ctccacctgg tctcccgcca acccacggag ctggaggtgg
      901 cttggactcc aggcctgagc ggcatctacc ccctgaccca ctgcaccctg caggctgtgc
      961 tgtcagacga tgggatgggc atccaggcgg gagaaccaga ccccccagag gagcccctca
     1021 cctcgcaagc atccgtgccc ccccatcagc ttcggctagg cagcctccat cctcacaccc
     1081 cttatcacat ccgcgtggca tgcaccagca gccagggccc ctcatcctgg acccactggc
     1141 ttcctgtgga gacgccggag ggagtgcccc tgggcccccc tgagaacatt agtgctacgc
     1201 ggaatgggag ccaggccttc gtgcattggc aagagccccg ggcgcccctg cagggtaccc
     1261 tgttagggta ccggctggcg tatcaaggcc aggacacccc agaggtgcta atggacatag
     1321 ggctaaggca agaggtgacc ctggagctgc agggggacgg gtctgtgtcc aatctgacag
     1381 tgtgtgtggc agcctacact gctgctgggg atggaccctg gagcctccca gtacccctgg
     1441 aggcctggcg cccagggcaa gcacagccag tccaccagct ggtgaaggaa ccttcaactc
     1501 ctgccttctc gtggccctgg tggtatgtac tgctaggagc agtcgtggcc gctgcctgtg
     1561 tcctcatctt ggctctcttc cttgtccacc ggcgaaagaa ggagacccgt tatggagaag
     1621 tgtttgaacc aacagtggaa agaggtgaac tggtagtcag gtaccgcgtg cgcaagtcct
     1681 acagtcgtcg gaccactgaa gctaccttga acagcctggg catcagtgaa gagctgaagg
     1741 agaagctgcg ggatgtgatg gtggaccggc acaaggtggc cctggggaag actctgggag
     1801 agggagagtt tggagctgtg atggaaggcc agctcaacca ggacgactcc atcctcaagg
     1861 tggctgtgaa gacgatgaag attgccatct gcacgaggtc agagctggag gatttcctga
     1921 gtgaagcggt ctgcatgaag gaatttgacc atcccaacgt catgaggctc atcggtgtct
     1981 gtttccaggg ttctgaacga gagagcttcc cagcacctgt ggtcatctta cctttcatga
     2041 aacatggaga cctacacagc ttcctcctct attcccggct cggggaccag ccagtgtacc
     2101 tgcccactca gatgctagtg aagttcatgg cagacatcgc cagtggcatg gagtatctga
     2161 gtaccaagag attcatacac cgggacctgg cggccaggaa ctgcatgctg aatgagaaca
     2221 tgtccgtgtg tgtggcggac ttcgggctct ccaagaagat ctacaatggg gactactacc
     2281 gccagggacg tatcgccaag atgccagtca agtggattgc cattgagagt ctagctgacc
     2341 gtgtctacac cagcaagagc gatgtgtggt ccttcggggt gacaatgtgg gagattgcca
     2401 caagaggcca aaccccatat ccgggcgtgg agaacagcga gatttatgac tatctgcgcc
     2461 agggaaatcg cctgaagcag cctgcggact gtctggatgg actgtatgcc ttgatgtcgc
     2521 ggtgctggga gctaaatccc caggaccggc caagttttac agagctgcgg gaagatttgg
     2581 agaacacact gaaggccttg cctcctgccc aggagcctga cgaaatcctc tatgtcaaca
     2641 tggatgaggg tggaggttat cctgaacccc ctggagctgc aggaggagct gaccccccaa
     2701 cccagccaga ccctaaggat tcctgtagct gcctcactgc ggctgaggtc catcctgctg
     2761 gacgctatgt cctctgccct tccacaaccc ctagccccgc tcagcctgct gataggggct
     2821 ccccagcagc cccagggcag gaggatggtg cctgagacaa ccctccacct ggtactccct
     2881 ctcaggatcc aagctaagca ctgccactgg ggaaaactcc accttcccac tttcccaccc
     2941 cacgccttat ccccacttgc agccctgtct tcctacctat cccacctcca tcccagacag
     3001 gtccctcccc ttctctgtgc agtagcatca ccttgaaagc agtagcatca ccatctgtaa
     3061 aaggaagggg ttggattgca atatctgaag ccctcccagg tgttaacatt ccaagactct
     3121 agagtccaag gtttaaagag tctagattca aaggttctag gtttcaaaga tgctgtgagt
     3181 ctttggttct aaggacctga aattccaaag tctctaattc tattaaagtg ctaaggttct
     3241 aaggcctact tttttttttt tttttttttt tttttttttt gcgatagagt ctcactgtgt
     3301 cacccaggct ggagtgcagt ggtgcaatct cgcctcactg caaccttcac ctaccgagtt
     3361 caagtgattt tcctgccttg gcctcccaag tagctgggat tacaggtgtg tgccaccaca
     3421 cccggctaat ttttatattt ttagtagaga cagggtttca ccatgttggc caggctggtc
     3481 taaaactcct gacctcaagt gatctgccca cctcagcctc ccaaagtgct gagattacag
     3541 gcatgagcca ctgcactcaa ccttaagacc tactgttcta aagctctgac attatgtggt
     3601 tttagatttt ctggttctaa catttttgat aaagcctcaa ggttttaggt tctaaagttc
     3661 taagattctg attttaggag ctaaggctct atgagtctag atgtttattc ttctagagtt
     3721 cagagtcctt aaaatgtaag attatagatt ctaaagattc tatagttcta gacatggagg
     3781 ttctaaggcc taggattcta aaatgtgatg ttctaaggct ctgagagtct agattctctg
     3841 gctgtaaggc tctagatcat aaggcttcaa aatgttatct tctcaagttc taagattcta
     3901 atgatgatca attatagttt ctgaggcttt atgataatag attctcttgt ataagatcct
     3961 agatcctaag ggtcgaaagc tctagaatct gcaattcaaa agttccaaga gtctaaagat
     4021 ggagtttcta aggtccggtg ttctaagatg tgatattcta agacttactc taagatctta
     4081 gattctctgt gtctaagatt ctagatcaga tgctccaaga ttctagatga ttaaataaga
     4141 ttctaacggt ctgttctgtt tcaaggcact ctagattcca ttggtccaag attccggatc
     4201 ctaagcatct aagttataag actctcacac tcagttgtga ctaactagac accaaagttc
     4261 taataatttc taatgttgga cacctttagg ttctttgctg cattctgcct ctctaggacc
     4321 atggttaaga gtccaagaat ccacatttct aaaatcttat agttctaggc actgtagttc
     4381 taagactcaa atgttctaag tttctaagat tctaaaggtc cacaggtcta gactattagg
     4441 tgcaatttca aggttctaac cctatactgt agtattcttt ggggtgcccc tctccttctt
     4501 agctatcatt gcttcctcct ccccaactgt gggggtgtgc ccccttcaag cctgtgcaat
     4561 gcattaggga tgcctccttt cccgcagggg atggacgatc tcccaccttt cgggccatgt
     4621 tgcccccgtg agccaatccc tcaccttctg agtacagagt gtggactctg gtgcctccag
     4681 aggggctcag gtcacataaa actttgtata tcaacga
//
